Prognostic factors determining survival in patients with node positive differentiated thyroid cancer: a retrospective cross-sectional study

Abstract Background In contrast to the rapid increase in thyroid cancer incidence, the mortality has remained low and stable over the last decades. In Ecuador, however, thyroid cancer mortality has increased. The objective of this study is to determine possible drivers of high rates of thyroid cancer mortality, through a cross-sectional analysis of all patients attending a thyroid cancer referral center in Ecuador. Methods From June 2014 to December 2017, a cross-sectional study was conducted at the Hospital de Especialidades Eugenio Espejo, a regional reference public hospital for endocrine neoplasia in adults in Quito, Ecuador. We identified the mechanism of detection, histopathology and treatment modalities from a patient interview and review of clinical records. Results Among 452 patients, 74.8% were young adults and 94.2% (426) were female. 13.7% had a family history of thyroid cancer, and patients’ median tumor size was 2 cm. The incidental finding was 54.2% whereas 45.8% was non-incidental. Thyroid cancer histology reported that 93.3% had papillary thyroid cancer (PTC), 2.7% follicular, 1.5% Hurtle cells, 1.6% medullary, 0.7% poor differentiated, and 0.2% anaplastic carcinoma. The mean MACIS (metastasis, age, completeness, invasion, and size) score was 4.95 (CI 4.15–5.95) with 76.2% of the thyroid cancer patients having MACIS score less than or equal to 6. The very low and low risk of recurrence was 18.1% (79) and 62% (271) respectively. An analysis of 319 patients with non-metastatic thyroid cancer showed that 10.7% (34) of patients had surgical complications. Moreover, around 62.5% (80 from 128 patients with thyroglobulin laboratory results) of TC patients had a stimulated-thyroglobulin value equal or higher than 2 ng/ml. Overall, a poor surgical outcome was present in 35.1% (112) patients. Out of 436 patients with differentiated thyroid carcinoma, 86% (375) received radioactive iodine. Conclusion Thyroid cancer histological characteristics and method of diagnosis are like those described in other reports without any evidence of the high frequency of aggressive thyroid cancer histology. However, we observed evidence of overtreatment and poor surgical outcomes that demand additional studies to understand their association with thyroid cancer mortality in Ecuador.

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Prevalence of thyroid cancer in patients with acromegaly and non-growth hormone secreting pituitary adenomas: A prospective cross-sectional study

Growth Hormone & IGF Research ◽

10.1016/j.ghir.2021.101378 ◽

2021 ◽

Vol 56 ◽

pp. 101378

Author(s):

Isadora Yasbick Spricido ◽

Carolina Monteguti Feckinghaus ◽

Rômulo Henrique Malaquias Silva ◽

Cleo Otaviano Mesa Junior ◽

Cesar Luiz Boguszewski

Keyword(s):

Growth Hormone ◽

Thyroid Cancer ◽

Pituitary Adenomas ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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A CROSS SECTIONAL STUDY OF BREAST CANCER HISTOMORPHOLOGY AND ITS CORRELATION WITH ER/PR, HER 2NEU AND KI-67 EXPRESSION IN A TERTIARY CARE HOSPITAL AT KANPUR

10.36106/ijar/9500487 ◽

2021 ◽

pp. 9-12

Author(s):

Mahendra Singh ◽

Shobha Dwivedi ◽

Yukteshwar Mishra ◽

Sakshi Tripathi

Keyword(s):

Prognostic Factors ◽

Breast Carcinoma ◽

Tertiary Care ◽

Radical Mastectomy ◽

Cross Sectional Study ◽

Low Grade ◽

Care Hospital ◽

Sectional Study ◽

Ki 67 ◽

Cross Sectional

BACKGROUND Breast carcinoma is the most well-known malignancy in women. Different predictive and prognostic factors, for example, estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor (Her2neu), and Ki67 could inuence breast carcinoma behaviour, yet to date no authoritative connection has been set up among them and breast carcinoma subtypes. In this way present study was done to determine the interrelationships of these predictive and prognostic factors for breast carcinoma. METHODS In this cross sectional study, a total of 50 lumpectomy, modied radical mastectomy specimens of diagnosed carcinoma breast were included in this study. The histopathological grading of the breast carcinoma was performed by Nottingham modication of the Bloom Richardson grading system. All the cases went through immunohistochemistry for ER, PR, Her2neu and Ki67 expression. Association of ER, PR, Her2neu and Ki67 with different histomorphology was established. RESULTS The ER positivity was signicantly lower in tumors >5 cm size whereas Ki67was signicantly increased with increased tumor size. The ER positivity was signicantly lower in high grade tumors as compared to low grade tumors. The positive ER, PR, Her2neu and Ki67 were comparable in between premenopausal and post-menopausal age groups CONCLUSION The present study concludes that ER, PR show inverse while ki67 showed a direct relationship with the tumor grade. Correlation of histomorphology of breast tumor and Her2neu status could not be established.

