Faculty Opinions recommendation of The relationship between UV exposure and incidence of skin cancer.

RESUMOA incidência do câncer de pele vem aumentando a cada ano. Sabe-se que entre outros fatores, a radiação solar é a principal responsável pelo desenvolvimento dessa patologia. A prevenção, feita através da fotoproteção, teria grande impacto nesse cenário. No entanto, as orientações sobre como se proteger dos malefícios do sol devem ser coerentes com a incidência solar da região, os hábitos da população e o fototipo da pele. Os conceitos sobre fotoproteção foram definidos por entidades européias e norte americanas e não devem ser reproduzidos para o Brasil de forma aleatória, pois a incidência solar no Brasil é muito maior, a população tem fototipos diferentes e o hábito de se expor ao sol é muito mais frequente. Portanto, faz-se necessário elaborar conceitos próprios para o Brasil e conscientizar a população sobre os perigos da radiação solar para que a incidência do câncer de pele reduza definitivamente. Essa revisão visa mostrar a relação da radiação solar no Brasil com a pele dos brasileiros e evidenciar a importância da fotoproteção para essa população. Para isso foi feito um levantamento de artigos originais, revisões de literatura, consensos brasileiros e internacionais e livros de dermatologia.Palavras-chave: Fotoproteção, Câncer de pele, Exposição solar, Radiação ultravioleta, Vitamina D. ABSTRACTThe incidence of skin cancer is increasing every year. It is known that among other factors, solar radiation is the main responsible for the development of this pathology. Prevention, made by photoprotection, would have great impact in this scenario. However, the guidelines on how to protect themselves from the sun's harmful effects should be consistent with the sunlight of the region, the habits of the population and the phototype skin. The concepts of photoprotection were defined by European and North American entities and should not be played for Brazil at random, as the solar incidence in Brazil is much higher, people have different skin types and the habit of sun exposure is much more frequent. Therefore, it is necessary to draw up own concepts for Brazil and raise awareness about the dangers of solar radiation, so that the incidence of skin cancer can be definitely reduced. This review aims to show the relationship of solar radiation in Brazil with the skin of Brazilian and to highlight the importance of sun protection for this population. With this purpose, it was made a survey of original articles, literature reviews , Brazilian and international consensus and dermatology books.Keywords: Photoprotection, Skin cancer, Sun exposure, Ultraviolet radiation, D vitamin.

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THE RELATIONSHIP OF SKIN CANCER TO PUVA THERAPY IN AUSTRALIA

Australasian Journal of Dermatology ◽

10.1111/j.1440-0960.1981.tb00036.x ◽

1981 ◽

Vol 22 (3) ◽

pp. 100-103 ◽

Cited By ~ 10

Author(s):

E. Lobel ◽

K. Paver ◽

R. King ◽

J. Le Guay ◽

K. Poyzer ◽

...

Keyword(s):

Skin Cancer ◽

Puva Therapy ◽

Relationship Of ◽

The Relationship

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Platelet-activating Factor, a Molecular Sensor for Cellular Damage, Activates Systemic Immune Suppression

Journal of Experimental Medicine ◽

10.1084/jem.20011450 ◽

2002 ◽

Vol 195 (2) ◽

pp. 171-179 ◽

Cited By ~ 168

Author(s):

Jeffrey P. Walterscheid ◽

Stephen E. Ullrich ◽

Dat X. Nghiem

Keyword(s):

Skin Cancer ◽

Uv Radiation ◽

Immune Suppression ◽

Critical Role ◽

Platelet Activating Factor ◽

Cellular Damage ◽

Uv Exposure ◽

Delayed Type Hypersensitivity ◽

Lipid Mediator ◽

Paf Receptor

Ultraviolet (UV) radiation plays a critical role in the induction of nonmelanoma skin cancer. UV radiation is also immune suppressive, and the immune suppression induced by UV irradiation has been identified as a major risk factor for skin cancer induction. Previously, we showed that UV exposure activates a cytokine cascade involving prostaglandin (PG)E2, interleukin (IL)-4, and IL-10 that induces immune suppression. However, the earliest molecular events that occur immediately after UV exposure, especially those upstream of PGE2, are not well defined. UV-irradiated keratinocytes secrete the inflammatory phospholipid mediator, platelet-activating factor (PAF). Because PAF upregulates the production of immunomodulatory compounds, including PGE2, we tested the hypothesis that UV-induced PAF activates cytokine production and initiates UV-induced immune suppression. Both UV and PAF activated cyclooxygenase (COX)-2 and IL-10 reporter gene construct transcription. PAF mimicked the effects of UV in vivo and suppressed delayed-type hypersensitivity (DTH). Furthermore, immune suppression was blocked when UV-irradiated mice were injected with PAF receptor antagonists. In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression.

