Physiotherapy of cicatricial skin changes in the conditions of metabolic syndrome

2020 ◽  
pp. 15-21
Author(s):  
K. V. Kazantseva ◽  
S. N. Nagornev ◽  
V. K. Frolkov
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Therapeutic Potential ◽  
Skin Changes ◽  
Fractional Photothermolysis ◽  
Combined Application ◽  
The Metabolic Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
Lipid Metabolism Disorders

The article analyzes the effectiveness of combined application of fractional photothermolysis and fermencol ultraphonophoresis against the background of metabolic syndrome in patients with cicatricial skin changes. It is shown that the efficiency of combined physiotherapy is reduced if it is performed against the background of metabolic syndrome. It is proved that the leading pathogenetic factors of the metabolic syndrome that reduce the therapeutic potential of physiotherapy procedures are insulin resistance and lipid metabolism disorders. It is found that the use of fractional photothermolysis and fermencol ultraphonophoresis does not affect significantly the main parameters of the metabolic syndrome in patients with or without metabolic syndrome. It is suggested that to increase the effectiveness of physiotherapy in patients with cicatricial skin changes in the presence of disorders of carbohydrate and lipid metabolism, provoked by the development of insulin resistance, additional use of therapeutic factors used to correct metabolic disorders is necessary.

scholarly journals Metabolic syndromes, carbohydrate and lipid metabolism disorders in helminthic infections: review of the literature

2018 ◽  
Vol 17 (4) ◽  
pp. 187-198
Author(s):  
E. A. Golovach ◽  
O. S. Fedorova ◽  
T. V. Saprina ◽  
V. V. Ivanov ◽  
E. A. Perina ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Pathological Condition ◽  
Experimental Studies ◽  
Review Of The Literature ◽  
The Metabolic Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
Helminth Infections ◽  
Lipid Metabolism Disorders ◽  
Helminthic Infections

Metabolic syndrome is a common pathological condition based on an increase of the mass of visceral fat, insulin resistance with hyperinsulinemia, carbohydrate, lipid and protein disorders. The natural course of the metabolic syndrome can be affected by the presence of intercurrent diseases connected with metabolic disorder, and helminthic infections are among them. This review presents an analysis of the results of current epidemiological and experimental studies of metabolic syndrome and abnormalities of carbohydrate and lipid metabolism associated with helminth infections.

Drinking mineral water in the correction of metabolic syndrome in patients with cicatricial skin changes

2021 ◽  
pp. 56-61 ◽  
Author(s):  
V. K. Frolkov ◽  
S. N Nagornev ◽  
K. V. Kazantseva
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Water Intake ◽  
Mineral Water ◽  
Clinical Manifestations ◽  
Practical Interest ◽  
Resistance Index ◽  
Mineral Waters ◽  
Skin Changes ◽  
Lipid Metabolism Disorders

The article analyzes the efficiency of complex physiotherapy in combination with internal intake of medium-mineralized water “Essentuki № 17” in patients with cicatricial skin changes in the presence or absence of metabolic syndrome. It was found that internal mineral water intake supplementing physiotherapy effectively corrected carbohydrate and lipid metabolism disorders by reducing the insulin resistance index, which contributed to a greater regression of clinical manifestations of cicatricial skin changes in patients with metabolic syndrome. Meanwhile, in the absence of metabolic syndrome, the course intake of mineral water did not signifi cantly affect complex physiotherapy, although the index of insulin resistance and body weight of patients significantly decreased. It is suggested that, given the presence of nonspecifi c preventive potential of the course of drinking mineral waters intake, there is some theoretical and possibly practical interest in research on pre-course mineral water intake before performing cosmetic operations to accelerate the process of skin regeneration and the formation of scarring in a less pronounced form.

scholarly journals Evaluation of the hemostatic state, carbohydrate and lipid metabolism in young women with abdominal obesity and hypertension

2015 ◽  
Vol 12 (4) ◽  
pp. 29-33
Author(s):  
Veronika Andreevna Sumerkina ◽  
Vasiliy Sergeevich Chulkov ◽  
Vladislav Sergeevich Chulkov ◽  
Elena Stanislavovna Golovneva ◽  
Larisa Fedorovna Telesheva ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Arterial Hypertension ◽  
Total Cholesterol ◽  
Blood Coagulation ◽  
Abdominal Obesity ◽  
Young Women ◽  
The Metabolic Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
The Individual

