HPV VACCINE AND CERVICAL CANCER

2011 ◽  
pp. 108-115
Author(s):  
Vu Quoc Huy Nguyen

Persistent infection with high-risk Human Papilloma Virus (HPV) has been identified as the causal factor of cervical cancer, with relative risk up to 300-400 folds. This very close relationship leads to the preventive strategy of vaccination against HPV infections and HPV-related lesions. The article describes molecular and immunologic characteristics of HPV, currently available HPV vaccines and its protective effects; the relationship between HPV vaccination and cervical cancer screening, and an introduction to therapeutic HPV vaccine trials.

2019 ◽  
Vol 35 (6) ◽  
pp. 1197-1205 ◽  
Author(s):  
Yu-e Ning ◽  
Yao Liu ◽  
Xiao-yu Xu ◽  
Xin-yu Zhang ◽  
Ning Wang ◽  
...  

AbstractThis study aimed to research the understanding and knowledge of cervical cancer, human papilloma virus (HPV), and HPV vaccination, and the acceptance of HPV vaccination, among a population of women in northeastern China. A cross-sectional survey was carried out by questionnaire to investigate knowledge of cervical cancer, HPV, and HPV vaccination. The 230 female participants were native residents of northeastern China, and their ages ranged between 18 and 65 years. Questionnaires were randomly acquired by the respondents from online and paper questionnaire distribution. The questionnaire included questions on three major aspects to record people’s perceptions of cervical cancer, HPV, and vaccines. Of the sample of 230 women surveyed, 80.9% had heard of cervical cancer, but understanding was only 15.7%; 38.3% knew about HPV; 20% knew about HPV vaccine; 39.6% agreed to receive HPV vaccination, and the remainder were mainly concerned about its safety and effectiveness. Data analysis showed that age, family income, and whether there was experience of screening all influenced knowledge of cervical cancer, but this was not statistically significant. The level of education had no obvious effect on the degree of knowledge about cervical cancer; however, with an improvement in education, women’s awareness of HPV vaccine improved significantly (p < 0.05). Women who have received cervical cancer screening had significantly greater knowledge about cervical cancer and HPV than those with no screening (p < 0.05). Women in northeastern China have little knowledge of cervical cancer, HPV, and HPV vaccine, lack disease knowledge, and hold a skeptical attitude about HPV vaccination. Medical institutions are the main channel providing information to these women.


Author(s):  
Suchith Hoblidar ◽  
Suma S. Moni ◽  
Rathnamala M. Desai ◽  
Asha Neravi

Background: Cervical cancer is the second leading cause of death in india. it is also one of the few malignancies where an infectious etiological agent human papilloma virus (HPV) has been identified. With the advent of HPV vaccination, it is possible to reduce the morbidity and mortality associated with carcinoma cervix. But biggest hurdle to achieve this is the lack of awareness about the availability and use of HPV vaccine. This study was conducted to know knowledge and awareness of HPV infection and vaccination among medical and paramedical students. We also evaluated the acceptability and coverage of HPV vaccine among these students.Methods: This study was conducted among a total of 520 female students of the Sri Dharmasthala Manjunatheshwara University with the help of a questionnaire. The study group included 207 MBBS students, 167 BDS students, 89 nursing students and 57 physiotherapy students.Results: Most of the students were in 18-20 years’ age group. Nearly 40.57% of the students knew that HPV is sexually transmitted and 29.80% were aware that this infection can be prevented. Availability of HPV vaccine was known to 75% of the students and the main source of their information was through their college teachings. Nearly 43.75% of the students knew HPV vaccine protects against cervical cancer and 26.73% of the students were vaccinated. Overall knowledge and awareness were better among medical students.Conclusions: A lot of work needs to be done so as to make the target population accept HPV vaccine. There is a great difference between awareness of availability of the vaccine and its use. This emphasizes the need for health care professionals to take special interest in promoting this vaccine in the general population.


Author(s):  
Magbagbeola David Dairo ◽  
Moradeke Omoyemi Adeleke ◽  
Adetokunbo Taophic Salawu ◽  
Ayobami David Adewole

Abstract Background: Despite changing sexual norms and mores generally perceived to be permissive of sexual expression, parents continue to serve as gateways to uptake of reproductive health services and commodities in our cultural settings. However, their support for adolescent uptake of human papilloma virus (HPV) vaccine are not well explored and documented. This study aims to assess parental knowledge and awareness of HPV infection and cervical cancer and their support for HPV vaccination for their adolescent children. Methods: In a descriptive cross sectional study 612 parents from in Ibadan North Local Government Area were interviewed using a pre-tested semi structured interviewer administered questionnaire to assess the awareness of HPV infection and cervical cancer as well as parental support for the vaccine. Results: Only a few of the respondents were aware of HPV infection (10.5%) and the HPV vaccine (6.5%), respectively. About 64.3% of those that were aware of HPV knew it can be transmitted through sexual intercourse. However, 78.4% supported the administration of the vaccine to their adolescent daughters. Reported reasons for not supporting HPV vaccination were high cost of the vaccine (32.2%) and lack of awareness of the vaccine (49.2%). Earning a monthly income above the minimum wage of 18,000 Naira increases the likelihood of parental support for HPV vaccination uptake for adolescents (p<0.001). Conclusion: Ignorance and poverty remain as barriers to widespread coverage of the vaccine among adolescents. Health education and promotion on HPV infection and the HPV vaccine to the general public and subsidization of the vaccine to promote its uptake is advocated.


