scholarly journals Increased PACAP- and DβH-Positive Hepatic Nerve Fibers after Bisphenol A Exposure

Toxics ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 110
Author(s):  
Michael Thoene ◽  
Liliana Rytel ◽  
Ewa Dzika ◽  
Joanna Wojtkiewicz
Keyword(s):  
Bisphenol A ◽  
Psychological Disorders ◽  
Nerve Fibers ◽  
Childhood Exposure ◽  
Correlation Studies ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Exposure Levels ◽  
Neural Marker ◽  
Sympathetic Nervous

Bisphenol A (BPA) is an endocrine-disrupting compound (EDC) that can be found nearly everywhere in our polluted world. BPA has been correlated with pathophysiologies that include psychological disorders, especially in children. This study used juvenile porcine models to investigate the effects of BPA on the liver of developing vertebrates in order to determine the effects of BPA on innervated hepatic samples with the use of double-labeled immunofluorescence. This study specifically investigated the sympathetic nervous system (SNS) colocalized with a specific neural marker (PACAP) that has previously been correlated with specific pathophysiologies in the literature. In the liver, it was observed that there were significantly increased nerve fibers in the SNS colocalized with the neural marker PACAP after exposure to BPA at concentrations considered to be “safe” with the same or more profound effects at higher exposure levels. The implications of childhood exposure to BPA are then discussed with regard to several correlation studies that have linked BPA exposure to behavioral/psychological disorders. It is possible that BPA exposure in childhood may upregulate the SNS and PACAP levels, thereby contributing to the correlations in the literature.

scholarly journals Facile Synthesis of Porous ZnO Nanoparticles Efficient for Photocatalytic Degradation of Biomass-Derived Bisphenol A Under Simulated Sunlight Irradiation

2021 ◽  
Vol 8 ◽  
Author(s):  
Yujie Wang ◽  
Kang Hu ◽  
Zhiyu Yang ◽  
Chenlu Ye ◽  
Xin Li ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Photocatalytic Degradation ◽  
Inorganic Ions ◽  
Endocrine Disrupting Compounds ◽  
Degradation Process ◽  
Sunlight Irradiation ◽  
Calcination Temperatures ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Photocatalytic Removal

Bisphenol A (BPA) produced from biomass is a typical endocrine disrupting compound that is carcinogenic and genotoxic and can be accumulated in water due to its extensive use and difficult degradation. In this study, the porous ZnO photocatalyst with core-shell structure and large surface area was successfully developed for the efficient photocatalytic degradation of BPA. The various effects of calcination temperatures, BPA concentrations, ZnO dosages, pH and inorganic ions on the degradation performance were systemically studied. The results showed that 99% degradation of BPA was achieved in 1 h using the porous ZnO calcined at 550°C under the conditions of 30 mg/L BPA, 1 g/L ZnO, and pH of 6.5. Besides, the inhibition effects of anions for the photocatalytic removal of BPA decreased in the order of H2PO4- > HCO3- > SO42- > Cl−, while the cations K+, Ca2+, and Na+ had little effect on the photocatalytic degradation of BPA. The results of scavenging experiments showed that h+, ·O2-, and e− played the key role in the photocatalytic degradation process. Finally, the main pathways of BPA degradation were proposed based on ten intermediates found in the degradation process. This work may provide a good guideline to degrade various endocrine disrupting compounds in wastewater treatment.

Degradation of Bisphenol-A by Ozonation

2009 ◽  
Vol 12 (2) ◽  
Author(s):  
Isil Gultekin ◽  
Valko Mavrov ◽  
Nilsun H. Ince
Keyword(s):  
Bisphenol A ◽  
Mass Transfer Rate ◽  
Degradation Process ◽  
Bimolecular Reaction ◽  
Reaction Rate Constant ◽  
Operational Parameters ◽  
Endocrine Disrupting Compound ◽  
Ozone Addition ◽  
Endocrine Disrupting ◽  
Addition Rate