Aim of this study was to determine the characteristics of the laboratory parameters of hemostasis, carbohydrate and lipid metabolism in women with metabolic syndrome, isolated abdominal obesity or with hypertension.Materials and methods. The study included 71 women aged 30 – 44 years and was conducted at laboratory study of hemostasis system, carbohydrate and lipid metabolism.Results. In women with abdominal obesity and arterial hypertension we found an increased levels of glucose, total cholesterol, LDL-C and triglycerides and a decrease in a concentration of HDL-C compared to healthy women. The study of hemostasis revealed prothrombotic changes in the form of activation of coagulation hemostasis and fibrinolysis system activity.Conclusions. The disorders of carbohydrate and lipid metabolism are very prevalent in young women with abdominal obesity and hypertension with every second woman meeting the criteria for the metabolic syndrome. The most pronounced signs of activation of blood coagulation markes was seen in women with abdominal obesity and hypertension. In women with the individual components of the metabolic syndrome there were no significant changes in carbohydrate and lipid metabolism, although we saw an early signs of activation of hemocoagulation.

scholarly journals Prevalence and characteristics of lipid metabolism disorders in children from Krasnodar region of Russia

2014 ◽  
Vol 11 (1) ◽  
pp. 38-41
Author(s):  
S A Shadrin ◽  
A V Statova
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Lipid Metabolism ◽  
Metabolic Disorders ◽  
Thyroid Stimulating Hormone ◽  
Excess Body Weight ◽  
Lipid Disorders ◽  
The Metabolic Syndrome ◽  
Lipid Metabolism Disorders ◽  
Krasnodar Region

The goal of our study was to assess the prevalence and characteristics of lipid metabolism disorders in children Krasnodar region of Russia. Overall 6,000 children 10-17 years were included in the study. Lipid disorders were observed in 11.3 %, excess body weight in 6.3%, and obesity in 5.0% of children. The above pathologies were more common in boys (14%) than girls (8.8%). The study revealed that hormonal disorders were the cause of every second obesity as an increased thyroid-stimulating hormone was observed in 9.5 %, increased prolactin - in 38.8 %, and hyperinsulinemia - in 22.0 % of children. Metabolic disorders that were observed were: hypercholesterolemia - in 24.0 % of children with obesity, impaired glucose tolerance - in 13.0%, and the presence of three or four components of the metabolic syndrome in various combinations, identified in 18.0 % of children with obesity.

scholarly journals Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-18 ◽  
Author(s):  
Francisco A. Monsalve ◽  
Radha D. Pyarasani ◽  
Fernando Delgado-Lopez ◽  
Rodrigo Moore-Carrasco
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Glucose Homeostasis ◽  
Metabolic Diseases ◽  
Therapeutic Potential ◽  
Atherogenic Dyslipidemia ◽  
Acid Oxidation ◽  
Peroxisome Proliferator ◽  
The Metabolic Syndrome

Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is growing in the adult and pediatric populations. The most widely recognized metabolic risk factors are atherogenic dyslipidemia, elevated blood pressure, and elevated plasma glucose. Individuals with these characteristics commonly manifest a prothrombotic state and a proinflammatory state as well. Peroxisome proliferator-activated receptors (PPARs) may serve as potential therapeutic targets for treating the metabolic syndrome and its related risk factors. The PPARs are transcriptional factors belonging to the ligand-activated nuclear receptor superfamily. So far, three isoforms of PPARs have been identified, namely, PPAR-α, PPAR-β/δ, and PPAR-γ. Various endogenous and exogenous ligands of PPARs have been identified. PPAR-αand PPAR-γare mainly involved in regulating lipid metabolism, insulin sensitivity, and glucose homeostasis, and their agonists are used in the treatment of hyperlipidemia and T2DM. Whereas PPAR-β/δfunction is to regulate lipid metabolism, glucose homeostasis, anti-inflammation, and fatty acid oxidation and its agonists are used in the treatment of metabolic syndrome and cardiovascular diseases. This review mainly focuses on the biological role of PPARs in gene regulation and metabolic diseases, with particular focus on the therapeutic potential of PPAR modulators in the treatment of thrombosis.

