scholarly journals Three-Flavor Oscillations with Accelerator Neutrino Beams

Universe ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. 32 ◽  
Author(s):  
Mauro Mezzetto ◽  
Francesco Terranova
Keyword(s):  
Neutrino Physics ◽  
High Power ◽  
Particle Physics ◽  
Uncertainty Reduction ◽  
Neutrino Beam ◽  
Future Perspectives ◽  
Flavor Oscillations ◽  
Massive Neutrinos ◽  
Neutrino Experiments

The three-flavor neutrino oscillation paradigm is well established in particle physics thanks to the crucial contribution of accelerator neutrino beam experiments. In this paper, we review the most important contributions of these experiments to the physics of massive neutrinos after the discovery of θ 13 and future perspectives in such a lively field of research. Special emphasis is given to the technical challenges of high power beams and the oscillation results of T2K, OPERA, ICARUS, and NO ν A. We discuss in detail the role of accelerator neutrino experiments in the precision era of neutrino physics in view of DUNE and Hyper-Kamiokande, the program of systematic uncertainty reduction and the development of new beam facilities.

scholarly journals The Role of Particle Physics in Cosmology and Galactic Astronomy

1983 ◽  
Vol 104 ◽  
pp. 493-506
Author(s):  
D. W. Sciama
Keyword(s):  
Particle Physics ◽  
Baryon Asymmetry ◽  
Inflationary Universe ◽  
Massive Neutrinos ◽  
Galactic Astronomy ◽  
Supersymmetric Theories

A non-technical introduction is given to (a) the inflationary universe, (b) the production of baryon asymmetry by GUTs, (c) the possible role of massive neutrinos and (d) the possible role of the massive photinos and goldstinos of broken supersymmetric theories.

scholarly journals THEORETICAL OVERVIEW OF NEUTRINO PROPERTIES

2008 ◽  
Vol 23 (26) ◽  
pp. 4255-4272 ◽  
Author(s):  
ZHI-ZHONG XING
Keyword(s):  
Mass Spectrum ◽  
Neutrino Physics ◽  
Neutrino Oscillations ◽  
Ultrahigh Energy ◽  
Neutrino Telescopes ◽  
Flavor Oscillations ◽  
The Road ◽  
Neutrino Astrophysics ◽  
Massive Neutrinos ◽  
Theoretical Overview

I give an overview of some basic properties of massive neutrinos. The first part of this talk is devoted to three fundamental questions about three known neutrinos and to their flavor issues — the mass spectrum, mixing pattern and CP violation. The second part of this talk is to highlight a few hot topics at the frontiers of neutrino physics and neutrino astrophysics, including the naturalness and testability of TeV seesaw mechanisms at the LHC, effects of nonstandard interactions on neutrino oscillations, flavor distributions of ultrahigh-energy cosmic neutrinos at neutrino telescopes, collective flavor oscillations of supernova neutrinos, flavor effects in thermal leptogenesis, the GSI anomaly and Mössbauer neutrino oscillations, and so on. I finally make some concluding remarks for the road ahead.

Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives

2018 ◽  
Vol 23 (37) ◽  
pp. 5760-5765 ◽  
Author(s):  
Antonio Gambardella ◽  
Angelo Labate ◽  
Laura Mumoli ◽  
Iscia Lopes-Cendes ◽  
Fernando Cendes
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Current Status ◽  
Future Perspectives ◽  
Antiepileptic Drug Therapy

Feeling Guilty and Flattering God: The Mediating Role of Prayer

2021 ◽  
pp. 009164712199242
Author(s):  
Beata Zarzycka ◽  
Kamil Tomaka ◽  
Katarzyna Zając ◽  
Klaudia Marek
Keyword(s):  
Low Power ◽  
High Power ◽  
Mediating Role ◽  
Shame Proneness ◽  
The Relationship ◽  
Significant Mediator

Ingratiation refers to acts of flattery, typically given by a low-power person to a high-power one, performed to gain acceptance and approval. This study investigates ingratiation in the religious setting, asking whether people feeling high levels of guilt or shame tend to manifest such ingratiating behavior toward God. The study aimed to examine the mediating role of prayer in the relationship between guilt and shame and ingratiation toward God. A total of 148 respondents (80 women and 68 men) participated in the study. The Religious Ingratiation Scale, the Content of Prayer Scale, and the Guilt and Shame Proneness Scale were applied to the research. The results showed that feeling guilty increased the tendency to ingratiation toward God. Prayer was the significant mediator in this relationship. People high in guilt tend to flatter God by offering more adoration and fewer repine prayers.

