scholarly journals Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode

Sensors ◽  
2021 ◽  
Vol 21 (17) ◽  
pp. 5792
Author(s):  
Marek Szlósarczyk ◽  
Robert Piech ◽  
Anna Milc ◽  
Urszula Hubicka
Keyword(s):  
Supporting Electrolyte ◽  
Pulse Height ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Film Electrode ◽  
Optimal Conditions ◽  
Step Potential ◽  
Voltammetric Method ◽  
Deposition Step

In this work, a new sensitive voltammetric method for the determination of rifampicin without time-consuming preconcentration is presented. The objective was to develop a simple, fast and sensitive voltammetric procedure for the analysis of rifampicin in pharmaceutical products. The cyclic renewable mercury film silver-based electrode (Hg(Ag)FE) was applied as a working electrode for this purpose. The optimal conditions for the determination of rifampicin were defined, in terms of the composition of supporting electrolyte (including pH) and instrumental parameters (potential and time of deposition, step potential, pulse height). The method was validated resulting in a satisfactory linearity range of 0.4–250.0 µgmL−1; the limits of detection and quantification are 0.12 µgmL−1 and 0.4 µgmL−1, respectively; and the repeatability of the method expressed as RSD is 4.1% (n = 6) with a surface area of 10.9 mm2. The proposed method was successfully applied in the analysis of rifampicin in simple and composed pharmaceutical formulations.

Analysis of Nicotine in Antismoking Pharmaceutical Products by Differential Pulse Polarography and Voltammetry

2007 ◽  
Vol 72 (9) ◽  
pp. 1207-1213 ◽  
Author(s):  
Atle Hannisdal ◽  
Øyvind Mikkelsen ◽  
Knut H. Schrøder
Keyword(s):  
Supporting Electrolyte ◽  
Extraction Procedure ◽  
Pharmaceutical Formulations ◽  
Differential Pulse ◽  
Pharmaceutical Products ◽  
Chewing Gum ◽  
Simple Liquid ◽  
Polarographic Analysis ◽  
Dropping Mercury Electrode

A fast and simple differential pulse polarographic method was developed for analysis of nicotine in various pharmaceutical formulations (chewing gum, tablets (drops) and patches). This method requires a simple liquid-liquid extraction procedure for chewing gum and patches, or a direct dilution in supporting electrolyte for tablets before polarographic analysis. The polarographic analysis was done in a Britton-Robinson buffer (pH 6.2) as supporting electrolyte. The multimode electrode from Metrohm was used as working electrode (dropping mercury electrode). This method was applied to the determination of the nicotine content in chewing gum, tablets and patches by using the standard addition method. The results are in good agreement with the content declared by the manufacturer. The method is fast, simple and reliable, and it is a complementary method to the chromatographic method being used today for quantitative analysis of nicotine in pharmaceutical formulations. The limit of quantification is assumed to be far below 0.1 mg/l in the polarographic vessel. The method uses simple dilution and/or extraction procedures for sample preparation before polarographic analysis. It is also shown that it is possible to use a glassy carbon electrode with a mercury film (MTFE electrode) for the determination of nicotine in antismoking pharmaceutical products.

scholarly journals Voltammetric Determination of Pd(II) Using 5-Hydroxyimino-4-imino-1,3-thiazolidin-2-one after a Thermal Activation of the Interaction

2021 ◽  
Vol 15 (3) ◽  
pp. 324-329
Author(s):  
Petro Rydchuk ◽  
◽  
Oksana Labyk ◽  
Lesya Oleksiv ◽  
Oleksandr Tymoshuk ◽  
...  
Keyword(s):  
Thermal Activation ◽  
Limit Of Detection ◽  
Supporting Electrolyte ◽  
Voltammetric Determination ◽  
Real Sample ◽  
Optimal Conditions ◽  
Voltammetric Method ◽  
The Real ◽  
Ph Range

The interaction of Pd(II) with 5-hydroxyimino-4-imino-1,3-thiazolidin-2-one (HITO) was investigated over the pH range of 1.0–10.0. Optimal conditions for the voltammetric determination of Pd(II) were established. A new voltammetric method of Pd(II) determination by the peak of complex using NaCl as a supporting electrolyte at pH 2.0 was developed with the limit of detection 2.0∙10-7 M. The study of the method’s selectivity was presented in the work. The correctness of the method was confirmed by the analysis of model solutions and the real sample (resistor SP5-35B).

