scholarly journals IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms

Sensors ◽  
2020 ◽  
Vol 20 (9) ◽  
pp. 2556
Author(s):  
Liyang Wang ◽  
Yao Mu ◽  
Jing Zhao ◽  
Xiaoya Wang ◽  
Huilian Che

The clinical symptoms of prediabetes are mild and easy to overlook, but prediabetes may develop into diabetes if early intervention is not performed. In this study, a deep learning model—referred to as IGRNet—is developed to effectively detect and diagnose prediabetes in a non-invasive, real-time manner using a 12-lead electrocardiogram (ECG) lasting 5 s. After searching for an appropriate activation function, we compared two mainstream deep neural networks (AlexNet and GoogLeNet) and three traditional machine learning algorithms to verify the superiority of our method. The diagnostic accuracy of IGRNet is 0.781, and the area under the receiver operating characteristic curve (AUC) is 0.777 after testing on the independent test set including mixed group. Furthermore, the accuracy and AUC are 0.856 and 0.825, respectively, in the normal-weight-range test set. The experimental results indicate that IGRNet diagnoses prediabetes with high accuracy using ECGs, outperforming existing other machine learning methods; this suggests its potential for application in clinical practice as a non-invasive, prediabetes diagnosis technology.

2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Sen Yang ◽  
Yaping Zhang ◽  
Siu-Yeung Cho ◽  
Ricardo Correia ◽  
Stephen P. Morgan

AbstractConventional blood pressure (BP) measurement methods have different drawbacks such as being invasive, cuff-based or requiring manual operations. There is significant interest in the development of non-invasive, cuff-less and continual BP measurement based on physiological measurement. However, in these methods, extracting features from signals is challenging in the presence of noise or signal distortion. When using machine learning, errors in feature extraction result in errors in BP estimation, therefore, this study explores the use of raw signals as a direct input to a deep learning model. To enable comparison with the traditional machine learning models which use features from the photoplethysmogram and electrocardiogram, a hybrid deep learning model that utilises both raw signals and physical characteristics (age, height, weight and gender) is developed. This hybrid model performs best in terms of both diastolic BP (DBP) and systolic BP (SBP) with the mean absolute error being 3.23 ± 4.75 mmHg and 4.43 ± 6.09 mmHg respectively. DBP and SBP meet the Grade A and Grade B performance requirements of the British Hypertension Society respectively.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rajat Garg ◽  
Anil Kumar ◽  
Nikunj Bansal ◽  
Manish Prateek ◽  
Shashi Kumar

AbstractUrban area mapping is an important application of remote sensing which aims at both estimation and change in land cover under the urban area. A major challenge being faced while analyzing Synthetic Aperture Radar (SAR) based remote sensing data is that there is a lot of similarity between highly vegetated urban areas and oriented urban targets with that of actual vegetation. This similarity between some urban areas and vegetation leads to misclassification of the urban area into forest cover. The present work is a precursor study for the dual-frequency L and S-band NASA-ISRO Synthetic Aperture Radar (NISAR) mission and aims at minimizing the misclassification of such highly vegetated and oriented urban targets into vegetation class with the help of deep learning. In this study, three machine learning algorithms Random Forest (RF), K-Nearest Neighbour (KNN), and Support Vector Machine (SVM) have been implemented along with a deep learning model DeepLabv3+ for semantic segmentation of Polarimetric SAR (PolSAR) data. It is a general perception that a large dataset is required for the successful implementation of any deep learning model but in the field of SAR based remote sensing, a major issue is the unavailability of a large benchmark labeled dataset for the implementation of deep learning algorithms from scratch. In current work, it has been shown that a pre-trained deep learning model DeepLabv3+ outperforms the machine learning algorithms for land use and land cover (LULC) classification task even with a small dataset using transfer learning. The highest pixel accuracy of 87.78% and overall pixel accuracy of 85.65% have been achieved with DeepLabv3+ and Random Forest performs best among the machine learning algorithms with overall pixel accuracy of 77.91% while SVM and KNN trail with an overall accuracy of 77.01% and 76.47% respectively. The highest precision of 0.9228 is recorded for the urban class for semantic segmentation task with DeepLabv3+ while machine learning algorithms SVM and RF gave comparable results with a precision of 0.8977 and 0.8958 respectively.