Author(s):  
Hafizur Rahman ◽  
Ezzat Khalda

Background: To have a successful cervical cancer control programme in developing countries, nursing staff must be aware of the facts about the disease preventive methods and the prophylactic human papilloma virus (HPV) vaccine. The aims of the present study were to assess knowledge of, attitudes toward and concerns to HPV vaccine among female Sikkimese nursing staff in India.Methods: Between April 2012 and February 2013, a pre-designed, pretested, self administered multiple responses questionnaire survey was conducted among female Sikkimese nursing staff in India.Results: Overall, 77.4% nursing staff responded that they had ever heard of a HPV vaccine. Trainee nurses were significantly more aware of the vaccine than regular working nurses. Actual knowledge of the vaccine was poor. Recommended age of HPV vaccination was aware by only 38.7% and only 30% nurses knew number of doses of vaccine, while over 90% nursing staff were not aware of time schedule of the vaccine. According to summarized knowledge index only 13.5% nurses had actual knowledge of HPV vaccine. Sixty five percent nurses wanted to vaccinate themselves or to their daughters. Top three aspects of HPV vaccine that nursing staff were most concerned were effectiveness, effect duration and long term effects. Eighty four percent nurses wanted more education and training sessions about cervical cancer prevention and HPV vaccine.Conclusions: Nursing staff in India need to be updated urgently with continuing medical education about cervical cancer prevention and HPV vaccination.


Author(s):  
Chaluvaraj Talkad Seshaiyengar ◽  
Lokesh Kabbalu Chikkegowda ◽  
Madhusudan Madaiah ◽  
Santhosh Munipapanna ◽  
Suresha Doddasabbenahalli Sonnappa

Background: In India, cancer cervix is the leading type of cancer. It is estimated that nearly 100,000 new cases of cervical cancer occurring annually contributing significantly for death of Indian women and it is on the progressive increase. HPV has been incriminated as important cause of cancer cervix. Thus, the study aimed at assessing the extent of awareness and attitude towards Human papilloma virus, HPV vaccine and cervical cancer among young Women in Medical and Nursing College.Methods: Cross sectional study done on 1st year female medical and nursing students (18-21years of age) for the period of One month. Pre-tested, semi structured, self-administered questionnaire was used for the collection of data regarding HPV and its vaccine. Statistical analysis was done by simple percentages and proportions. Frequency and percentages were evaluated for categorical variables. Fisher’s exact test is used to identify the association between categorical variables.Results: In this study 83% of the study Subjects were aware of the disease cancer cervix and 79% of the study Subjects were aware of the Human Papilloma Virus and the association between the causation of cancer cervix by HPV virus is known only by 46%. Awareness about HPV vaccination was 59%, out of which 19% were vaccinated; 41% were neither aware of HPV vaccine nor taken vaccination. However, study showed a strong association between awareness about HPV vaccination and vaccinated, which is statistically significant with Fisher’s Exact p value <0.05.Conclusions: There is need to augment the Information, Education and Communication (IEC) activities to create awareness at all levels in the community in general and among young Women in particular to avert future misery of Women folk who suffer silently. Delhi, first state to launch HPV vaccine as public health programme in schools from March 1st 2016.


Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 496
Author(s):  
Caroline Deignan ◽  
Alison Swartz ◽  
Sara Cooper ◽  
Christopher J. Colvin

Cervical cancer rates in Sub-Saharan Africa (SSA) are amongst the highest worldwide. All three of the Human Papillomavirus (HPV) vaccines (9-valent, quadrivalent and bivalent HPV vaccine) provide primary protection against the most common cancer-causing strains of HPV (types 16 and 18) that are known to cause 70% of cervical cancers. Over the last five years, there has been an increase in Sub-Saharan African countries that have introduced the HPV vaccine. The majority of research has been conducted on supply-side barriers and facilitators to HPV vaccination uptake in SSA, yet little research has been conducted on demand-side or end-user perspectives of, and decisions around, HPV vaccination. In order to complement existing research, and inform current and future HPV vaccination implementation approaches, this qualitative systematic review explored Stakeholders’ understandings of HPV vaccination in SSA. This review searched the following databases: Embase (via Scopus), Scopus, MEDLINE (via PubMed), PubMed, EBSCOhost, Academic Search Premier, Africa-Wide Information, CINAHL, PsycARTICLES, PsycINFO, SocINDEX, Web of Science, and the Cochrane Controlled Register of Trials (CENTRAL) and found a total of 259 articles. Thirty-one studies were found eligible for inclusion and were analyzed thematically using Braun and Clarke’s methods for conducting a thematic analysis. The quality of included studies was assessed using the Critical Appraisal Skills Programme (CASP) checklist. Three major themes emerged from this analysis; knowledge of HPV vaccination and cervical cancer is intertwined with misinformation; fear has shaped contradictory perceptions about HPV vaccination and gender dynamics are relevant in how stakeholders understand HPV vaccination in SSA.