Interference by Tin in AOAC Dry-Ash Voltammetric Method for Determination of Lead and Cadmium in Canned Foods

1988 ◽  
Vol 71 (4) ◽  
pp. 857-859
Author(s):  
Walter Holak ◽  
John J Specchio
Keyword(s):  
Tartaric Acid ◽  
False Positive ◽  
Supporting Electrolyte ◽  
Canned Food ◽  
Voltammetric Method ◽  
Lead And Cadmium ◽  
Anodic Stripping ◽  
Canned Foods ◽  
Positive Results

Abstract When lead and cadmium were determined in samples of canned food by the AOAC anodic stripping voltammetric method, an interference was observed which was believed to be tin(IV). This interference could cause false positive results for lead and cadmium. The electroactivity of tin(IV) was suppressed by increasing the concentration of tartaric acid in the supporting electrolyte from 0.005M to 0.1M after mixing with an equal volume of sample solution.

scholarly journals First Electrochemical Method of Nitrothal-Isopropyl Determination in Water Samples

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Dariusz Guziejewski ◽  
Agnieszka Nosal-Wiercińska ◽  
Sławomira Skrzypek ◽  
Witold Ciesielski ◽  
Sylwia Smarzewska
Keyword(s):  
Environmental Samples ◽  
Electrochemical Method ◽  
Concentration Level ◽  
Stripping Voltammetry ◽  
Adsorptive Stripping Voltammetry ◽  
Hanging Mercury Drop Electrode ◽  
Optimal Conditions ◽  
Step Potential ◽  
Accumulation Time

The aim of the research was the use of square wave adsorptive stripping voltammetry (SWAdSV) in conjunction with a hanging mercury drop electrode (HMDE) for the determination of nitrothal-isopropyl. It was found that optimal SW technique parameters were frequency, 200 Hz; amplitude, 50 mV; and step potential, 5 mV. Accumulation time and potential were studied to select the optimal conditions in adsorptive stripping voltammetry: 45 s at 0.0 V, respectively. The calibration curve (SWSV) was linear in the nitrothal-isopropyl concentration range from 2.0 × 10−7 to 2.0 × 10−6 mol L−1 with detection limit of 3.46 × 10−8 mol L−1. The repeatability of the method was determined at a nitrothal-isopropyl concentration level equal to 6.0 × 10−7 mol L−1 and expressed as RSD = 5.5% (n=6). The proposed method was successfully validated by studying the recovery of nitrothal-isopropyl in spiked environmental samples.

scholarly journals A novel catalytic adsorptive stripping voltammetric method for the determination of germanium ultratraces in the presence of chloranilic acid and the V(IV)·HEDTA complex

2020 ◽  
Vol 24 (11-12) ◽  
pp. 2891-2899
Author(s):  
Jerzy Zarębski ◽  
Andrzej Bobrowski ◽  
Agnieszka Królicka ◽  
Julia Gonciarczyk ◽  
Vasiliki Manolopoulou ◽  
...  
Keyword(s):  
Limit Of Detection ◽  
Electrolyte Composition ◽  
Hanging Mercury Drop Electrode ◽  
Film Electrode ◽  
Optimal Conditions ◽  
Subsequent Reduction ◽  
Adsorbed State ◽  
Chloranilic Acid ◽  
Effects Of Ph

Abstract A novel, sensitive catalytic adsorptive stripping voltammetric procedure which can be used to determine trace amounts of germanium is described. The method is based on the interfacial accumulation of the complex formed by Ge(IV) and the product of the reduction of chloranilic acid on the hanging mercury drop electrode or the renewable silver amalgam film electrode, and its subsequent reduction from the adsorbed state followed by the catalytic action of the V(IV)·HEDTA complex. The presence of V(IV)·HEDTA greatly enhances the adsorptive stripping response of Ge. The reduction of the Ge(IV) in the presence of chloranilic acid and V(IV)·HEDTA was investigated in detail and the effects of pH, electrolyte composition, and instrumental parameters were studied. Under optimal conditions, the catalytic peak current of germanium exhibited good linearity for Ge(IV) concentrations in the range of 0.75–60 nM (for 60 s of accumulation at −0.1 V, r2 = 0.995) and a low limit of detection (LOD = 0.085 nM). The procedure was successfully applied to determine Ge in water samples.