2021 ◽  
Author(s):  
Lukman Ismael ◽  
Pejman Rasti ◽  
Florian Bernard ◽  
Philippe Menei ◽  
Aram Ter Minassian ◽  
...  

BACKGROUND The functional MRI (fMRI) is an essential tool for the presurgical planning of brain tumor removal, allowing the identification of functional brain networks in order to preserve the patient’s neurological functions. One fMRI technique used to identify the functional brain network is the resting-state-fMRI (rsfMRI). However, this technique is not routinely used because of the necessity to have a expert reviewer to identify manually each functional networks. OBJECTIVE We aimed to automatize the detection of brain functional networks in rsfMRI data using deep learning and machine learning algorithms METHODS We used the rsfMRI data of 82 healthy patients to test the diagnostic performance of our proposed end-to-end deep learning model to the reference functional networks identified manually by 2 expert reviewers. RESULTS Experiment results show the best performance of 86% correct recognition rate obtained from the proposed deep learning architecture which shows its superiority over other machine learning algorithms that were equally tested for this classification task. CONCLUSIONS The proposed end-to-end deep learning model was the most performant machine learning algorithm. The use of this model to automatize the functional networks detection in rsfMRI may allow to broaden the use of the rsfMRI, allowing the presurgical identification of these networks and thus help to preserve the patient’s neurological status. CLINICALTRIAL Comité de protection des personnes Ouest II, decision reference CPP 2012-25)


2021 ◽  
Vol 11 (4) ◽  
pp. 286-290
Author(s):  
Md. Golam Kibria ◽  
◽  
Mehmet Sevkli

The increased credit card defaulters have forced the companies to think carefully before the approval of credit applications. Credit card companies usually use their judgment to determine whether a credit card should be issued to the customer satisfying certain criteria. Some machine learning algorithms have also been used to support the decision. The main objective of this paper is to build a deep learning model based on the UCI (University of California, Irvine) data sets, which can support the credit card approval decision. Secondly, the performance of the built model is compared with the other two traditional machine learning algorithms: logistic regression (LR) and support vector machine (SVM). Our results show that the overall performance of our deep learning model is slightly better than that of the other two models.


Electronics ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 39
Author(s):  
Zhiyuan Xie ◽  
Shichang Du ◽  
Jun Lv ◽  
Yafei Deng ◽  
Shiyao Jia

Remaining Useful Life (RUL) prediction is significant in indicating the health status of the sophisticated equipment, and it requires historical data because of its complexity. The number and complexity of such environmental parameters as vibration and temperature can cause non-linear states of data, making prediction tremendously difficult. Conventional machine learning models such as support vector machine (SVM), random forest, and back propagation neural network (BPNN), however, have limited capacity to predict accurately. In this paper, a two-phase deep-learning-model attention-convolutional forget-gate recurrent network (AM-ConvFGRNET) for RUL prediction is proposed. The first phase, forget-gate convolutional recurrent network (ConvFGRNET) is proposed based on a one-dimensional analog long short-term memory (LSTM), which removes all the gates except the forget gate and uses chrono-initialized biases. The second phase is the attention mechanism, which ensures the model to extract more specific features for generating an output, compensating the drawbacks of the FGRNET that it is a black box model and improving the interpretability. The performance and effectiveness of AM-ConvFGRNET for RUL prediction is validated by comparing it with other machine learning methods and deep learning methods on the Commercial Modular Aero-Propulsion System Simulation (C-MAPSS) dataset and a dataset of ball screw experiment.


2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 8536-8536
Author(s):  
Gouji Toyokawa ◽  
Fahdi Kanavati ◽  
Seiya Momosaki ◽  
Kengo Tateishi ◽  
Hiroaki Takeoka ◽  
...  