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Association between Family Histories of Thyroid Cancer and Thyroid Cancer Incidence: A Cross-Sectional Study Using the Korean Genome and Epidemiology Study Data

Genes ◽

10.3390/genes11091039 ◽

2020 ◽

Vol 11 (9) ◽

pp. 1039

Author(s):

Soo-Hwan Byun ◽

Chanyang Min ◽

Hyo-Geun Choi ◽

Seok-Jin Hong

Keyword(s):

Thyroid Cancer ◽

Family History ◽

Cancer Incidence ◽

Age At Onset ◽

Cross Sectional Study ◽

Sectional Study ◽

Epidemiology Study ◽

Cross Sectional ◽

Family Histories ◽

Thyroid Cancer Incidence

This study assessed the association between thyroid cancer and family history. This cross-sectional study used epidemiological data from the Korean Genome and Epidemiology Study from 2001 to 2013. Among 211,708 participants, 988 were in the thyroid cancer group and 199,588 were in the control group. Trained interviewers questioned the participants to obtain their thyroid cancer history and age at onset. The participants were examined according to their age, sex, monthly household income, obesity, smoking, alcohol consumption, and past medical history. The adjusted odds ratios (95% confidence intervals) for the family histories of fathers, mothers, and siblings were 6.59 (2.05–21.21), 4.76 (2.59–8.74), and 9.53 (6.92–13.11), respectively, and were significant. The results for the subgroup analyses according to sex were consistent. The rate of family histories of thyroid cancer for fathers and siblings were not different according to the thyroid cancer onset, while that of mothers were higher in participants with a younger age at onset (<50 years old group, 11/523 [2.1%], p = 0.007). This study demonstrated that thyroid cancer incidence was associated with thyroid cancer family history. This supports regular examination of individuals with a family history of thyroid cancer to prevent disease progression and ensure early management.

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Prognostic Factors Influencing the Selection of Bevacizumab Combined With Chemotherapy in Patients With HER2-Negative Metastatic Breast Cancer in Routine Clinical Practice. Oncosur-Avalox: Observational Cross-Sectional Study

Annals of Oncology ◽

10.1016/s0923-7534(20)32906-9 ◽

2012 ◽

Vol 23 ◽

pp. ix125

Author(s):

L. Manso ◽

R. Perez-Carrion ◽

J.I. Chacon Lopez-Muniz ◽

A. García Palomo ◽

E. Galve Calvo ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Metastatic Breast Cancer ◽

Metastatic Breast ◽

Cross Sectional Study ◽

Routine Clinical Practice ◽

Sectional Study ◽

Cross Sectional ◽

Factors Influencing ◽

Selection Of

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The epidemiology of lymphangioleiomyomatosis in Japan: A nationwide cross-sectional study of presenting features and prognostic factors

Respirology ◽

10.1111/j.1440-1843.2007.01101.x ◽

2007 ◽

Vol 12 (4) ◽

pp. 523-530 ◽

Cited By ~ 62

Author(s):

Mie HAYASHIDA ◽

Kuniaki SEYAMA ◽

Yoshikazu INOUE ◽

Keisaku FUJIMOTO ◽

Keishi KUBO ◽

...

Keyword(s):

Prognostic Factors ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Thyroid Cancer Overdiagnosis and Overtreatment: a cross- sectional study at a thyroid cancer referral center in Ecuador

10.21203/rs.2.16716/v2 ◽

2020 ◽

Author(s):

Paola Solis-Pazmino ◽

Jorge Salazar-Vega ◽

Eddy Lincango-Naranjo ◽

Cristhian Garcia ◽

Gabriela Jaramillo Koupermann ◽

...

Keyword(s):