scholarly journals Therapeutic Role of Tocilizumab in SARS-CoV-2-Induced Cytokine Storm: Rationale and Current Evidence

2021 ◽  
Vol 22 (6) ◽  
pp. 3059
Author(s):  
Corrado Pelaia ◽  
Cecilia Calabrese ◽  
Eugenio Garofalo ◽  
Andrea Bruni ◽  
Alessandro Vatrella ◽  
...  
Keyword(s):  
Review Article ◽  
Lung Damage ◽  
Current Evidence ◽  
Therapeutic Effects ◽  
Cytokine Storm ◽  
Future Perspectives ◽  
Pathogenic Role ◽  
Refractory Rheumatoid Arthritis ◽  
Life Threatening

Among patients suffering from coronavirus disease 2019 (COVID-19) syndrome, one of the worst possible scenarios is represented by the critical lung damage caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced cytokine storm, responsible for a potentially very dangerous hyperinflammatory condition. Within such a context, interleukin-6 (IL-6) plays a key pathogenic role, thus being a suitable therapeutic target. Indeed, the IL-6-receptor antagonist tocilizumab, already approved for treatment of refractory rheumatoid arthritis, is often used to treat patients with severe COVID-19 symptoms and lung involvement. Therefore, the aim of this review article is to focus on the rationale of tocilizumab utilization in the SARS-CoV-2-triggered cytokine storm, as well as to discuss current evidence and future perspectives, especially with regard to ongoing trials referring to the evaluation of tocilizumab’s therapeutic effects in patients with life-threatening SARS-CoV-2 infection.

scholarly journals Current role of ultrasound in hemodialysis access evaluation

2021 ◽  
pp. 112972982110346
Author(s):  
Meola Mario ◽  
Jose Ibeas ◽  
Jan Malik
Keyword(s):  
Turning Point ◽  
Point Of Care ◽  
Low Cost ◽  
Wireless Systems ◽  
Future Perspectives ◽  
Maturation Period ◽  
Surveillance Programs ◽  
Dialysis Nurses

Physical examination (PE) is considered the backbone before vascular access (VA) placement, during maturation period and for follow-up. However, it may be inadequate in identifying suitable vasculature, mainly in comorbid patients, or in detecting complications. This review highlights the advantages of ultrasound imaging to manage VA before placement, during maturation and follow-up. Furthermore, it analyses the future perspectives in evaluating early and late VA complications thank to the availability of multiparametric platforms, point of care of ultrasound, and portable/wireless systems. Technical improvements and low-cost systems should favor the widespread ultrasound-based VA surveillance programs. This significant turning point needs an adequate training of nephrologists and dialysis nurses and the standardization of exams, parameters, and procedures.

scholarly journals Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer

Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 15
Author(s):  
Aishat Motolani ◽  
Matthew Martin ◽  
Mengyao Sun ◽  
Tao Lu
Keyword(s):  
Transcription Factor ◽  
Cardiovascular Diseases ◽  
Cancer Progression ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Malignant Diseases ◽  
Future Perspectives ◽  
Post Translational Modifications ◽  
Site Specific

The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including phosphorylation, one of the most popular PTM formats in NF-κB signaling. The regulation by phosphorylation modification is not limited to NF-κB subunits, but it also encompasses the diverse regulators of NF-κB signaling. The differential site-specific phosphorylation of NF-κB itself or some NF-κB regulators can result in dysregulated NF-κB signaling, often culminating in events that induce cancer progression and other hyper NF-κB related diseases, such as inflammation, cardiovascular diseases, diabetes, as well as neurodegenerative diseases, etc. In this review, we discuss the regulatory role of phosphorylation in NF-κB signaling and the mechanisms through which they aid cancer progression. Additionally, we highlight some of the known and novel NF-κB regulators that are frequently subjected to phosphorylation. Finally, we provide some future perspectives in terms of drug development to target kinases that regulate NF-κB signaling for cancer therapeutic purposes.

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