scholarly journals The Absence of Yellow Fever in Asia: History, Hypotheses, Vector Dispersal, Possibility of YF in Asia, and Other Enigmas

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1349
Author(s):  
Goro Kuno
Keyword(s):  
Yellow Fever ◽  
Current Knowledge ◽  
Vector Competence ◽  
Viral Persistence ◽  
Critical Factor ◽  
Holistic Approach ◽  
Principal Vector ◽  
Transmission Mechanisms ◽  
History Of ◽  
Rich History

Since the recent epidemics of yellow fever in Angola and Brazil as well as the importation of cases to China in 2016, there has been an increased interest in the century-old enigma, absence of yellow fever in Asia. Although this topic has been repeatedly reviewed before, the history of human intervention has never been considered a critical factor. A two-stage literature search online for this review, however, yielded a rich history indispensable for the debate over this medical enigma. As we combat the pandemic of COVID-19 coronavirus worldwide today, we can learn invaluable lessons from the historical events in Asia. In this review, I explore the history first and then critically examine in depth major hypotheses proposed in light of accumulated data, global dispersal of the principal vector, patterns of YF transmission, persistence of urban transmission, and the possibility of YF in Asia. Through this process of re-examination of the current knowledge, the subjects for research that should be conducted are identified. This review also reveals the importance of holistic approach incorporating ecological and human factors for many unresolved subjects, such as the enigma of YF absence in Asia, vector competence, vector dispersal, spillback, viral persistence and transmission mechanisms.

X.—The Natural History of Yellow Fever in Africa

1969 ◽  
Vol 70 (3) ◽  
pp. 191-227 ◽  
Author(s):  
A. J. Haddow
Keyword(s):  
Natural History ◽  
Aedes Aegypti ◽  
Yellow Fever ◽  
Narrative Form ◽  
Tropical Africa ◽  
Principal Vector ◽  
Vector Mosquito ◽  
Natural Hosts ◽  
History Of ◽  
Classical Vector

SynopsisThe studies on the epidemiology of yellow fever which have been carried out in Africa in the period 1925–1966 are presented in narrative form.The original isolation of the virus is described, leading on to the survey work which showed that the infection is widespread in tropical Africa and that monkeys are very important hosts—perhaps the definitive mammalian hosts—of the virus. The discoveries of a monkey-to-man cycle in which the classical vector mosquito,Aedes aegypti, is replaced byA. simpsoniand of a monkey-to-monkey cycle, in whichA. africanusis the vector, are described.Recent epidemics are discussed, particularly that in Ethiopia, where there were about 200,000 cases, with 30,000 deaths, in the period 1960–62 and where the principal vector in the man-to-man cycle wasA. simpsoni.Work on groups of animals other than monkeys is reviewed, with particular reference to studies on the lemuroid Primates of the genusGalago, which are believed to be natural hosts of the virus. It is concluded that there are still many unknown facets in the epidemiology.

FORMATION AND DEVELOPMENT OF RURAL ARCHITECTURE IN THE FORMER KETSKAYA VOLOST

2020 ◽  
Vol 22 (2) ◽  
pp. 9-28 ◽  
Author(s):  
E. V. Sitnikova
Keyword(s):  
Cultural Heritage ◽  
18Th Century ◽  
Scientific Methods ◽  
Architectural Analysis ◽  
Tomsk Region ◽  
History Of ◽  
The Rich ◽  
Rural Architecture ◽  
The Village ◽  
Rich History

The article considers the historical and cultural heritage of villages of the former Ketskaya volost, which is currently a part of the Tomsk region. The formation of Ketsky prison and the architecture of large settlements of the former Ketskaya volost are studied. Little is known about the historical and cultural heritage of villages of the Tomsk region and the problems of preserving historical settlements of the country.The aim of this work is to study the formation and development of the village architecture of the former Ketskaya volost, currently included in the Tomsk region.The following scientific methods are used: a critical analysis of the literature, comparative architectural analysis and systems analysis of information, creative synthesis of the findings. The obtained results can be used in preparation of lectures, reports and communication on the history of the Siberian architecture.The scientific novelty is a study of the historical and cultural heritage of large settlements of the former Ketskaya volost, which has not been studied and published before. The methodological and theoretical basis of the study is theoretical works of historians and architects regarding the issue under study as well as the previous  author’s work in the field.It is found that the historical and cultural heritage of the villages of the former Ketskaya volost has a rich history. Old historical buildings, including religious ones are preserved in villages of Togur and Novoilinka. The urban planning of the villages reflects the design and construction principles of the 18th century. The rich natural environment gives this area a special touch. 