8536 Background: Lung cancer is the leading cause of cancer-related death in many countries, and its prognosis remains unsatisfactory. Since treatment approaches differ substantially based on the subtype, such as adenocarcinoma (ADC), squamous cell carcinoma (SCC) and small cell lung cancer (SCLC), an accurate histopathological diagnosis is of great importance. However, if the specimen is solely composed of poorly differentiated cancer cells, distinguishing between histological subtypes can be difficult. The present study developed a deep learning model to classify lung cancer subtypes from whole slide images (WSIs) of transbronchial lung biopsy (TBLB) specimens, in particular with the aim of using this model to evaluate a challenging test set of indeterminate cases. Methods: Our deep learning model consisted of two separately trained components: a convolutional neural network tile classifier and a recurrent neural network tile aggregator for the WSI diagnosis. We used a training set consisting of 638 WSIs of TBLB specimens to train a deep learning model to classify lung cancer subtypes (ADC, SCC and SCLC) and non-neoplastic lesions. The training set consisted of 593 WSIs for which the diagnosis had been determined by pathologists based on the visual inspection of Hematoxylin-Eosin (HE) slides and of 45 WSIs of indeterminate cases (64 ADCs and 19 SCCs). We then evaluated the models using five independent test sets. For each test set, we computed the receiver operator curve (ROC) area under the curve (AUC). Results: We applied the model to an indeterminate test set of WSIs obtained from TBLB specimens that pathologists had not been able to conclusively diagnose by examining the HE-stained specimens alone. Overall, the model achieved ROC AUCs of 0.993 (confidence interval [CI] 0.971-1.0) and 0.996 (0.981-1.0) for ADC and SCC, respectively. We further evaluated the model using five independent test sets consisting of both TBLB and surgically resected lung specimens (combined total of 2490 WSIs) and obtained highly promising results with ROC AUCs ranging from 0.94 to 0.99. Conclusions: In this study, we demonstrated that a deep learning model could be trained to predict lung cancer subtypes in indeterminate TBLB specimens. The extremely promising results obtained show that if deployed in clinical practice, a deep learning model that is capable of aiding pathologists in diagnosing indeterminate cases would be extremely beneficial as it would allow a diagnosis to be obtained sooner and reduce costs that would result from further investigations.


Author(s):  
Tossaporn Santad ◽  
Piyarat Silapasupphakornwong ◽  
Worawat Choensawat ◽  
Kingkarn Sookhanaphibarn

2019 ◽  
Author(s):  
Mojtaba Haghighatlari ◽  
Gaurav Vishwakarma ◽  
Mohammad Atif Faiz Afzal ◽  
Johannes Hachmann

<div><div><div><p>We present a multitask, physics-infused deep learning model to accurately and efficiently predict refractive indices (RIs) of organic molecules, and we apply it to a library of 1.5 million compounds. We show that it outperforms earlier machine learning models by a significant margin, and that incorporating known physics into data-derived models provides valuable guardrails. Using a transfer learning approach, we augment the model to reproduce results consistent with higher-level computational chemistry training data, but with a considerably reduced number of corresponding calculations. Prediction errors of machine learning models are typically smallest for commonly observed target property values, consistent with the distribution of the training data. However, since our goal is to identify candidates with unusually large RI values, we propose a strategy to boost the performance of our model in the remoter areas of the RI distribution: We bias the model with respect to the under-represented classes of molecules that have values in the high-RI regime. By adopting a metric popular in web search engines, we evaluate our effectiveness in ranking top candidates. We confirm that the models developed in this study can reliably predict the RIs of the top 1,000 compounds, and are thus able to capture their ranking. We believe that this is the first study to develop a data-derived model that ensures the reliability of RI predictions by model augmentation in the extrapolation region on such a large scale. These results underscore the tremendous potential of machine learning in facilitating molecular (hyper)screening approaches on a massive scale and in accelerating the discovery of new compounds and materials, such as organic molecules with high-RI for applications in opto-electronics.</p></div></div></div>


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