AbstractThe study reports the degradation of an endocrine disrupting compound- bisphenol A (BPA) by ozonation at slightly acidic pH with emphasis on the operational parameters (e.g. BPA concentration, ozone addition and mass transfer rate, contact time), reaction kinetics, rate constants and oxidation byproducts. It was found that the rate of BPA decay (pseudo-first order with respect to concentration) was accelerated with increased ozone addition rate and decreased BPA initial concentration. The profile of aqueous ozone concentration was such that it remained constant during 1-3 min of contact and increased thereafter. The bimolecular reaction rate constant was estimated using the steady state concentration of ozone and the value found was in good agreement with those reported in the literature for similar pH. Total mineralization was most rapid before complete conversion of BPA and much slower thereafter, implying low reactivity of the intermediate products with ozone. Mineralization was enhanced by alkalinization to pH 10.8, which facilitated the overall degradation process via the formation of radical species that were less selective than ozone. Byproducts of oxidation in successive order of formation were p-tert-butylphenol, hydroquinone, methyl-dihydrobenzofuran and n-butyl acetate, none of which are classified as endocrine disruptors.

Exposure to bisphenol A modulates hormone concentrations in Gammarus pseudolimnaeus

2012 ◽  
Vol 90 (12) ◽  
pp. 1414-1421 ◽  
Author(s):  
S.E. Lewis ◽  
A. Yokofich ◽  
M. Mohr ◽  
C. Kurth ◽  
R. Giuliani ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Freshwater Ecosystems ◽  
Adult Males ◽  
Endocrine Disrupting Compound ◽  
Tissue Extracts ◽  
Low Concentrations ◽  
Endocrine Disrupting ◽  
Gammarus Pseudolimnaeus ◽  
High Concentrations ◽  
Four Levels

Bisphenol A (BPA) is an endocrine-disrupting compound that can enter aquatic systems through landfill leachate or wastewater effluent. Although impacts of BPA on vertebrates are well documented, its effects on invertebrates are less clear. Amphipods such as Gammarus pseudolimnaeus Bousfield, 1958 are often prevalent invertebrates in freshwater ecosystems and can provide a powerful invertebrate model system to investigate the endocrine-disruptive capabilities of BPA. However, techniques to assay hormone concentrations in amphipods, especially vertebrate-like steroid sex hormones, are not widespread. In this study, we (i) quantified estrogen concentrations in juveniles and in adult female amphipods; (ii) quantified testosterone concentrations in juveniles and in adult male amphipods; and (iii) delineated changes to estrogen and testosterone concentrations of adults and juveniles following a 9-day exposure to BPA at four levels: 0 (control), 10, 50, and 100 µg/L BPA. Tissue extracts from homogenized samples were analyzed for estrogen or testosterone concentrations via radioimmunoassay for each reproductive class of amphipod. Low concentrations of BPA significantly increased estrogen concentrations in adult females and in juveniles. Moderate and high concentrations of BPA significantly increased testosterone concentrations in adult males, and low and moderate concentrations of BPA significantly increased testosterone concentrations of juveniles.

scholarly journals Ecotoxicological risk assessment due to the presence of bisphenol A and caffeine in surface waters in the Sinos River Basin - Rio Grande do Sul - Brazil

2019 ◽  
Vol 79 (4) ◽  
pp. 712-712 ◽  
Author(s):  
G. P. Peteffi ◽  
J. D. Fleck ◽  
I. M. Kael ◽  
D. C. Rosa ◽  
M. V. Antunes ◽  
...  
Keyword(s):  
Bisphenol A ◽  
River Basin ◽  
Surface Waters ◽  
Water Samples ◽  
Rio Grande ◽  
Low Risk ◽  
Rio Grande Do Sul ◽  
Ecotoxicological Risk ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting

