scholarly journals Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leonians

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2325
Author(s):  
Rodrigo Borrega ◽  
Diana K. S. Nelson ◽  
Anatoliy P. Koval ◽  
Nell G. Bond ◽  
Megan L. Heinrich ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Blood Donors ◽  
Middle Eastern ◽  
The United States ◽  
Lassa Fever ◽  
Sub Saharan Africa ◽  
Blood Samples ◽  
Sierra Leonean ◽  
Potential Factor ◽  
Sub Saharan

Many countries in sub-Saharan Africa have experienced lower COVID-19 caseloads and fewer deaths than countries in other regions worldwide. Under-reporting of cases and a younger population could partly account for these differences, but pre-existing immunity to coronaviruses is another potential factor. Blood samples from Sierra Leonean Lassa fever and Ebola survivors and their contacts collected before the first reported COVID-19 cases were assessed using enzyme-linked immunosorbent assays for the presence of antibodies binding to proteins of coronaviruses that infect humans. Results were compared to COVID-19 subjects and healthy blood donors from the United States. Prior to the pandemic, Sierra Leoneans had more frequent exposures than Americans to coronaviruses with epitopes that cross-react with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARS-CoV, and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). The percentage of Sierra Leoneans with antibodies reacting to seasonal coronaviruses was also higher than for American blood donors. Serological responses to coronaviruses by Sierra Leoneans did not differ by age or sex. Approximately a quarter of Sierra Leonian pre-pandemic blood samples had neutralizing antibodies against SARS-CoV-2 pseudovirus, while about a third neutralized MERS-CoV pseudovirus. Prior exposures to coronaviruses that induce cross-protective immunity may contribute to reduced COVID-19 cases and deaths in Sierra Leone.

scholarly journals Adenovirus-Based Vaccines: Comparison of Vectors from Three Species of Adenoviridae

2010 ◽  
Vol 84 (20) ◽  
pp. 10522-10532 ◽  
Author(s):  
H. Chen ◽  
Z. Q. Xiang ◽  
Y. Li ◽  
R. K. Kurupati ◽  
B. Jia ◽  
...  
Keyword(s):  
T Cell ◽  
Neutralizing Antibodies ◽  
T Cell Responses ◽  
Neutralizing Antibody ◽  
The United States ◽  
Antibody Responses ◽  
Sub Saharan Africa ◽  
Healthy Human ◽  
Cell Responses ◽  
Sub Saharan

ABSTRACT In order to better understand the broad applicability of adenovirus (Ad) as a vector for human vaccine studies, we compared four adenovirus (Ad) vectors from families C (Ad human serotype 5 [HAdV-5; here referred to as AdHu5]), D (HAdV-26; here referred to as AdHu26), and E (simian serotypes SAdV-23 and SAdV-24; here referred to as chimpanzee serotypes 6 and 7 [AdC6 and AdC7, respectively]) of the Adenoviridae. Seroprevalence rates and titers of neutralizing antibodies to the two human-origin Ads were found to be higher than those reported previously, especially in countries of sub-Saharan Africa. Conversely, prevalence rates and titers to AdC6 and AdC7 were markedly lower. Healthy human adults from the United States had readily detectable circulating T cells recognizing Ad viruses, the levels of which in some individuals were unexpectedly high in response to AdHu26. The magnitude of T-cell responses to AdHu5 correlated with those to AdHu26, suggesting T-cell recognition of conserved epitopes. In mice, all of the different Ad vectors induced CD8+ T-cell responses that were comparable in their magnitudes and cytokine production profiles. Prime-boost regimens comparing different combinations of Ad vectors failed to indicate that the sequential use of Ad vectors from distinct families resulted in higher immune responses than the use of serologically distinct Ad vectors from the same family. Moreover, the transgene product-specific antibody responses induced by the AdHu26 and AdC vectors were markedly lower than those induced by the AdHu5 vector. AdHu26 vectors and, to a lesser extent, AdC vectors induced more potent Ad-neutralizing antibody responses. These results suggest that the potential of AdHu26 as a vaccine vector may suffer from limitations similar to those found for vectors based on other prevalent human Ads.