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The relationship between basal and squamous cell skin cancer and smoking related cancers

BMC Research Notes ◽

10.1186/1756-0500-4-556 ◽

2011 ◽

Vol 4 (1) ◽

Cited By ~ 7

Author(s):

Freddy Sitas ◽

Xue Qin Yu ◽

Dianne L O'Connell ◽

Leigh Blizzard ◽

Petr Otahal ◽

...

Keyword(s):

Skin Cancer ◽

Squamous Cell ◽

The Relationship

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Campanha de Prevenção ao Câncer da Pele (Rio Grande - RS): Perfil Epidemiológico dos Atendidos

Saúde e Pesquisa ◽

10.17765/1983-1870.2015v8n1p113-123 ◽

2015 ◽

Vol 8 (1) ◽

pp. 113

Author(s):

Leandro Sampaio Clavico ◽

Gilma Santos Trindade ◽

Obirajara Rodrigues ◽

Régis Augusto Reis Trindade

Keyword(s):

Skin Cancer ◽

Uv Radiation ◽

Rio Grande ◽

Rio Grande Do Sul ◽

Brazil Current ◽

Prevention Campaign ◽

Occupational Activities ◽

Epidemiological Profile ◽

The Relationship ◽

The City

A cidade de Rio Grande ocupa o segundo lugar nos registros de câncer da pele no Estado do Rio Grande do Sul. Este estudo visa investigar o perfil epidemiológico dos atendidos pelas Campanhas de Prevenção ao Câncer de Pele de 2010, 2011 e 2012 realizadas em Rio Grande. Para isso foram realizadas observações participantes e semidirigidas. Foi demonstrado que foram mulheres brancas e pardas quem mais participaram e que os homens estão em um processo crescente de participação. Dos participantes, no mínimo 50% expõem-se ao sol sem qualquer proteção, principalmente por suas atividades ocupacionais. Foi constatado que o uso de protetores solares está bem aquém do necessário, sendo que em 2010 e 2011 os percentuais de indivíduos que não fizeram uso de protetores solares foi de 53,01% e 45,58%, respectivamente. Dicotomicamente, foram semelhantes os percentuais de quem nunca teve história de queimaduras solares ao longo da vida e daqueles que tiveram mais de três episódios, bem como os percentuais de quem não teve e de quem já teve história prévia de câncer de pele. Foi praticamente consenso a importância de conhecer os índices de radiação ultravioleta diário e seus riscos à saúde e que é a escola a fonte mais apropriada para divulgar e trabalhar informações sobre este tema. Nossos dados permitem propor políticas educacionais e sociais sobre a relação entre a exposição à radiação ultravioleta e o câncer de pele. Prevention Campaign Against Skin Cancer in Rio Grande, Brazil: An Epidemiological Profile ABSTRACT: The city of Rio Grande ranks second in skin cancer in the state of Rio Grande do Sul, Brazil. Current study investigates the epidemiological profile of people attended to in the campaign against skin cancer in Rio Grande in 2010, 2011 and 2012. Participating and semi-directed observations were undertaken. White and brown-skinned females participated most, although males were on the increase. At least, 50% of the participating population expose themselves to the sun without any protection, especially during their occupational activities. Solar protection is not sufficiently used: in 2010 and 2011, the percentages of people who failed to use solar protectors were respectively 53.01% and 45.58%. Contrastingly, percentages were similar to those who never had sun burns and those with more than three episodes, similar to percentages of who never had and who had a previous skin cancer episode. All agreed on the importance of being informed on daily UV radiation and health risks. All agree that the school is the most appropriate place to disseminate information and discuss such issues. Data suggest educational and social policies on the relationship between exposure to UV radiation and skin cancer.

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P691 UV exposure and skin type are more important than thiopurine exposure for non-melanoma skin cancer risk in IBD

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjx002.815 ◽

2017 ◽

Vol 11 (suppl_1) ◽

pp. S433-S434

Author(s):

Y. Wu ◽

S. Ghaly ◽

S. Kerr ◽

K. Krishnaprasad ◽

R. Prosser ