Features of the immunological profile in various phenotypes of occupational bronchial asthma

2021 ◽  
pp. 19-26
Author(s):  
S.A. Babanov ◽  
A. G. Baykova
Keyword(s):  
Forced Vital Capacity ◽  
Occupational Asthma ◽  
Vital Capacity ◽  
Acute Phase Proteins ◽  
Solid Phase ◽  
Pulmonary Function Tests ◽  
Control Group ◽  
Chronic Obstructive ◽  
Fibrinogen Concentration ◽  
Expiratory Flow

Introduction. Occupational asthma is a complex and heterogeneous disease. Development of personalized treatment and prevention tactics becomes feasible due to phenotyping, which means identifying of markers to combine cases of occupational asthma with similar manifestations (clinical, instrumental, laboratory) and prognosis to phenotypes. The study aims to determination and comparative analysis of spirographic and immunological parameters for different phenotypes of occupational asthma. Materials and methods. In this study, we included 170 patients with different phenotypes of occupational asthma and 50 participants in control group. The spirographic examination was performed using computer spirograph with determination of the following parameters: forced vital capacity (FVC), forced expiratory volume during the first second (FEV1), Tiffeneau-Pinelli index (FEV1/FVC), peak expiratory flow (PEF), maximal expiratory flow at 75 %, 50 %, 25 % of the forced vital capacity (MEF75 %VC, MEF50 %VC, MEF25 %VC). Quantification of the immunoglobulins IgA, IgM, and IgG in human serum was conducted by Mancini method; levels of IgE, C-reactive protein and fibronectin were determined using a solid-phase enzyme immunoassay. Fibrinogen concentration in plasma was measured by an automatic coagulometer. Haptoglobin concentration in serum was determined by spectrophotometry. Results. According to spirometry and laboratory results obtained, there is a strong evidence, that the phenotype «occupational asthma — occupational chronic obstructive pulmonary disease» has the lowest values in pulmonary function tests and the most significant changes in immunoglobulins, fibronectin and acute phase proteins levels among other studied phenotypes of occupational asthma.

Clinical and immunological features and prognosis of different phenotypes of occupational asthma

2021 ◽  
Vol 61 (7) ◽  
pp. 436-441
Author(s):  
Sergey A. Babanov ◽  
Leonid A. Strizhakov ◽  
Antonina G. Baikova ◽  
Darya S. Budash ◽  
Anna S. Agarkova ◽  
...  
Keyword(s):  
Acute Phase ◽  
Forced Vital Capacity ◽  
Occupational Asthma ◽  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Immunological Parameters ◽  
Expiratory Flow

Introduction. Occupational asthma is a complex and heterogeneous disease. Development of personalized treatment and prevention tactics becomes feasible due to phenotyping, which means identifying of markers to combine cases of occupational asthma with similar manifestations (clinical, instrumental, laboratory) and prognosis to phenotypes. The study aims to determination and comparative analysis of spirographic and immunological parameters for different phenotypes of occupational asthma. Materials and methods. In this study, we included 170 patients with different phenotypes of occupational asthma and 50 participants in control group. The spirographic examination was performed using computer spirograph with determination of the following parameters: forced vital capacity (FVC), forced expiratory volume during the first second (FEV1), Tiffeneau-Pinelli index (FEV1/FVC), peak expiratory flow (PEF), maximal expiratory flow at 75%, 50%, 25% of the forced vital capacity (MEF75%VC, MEF50%VC, MEF25%VC). Quantification of the immunoglobulins IgA, IgM, and IgG in human serum was conducted by Mancini method; levels of IgE, C-reactive protein and fibronectin were determined using a solid-phase enzyme immunoassay. Fibrinogen concentration in plasma was measured by an automatic coagulometer. Haptoglobin concentration in serum was determined by spectrophotometry. Results. According to spirometry and laboratory results obtained, there is a strong evidence, that the phenotype "occupational asthma - occupational chronic obstructive pulmonary disease" has the lowest values in pulmonary function tests and the most significant changes in immunoglobulins, fibronectin and acute phase proteins levels among other studied phenotypes of occupational asthma. Conclusions. Dynamic determination of spirometric, immunological parameters, fibronectin and proteins of the acute phase of inflammation in workers at risk for the formation of occupational bronchial asthma may be recommended to be carried out once every 6 months, followed by the isolation of disease phenotypes. This will optimize diagnostics, therapeutic and preventive tactics, as well as predict the course of this pathology.

