scholarly journals Drinking Water Arsenic and Adverse Reproductive Outcomes in Men and Women: A Systematic PRISMA Review

Water ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 1885
Author(s):  
Ida M. Barsøe ◽  
Ninna H. Ebdrup ◽  
Hannah S. Clausen ◽  
Julie Lyngsø ◽  
Jörg Schullehner ◽  
...  
Keyword(s):  
Drinking Water ◽  
Spontaneous Abortion ◽  
Semen Quality ◽  
Arsenic Exposure ◽  
Quality Characteristics ◽  
Reproductive Outcomes ◽  
Case Control Studies ◽  
Time To Pregnancy ◽  
Cross Sectional ◽  
Men And Women

Infertility is a worldwide health issue, but mechanisms of both male and female reproductive toxicity remain to be elucidated. So far, a limited focus has been on potentially harmful environmental factors such as arsenic, which is naturally occurring in groundwater. The objective of this review was to systematically investigate the association between arsenic in drinking water and adverse reproductive outcomes in men and women of fertile age. We conducted a systematic literature search and included case-control studies and cohort studies reporting on decreased semen quality characteristics, increased time to pregnancy, infertility, or spontaneous abortion. In total, 433 articles were screened and ultimately, eight studies were included. Included literature was quality assessed with the Newcastle-Ottawa Scale. Findings were reported in a narrative synthesis. Only one study investigated male fertility. An association between increasing arsenic exposure and decreasing semen quality characteristics was found, as well as an indication of arsenic accumulation in seminal plasma. These findings are, however, at high arsenic levels (>1000 µg/L). No consistent evidence was found to support the hypothesis that arsenic exposure from drinking water is a cause of longer waiting time to pregnancy or spontaneous abortion, being the only endpoints investigated in the included literature. In conclusion; the evidence is sparse and of varying quality, however, it does warrant attention, as it conflicts with existing evidence, mainly from cross-sectional or ecologic studies.

scholarly journals Association between Drinking Water Nitrate and Adverse Reproductive Outcomes: A Systematic PRISMA Review

Water ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2287
Author(s):  
Hannah S. Clausen ◽  
Ninna H. Ebdrup ◽  
Ida M. Barsøe ◽  
Julie Lyngsø ◽  
Jörg Schullehner ◽  
...  
Keyword(s):  
Drinking Water ◽  
Spontaneous Abortion ◽  
Animal Studies ◽  
Assisted Reproductive Technologies ◽  
Semen Quality ◽  
Human Study ◽  
Reproductive Technologies ◽  
Quality Parameters ◽  
Small Sample ◽  
Reproductive Outcomes

One in six couples experience fertility problems. Environmental factors may affect reproductive health; however, evidence is lacking regarding drinking water nitrates and outcomes of male and female fertility. The aim of this study was to investigate if exposure to nitrates in drinking water is associated with adverse reproductive outcomes in humans, and animals of fertile age. We conducted a systematic literature search and included case-control studies, cohort studies, and randomized control trials reporting on the association between drinking water nitrate exposure of men, women, or animals and adverse reproductive outcomes, specified as: Semen quality parameters, time to pregnancy (TTP), pregnancy rates, assisted reproductive technologies (ART), and spontaneous abortion. Findings were reported in a narrative synthesis. A total of 12 studies were included. The only human study included reported a decrease in spontaneous abortion at any detectable nitrate level. Overall, the 11 included animal studies support a potential negative effect on semen quality parameters but report equivocal results on TTP and number of offspring produced, and higher risk of spontaneous abortion. In conclusion, animal studies indicate possible effects on semen quality parameters and spontaneous abortion. However, with a few studies, including some with methodological limitations and small sample sizes, caution must be applied when interpreting these results.

scholarly journals Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3057
Author(s):  
Chang-Mu Chen ◽  
Min-Ni Chung ◽  
Chen-Yuan Chiu ◽  
Shing-Hwa Liu ◽  
Kuo-Cheng Lan
Keyword(s):  
Drinking Water ◽  
Protein Expression ◽  
Muscle Mass ◽  
Muscle Atrophy ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Cross Sectional Area ◽  
Muscle Endurance ◽  
Sectional Area ◽  
Cross Sectional