Abstract Bisphenol A (BPA) is an emerging contaminant, regularly detected in aquatic ecosystems, considered as an endocrine disrupting compound (EDC). Caffeine is another chemical related to human activity, often found in surface waters. The objective of this study was to evaluate the ecotoxicological risk due to BPA and caffeine in water samples from the Sinos River basin, Rio Grande do Sul, Brazil. Water samples were collected at three sites monthly from May 9 th, 2016 to April 11th, 2017 (n = 36). BPA concentrations in water samples collected were in the range of not detected to 517 ng L-1 and caffeine concentrations in the range of 41.7 to 28,439.6 ng L-1. The concentration of BPA in the analyzed samples had a moderate correlation with caffeine (rs = 0.402). High ecotoxicological risk for BPA was characterized in 77.77% of samples, with 11.11% presenting medium and 11.1% presenting low risk. For caffeine 13.9%, 50% and 36.11% of the samples presented high, medium and low risk, respectively. Caffeine concentrations in water can be used as predictors of BPA concentrations above 10 ng L-1, the lower concentration of ecotoxicological risk, with specificity of 66.7% and sensitivity of 70.4%. The assessment of aquatic risks has shown that both investigated compounds pose risks to organisms in the studied surface waters, mouth of the Pampa stream, mouth of the Luiz Rau stream and catchment point for public supply in Lomba Grande.

scholarly journals Bisphenol A and Its Analogues in Chinese Total Diets: Contaminated Levels and Risk Assessment

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Kai Yao ◽  
Jing Zhang ◽  
Jie Yin ◽  
Yunfeng Zhao ◽  
Jianzhong Shen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Food Packaging ◽  
Endocrine Disrupting Chemicals ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Food Samples ◽  
Dietary Intakes ◽  
Bisphenol S ◽  
Endocrine Disrupting ◽  
Exposure Levels

Bisphenol A (BPA) and its analogues (BPs) are suspected posing potential endocrine disrupting properties. They might migrate into foodstuffs through food packaging materials or contaminated water and soil. Dietary exposure is of paramount importance way for human health. European Food Safety Authority (EFSA) lowered the value of tolerable daily intake (TDI) from 50 μg/kg bw/day (d) to a temporary (t) TDI (t-TDI) of 4 μg/kg bw/d. In this study, the Chinese total dietary samples were analyzed for assessing the exposure risk of BPs by diets. BPA, bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) were found in 12 kinds of food samples except for bisphenol B (BPB). A deterministic approach was used to calculate the dietary intakes of 4 kinds of compounds. For different age and gender groups, the exposure levels of BPA (178.440-403.672 ng/kg bw/d) was the highest, followed by BPS (21.372-52.112 ng/kg bw/d), BPF (20.641-50.507 ng/kg bw/d), and BPAF (0.434-1.210 ng/kg bw/d). Based on the t-TDI set by EFSA (4 μg/kg bw/d for BPA), the BPs through dietary intake pose low risks on the Chinese general population even summarization exposure levels of different BPs. However, human can be exposed to multiple endocrine disrupting chemicals rather than BPs alone; combined exposure risks should be further considered.

scholarly journals Treatment of Bisphenol-A Using Sonication-assisted Photo-Fenton Hybrid Process

2019 ◽  
Vol 33 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Meral Dükkancı
Keyword(s):  
Bisphenol A ◽  
Ph Value ◽  
Fenton Oxidation ◽  
Toxicity Tests ◽  
Catalyst Loading ◽  
Endocrine Disrupting Compound ◽  
Toc Removal ◽  
Endocrine Disrupting ◽  
Initial Ph ◽  
Solution Volume

Sonication-assisted photo-Fenton oxidation of an endocrine disrupting compound, bisphenol-A (BPA), was studied under visible-light irradiation in the presence of a LaFeO3 perovskite catalyst. The effects of the parameters: initial BPA concentration ([BPA]0), H2O2 concentration ([H2O2]0), catalyst loading, initial pH of the BPA solution, and reaction temperature were studied on the sonication-assisted photo-Fenton oxidation of an aqueous BPA solution. The optimum conditions for the oxidation were determined to be: [BPA]0 = 10 ppm, [H2O2]0 = 4.8 mM, catalyst loading = 0.75 g L–1, pH = 2.6, temperature = 313 K. During all runs, sonication power of 40 W, visible lights power of 150 W+150 W, BPA solution volume (0.5 L), and stirring speed of 500 rpm were kept constant. Under these conditions, degradation of 56.3 %, COD removal of 50.9 %, and TOC removal of 15.6 % were achieved after 6 h of reaction. The small amount of iron that leached into the solution indicated high stability of the catalyst. The sonication-assisted photo-Fenton oxidation of BPA was described by the second order kinetics with an activation energy of 15.34 kJ mol–1. Toxicity tests were also performed and the results revealed that the intermediates formed in the sonication-assisted photo-Fenton oxidation of BPA were less toxic compared to the parent BPA molecule at a neutral pH value. However, the same interpretation was not valid at the acidic pH of 2.6.