scholarly journals Pulmonary functions in car air conditioner users and non-air conditioner users in tertiary care centre, South Tamilnadu, India

2019 ◽  
Vol 7 (9) ◽  
pp. 3510
Author(s):  
Hoshea Jeba Ruth S. ◽  
Lisha Vincent
Keyword(s):  
Pulmonary Function ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Control Group ◽  
Air Conditioner ◽  
Air Conditioners ◽  
Function Tests ◽  
Expiratory Flow

Background: Air conditioners are used extensively these days of the modern lifestyle. Inhalation of cold dry air while using Air conditioners causes bronchoconstriction due to which alteration may occur in pulmonary function. This study was aimed to compare the Pulmonary Function tests of Car AC users and non AC users. Methods: The Study included 52 employees not exposed to car air conditioner as a control (group I) and 52 employees exposed to car air conditioner  with minimum exposure of 1 hour per day for 6 months as a subject (group II). Pulmonary function tests were performed using computerised spirometer. Statistical analysis was done by unpaired t test.Results: Age, Height and weight are not statistically significant between study group and control group. Forced vital capacity, forced expiratory volume in 1 second, Ratio of Forced vital capacity and Forced expiratory volume in 1 second, Inspiratory reserve volume, Expiratory reserve volume, Maximum voluntary ventilation are decreased in car air conditioner users compared to non-users, but was not significant. Forced expiratory flow (FEF), Peak expiratory flow rate (PEFR) values shows statistically significant decreased in car air conditioner users.Conclusions: The present study shows hyper-responsive airways on exposure to cold air which leads to bronchoconstriction. The significant decrease in PEFR, FEF suggest that upper airways as well as smaller airways are affected on exposure to car AC. So, Exposure to car Air Conditioner leads to risk of developing respiratory dysfunction.

scholarly journals Forced vital capacity (FVC), peaked expiratory flow rate (PEFR), are additional parameters in the assessment of the reversibility test.

2018 ◽  
Vol 60 (1) ◽  
pp. 24-27
Author(s):  
Mustafa N. Abd Ali ◽  
Ahmed H. Jasim ◽  
Abdulrasool N. Nassr ◽  
Monqith A. Kaddish
Keyword(s):  
Pulmonary Function ◽  
Airway Obstruction ◽  
Flow Rate ◽  
Forced Vital Capacity ◽  
Social Order ◽  
Vital Capacity ◽  
Chronic Obstructive ◽  
P Value ◽  
Cross Sectional ◽  
Expiratory Flow