Roles of microRNAs in carbohydrate and lipid metabolism disorders and their therapeutic potential

Biochimie ◽  
2021 ◽  
Author(s):  
Sujay Paul ◽  
Luis Alberto Bravo Vázquez ◽  
Samantha Pérez Uribe ◽  
Luis Aarón Manzanero Cárdenas ◽  
María Fernanda Ruíz Aguilar ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Potential ◽  
Carbohydrate And Lipid Metabolism ◽  
Lipid Metabolism Disorders

scholarly journals Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 524 ◽  
Author(s):  
Dmitrii Tanianskii ◽  
Natalia Jarzebska ◽  
Andreas Birkenfeld ◽  
John O’Sullivan ◽  
Roman Rodionov
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Treatment Strategies ◽  
Cardiovascular Complications ◽  
Metabolic Effects ◽  
Aminoisobutyric Acid ◽  
The Metabolic Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
Sedentary Life Style

The prevalence and incidence of metabolic syndrome is reaching pandemic proportions worldwide, thus warranting an intensive search for novel preventive and treatment strategies. Recent studies have identified a number of soluble factors secreted by adipocytes and myocytes (adipo-/myokines), which link sedentary life style, abdominal obesity, and impairments in carbohydrate and lipid metabolism. In this review, we discuss the metabolic roles of the recently discovered myokine β-aminoisobutyric acid (BAIBA), which is produced by skeletal muscle during physical activity. In addition to physical activity, the circulating levels of BAIBA are controlled by the mitochondrial enzyme alanine: glyoxylate aminotransferase 2 (AGXT2), which is primarily expressed in the liver and kidneys. Recent studies have shown that BAIBA can protect from diet-induced obesity in animal models. It induces transition of white adipose tissue to a “beige” phenotype, which induces fatty acids oxidation and increases insulin sensitivity. While the exact mechanisms of BAIBA-induced metabolic effects are still not well understood, we discuss some of the proposed pathways. The reviewed data provide new insights into the connection between physical activity and energy metabolism and suggest that BAIBA might be a potential novel drug for treatment of the metabolic syndrome and its cardiovascular complications.

scholarly journals Therapeutic Potential of Retinoid X Receptor Modulators for the Treatment of the Metabolic Syndrome

PPAR Research ◽  
2007 ◽  
Vol 2007 ◽  
pp. 1-12 ◽  
Author(s):  
Jane A. Pinaire ◽  
Anne Reifel-Miller
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Therapeutic Potential ◽  
Treatment Options ◽  
Additional Treatment ◽  
The Metabolic Syndrome ◽  
Prevalence Of Obesity ◽  
Receptor Modulators

The increasing prevalence of obesity is a fundamental contributor to the growing prevalence of the metabolic syndrome. Rexinoids, a class of compounds that selectively bind and activate RXR, are being studied as a potential option for the treatment of metabolic syndrome. These compounds have glucose-lowering, insulin-sensitizing, and antiobesity effects in animal models of insulin resistance and type 2 diabetes. However, undesirable side effects such as hypertriglyceridemia and suppression of the thyroid hormone axis also occur. This review examines and compares the effects of four RXR-selective ligands: LGD1069, LG100268, AGN194204, and LG101506, a selective RXR modulator. Similar to selective modulators of other nuclear receptors such as the estrogen receptor (SERMs), LG101506 binding to RXR selectively maintains the desirable characteristic effects of rexinoids while minimizing the undesirable effects. These recent findings suggest that, with continued research efforts, RXR-specific ligands with improved pharmacological profiles may eventually be available as additional treatment options for the current epidemic of obesity, insulin resistance, type 2 diabetes, and all of the associated metabolic sequelae.

scholarly journals Assessment of Carbohydrate and Lipid Metabolism in People With Hypertension Disease

2020 ◽  
Vol 6 (6) ◽  
pp. 92-102
Author(s):  
A. Chaldanbaeva ◽  
A. Gainatulina
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Older Women ◽  
Diagnostic Methods ◽  
Modern World ◽  
Men And Women ◽  
The Metabolic Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
Diagnostic Criterion

Violation of carbohydrate and lipid exchanges are quite common, especially recently. These disorders seriously worsen the prognosis of patients with cardiovascular diseases. In the modern world, these disorders are defined as the main diagnostic criterion for the metabolic syndrome, which in 2003 was added to the international recommendations on arterial hypertension as one of the main cardiovascular risk factors. This is the relevance of the work. The paper presents the features of the state of carbohydrate and lipid metabolism and their relationship with hypertension in mature and elderly people, among men and women using modern biochemical diagnostic methods. It was found that among men in adulthood with hypertension, the average indicators of lipid metabolism only (OH, LDL and TG) are higher than normal. Among older women, the most characteristic changes were found in both carbohydrate and lipid metabolism.

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