Paleontology and stratigraphy of Middle Eocene rock units in the southern Green River and Uinta Basins, Wyoming and Utah

2017 ◽  
Vol 4 ◽  
pp. 1-53 ◽  
Author(s):  
Paul Murphey ◽  
K.E. Townsend ◽  
Anthony Friscia ◽  
James Westgate ◽  
Emmett Evanoff ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Middle Eocene ◽  
Green River Basin ◽  
Green River ◽  
Scientific Exploration ◽  
History Of ◽  
Climatic History ◽  
Field Excursion ◽  
Land Mammal ◽  
Bridger Formation

The Bridger Formation is restricted to the Green River Basin in southwest Wyoming, and the Uinta and Duchesne River Formations are located in the Uinta Basin in Utah. These three rock units and their diverse fossil assemblages are of great scientific importance and historic interest to vertebrate paleontologists. Notably, they are also the stratotypes from oldest to youngest for the three middle Eocene North American Land Mammal Ages—the Bridgerian, Uintan, and Duchesnean. The fossils and sediments of these formations provide a critically important record of biotic, environmental, and climatic history spanning approximately 10 million years (49 to 39 Ma). This article provides a detailed field excursion through portions of the Green River and Uinta Basins that focuses on locations of geologic, paleontologic, and historical interest. In support of the field excursion, we also provide a review of current knowledge of these formations with emphasis on lithostratigraphy, biochronology, depositional, and paleoenvironmental history, and the history of scientific exploration.

scholarly journals L2HGDH Missense Variant in a Cat with L-2-Hydroxyglutaric Aciduria

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 682
Author(s):  
Matthias Christen ◽  
Nils Janzen ◽  
Anne Fraser ◽  
Adrian C. Sewell ◽  
Vidhya Jagannathan ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Genetic Defect ◽  
Clinical Signs ◽  
Missense Variant ◽  
Microcytic Anemia ◽  
Abnormal Behavior ◽  
Functional Candidate Gene ◽  
History Of ◽  
The Brain ◽  
Hydroxyglutaric Acid

A 7-month-old, spayed female, domestic longhair cat with L-2-hydroxyglutaric aciduria (L-2-HGA) was investigated. The aim of this study was to investigate the clinical signs, metabolic changes and underlying genetic defect. The owner of the cat reported a 4-month history of multiple paroxysmal seizure-like episodes, characterized by running around the house, often in circles, with abnormal behavior, bumping into obstacles, salivating and often urinating. The episodes were followed by a period of disorientation and inappetence. Neurological examination revealed an absent bilateral menace response. Routine blood work revealed mild microcytic anemia but biochemistry, ammonia, lactate and pre- and post-prandial bile acids were unremarkable. MRI of the brain identified multifocal, bilaterally symmetrical and T2-weighted hyperintensities within the prosencephalon, mesencephalon and metencephalon, primarily affecting the grey matter. Urinary organic acids identified highly increased levels of L-2-hydroxyglutaric acid. The cat was treated with the anticonvulsants levetiracetam and phenobarbitone and has been seizure-free for 16 months. We sequenced the genome of the affected cat and compared the data to 48 control genomes. L2HGDH, coding for L-2-hydroxyglutarate dehydrogenase, was investigated as the top functional candidate gene. This search revealed a single private protein-changing variant in the affected cat. The identified homozygous variant, XM_023255678.1:c.1301A>G, is predicted to result in an amino acid change in the L2HGDH protein, XP_023111446.1:p.His434Arg. The available clinical and biochemical data together with current knowledge about L2HGDH variants and their functional impact in humans and dogs allow us to classify the p.His434Arg variant as a causative variant for the observed neurological signs in this cat.