Background: Spirometry is an important test performed in patients expect to have airway obstruction, assessment of intense reaction to inhalers (the trial of reversibility of airway blockade) is a normally utilized technique in clinical and academic studies. The consequences of this test are utilized to take choices on treatment, consideration, exclusion from diagnosis and other research think about, and for analytic marking [asthma versus chronic obstructive airway disease (COPD)]. Usually, the (FEV1) or (FVC) standards before and after giving of the bronchodilator are compared and the adjustment is processed to distinguish variations from the norm in lung volumes and air flow.Objective: The aim of this study was to investigate the effectiveness of FVC and PEFR as further constraints to evaluate bronchodilator reaction in asthmatic peoples with severe or moderate airflow blockade.Patients and methods: This study is cross sectional study performed in Baghdad teaching hospital where one hundred patient were enrolled in this study patients were detected with asthma and confirm airway blockade according to (GINA) guide lines. The pulmonary function for all members was investigated with a convenient spirometer (spiro-lab3 Spirometer) as stated by those measures from claiming American thoracic particular social order, The mean and standard deviation results of the predicted% values pulmonary function test were also used for comparisons were measured by t-test. A p-value of ≤ 0.05 considered to be significant statistically.Results: The post bronchodilator (post –BD) results of FVC, PEFR are greater than pre- bronchodilator where are statistically significant P value = 0.00. the amount of the changes of FVC post (BD) was more than 400ml from pre (BD) and the amount of the changes of PEFR post (BD) more than 1000ml from the pre (BD) both were p-value = 0.00.Conclusion: The asthmatic patients with moderate and severe airway obstruction, we observed that FVC and PEFR is a valuable important limit to FEV1 to evaluate reversibility reactionKeyword: forced vital capacity(FVC), peaked expiratory flow rate (PEFR), spirometry and forced expiratory volume in 1st second (FEV1). السعة الحيويه القصوى ومعدل الجريان الزفيري الاعلى وصفات اضافية في تقييم اختبار المعاكسه القصبيه أ.د. مصطفى نعمه عبد علي  احمد حسين جاسم عبد الرسول نوري نصر منقذ عبد المحسن كاظم  الخلاصه : خلفية البحث : ان جهاز قياس التنفس هو وسيله لقياس تضيق المجاري الهوائية ومدى استجابتها لموسع القصبات عند التشخيص للحالات السريريه , وفي تحديد نوع العلاج , وفي التمييز بين الربو القصبي وانسداد القصبات المزمن . في هذا البحث تم قياس السعة الحيويه القصوى والحجم الزفيري الاعلى في الثانيه وذلك قبل وبعد اعطاء موسع القصبات وقياس الفرق في الحالات الطبيعيه لحجوم الرئه وجريان الهواء فيها . هدف البحث : استخدام عنصر السعة الحيويه القصوى وعنصر معدل الجريان الزفيري الاعلى كعوامل اضافية لتقييم اختبار توسع القصبات في مرضىالربو القصبي ذوي تضيق القصبات المتوسط والشديد. المرضى وطرق العمل:اجريت دراسه مقطعيه في مستشفى بغداد التعليمي على 100 مريض يعانون من الربو مع تضيق المجاري الهوائية حسب التصنيف العالمي (GINA) , وقد اجريت لهم وظائف الرئه  . تم استخدام اختبار - testt و    p – value على مستوى معنويه اقل او يساوي 0.05. النتائج : اظهرت نتائج السعة الحيويه ومعدل الجريان الزفيري الاعلى بعد اعطاء موسع القصبات هي اكبر من قبل اعطائه مع قيمة p- value  تساوي صفر .كما ان معدل التغيير للسعة الحيويه بعد اعطاء موسع القصبات كانت اكثر من 400ml من قبل اعطاء موسع القصبات . وقد بلغ  معدل التغيير في الجريان  الزفيري الاعلى بعد اعطاء موسع القصبات اكثر من 1000ml بالمقارنة ما قبل اعطاء موسع القصبات , وكانت p- value تساوي صفر . الاستنتاج : في هذا البحث ,كانت السعة الحيويه القصوى ومعدل الجريان الزفيري الاعلى لمرضى الربو  القصبي ذات قيمه مهمه لدعم الحجم الزفيري الاقصى في الثانية الاولى لتقييم تفاعل المعاكسة  لتوسع القصبات . مفتاح الكلمات : السعه الحيوية القصوى , معدل الجريان الزفيري الاعلى , جهاز قياس التنفس , لحجم الزفيري الاقصى في الثانية الاولى 

scholarly journals Effects of PM2.5 on Cardio-Pulmonary Function Injury in Open Manganese Mine Workers

