scholarly journals Omega-3 polyunsaturated fatty acid profiles and relationship with cardiometabolic risk factors in Cree (Eeyouch) of Northern Québec

2016 ◽  
Vol 75 (1) ◽  
pp. 30361 ◽  
Author(s):  
Françoise Proust ◽  
Olivia Drescher ◽  
Elhadji A. Laouan-Sidi ◽  
Elizabeth Robinson ◽  
Michel Lucas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Fatty Acid Profiles ◽  
Omega 3

Cardiometabolic Risk Factors at 5 Years After Omega-3 Fatty Acid Supplementation in Infancy

PEDIATRICS ◽  
2018 ◽  
Vol 142 (1) ◽  
pp. e20162623 ◽  
Author(s):  
Valene H.L. See ◽  
Trevor A. Mori ◽  
Susan L. Prescott ◽  
Lawrence J. Beilin ◽  
Sally Burrows ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acid ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

scholarly journals Effect of a Family-Based Intervention on Nutrient Biomarkers, Desaturase Enzyme Activities, and Cardiometabolic Risk Factors in Children with Overweight and Obesity

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Nirupa R Matthan ◽  
Judith Wylie-Rosett ◽  
Xiaonan Xue ◽  
Qi Gao ◽  
Adriana E Groisman-Perelstein ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acid ◽  
Glucose Metabolism ◽  
Lipid Profile ◽  
Cardiometabolic Risk ◽  
Liver Enzymes ◽  
Overweight And Obesity ◽  
Cardiometabolic Risk Factors ◽  
Family Based ◽  
The Impact

ABSTRACT Background Developing dietary strategies to prevent excess weight gain during childhood is critical to stem the current obesity epidemic and associated adverse cardiometabolic consequences. Objectives We aimed to assess how participation in a family-based weight-management intervention affected nutrient biomarkers and cardiometabolic risk factors (CMRFs) in children (7–12 y old; n = 321) with baseline BMI z score (BMIz) ≥85th percentile. Methods This was a secondary analysis from a randomized-controlled, parallel-arm clinical trial. Families of children, recruited from a largely Hispanic population, were assigned to Standard Care (SC; American Academy of Pediatrics overweight/obesity recommendations), or SC + Enhanced Program (SC + EP; 8 skill-building cores, monthly support sessions, targeted diet/physical activity strategies). Nutrient biomarkers (plasma carotenoids, fat-soluble vitamins, RBC fatty acid profiles, desaturase indexes) and CMRFs were measured in archived blood samples collected at baseline and the end of the 1-y intervention. Results Children in both groups had significantly lower trans fatty acid and higher pentadecylic acid (15:0), PUFA n–3, and β-carotene concentrations, indicative of decreased hydrogenated fat and increased dairy, vegetable oil, fish, and fruit/vegetable intake, respectively. Similar changes were seen in de novo lipogenesis and desaturase indexes, as well as CMRFs (BMIz, lipid profile, inflammation, adipokines, liver enzymes) in both groups. Using multiple logistic regression, increase in carotenoids and decrease in endogenously synthesized SFA, MUFA, PUFA n–6, and desaturase indexes were associated with improvements in BMIz, blood pressure, lipid profile, glucose metabolism, inflammatory biomarkers, adipokines, and liver enzymes. Trans fatty acids were associated with improvements in BMIz, glucose metabolism, and leptin, with less favorable effects on inflammatory markers and adiponectin. Conclusions Providing targeted family-based behavioral counseling, as part of SC, can help overweight/obese children adopt healthier eating patterns that are associated with modest improvements in BMIz and several CMRFs. Limited additional benefit was observed with SC + EP. These results provide critical data to design subsequent interventions to increase the impact of family-based obesity prevention programs. This trial was registered at clinicaltrials.gov as NCT00851201.

scholarly journals Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction

2009 ◽  
Vol 102 (9) ◽  
pp. 1355-1361 ◽  
Author(s):  
Yongsoon Park ◽  
Jeehyun Lim ◽  
Jaeung Lee ◽  
Soon-gil Kim
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Characteristic Curve ◽  
Fatty Acid Profiles ◽  
Omega 3 ◽  
Framingham Risk ◽  
Increased Risk ◽  
Fatal Myocardial Infarction

The risk of CHD has been linked to n-3 and trans-fatty acids. The purpose of the present study was to evaluate the hypothesis that lower n-3 fatty acids and higher trans-fatty acids in erythrocytes are associated with an increased risk of acute non-fatal myocardial infarction (MI), and that fatty acid profiles can discriminate MI cases from controls. Fifty cases with acute non-fatal MI and fifty age- and sex-matched controls without MI were recruited. The Omega-3 Index (the sum of EPA and DHA in erythrocytes) was significantly lower in cases than controls (9·57 (sem 0·28) v. 11·81 (sem 0·35) %; P < 0·001), while total trans-fatty acids were significantly higher (1·01 (sem 0·04) v. 0·56 (sem 0·03) %; P < 0·001). The Omega-3 Index was associated with decreased risk of MI (OR 0·08 (95 % CI 0·02, 0·38); P = 0·001), while total trans-fatty acids were associated with an increased risk of MI (OR 72·67 (95 % CI 6·68, 790·74); P < 0·001). The area under the receiver operating characteristic curve of fatty acid profiles was larger than that for traditional risk factors, suggesting that fatty acid profiles make a higher contribution to the discrimination of MI cases from controls compared with modified Framingham risk factors. In conclusion, a higher Omega-3 Index and lower trans-fatty acids in erythrocytes are associated with a decreased risk of MI. Furthermore, fatty acid profiles improve discrimination of acute non-fatal MI compared with established risk factors.

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