2018 ◽  
Vol 18 (1) ◽  
pp. 215
Author(s):  
Nia Nurzia

Abnormal cervical is still  in high levels of  which marked by the outbreak of the Human Papilloma Virus, It is not offset by the use of vaccination (HPV) Human Papilloma Virus which as the primary prevention of the spread of Human Papilloma Virus . recorded in Dara Jingga clinic in  2015, there were 226 people in the state of the cervix abnormal while those who making vaccination extremely low at only 40 people. Likewise, in 2016 there were 301 people in a state of abnormal cervical and vaccinated only 16 people . Based on it, this research is the research which aimed to determine the relationship between knowledge, economic status, family role and the role of health personnel  against the Human Papilloma Virus vaccination in Dara Jingga Clinic  Jambi City. This research is descriptive analytic with cross sectional design, the data collected through questionnaires, with a population was 321 people. using  acidental sampling technique with  sample was 32 people, research has been conducted on 22 to 24 August 2016 using univariate  and bivariate analysis assisted by a computer program. The results of the univariate analysis of vaccination picture were 10 respondents (31.3%) take advantage of HPV vaccination and 22 respondents (68,8%) did not take advantage of the HPV vaccination, an overview of knowledge were five respondents (15,6%) have sufficient knowledge, 15 respondents (46,9%) had a good knowledge,12 respondents (37,5%) had poor knowledge, an overview of economic status,  13 respondents (40,6%) had high economic status and  19 respondents (59,4% ) have lower economic status, description of the role of health workers13 respondents (40,6%) have a good role of health personnel and  19 respondents (59,4%) has the role of health personnel is not good. Overview of the role of the family, 11 respondents (34,4%) has the role of a good family and  21 respondents (65,6%) had a family roles goodles. the result of these studies show a relationship between the mother's knowledge by vaccination with HPV (Human Papilloma Virus ) with a p value of 0,035, the relationship between economic status with vaccination HPV (Human Papilloma Virus with p value 0,002, their relationship with the role of HPV vaccination of health workers with p value 0,002, their relationship with the family role of HPV vaccination with a p value of 0,004.Keywords: Knowledge, Economic Status, Role of health personnel, Role of Family,HPV Vaccination (Human Papilloma Virus)


2019 ◽  
Vol 14 (41) ◽  
pp. 1800 ◽  
Author(s):  
Miguel Pizzanelli ◽  
Marc Jamoulle

In spite of the demonstrated benefits, the question of HPV massive vaccination is still subject to intense discussions and controversies. The protection against cancer is still unproven and need more time to be accurate about the quantification of the decrease in cervical cancer. The analysis of HPV vaccine relevance is very complex due to several overlapped levels to be considered. The authors analyze many of the ethical, sociological, economic, political and finally scientific issues involved. The population trust in vaccines has been affected owing to dubious practices of many pharmaceutical companies. Faced with this manipulation of information on a worldwide scale, general practitioners have organized themselves to fight this uncertainty. Quaternary prevention, a concept supported by the World Organization of Family doctors, advocates the application of ethically acceptable procedures in health care. This opinion article addresses some of the multiple dimensions involved to encourage reflection on this issue.


2018 ◽  
Vol 46 (2) ◽  
pp. 501-510 ◽  
Author(s):  
Michelle J. Bayefsky

When the HPV vaccine was released over a decade ago, there was intense opposition to mandating the vaccine, including among bioethics and legal scholars. Some of the original concerns are now obsolete, while other objections continue to present an obstacle to mandating the vaccine. This essay responds to earlier critiques of mandatory HPV vaccination and offers a series of arguments in support of a vaccine mandate. The first section briefly addresses initial concerns that are no longer relevant. The second section makes the ethical case for mandating HPV vaccination, based on three principles: 1) the best interests of children, 2) solidarity, and 3) health equity. The final section addresses concerns related to implementation of the vaccine, including the validity of linking vaccination to school entry. The essay concludes that we have a moral imperative to protect children from the leading cause of cervical cancer, and that mandating HPV vaccination is the best way to ensure that children of all backgrounds receive the vaccine before they have been exposed to the virus.


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