scholarly journals Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode

Revista Vitae ◽  
2021 ◽  
Vol 28 (2) ◽  
Author(s):  
Mohammad Amayreh ◽  
Wafa Hourani ◽  
Mohammed Khair Hourani
Keyword(s):  
Ascorbic Acid ◽  
Platinum Electrode ◽  
Limit Of Detection ◽  
Statistical Tests ◽  
Supporting Electrolyte ◽  
Pharmaceutical Formulations ◽  
Cyclic Voltammograms ◽  
Limit Of Quantitation ◽  
Significant Difference

Background: Despite the high reactivity of the platinum electrode, the iodine-coated platinum electrode shows obvious inertness toward adsorption and surface processes. For that, iodine-coated platinum electrodes accommodate themselves to interesting voltammetric applications. Objectives: This study reports using the modified iodine-coated polycrystalline platinum electrode as a voltammetric sensor for ascorbic acid determination in pharmaceutical formulations. Methods: The developed voltammetric method based on recording cyclic voltammograms of ascorbic acid at iodine-coated electrode The optimized experimental parameters for the determination of ascorbic acid were using 0.1 M KCl as a supporting electrolyte with a scan rate of 50mV/s. Results: The anodic peak related to ascorbic acid oxidation was centered at nearly 0.28V. An excellent and extended linear dependence of the oxidative peak current on the concentration of ascorbic acid was observed in the range 2.84x10-3 - 5.68 mM. The limit of detection (LOD) and limit of quantitation (LOQ) were 1.0 µM and 3.01 µM, respectively, attesting to the method’s sensitivity. The investigation for the effect of potential interference from multivitamin tablet ingredients (vitamins B1, B6, B12, folic acid, citric acid, sucrose, glucose, and zinc) indicated specific selectivity toward ascorbic acid and the absence of any electrochemical response toward these components. Recovery results in the range 98.93±2.78 - 99.98±5.20 for spiked standard ascorbic acid in pharmaceutical formulations further confirmed the potential applicability of the developed method for the determination of ascorbic acid in real samples. Conclusions: The developed method was successfully applied to the analysis of ascorbic acid (vitamin C), and the obtained results were in good agreement with the labeled values; besides, the statistical tests indicated no significant difference at p=0.05 with a 95% confidence level.

Direct Spectrophotometric Determination of Perindopril Erbumine and Enalapril Maleate in Pure and Pharmaceutical Dosage Forms using Bromocresol Green

2021 ◽  
pp. 3276-3282
Author(s):  
Amir Alhaj Sakur ◽  
Bayan Balid
Keyword(s):  
Limit Of Detection ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Dosage Forms ◽  
Bromocresol Green ◽  
Pharmaceutical Dosage Forms ◽  
Enalapril Maleate ◽  
Spectrophotometric Methods ◽  
Perindopril Erbumine

In this article, it has been reported new, simple, sensitive and direct spectrophotometric methods for the determination of Perindopril Erbumine (PPE) and Enalapril Maleate (ENL) in pure and in pharmaceutical forms. Spectrophotometric methods are based on the formation of yellow colored ion-pair complexes between PPE, ENL and sulphonphthalein acid dye, Bromocresol green (BCG) into chloroform were measured at the wavelength of 414 and 415nm for PPE and ENL, respectively. The optimal analytical conditions were determined. The obtained complexes (BCG: PPE) and (BCG: ENL) reached maximum absorbance directly after formation at room temperature for a stability period of 24 h. Beer’s law were obeyed in the concentration ranges of (2-20)µg/mL for PPE and (8- 44)µg/mL for ENL, the limit of detection of 0.125μg/mL and 0.230μg/mL were found for PPE and ENL, respectively. The molar absorptivity coefficients were 4.4045*104 L.moL-1.cm-1 for PPE and 1,9330*104 L.moL-1.cm-1 for ENL. The stoichiometry of the complexes formed between PPE, ENL and BCG were 1:1. No interference was observed from common excipients occurred in pharmaceutical formulations and the proposed methods have been successfully applied to determine the PPE and ENL in some pharmaceutical products and in ENL combination dosage forms with hydrochlorothiazide (HCTZ). The proposed methods were successfully validated to be utilized in the quantitative analysis of PPE and ENL in their pure and pharmaceutical products. A good agreement between the developed spectrophotometric methods with the results obtained from official reference methods for the determination of the two drugs in some real samples demonstrate that the proposed methods were suitable to quantify PPE and ENL in pharmaceutical formulations.

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