scholarly journals The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals

Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 256 ◽  
Author(s):  
Yasaman Mortazavi ◽  
Salum J. Lidenge ◽  
Tara Tran ◽  
John T. West ◽  
Charles Wood ◽  
...  
Keyword(s):  
Antigenic Determinant ◽  
Neutralizing Antibodies ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Sub Saharan Africa ◽  
People Living With Hiv ◽  
Viral Glycoproteins ◽  
Kaposi's Sarcoma Associated Herpesvirus ◽  
Sub Saharan ◽  
Kaposi’S Sarcoma Associated Herpesvirus

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma (KS), one of the most prevalent cancers of people living with HIV/AIDS in sub-Saharan Africa. The seroprevalence for KSHV is high in the region, and no prophylactic vaccine against the virus is available. In this study, we characterized the antigenic targets of KSHV-specific neutralizing antibodies (nAbs) in asymptomatic KSHV-infected individuals and KS patients with high nAbs titers. We quantified the extent to which various KSHV envelope glycoproteins (gB, ORF28, ORF68, gH, gL, gM, gN and gpK8.1) adsorbed/removed KSHV-specific nAbs from the plasma of infected individuals. Our study revealed that plasma from a majority of KSHV neutralizers recognizes multiple viral glycoproteins. Moreover, the breadth of nAbs responses against these viral glycoproteins varies among endemic KS, epidemic KS and asymptomatic KSHV-infected individuals. Importantly, among the KSHV glycoproteins, the gH/gL complex, but neither gH nor gL alone, showed the highest adsorption of KSHV-specific nAbs. This activity was detected in 80% of the KSHV-infected individuals regardless of their KS status. The findings suggest that the gH/gL complex is the predominant antigenic determinant of KSHV-specific nAbs. Therefore, gH/gL is a potential target for development of KSHV prophylactic vaccines.

Comparing breast cancer characteristics across Sub-Saharan Africa and the United States

2018 ◽  
Vol 92 ◽  
pp. S155 ◽  
Author(s):  
S. Grover ◽  
M. Narasimhamurthy ◽  
R. Bhatia ◽  
C. Benn ◽  
K. Fearnhead ◽  
...  
Keyword(s):  
Breast Cancer ◽  
United States ◽  
The United States ◽  
Sub Saharan Africa ◽  
Sub Saharan

Letter To The Editor

PEDIATRICS ◽  
1996 ◽  
Vol 98 (4) ◽  
pp. 796-796
Author(s):  
Samuel L. Katz
Keyword(s):  
Oral Polio Vaccine ◽  
The United States ◽  
Sub Saharan Africa ◽  
Intestinal Immunity ◽  
Polio Vaccine ◽  
Polio Immunization ◽  
Individual Protection ◽  
Sub Saharan ◽  
Community Protection ◽  
Central Nervous System Invasion

Drs Terry and Schneider raise legitimate questions regarding changes in polio immunization recommendations. In response to the former, although two doses of inactivated polio vaccine provide humoral immunity that will protect an individual against central nervous system invasion by wild or revertant attenuated polioviruses, they do not provide intestinal immunity, a valued asset of oral polio vaccine (OPV). Because we live in a global community where jet transportation enables one to move from a polio-endemic area to a polio-free area in less than one day, the introduction of wild polio viruses from sub-Saharan Africa or Southeast Asia poses a legitimate threat and concern to those who wish to maintain community protection, in addition to individual protection, against possible reintroduction of wild virus to the United States.

There Is a Balm in Gilead

2020 ◽  
pp. 135-164
Author(s):  
Dan Royles
Keyword(s):  
International Security ◽  
The United States ◽  
Black Churches ◽  
Bill Clinton ◽  
Sub Saharan Africa ◽  
Aids Education ◽  
Religious Institutions ◽  
Faith Leaders ◽  
Control And Prevention ◽  
Sub Saharan