2019 ◽  
Vol 16 (11) ◽  
pp. 2017 ◽  
Author(s):  
Yuanni Huang ◽  
Mian Bao ◽  
Jiefeng Xiao ◽  
Zhaolong Qiu ◽  
Kusheng Wu
Keyword(s):  
Pulmonary Function ◽  
Forced Vital Capacity ◽  
Prevalence Rate ◽  
Vital Capacity ◽  
Open Pit ◽  
Control Group ◽  
Significant Difference ◽  
Forced Expiratory Flow ◽  
Pm2.5 Exposure ◽  
Expiratory Flow

Exposure to fine particulate matter 2.5 (PM2.5) is associated with adverse health effects, varying by its components. The health-related effects of PM2.5 exposure from ore mining may be different from those of environment pollution. The aim of this study was to investigate the effects of different concentrations of PM2.5 exposure on the cardio-pulmonary function of manganese mining workers. A total of 280 dust-exposed workers who were involved in different types of work in an open-pit manganese mine were randomly selected. According to the different concentrations of PM2.5 in the working environment, the workers were divided into an exposed group and a control group. The electrocardiogram, blood pressure, and multiple lung function parameters of the two groups were measured and analyzed. The PM2.5 exposed group had significantly lower values in the pulmonary function indexes of forced expiratory volume in one second (FEV1.0), maximum mid expiratory flow (MMEF), peak expiratory flow rate (PEFR), percentage of peak expiratory flow out of the overall expiratory flow volume (PEFR%), forced expiratory flow at 25% and 75% of forced vital capacity (FEF 25, FEF75), forced expiratory flow when 25%, 50%, and 75% of forced vital capacity has been exhaled (FEF25%,FEF50%, FEF75%), and FEV1.0/FVC% (the percentage of the predicted value of forced vital capacity) than the control group (all p < 0.05). Both groups had mild or moderate lung injury, most of which was restrictive ventilatory disorder, and there was significant difference in the prevalence rate of restrictive respiratory dysfunction between the two groups (41.4% vs. 23.6%, p = 0.016). Electrocardiogram (ECG) abnormalities, especially sinus bradycardia, were shown in both groups, but there was no statistical difference of the prevalence rate between the two groups (p > 0.05). Also, no significant difference of the prevalence rate of hypertension was observed between the PM2.5 exposure and control groups (p > 0.05). PM2.5 exposure was associated with pulmonary function damage of the workers in the open-pit manganese mine, and the major injury was restrictive ventilatory disorder. The early effect of PM2.5 exposure on the cardiovascular system was uncertain at current exposure levels and exposure time.

Pulmonary function severity in relation to interleukin-23 levels in patients with psoriasis vulgaris

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Vasann Saranya ◽  
Saranya Kuppusamy ◽  
Pravati Pal ◽  
Munisamy Malathi ◽  
Medha Rajappa ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Control Group ◽  
Chronic Obstructive ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Expiratory Flow ◽  
Interleukin 23

AbstractBackgroundInterleukin-23 (IL-23), a key inflammatory regulator in the pathogenesis of psoriasis, is suspected to play a role in the onset of pulmonary dysfunction (chronic obstructive pulmonary disease) in psoriasis. Despite that, pulmonary function tests are rarely studied in these subjects. This study aims to seek a possible relation between pulmonary function in psoriasis patients serum IL-23.MethodsFor this analytical cross-sectional study, male psoriasis patients in the age group of 25–45 years were recruited from dermatology out patient department (n = 40). Age and BMI matched apparently healthy individuals were recruited as control group (n = 40). After obtaining demographic and personal details, anthropometric parameters and blood pressure were recorded. The severity of psoriasis was assessed using Psoriasis Area and Severity Index score. Pulmonary function was assessed using computerized spirometry, and serum IL-23 was measured using ELISA.ResultsForced vital capacity, forced expiratory volume in 1 s, peak expiratory flow rate, and forced expiratory flow at 25%–75% of the pulmonary volume (FEF25%–75%) were significantly reduced in psoriasis. Based on the percentage of predicted values FEF25%–75% was significantly reduced in psoriasis. Serum IL-23 (pg/mL) was significantly higher in psoriasis. The increase in IL-23 in psoriasis subjects does not correlate with their pulmonary function.ConclusionsPsoriasis may be associated with a reduced lung function even when the disease is in the mild stage. Increased IL-23 found in these subjects is suggestive of systemic inflammation, which indirectly lowers lung function.

