scholarly journals Effect of the Age and Body Weight of the Broiler Breeders Male on the Presentation of Oxidative Stress and Its Correlation with the Quality of Testicular Parenchyma and Physiological Antioxidant Levels

2020 ◽  
Vol 7 (2) ◽  
pp. 69
Author(s):  
Magdalena Escorcia ◽  
Félix Sánchez-Godoy ◽  
David Ramos-Vidales ◽  
Omar Noel Medina-Campos ◽  
José Pedraza-Chaverri
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Histological Analysis ◽  
Seminiferous Epithelium ◽  
Reproductive Capacity ◽  
Seminiferous Tubules ◽  
Biochemical Tests ◽  
Enzymatic Antioxidant ◽  
Fertilization Capacity

Chicken meat is a food of high nutritional quality; its production requires birds called broilers breeders and looking after all aspects that influence their reproductive capacity. An ongoing controversy exists among researchers related to the weight of the rooster and its fertilization capacity. By histological and biochemical tests, the association between weight and age with oxidant damage, testicular parenchyma and antioxidant capacity was evaluated in Ross 308 roosters. Testicular integrity was assessed by histological analysis, oxidative stress was determined by malondialdehyde content, non-enzymatic antioxidant capacity was determined by oxygen radical absorbance capacity assay and enzymatic antioxidant capacity through glutathione peroxidase, glutathione reductase and glutathione-S-transferase activities. Histological analysis showed vacuolization of the epithelium from the seminiferous tubules. A significant negative association was observed between malondialdehyde and the deterioration of the integrity of the seminiferous epithelium, as well as between age and integrity of the seminiferous epithelium. It became evident that oxidative damage directly affects the quality of testicular parenchyma. Weight and age were not associated with the antioxidant enzymes activities, but with non-enzymatic capacity. The data obtained suggest that weight is not the most important factor that influences the fertility of the rooster.

scholarly journals Antioxidant Capacity of Preterm Neonates Assessed by Hydrogen Donor Value

Medicina ◽  
2019 ◽  
Vol 55 (11) ◽  
pp. 720 ◽  
Author(s):  
Melinda Matyas ◽  
Monica G. Hasmasanu ◽  
Gabriela Zaharie
Keyword(s):  
Oxidative Stress ◽  
Respiratory Distress ◽  
Antioxidant Capacity ◽  
Antioxidant Defense ◽  
Hydrogen Donor ◽  
Study Group ◽  
Enzymatic Antioxidants ◽  
Premature Newborns ◽  
Enzymatic Antioxidant ◽  
Hydrogen Donors

Background and objectives: Premature newborns have a number of oxidative stress-inducing disorders. Antioxidant defense is deficient in premature newborns. Hydrogen donors can be used to evaluate the non-enzymatic antioxidant defense. By measuring hydrogen donors, a group of antioxidants can be assessed: tocopherol, ascorbic acid, and glutathione. These represent the most relevant group of non-enzymatic antioxidants. The main aim of this study was to evaluate the non-enzymatic antioxidant defense capacity of premature newborns by measuring hydrogen donors. Materials and Methods: We evaluated the non-enzymatic antioxidant capacity by hydrogen donor measurement in 24 premature newborns with various oxidative stress-inducing disorders and in 14 premature newborns without oxidative stress-inducing conditions. Statistical analysis was performed using the Statistica program (v. 8, StatSoft, Round Rock, TX, USA). Differences between groups were tested with Wilcoxon matched test for quantitative paired data or Mann–Whitney test for quantitative independent data. The Z test for proportions was used to compare qualitative data among subgroups. Results: Hydrogen donors in the study group had a significantly lower value on the first day of life compared to the value of the control group. Also, the hydrogen donor value in the study group was significantly lower on the first day compared to the third day of life (p < 0.05). Neonates with mild respiratory distress (14 cases) had increased hydrogen donor values on their third day of life compared to the first day of life. Conclusions: The antioxidant capacity is influenced by oxidative stress-inducing disorders. Respiratory distress influenced the hydrogen donor value and antioxidant defense. Antioxidant defense gradually improves after birth according to gestational age.

scholarly journals Abnormalities in the ovaries of sockeye salmon spawners in the Kamchatka River in 2019

2021 ◽  
pp. 69-73
Author(s):  
S. B. Gorodovskaya ◽  
L. N. Smorodina
Keyword(s):  
Body Length ◽  
Sockeye Salmon ◽  
Histological Analysis ◽  
Mature Female ◽  
Reproductive Capacity ◽  
Kamchatka River ◽  
Natural Regulation ◽  
Oocyte Resorption