This chapter describes the work of The Balm in Gilead, which grew out of the efforts of Pernessa Seele, an immunologist at Harlem Hospital, to organize local Black faith leaders to address AIDS through the Harlem Week of Prayer for the Healing of AIDS. As Seele trained African American clergy to incorporate AIDS education into their ministry, she also confronted entrenched homophobia in Black religious institutions. Accordingly, The Balm in Gilead designed programs that would help churches accept and include gay members. In 2001, Seele contracted with the Centers for Disease Control and Prevention to extend her work with Black churches to sub-Saharan Africa, setting up programs in Côte d’Ivoire, Kenya, Nigeria, Zimbabwe, and Tanzania. She argued that because of Black people’s particular relationship with church and faith, the approach that The Balm in Gilead had developed in the United States would work in Africa as well. At the same time, this work intersected with a growing interest in addressing “global AIDS” among U.S. leaders, including Presidents Bill Clinton and George W. Bush, who saw the spread of the disease in Africa as a growing threat to international security.

Perspectives from Four Stages of Development

2019 ◽  
pp. 159-178
Author(s):  
Eleanor M. Fox ◽  
Mor Bakhoum
Keyword(s):  
South African ◽  
Gold Standard ◽  
Developed Countries ◽  
The United States ◽  
Point Of View ◽  
Sub Saharan Africa ◽  
The European Union ◽  
African Countries ◽  
Sub Saharan ◽  
The Developed Countries

This chapter identifies four clusters of nations based on state of development, in order to highlight significant qualitative differences that may call for different law and policies. The first cluster comprises the least developed sub-Saharan African countries with the most resource-challenged competition authorities, such as Benin and Togo. The second cluster compromises nations that have advanced economically to a perceptibly higher level. The third cluster is a “group” of one—South Africa. With all of its challenges, the South African competition regime is as close to a gold standard as there is in sub-Saharan Africa. Finally, for comparison, the fourth cluster comprises the developed countries, led in particular by the European Union and the United States. These nations have open economies, fairly robust markets, good infrastructure, and good institutions. The chapter proceeds to identify, from the point of view of each of the clusters, the most fitting competition framework nationally and globally. The chapter proposes how the divergences can be brought into sympathy.

Introduction

ESC CardioMed ◽  
2018 ◽  
pp. 1185-1186
Author(s):  
Nombulelo P. Magula ◽  
Akira Singh
Keyword(s):  
Black Women ◽  
Hiv Infection ◽  
The United States ◽  
Sub Saharan Africa ◽  
Middle Income ◽  
High Burden ◽  
Immunodeficiency Virus ◽  
Widespread Availability ◽  
Sub Saharan ◽  
Young Black Women

Life expectancy has increased significantly with the widespread availability of antiretroviral therapy. Despite this, new human immunodeficiency virus (HIV) infection rates in low- to middle-income, high-burden countries remain a cause for concern. The greatest impact of infection remains in sub-Saharan Africa, among young black women. However, the majority of studies investigating cardiovascular disease associated with HIV infection have been conducted in the United States and Europe, in predominantly male cohorts.

The Emerging Market of Sub-Saharan Africa and Technology Adoption

2012 ◽  
Vol 3 (1) ◽  
pp. 14-26 ◽  
Author(s):  
Alice S. Etim
Keyword(s):  
Mobile Phones ◽  
Personal Development ◽  
Emerging Market ◽  
The United States ◽  
Emerging Economy ◽  
Sub Saharan Africa ◽  
Mobile Technologies ◽  
Information And Communication ◽  
Sub Saharan ◽  
Study Participants

In the United States, Organization for Economic Co-operation and Development (OECD) countries and several emerging economies in Asia, mobile technologies have become ubiquitous and core to everyday lives. The same cannot be said for many countries in Sub Saharan Africa (SSA). The availability, affordability and use of information and communication technology (ICT) continue to pose a major challenge to the progress of this important emerging economy and their participation in a networked and “flat world.” Writers (Bishop et al., 1999; ADB, 2003; Fisher et al., 2004; Elijah & Ogunlade, 2006; Etim, 2009; Ssewanyana, 2007) argue for the use of ICT to enable the SSA population in the area of economic and personal development. This paper examines the emerging economy of SSA adoption of mobile technologies in comparison to the U.S.A and reports a study on the features that SSA students desire in mobile phones. The key finding was that study participants desired Internet access via mobile phones.

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