scholarly journals Acute Exposure to Bisphenol A Causes Oxidative Stress Induction with Mitochondrial Origin in Saccharomyces cerevisiae Cells

2021 ◽  
Vol 7 (7) ◽  
pp. 543
Author(s):  
Ivana Ďurovcová ◽  
Eduard Goffa ◽  
Zuzana Šestáková ◽  
Dominika Mániková ◽  
Katarína Gaplovská-Kyselá ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Bisphenol A ◽  
Fluorescent Microscopy ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Mitochondrial Origin ◽  
High Concentrations ◽  
Living Organisms ◽  
Independent Effects

Bisphenol A (BPA) is a major component of the most commonly used plastic products, such as disposable plastics, Tetra Paks, cans, sport protective equipment, or medical devices. Due to the accumulation of excessive amounts of plastic waste and the subsequent release of BPA into the environment, BPA is classified as a pollutant that is undesirable in the environment. To date, the most interesting finding is the ability of BPA to act as an endocrine disrupting compound due to its binding to estrogen receptors (ERs), and adverse physiological effects on living organisms may result from this action. Since evidence of the potential pro-oxidizing effects of BPA has accumulated over the last years, herein, we focus on the detection of oxidative stress and its origin following BPA exposure using pulsed-field gel electrophoresis, flow cytometry, fluorescent microscopy, and Western blot analysis. Saccharomyces cerevisiae cells served as a model system, as these cells lack ERs allowing us to dissect the ER-dependent and -independent effects of BPA. Our data show that high concentrations of BPA affect cell survival and cause increased intracellular oxidation in yeast, which is primarily generated in the mitochondrion. However, an acute BPA exposure does not lead to significant oxidative damage to DNA or proteins.

Effect of Polyphosphate on Removal of Endocrine-Disrupting Chemicals of Nonylphenol and Bisphenol-A by Activated Carbons

2005 ◽  
Vol 40 (4) ◽  
pp. 484-490 ◽  
Author(s):  
Keun J. Choi ◽  
Sang G. Kim ◽  
Chang W. Kim ◽  
Seung H. Kim
Keyword(s):  
Activated Carbon ◽  
Bisphenol A ◽  
Surface Charge ◽  
Activated Carbons ◽  
Endocrine Disrupting Chemicals ◽  
Dipole Interaction ◽  
High Affinity ◽  
Calcium Polyphosphate ◽  
Endocrine Disrupting ◽  
Positively Charged

Abstract This study examined the effect of polyphosphate on removal of endocrine-disrupting chemicals (EDCs) such as nonylphenol and bisphenol-A by activated carbons. It was found that polyphosphate aided in the removal of nonylphenol and bisphenol- A. Polyphosphate reacted with nonylphenol, likely through dipole-dipole interaction, which then improved the nonylphenol removal. Calcium interfered with this reaction by causing competition. It was found that polyphosphate could accumulate on carbon while treating a river. The accumulated polyphosphate then aided nonylphenol removal. The extent of accumulation was dependent on the type of carbon. The accumulation occurred more extensively with the wood-based used carbon than with the coal-based used carbon due to the surface charge of the carbon. The negatively charged wood-based carbon attracted the positively charged calcium-polyphosphate complex more strongly than the uncharged coal-based carbon. The polyphosphate-coated activated carbon was also effective in nonylphenol removal. The effect was different depending on the type of carbon. Polyphosphate readily attached onto the wood-based carbon due to its high affinity for polyphosphate. The attached polyphosphate then improved the nonylphenol removal. However, the coating failed to attach polyphosphate onto the coal-based carbon. The nonylphenol removal performance of the coal-based carbon remained unchanged after the polyphosphate coating.

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