Pulmonary Function Testing Reference Values and Interpretations in Pediatric Training Programs

PEDIATRICS ◽  
1990 ◽  
Vol 85 (5) ◽  
pp. 768-773
Author(s):  
Edward N. Pattishall
Keyword(s):  
Pulmonary Function ◽  
Statistical Methods ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Training Programs ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Reference Standards ◽  
Forced Expiratory Flow ◽  
Expiratory Flow

A questionnaire was sent to all pediatric training programs to evaluate the use of pulmonary function reference standards and the interpretation of pulmonary function test results. Responses were obtained from 107 of 130 institutions, and 94 of these had pulmonary function laboratories available. Of the 94, 60 used one of three reference standards. The primary reason the reference standards were chosen was either unknown or because they came with the spirometer (24), were recommended by another person or were those used in that person's training (34), or were thought to be the best standards available or most applicable to the population to be tested (31). To define abnormality, most used an 80% predicted cutoff for forced vital capacity, forced expiratory volume in 1 second, and forced expiratory flow at 25% to 75% vital capacity. For a change in an individual through time, most used a 10% change for forced vital capacity, forced expiratory volume in 1 second, and forced expiratory flow at 25% to 75% vital capacity. Thirteen used statistical methods to define abnormal individuals and none used statistical methods to define a significant change over time. Although there are a few guidelines for reference standards and interpretations of pulmonary function tests, it appears that most laboratories are not using those guidelines and that further guidelines and education are needed.

scholarly journals Evaluation of spirometry in asthmatic children

2017 ◽  
Vol 4 (3) ◽  
pp. 729
Author(s):  
Kriti Hegde ◽  
Amit S. Saxena ◽  
Rajesh Kumar Rai
Keyword(s):  
Peak Expiratory Flow ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Cold Weather ◽  
Asthmatic Children ◽  
Modifiable Factors ◽  
Forced Expiratory Flow ◽  
Expiratory Flow

Background:The use of spirometry in the assessment of children with asthma is taking on new importance with the realization that considerable airway obstruction may exist in the absence of clinically detectable abnormalities. Hence this study was planned to evaluate, forced expired volume in 1 second (FEV1), forced vital capacity (FVC), the forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) and Peak Expiratory Flow rates (PEFR) in asthmatic children aged 6-12 years. The objective of the study was to determine prevalence of asthma according to clinical classification and identify common trigger factors and to determine which is more sensitive between FEV1, FVC, FEV1/FVC, FEF 25-75 and PEFR in different age groups.Methods: The present study was conducted among 60 patients of age group 6 to 12 years with asthma. Forced vital capacity (FVC), Forced expiratory volume in 1 second (FEV1), Ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC), PEFR and Forced expiratory flow between 25-75% were recorded. Data was analyzed using chi-square test, Karl Pearson’s correlation coefficient. Level of significance was set at 5%. All p values less than 0.05 were treated as significant.Results:In Age and Sex wise correlation with classification of asthma, a male preponderance was seen in all the age groups i.e. between 6-8 years, 9-10 years and 11-12 years. Mosquito coils were the most common indoor agents to trigger an asthmatic accounting for nearly 80%. Amongst the outdoor triggers, exacerbation of symptoms during the cold weather accounted for 90 % followed by variation during festivals like Diwali, dust, pollution, exercise and insects. Comparison of Pre and Post bronchodilator FEF 25-75 values have shown a high statistical significance.Conclusions:Parents need to be educated regarding certain modifiable factors that can improve the prognosis. Pulmonary Function tests should be performed as a routine office procedure. Peak expiratory flow meter is a handy instrument. In all children above 6 years of age suspected to have asthma, this test should be performed before beginning therapy.

