scholarly journals Advances in Electrical Source Imaging: A Review of the Current Approaches, Applications and Challenges

Signals ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 378-391
Author(s):  
Ioannis Zorzos ◽  
Ioannis Kakkos ◽  
Errikos M. Ventouras ◽  
George K. Matsopoulos
Keyword(s):  
Review Paper ◽  
State Of The Art ◽  
High Temporal Resolution ◽  
Source Imaging ◽  
Basic Principles ◽  
Spatial Estimation ◽  
Current State ◽  
Methodological Aspects ◽  
The Brain ◽  
Electrical Source

Brain source localization has been consistently implemented over the recent years to elucidate complex brain operations, pairing the high temporal resolution of the EEG with the high spatial estimation of the estimated sources. This review paper aims to present the basic principles of Electrical source imaging (ESI) in the context of the recent progress for solving the forward and the inverse problems, and highlight the advantages and limitations of the different approaches. As such, a synthesis of the current state-of-the-art methodological aspects is provided, offering a complete overview of the present advances with regard to the ESI solutions. Moreover, the new dimensions for the analysis of the brain processes are indicated in terms of clinical and cognitive ESI applications, while the prevailing challenges and limitations are thoroughly discussed, providing insights for future approaches that could help to alleviate methodological and technical shortcomings.

scholarly journals Multifaceted origins of sex differences in the brain

2016 ◽  
Vol 371 (1688) ◽  
pp. 20150106 ◽  
Author(s):  
Margaret M. McCarthy
Keyword(s):  
Sex Differences ◽  
State Of The Art ◽  
Human Subjects ◽  
Special Issue ◽  
Molecular Analyses ◽  
The Past ◽  
Current State ◽  
Biological Variable ◽  
Males And Females ◽  
The Brain

Studies of sex differences in the brain range from reductionistic cell and molecular analyses in animal models to functional imaging in awake human subjects, with many other levels in between. Interpretations and conclusions about the importance of particular differences often vary with differing levels of analyses and can lead to discord and dissent. In the past two decades, the range of neurobiological, psychological and psychiatric endpoints found to differ between males and females has expanded beyond reproduction into every aspect of the healthy and diseased brain, and thereby demands our attention. A greater understanding of all aspects of neural functioning will only be achieved by incorporating sex as a biological variable. The goal of this review is to highlight the current state of the art of the discipline of sex differences research with an emphasis on the brain and to contextualize the articles appearing in the accompanying special issue.

scholarly journals Peritoneal Carcinomatosis: Current State of the Art and Schools of Thought

2021 ◽  
Vol 11 (1) ◽  
pp. 85-91
Author(s):  
Sh. Kh. Gantsev ◽  
M. V. Zabelin ◽  
K. Sh. Gantsev ◽  
A. A. Izmailov ◽  
Sh. R. Kzyrgalin
Keyword(s):  
Peritoneal Carcinomatosis ◽  
State Of The Art ◽  
Global Perspective ◽  
Basic Principles ◽  
Global Challenge ◽  
Current State ◽  
Emerging Therapies ◽  
The World ◽  
The Usa ◽  
Scientific Questions

Peritoneal carcinomatosis (PC) is a global challenge of modern oncology representing the most unfavourable scenario in diverse-locality tumourisation. Despite certain attention by the oncological community, the management of PC patients is currently palliative, which weakly promotes research into the basic principles of this morbidity. This literature review attempts to comprehensively cover the PC problematic from a global perspective and presents a key evidence on the world schools of thought in this area. Briefly taking, peritoneal carcinomatosis is viewed today as a local process in the conventional implantation theory, which imposes a locoregional character on all current or emerging therapies, such as cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Their inadequate efficacy is largely due to pronounced gaps in our understanding of PC logistics and signalling. PSOGI is a key organisation for centralising the specialty effort in peritoneal carcinomatosis. Despite its global geography and approach to PC discussion, a multitude of scientific questions remain unanswered impeding the establishment of novel effective therapies. The seven countries that nurtured distinguished schools of thought in PC studies are the USA, UK, Japan, China, Italy, France and Germany. Taking peritoneal carcinomatosis in a global perspective, an insufficient attention to its problematic in Russia should be addressed. The founding and fostering of national PC institutions will benefit cancer patients and progress in oncological science.