Arsenic is a toxic metalloid. Infants with a low birth-weight have been observed in areas with high-level arsenic in drinking water ranging from 463 to 1025 μg/L. A distal muscular atrophy side effect has been observed in acute promyelocytic leukemia patients treated with arsenic trioxide (As2O3) for therapy. The potential of As2O3 on muscle atrophy remains to be clarified. In this study, the myoatrophic effect of arsenic was evaluated in normal mice and sciatic nerve denervated mice exposed with or without As2O3 (0.05 and 0.5 ppm) in drinking water for 4 weeks. We found that both 0.05 and 0.5 ppm As2O3 increased the fasting plasma glucose level; but only 0.5 ppm arsenic exposure significantly decreased muscle mass, muscle endurance, and cross-sectional area of muscle fibers, and increased muscle Atrogin-1 protein expression in the normal mice. Both 0.05 and 0.5 ppm As2O3 also significantly enhanced the inhibitory effects on muscle endurance, muscle mass, and cross-sectional area of muscle fibers, and increased the effect on muscle Atrogin-1 protein expression in the denervated mice. These in vivo results suggest that inorganic arsenic at doses relevant to humans may possess myoatrophic potential.

scholarly journals No Association between Arsenic Exposure from Drinking Water and Diabetes Mellitus: A Cross-Sectional Study in Bangladesh

2010 ◽  
Vol 118 (9) ◽  
pp. 1299-1305 ◽  
Author(s):  
Yu Chen ◽  
Habibul Ahsan ◽  
Vesna Slavkovich ◽  
Gretchen Loeffler Peltier ◽  
Rebecca T. Gluskin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Drinking Water ◽  
Arsenic Exposure ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Drinking-Water Disinfection By-products and Semen Quality: A Cross-Sectional Study in China

2014 ◽  
Vol 122 (7) ◽  
pp. 741-746 ◽  
Author(s):  
Qiang Zeng ◽  
Yi-Xin Wang ◽  
Shao-Hua Xie ◽  
Liang Xu ◽  
Yong-Zhe Chen ◽  
...  
Keyword(s):  
Drinking Water ◽  
Semen Quality ◽  
Cross Sectional Study ◽  
Water Disinfection ◽  
Sectional Study ◽  
Cross Sectional ◽  
Drinking Water Disinfection ◽  
By Products

scholarly journals Association between type 2 diabetes and chronic arsenic exposure in drinking water: A cross sectional study in Bangladesh

2012 ◽  
Vol 11 (1) ◽  
Author(s):  
Md Rafiqul Islam ◽  
Ismail Khan ◽  
Sheikh Md Nazmul Hassan ◽  
Mark McEvoy ◽  
Catherine D’Este ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Drinking Water ◽  
Arsenic Exposure ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Chronic Arsenic Exposure

Abstract 149: Association Between Hypertension and Chronic Exposure in Bangladesh

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Md Rafiqul Islam ◽  
Ismail Khan ◽  
Sheikh Md Nazmul Hassan ◽  
Mark McEvoy ◽  
Catherine D'Este ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Drinking Water ◽  
Sex Education ◽  
Pulse Pressure ◽  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Participation Rate ◽  
Skin Lesions ◽  
Cross Sectional ◽  
Increased Risk

Objective: To determine the association between chronic arsenic exposure via drinking water and prevalence of hypertension among rural Bangladeshi adults. Design, Setting, Participants: This is an analytical cross sectional study among 1004 participants from 1682 eligible men and women (Participation rate 60%) aged >30 years living in Bangladesh who had continuously consumed arsenic-contaminated drinking water for at least 6 months. Main Outcome Measures: Hypertension was defined as systolic blood pressure > 140 mm of Hg or a diastolic blood pressure > 90 mm of Hg or in combination of the both. Results: A total of 1004 individuals participated in the study. The prevalence of hypertension was 6.6% (95% CI 5.1-8.3%). After adjustment for participant’s age, sex, education, religion, marital status, sign of arsenical skin lesions, monthly household income and BMI, no excess risk of hypertension was observed for drinking water arsenic exposure over 50μg/L. Also, there was no increased risk for higher concentration of arsenic in the drinking water. Arsenic concentration >50 μg/L in drinking water showed no association with systolic, diastolic hypertension separately however, it shows a strong relationship with increased pulse pressure when pulse pressure categorized as <55 and ≥55 mmHg (Adjusted OR: 3.06, CI: 1.22-7.65). Also, duration of exposure to arsenic didn’t show any impact on an increased risk to hypertension except pulse pressure when exposed to arsenic for ≥10 years (Adjusted OR: 4.74, CI: 1.25-17.88). Conclusion: Unlike other studies conducted in developing countries that reported a significant association, this study suggests no association between higher drinking water arsenic concentration and hypertension except for pulse pressure.

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