Chest wall muscle atrophy as a contributory factor for forced vital capacity decline in systemic sclerosis-associated interstitial lung disease

Rheumatology ◽  
2020 ◽  
Vol 60 (1) ◽  
pp. 250-255
Author(s):  
Takashi Nawata ◽  
Yuichiro Shirai ◽  
Mikito Suzuki ◽  
Masataka Kuwana
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Chest Wall ◽  
Muscle Atrophy ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Potential Contribution ◽  
Muscle Area ◽  
Chest Wall Muscle

Abstract Objective To investigate the potential contribution of accessory respiratory muscle atrophy to the decline of forced vital capacity (FVC) in patients with SSc-associated interstitial lung disease (ILD). Methods This single-centre, retrospective study enrolled 36 patients with SSc-ILD who underwent serial pulmonary function tests and chest high-resolution CT (HRCT) simultaneously at an interval of 1–3 years. The total extent of ILD and chest wall muscle area at the level of the ninth thoracic vertebra on CT images were evaluated by two independent evaluators blinded to the patient information. Changes in the FVC, ILD extent, and chest wall muscle area between the two measurements were assessed in terms of their correlations. Multiple regression analysis was conducted to identify the independent contributors to FVC decline. Results Interval changes in FVC and total ILD extent were variable among patients, whereas chest wall muscle area decreased significantly with time (P=0.0008). The FVC change was negatively correlated with the change in ILD extent (r=−0.48, P=0.003) and was positively correlated with the change in the chest wall muscle area (r = 0.53, P=0.001). Multivariate analysis revealed that changes in total ILD extent and chest wall muscle area were independent contributors to FVC decline. Conclusion In patients with SSc-ILD, FVC decline is attributable not only to the progression of ILD but also to the atrophy of accessory respiratory muscles. Our findings call attention to the interpretation of FVC changes in patients with SSc-ILD.

Pulmonary function in men after oxygen breathing at 3.0 ATA for 3.5 h

1991 ◽  
Vol 71 (3) ◽  
pp. 878-885 ◽  
Author(s):  
J. M. Clark ◽  
R. M. Jackson ◽  
C. J. Lambertsen ◽  
R. Gelfand ◽  
W. D. Hiller ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Large Change ◽  
Forced Expiratory Volume ◽  
Diffusing Capacity ◽  
Mild Degree ◽  
Oxygen Breathing ◽  
Multiple Organs ◽  
Expiratory Flow

As a pulmonary component of Predictive Studies V, designed to determine O2 tolerance of multiple organs and systems in humans at 3.0–1.5 ATA, pulmonary function was evaluated at 1.0 ATA in 13 healthy men before and after O2 exposure at 3.0 ATA for 3.5 h. Measurements included flow-volume loops, spirometry, and airway resistance (Raw) (n = 12); CO diffusing capacity (n = 11); closing volumes (n = 6); and air vs. HeO2 forced vital capacity maneuvers (n = 5). Chest discomfort, cough, and dyspnea were experienced during exposure in mild degree by most subjects. Mean forced expiratory volume in 1 s (FEV1) and forced expiratory flow at 25–75% of vital capacity (FEF25–75) were significantly reduced postexposure by 5.9 and 11.8%, respectively, whereas forced vital capacity was not significantly changed. The average difference in maximum midexpiratory flow rates at 50% vital capacity on air and HeO2 was significantly reduced postexposure by 18%. Raw and CO diffusing capacity were not changed postexposure. The relatively large change in FEF25–75 compared with FEV1, the reduction in density dependence of flow, and the normal Raw postexposure are all consistent with flow limitation in peripheral airways as a major cause of the observed reduction in expiratory flow. Postexposure pulmonary function changes in one subject who convulsed at 3.0 h of exposure are compared with corresponding average changes in 12 subjects who did not convulse.

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