scholarly journals Hydrothermal Carbonization of Organic Waste and Biomass: A Review on Process, Reactor, and Plant Modeling

2020 ◽  
Author(s):  
Giulia Ischia ◽  
Luca Fiori
Keyword(s):  
Organic Waste ◽  
Review Paper ◽  
Recent Literature ◽  
State Of The Art ◽  
Hydrothermal Carbonization ◽  
Residual Biomass ◽  
Current State ◽  
Potential Applications ◽  
Intrinsic Complexity ◽  
Context Models

Abstract Hydrothermal carbonization (HTC) is an emerging path to give a new life to organic waste and residual biomass. Fulfilling the principles of the circular economy, through HTC “unpleasant” organics can be transformed into useful materials and possibly energy carriers. The potential applications of HTC are tremendous and the recent literature is full of investigations. In this context, models capable to predict, simulate and optimize the HTC process, reactors, and plants are engineering tools that can significantly shift HTC research towards innovation by boosting the development of novel enterprises based on HTC technology. This review paper addresses such key-issue: where do we stand regarding the development of these tools? The literature presents many and simplified models to describe the reaction kinetics, some dealing with the process simulation, while few focused on the heart of an HTC system, the reactor. Statistical investigations and some life cycle assessment analyses also appear in the current state of the art. This work examines and analyzes these predicting tools, highlighting their potentialities and limits. Overall, the current models suffer from many aspects, from the lack of data to the intrinsic complexity of HTC reactions and HTC systems. Therefore, the emphasis is given to what is still necessary to make the HTC process duly simulated and therefore implementable on an industrial scale with sufficient predictive margins. Graphic Abstract

scholarly journals Review of Tailoring Methods for Joints with Additively Manufactured Adherends and Adhesives

Materials ◽  
2020 ◽  
Vol 13 (18) ◽  
pp. 3949
Author(s):  
Mattia Frascio ◽  
Eduardo André de Sousa Marques ◽  
Ricardo João Camilo Carbas ◽  
Lucas Filipe Martins da Silva ◽  
Margherita Monti ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Review Paper ◽  
State Of The Art ◽  
Manufacturing Processes ◽  
Bonded Joints ◽  
Design For Additive Manufacturing ◽  
Polymeric Additive ◽  
Current State ◽  
Bonded Joint ◽  
Current Modelling

This review aims to assess the current modelling and experimental achievements in the design for additive manufacturing of bonded joints, providing a summary of the current state of the art. To limit its scope, the document is focused only on polymeric additive manufacturing processes. As a result, this review paper contains a structured collection of the tailoring methods adopted for additively manufactured adherends and adhesives with the aim of maximizing bonded joint performance. The intent is, setting the state of the art, to produce an overview useful to identify the new opportunities provided by recent progresses in the design for additive manufacturing, additive manufacturing processes and materials’ developments.

Solid lipid nanoparticles as vehicles of drugs to the brain: Current state of the art

2014 ◽  
Vol 87 (3) ◽  
pp. 433-444 ◽  
Author(s):  
Lucia Gastaldi ◽  
Luigi Battaglia ◽  
Elena Peira ◽  
Daniela Chirio ◽  
Elisabetta Muntoni ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
State Of The Art ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Current State ◽  
The Brain

scholarly journals Robotic automation of “blind” and two-photon targeted patch-clamp electrophysiology in vivo

2021 ◽  
Author(s):  
Gema Vera Gonzalez ◽  
Phatsimo Kgwarae ◽  
Luca Annecchino ◽  
Simon Schultz
Keyword(s):  
Patch Clamp ◽  
Review Paper ◽  
State Of The Art ◽  
Two Photon ◽  
Current State ◽  
Patch Clamp Electrophysiology ◽  
Robotic Automation