Based on histological analysis of the ovaries of sockeye salmon spawners in the Kamchatka River, numerous abnormalities leading to resorption are shown in the structure of vitellogenic oocytes. Fertility of mature female sockeye salmon decreases due to the resorption of the vitellogenic oocytes. Presence of ovaries with abnormal oocytes implies oocyte resorption in fish being a phenomenon associated with mechanism of natural regulation of final fertility. Such mechanism is required in view of changing fish body length and weight in the sockeye salmon of the Kamchatka River. Numerous abnormalities in the ovaries indicate of a decreasing reproductive capacity of spawners and commercial quality of the eggs.

scholarly journals Lipopolysaccharide Prompts Oxidative Stress and Apoptosis in Rats’ Testicular Tissue

2018 ◽  
Vol 1 (3) ◽  
pp. 20-31 ◽  
Author(s):  
Amal A Halawa ◽  
Mohamed A El-Adl ◽  
Mohamed F Hamed ◽  
Ahmed Z Balboula ◽  
Mohammed A Elmetwally
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Caspase 3 ◽  
Reproductive Toxicity ◽  
Testicular Tissue ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Albino Rats ◽  
Histopathological Analysis ◽  
Total Antioxidant

Lipopolysaccharide (LPS) is a component of the outer membrane of gram negative bacteria. LPS challenging allows switching transcription of proinflammatory cytokines on via over stimulation of Toll-like receptors (TLRs) signaling pathway with subsequent pathogenic inflammatory response. We investigated the possible reproductive toxicity of LPS in male Wister albino rats. Oxidative stress markers, antioxidant status and caspase-3 activity were analyzed in testicular tissues of rats exposed to either saline or LPS (4 mg/kg BW, ip; 0.18 of the LD50). The samples were collected at 6 h and 72 h after injection of LPS. A significant reduction in testicular reduced glutathione (GSH), glutathione-S-transferase (GST) and superoxide dismutase (SOD) was observed at 72 h compared to control group. Total antioxidant capacity was decreased at 6 h with additional significant reduction at 72 h. Catalase activity was reduced significantly at both 6 and 72 h. Malondialdehyde (MDA) was increased (P ≤ 0.05) in LPS injected rats without variation between 6 and 72 h. A significant increase in nitric oxide (NO) was observed at 72 h after injection. A time-dependent increase in LPS-treated groups was observed in the concentration of caspase-3.Histopathological analysis revealed degenerative changes and necrosis of seminiferous tubules after 6 h with further accumulation of eosinophilic edematous transudate in its lumen after 72 h. In conclusion, by increasing time of exposure, LPS induced lipid peroxidation, oxidative stress, reduced testicular antioxidant capacity and encouraged testicular apoptosis which could be possible mechanisms for impairment of testicular function.

scholarly journals Endothelial Glycocalyx Integrity Is Preserved in Young, Healthy Men During a Single Bout of Strenuous Physical Exercise

2016 ◽  
pp. 281-291 ◽  
Author(s):  
J. MAJERCZAK ◽  
K. DUDA ◽  
S. CHLOPICKI ◽  
G. BARTOSZ ◽  
A. ZAKRZEWSKA ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Uric Acid ◽  
Heparan Sulfate ◽  
Antioxidant Capacity ◽  
Strenuous Exercise ◽  
Healthy Men ◽  
Enzymatic Antioxidant ◽  
Markers Of Inflammation ◽  
Single Bout

In the present study we aimed to evaluate whether oxidative stress and inflammation induced by strenuous exercise affect glycocalyx integrity and endothelial function. Twenty one young, untrained healthy men performed a maximal incremental cycling exercise – until exhaustion. Markers of glycocalyx shedding (syndecan-1, heparan sulfate and hyaluronic acid), endothelial status (nitric oxide and prostacyclin metabolites – nitrate, nitrite, 6-keto-prostaglandin F1α), oxidative stress (8-oxo-2’-deoxyguanosine) and antioxidant capacity (uric acid, non-enzymatic antioxidant capacity) as well as markers of inflammation (sVCAM-1 and sICAM-1) were analyzed in venous blood samples taken at rest and at the end of exercise. The applied strenuous exercise caused a 5-fold increase in plasma lactate and hypoxanthine concentrations (p<0.001), a fall in plasma uric acid concentration and non-enzymatic antioxidant capacity (p<10−4), accompanied by an increase (p=0.003) in sVCAM-1 concentration. Plasma 6-keto-prostaglandin F1α concentration increased (p=0.006) at exhaustion, while nitrate and nitrite concentrations were not affected. Surprisingly, no significant changes in serum syndecan-1 and heparan sulfate concentrations were observed. We have concluded, that a single bout of severe-intensity exercise is well accommodated by endothelium in young, healthy men as it neither results in evident glycocalyx disruption nor in the impairment of nitric oxide and prostacyclin production.