Thyroid Cancer ◽

Cancer Mortality ◽

Incidental Finding ◽

Cross Sectional Study ◽

Anaplastic Carcinoma ◽

Treatment Modalities ◽

Sectional Study ◽

Cross Sectional ◽

Referral Center ◽

Clinical Records

Abstract Background: In contrast to the rapid increase in thyroid cancer (TC) incidence, thyroid cancer mortality has remained low and stable over the last decades. In Ecuador, however, TC mortality has increased. The objective of this study is to determine possible drivers of high rates of thyroid cancer mortality, through a cross-sectional analysis of all patients attending a thyroid cancer referral center in Ecuador.Methods: From June 2014 to December 2017, a cross-sectional study was conducted at the Hospital de Especialidades Eugenio Espejo (HEEE), a regional reference public hospital for endocrine neoplasia in adults in Quito, Ecuador. We identified the mechanism of detection, histopathology and treatment modalities from a patient interview and review of clinical records. Results: Among 452 patients, 74.8% were young adults and 94.2% (426) were female. 13.7% had a family history of thyroid cancer, and patients’ median tumor size was 2 cm. The incidental finding was 54.2% whereas 45.8% was non-incidental. Thyroid cancer histology reported that 93.3% had papillary thyroid cancer (PTC), 2.7% follicular, 1.5% Hurtle cells, 1.6% medullary, 0.7% poor differentiated, and 0.2% anaplastic carcinoma. The mean MACIS (metastasis, age, completeness, invasion, and size) score was 4.95 (CI 4.15-5.95) with 76.2% of the thyroid cancer patients having MACIS score less than or equal to 6. The very low and low risk of recurrence was 18.1% (79) and 62% (271) respectively. An analysis of 319 patients with non-metastatic thyroid cancer showed that 10.7% (34) of patients had surgical complications. Moreover, around 62.5% (80 from 128 patients with thyroglobulin laboratory results) of TC patients had a stimulated-thyroglobulin (sTg) value equal or higher than 2 ng/ml. Overall, a poor surgical outcome was present in 35.1% (112) patients. Out of 436 patients with differentiated thyroid carcinoma (DTC), 86% (375) received radioactive iodine (RAI). Conclusion: Thyroid cancer histological characteristics and method of diagnosis are like those described in other reports without any evidence of the high frequency of aggressive thyroid cancer histology. However, we observed evidence of overtreatment and poor surgical outcomes that demand additional studies to understand their association with thyroid cancer mortality in Ecuador.

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Expression of CK-19 in Papillary Thyroid Carcinoma and Its Association with Prognostic Factors - A Cross-Sectional Study

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/174 ◽

2021 ◽

Vol 10 (11) ◽

pp. 813-818

Author(s):

Revathy V.J. ◽

Sarath Kumar A

Keyword(s):

Prognostic Factors ◽

Lymph Node ◽

Papillary Thyroid Carcinoma ◽

Lymph Node Metastasis ◽

Tumour Size ◽

Cross Sectional Study ◽

Papillary Thyroid ◽

Sectional Study ◽

Cross Sectional ◽

Node Metastasis

BACKGROUND Papillary thyroid carcinomas (PTC) are the most common carcinomas of the thyroid. Diagnosis of PTC is with its distinct nuclear features. Prognosis of PTC is favourable but can also be aggressive as demonstrated by its recurrence. So, we wanted to improve the present diagnostic tools to identify cases with aggressive course. Immunohistochemistry (IHC) markers which are thought to be useful are CK-19 and CD56. METHODS This is a cross sectional study, done in the Department of Pathology, Government Medical College, Thiruvananthapuram from January 2018 to May 2019. Histopathology slides were prepared from 80 samples, IHCs performed, and the data was analysed using statistical software SPSS version 23.0. RESULTS The classic variant was the most common. In the study, predominant population was below 45 years. There was a female predominance and majority of cases had a tumour size of more than 1 cm. 23.8 % of the cases showed lymph node metastasis. On evaluating CK-19 expression in PTC, 98.75 % showed a positive expression, but there was no association between CK-19 expression and factors like age, gender, tumour size, and lymph node metastasis. 96.3 % of cases showed a loss of expression of CD56. CONCLUSIONS Both CK-19 and CD56 can be used together as markers for PTC including all their variants but CK-19 cannot be used to assess the prognosis of PTC as no association was identified in the study between the expression of CK-19 and prognostic factors. KEY WORDS Papillary Thyroid Carcinoma, Immunohistochemistry

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Identification of Ocular Trauma Pattern with Risk and Prognostic Factors in the North Bund Area of Shanghai

Journal of Ophthalmology & Clinical Research ◽

10.33140/jocr.05.02.05 ◽

2021 ◽

Vol 5 (2) ◽

Keyword(s):

Prognostic Factors ◽

Ocular Trauma ◽

Visual Outcome ◽

Cross Sectional Study ◽

Trauma Patients ◽

Eye Injury ◽

Sectional Study ◽

Cross Sectional ◽

The North ◽

Treatment Objective

Background: Ocular trauma is a leading cause of blindness. Identification of ocular trauma pattern is necessary for better ocular trauma prevention and treatment. Objective: The aim of this study is to identify ocular trauma pattern in the North Bund area of Shanghai. Methods: A retrospective cross-sectional study was conducted with 206 ocular trauma patients at Shanghai General Hospital. Results: A gender related ocular trauma pattern was identified that consists of several risk and prognostic factors. Of 206 ocular trauma patients, 182 patients were males (88.35%) and only 24 patients were females (11.65%). Males had significantly higher percentage of penetrating/intraocular foreign body injuries compared to females, which is associated with age and occupation. A significantly higher average monthly percentage of ocular trauma is observed in summer, suggesting that season change alters the risk of eye injury. Although proper treatments of complications are beneficial for patients, the visual outcome is determined by the location and size of injuries. Conclusion: We identified a gender related ocular trauma pattern with several risk and prognostic factors in the North Bund area of Shanghai.

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