A review paper on the current state of the art in robotic automation of in vivo patch-clamp electrophysiology

Sentence Processing

2019 ◽  
pp. 675-709
Author(s):  
Ina Bornkessel-Schlesewsky ◽  
Matthias Schlesewsky
Keyword(s):  
Empirical Evidence ◽  
Sentence Processing ◽  
State Of The Art ◽  
Current State ◽  
Key Points ◽  
The Brain

Neurolinguistic approaches to sentence processing have recently begun to focus on neurobiological plausibility. Thus, rather than seeking primarily to establish mappings between linguistic and cognitive concepts and the brain, the question of how sentence processing is implemented by the brain’s unique biological hardware has become increasingly important. This chapter reviews the current state of the art with respect to the neurobiology of sentence processing, adopting both a neuroanatomical and a timing-based perspective. For both of these domains, the chapter provides an overview of current models and frameworks, as well as the empirical evidence supporting them. In each case, it highlights areas of consensus, as well as key points of difference between approaches where no consensus has yet been reached.

scholarly journals Advances in Analysis of Milk Proteases Activity at Surfaces and in a Volume by Acoustic Methods

Sensors ◽  
2020 ◽  
Vol 20 (19) ◽  
pp. 5594 ◽  
Author(s):  
Mark Dizon ◽  
Marek Tatarko ◽  
Tibor Hianik
Keyword(s):  
State Of The Art ◽  
Enzyme Reaction ◽  
Ultrasonic Spectroscopy ◽  
Basic Principles ◽  
Current State ◽  
Acoustic Methods ◽  
Milk Gelation ◽  
Kinetics Of ◽  
Increased Activity

This review is focused on the application of surface and volume-sensitive acoustic methods for the detection of milk proteases such as trypsin and plasmin. While trypsin is an important protein of human milk, plasmin is a protease that plays an important role in the quality of bovine, sheep and goat milks. The increased activity of plasmin can cause an extensive cleavage of β-casein and, thus, affect the milk gelation and taste. The basic principles of surface-sensitive acoustic methods, as well as high-resolution ultrasonic spectroscopy (HR-US), are presented. The current state-of-the-art examples of the application of acoustic sensors for protease detection in real time are discussed. The application of the HR-US method for studying the kinetics of the enzyme reaction is demonstrated. The sensitivity of the acoustics biosensors and HR-US methods for protease detection are compared.

scholarly journals Isotopic Techniques to Measure N2O, N2 and Their Sources

2021 ◽  
pp. 213-301
Author(s):  
M. Zaman ◽  
K. Kleineidam ◽  
L. Bakken ◽  
J. Berendt ◽  
C. Bracken ◽  
...  
Keyword(s):  
Stable Isotope ◽  
State Of The Art ◽  
Theoretical Background ◽  
Natural Abundance ◽  
Basic Principles ◽  
Link Type ◽  
Current State ◽  
Numerical Tools ◽  
Enrichment Techniques ◽  
Tracing Techniques

AbstractGHGemissions are usually the result of several simultaneous processes. Furthermore, some gases such as N2 are very difficult to quantify and require special techniques. Therefore, in this chapter, the focus is on stable isotopemethods. Both natural abundance techniques and enrichment techniques are used. Especially in the last decade, a number of methodological advances have been made. Thus, this chapter provides an overview and description of a number of current state-of-the-art techniques, especially techniques using the stable isotope15N. Basic principles and recent advances of the 15N gasflux method are presented to quantify N2 fluxes, but also the latest isotopologue and isotopomermethods to identify pathways for N2O production. The second part of the chapter is devoted to 15N tracing techniques, the theoretical background and recent methodological advances. A range of different methods is presented from analytical to numerical tools to identify and quantify pathway-specific N2O emissions. While this chapter is chiefly concerned with gaseous N emissions, a lot of the techniques can also be applied to other gases such as methane (CH4), as outlined in Sect. 10.1007/978-3-030-55396-8_5#Sec12.

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