107 Administration of antioxidants improves serum total antioxidant capacity, testosterone, and seminal quality of Magra rams

2021 ◽  
Vol 33 (2) ◽  
pp. 160
Author(s):  
A. Kumar ◽  
J. S. Mehta ◽  
A. Kumar ◽  
G. N. Purohit
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Vitamin C ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Sperm Concentration ◽  
Serum Testosterone ◽  
Semen Parameters ◽  
Total Antioxidant

Oxidative stress is one of the most important factors responsible for poor quality of semen, and it is defined as an imbalance between the formation of reactive oxygen species (ROS, including hydroxyl radicals, superoxide anions, and hydrogen peroxide) and antioxidant capacity of semen. Antioxidants act as a powerful defence system against ROS attack in sperm cells by decreasing oxidative stress and they improve semen quality, which could be useful in the management of male infertility. Magra is a dual-purpose (wool and meat) hardy sheep breed that originated in the eastern and southern parts of the Bikaner district of Rajasthan, India. The present study evaluated the effects of the administration of vitamin E with selenium or vitamin C on serum antioxidants, testosterone, and seminal quality of Magra rams. Twenty-one Magra rams, aged between 1.5 and 2.5 years, were randomly assigned to treatment at weekly intervals with administration of either 1mL of vitamin E (tocopherol, 50mg mL−1) and selenium (1.5mg sodium selenite; n=7; VES), 8mL of vitamin C (250mg mL−1 sodium ascorbate; n=7; VC), or 1mL of saline (n=7; control) subcutaneously for 5 consecutive weeks. After the fourth week, semen and blood were collected twice a week for 5 consecutive weeks and assayed for seminal quality parameters, serum testosterone, and serum antioxidants. Data obtained were analysed statistically using te SPSS software (version 25.0; IBM Corp.). Mean values were compared using Duncan’s multiple range test. The semen parameters sperm motility, sperm concentration, live sperm percentage, and% HOST (hypo-osmotic swelling test)-positive sperm were significantly elevated, whereas reaction time and percentage of abnormal sperm were lower in both the treated groups compared with controls (P&lt;0.05). Seminal pH declined significantly in the VES group (P&lt;0.05), whereas it was not different between the VC and control groups of rams (P&gt;0.05). Glutathione peroxidase, superoxide dismutase, and total antioxidant capacity concentrations were higher in serum and seminal plasma of treated rams (P&lt;0.05). Serum testosterone concentrations were significantly elevated in VES and VC groups (P&lt;0.05). We concluded that the administration of vitamin E and selenium or vitamin C improves the serum testosterone production and seminal quality of rams.

scholarly journals Phytotherapy in reducing glycemic index and testicular oxidative stress resulting from induced diabetes: a review

2017 ◽  
Vol 77 (1) ◽  
pp. 68-78 ◽  
Author(s):  
J. S. Oliveira ◽  
A. A. N. Silva ◽  
V. A. Silva Junior
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Plant Species ◽  
Gonadosomatic Index ◽  
Seminiferous Epithelium ◽  
Antioxidant Potential ◽  
Seminiferous Tubules ◽  
Main Role ◽  
Sperm Production ◽  
Damage And Failure

Abstract Oxidative stress plays a main role in the development of diabetes complications. The impairment of gonadal antioxidant potential and endocrine disturbance in diabetic males causes testicular damage and failure in sperm production. Plants have been widely used to control diabetes due their hypoglycemic and antioxidant potential, contributing towards the recovery of testicular function. Current study comprises a review of the literature on the main medicinal plants used in the recovery of testicular oxidative damage in animals with experimental diabetes. Eighteen plant species in the nineteen studies selected from the search strategy were evaluated. Plant extracts were evaluated according to their effects on blood glucose and insulin levels, antioxidant enzymes and oxidant levels, lipid peroxidation, total protein, testosterone levels, gonadosomatic index, diameter of seminiferous tubules, seminiferous epithelium height and integrity, number of germ cells at stage VII and apoptosis in the seminiferous epithelium, sperm production, motility, viability and morphology. After the analysis of the studies, it was observed that plant species, used alone or in combination, may control testicular oxidative damage triggered by diabetes. The antioxidant potential varies among species, with some plants proving to have a better performance in the recovery of reproduction parameters than others.