The History of Yellow Fever: An Essay on the Birth of Tropical Medicine

1992 ◽  
Vol 22 (3) ◽  
pp. 499
Author(s):  
John Duffy ◽  
Francois Delaporte
Keyword(s):  
Yellow Fever ◽  
Tropical Medicine ◽  
History Of

scholarly journals The Return of National Self-Sufficiency? Excavating Autarkic Thought in a De-Globalizing Era

2021 ◽  
Author(s):  
Eric Helleiner
Keyword(s):  
Intellectual History ◽  
International Political Economy ◽  
Economic Thought ◽  
John Maynard Keynes ◽  
New Politics ◽  
Self Sufficiency ◽  
National Economic ◽  
History Of ◽  
High Degree ◽  
Rich History

Abstract As the global crisis triggered by the COVID-19 virus unfolded, The Economist magazine published a cover in May 2020 titled “Goodbye globalization: the dangerous lure of self-sufficiency.” The title summed up well the new political interest in the ideology of national economic self-sufficiency in the pandemic context. Unfortunately, contemporary textbooks in the field of international political economy (IPE) say little about this kind of “autarkic” thought. No survey of the history of autarkic thought exists even within specialist IPE literature or in the fields of intellectual history and the history of economic thought. Filling this gap in existing scholarship, this article highlights a rich history of autarkic thought that includes the ideas of famous thinkers such as Jean-Jacques Rousseau, Johann Fichte, Mohandas Gandhi, and John Maynard Keynes. Three core rationales for a high degree of national self-sufficiency have been advanced in the past: (1) insulation from foreign economic influence, (2) insulation from foreign political and/or cultural influence, and (3) the promotion of international peace. At the same time, considerable disagreements have existed among autarkists about some of these rationales and their relative importance, as well as about the precise meaning of national self-sufficiency. These disagreements stemmed not just from differences in their specific goals but also from the different conditions across time and space in which autarkic thought was developed. In addition to improving understanding of the autarkic ideological tradition, this article contributes to emerging scholarship attempting to overcome Western-centrism in IPE scholarship as well as literature exploring the new politics of de-globalization in the current era.

Global Pests, National Pride, Local Problems, and the Crisis of Hungarian Wine, 1867–1914

2021 ◽  
pp. 1-16
Author(s):  
Robert Nemes
Keyword(s):  
World War I ◽  
World War ◽  
Folk Culture ◽  
Wine Production ◽  
National Imagination ◽  
Local Problems ◽  
History Of ◽  
Trade And Exchange ◽  
Rich History

Abstract Hungary has a long, rich history of wine production. Historians have emphasized wine's importance to the development of both the Hungarian economy and Hungarian nationalism. This article ties together these historiographical threads through a case study of a small village in one of Hungary's most famous wine regions. Tracing the village's history from the 1860s to World War I, the article makes three main claims. First, it demonstrates that from the start, this remote village belonged to wider networks of trade and exchange that stretched across the surrounding region, state, and continent. Second, it shows that even as Magyar elites celebrated the folk culture and peasant smallholders of this region, they also cheered the introduction of what they saw as scientific, rational agriculture. This leads to the last argument: wine achieved its place in the pantheon of Hungarian culture at a moment when the local communities that had grown up around its production and stirred the national imagination were undergoing dramatic and irreversible change.

scholarly journals CHEK2∗1100delC Mutation and Risk of Prostate Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Victoria Hale ◽  
Maren Weischer ◽  
Jong Y. Park
Keyword(s):  
Prostate Cancer ◽  
Current Knowledge ◽  
Prostate Cancer Screening ◽  
Critical Role ◽  
Prostate Cancer Risk ◽  
Conclusive Evidence ◽  
Increased Risk ◽  
History Of ◽  
Cancer Studies

Although the causes of prostate cancer are largely unknown, previous studies support the role of genetic factors in the development of prostate cancer.CHEK2plays a critical role in DNA replication by responding to double-stranded breaks. In this review, we provide an overview of the current knowledge of the role of a genetic variant, 1100delC, ofCHEK2on prostate cancer risk and discuss the implication for potential translation of this knowledge into clinical practice. Currently, twelve articles that discussedCHEK2∗1100delC and its association with prostate cancer were identified. Of the twelve prostate cancer studies, five studies had independent data to draw conclusive evidence from. The pooled results of OR and 95% CI were 1.98 (1.23–3.18) for unselected cases and 3.39 (1.78–6.47) for familial cases, indicating thatCHEK2∗1100delC mutation is associated with increased risk of prostate cancer. Screening for CHEK2∗1100delC should be considered in men with a familial history of prostate cancer.

scholarly journals The interplay between environmental factors, Vector Competence and vaccine immunodynamics as possible explanation of the 2019 Yellow fever Re-emergence in Nigeria

2021 ◽  
pp. 100858
Author(s):  
Idris Nasir Abdullahi ◽  
Abubakar Umar Anka ◽  
Anthony Uchenna Emeribe ◽  
Kabir Umar ◽  
Hafeez Aderinsayo Adekol ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Yellow Fever ◽  
Vector Competence
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