scholarly journals Oxidative stress among informal caregivers

2019 ◽  
Vol 22 (4) ◽  
Author(s):  
Natália Ramos Imamura de Vasconcelos ◽  
Gilsenir Maria Prevelato de Almeida Dátilo ◽  
Agnaldo Bruno Chies ◽  
Eduardo Federighi Baisi Chagas ◽  
Thiago José Querino de Vasconcelos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Informal Caregivers ◽  
The Body ◽  
Antioxidant Defenses ◽  
Control Group ◽  
Case Group ◽  
Enzymatic Antioxidant ◽  
Reducing Ability

Abstract Objective: to evaluate oxidative stress and non-enzymatic antioxidant defenses in informal caregivers, and correlations with anxiety, health satisfaction and quality of life. Method: a case-control analytical study was performed, where the case was represented by the main informal caregiver and the control was paired with individuals with identical characteristics to the case, but who were not informal caregivers. The following instruments were used: a sociodemographic questionnaire, the Beck anxiety scale and the WHOQoL-Bref. Oxidative stress was measured through blood by analysis of the Ferric Reducing Ability of Plasma (FRAP) and Thiobarbituric Acid Reactive Substances (TBARS) markets. Results: most informal caregivers were females. There was no difference in the degree of anxiety between the Case and Control groups. Among informal caregivers, 9.4% said they were very dissatisfied and 53.1% dissatisfied with their health. Most caregivers (43.8%) rated their quality of life as poor and 12.5% as very poor, while most controls rated it as good (68.8%). The TBARS and FRAP values were lower in the Case group than in the Control group. Conclusion: The informal caregivers, who were mostly women, defined themselves as dissatisfied or very dissatisfied with their health. Nevertheless, they did not manifest a higher degree of anxiety in comparison with the control population. In addition, they presented a lower degree of oxidative stress than the non-caregiving participants, perhaps due to a greater mobilization of the non-enzymatic antioxidant defenses present in the body.

The Role of Polyphenols in the Modulation of Plasma Non-Enzymatic Antioxidant Capacity (NEAC)

2012 ◽  
Vol 82 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Mauro Serafini ◽  
Giuseppa Morabito
Keyword(s):  
Antioxidant Capacity ◽  
Dietary Intervention ◽  
Ex Vivo ◽  
The Body ◽  
Dietary Polyphenols ◽  
Enzymatic Antioxidant ◽  
Endogenous Antioxidant

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.

Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers

2019 ◽  
Vol 22 (7) ◽  
pp. 496-501
Author(s):  
Fatemeh Ahmadi-Motamayel ◽  
Parisa Falsafi ◽  
Hamidreza Abolsamadi ◽  
Mohammad T. Goodarzi ◽  
Jalal Poorolajal
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Free Radicals ◽  
Antioxidant Capacity ◽  
Cigarette Smoke ◽  
Total Antioxidant Capacity ◽  
The Body ◽  
Total Antioxidant ◽  
The Mean ◽  
And Oxidative Stress

Background: Cigarette smoke free radicals can cause cellular damage and different diseases. All the body fluids have antioxidants which protect against free radicals. Objective: The aim of this study was to evaluate salivary total antioxidant capacity and peroxidase, uric acid and malondialdehyde levels in smokers and a nonsmoking control group. Methods: Unstimulated saliva was collected from 510 males. A total of 259 subjects were current smokers and 251 were non-smokers. The levels of salivary total antioxidant capacity, uric acid, peroxidase and malondialdehyde were measured using standard procedures. Data were analyzed with t test and ANOVA. Results: The smokers were younger and dental hygiene index was higher than healthy nonsmoking controls. The mean total antioxidant capacity in smokers and nonsmokers was 0.13±0.07 and 0.21±011, respectively (P=0.001). Smokers had significantly lower peroxidase and uric acid levels than healthy controls. In addition, the mean malondialdehyde levels in the smokers and nonsmokers were 4.55 ±2.61 and 2.79 ±2.21, respectively (P=0.001). Conclusion: Cigarette smoke produces free radical and oxidative stress, causing many side effects. Salivary antioxidant levels decreased and malondialdehyde levels increased in smokers, indicating the high oxidative stress among smokers compared to nonsmokers. Cigarette smoke had deleterious effects on main salivary antioxidants levels.

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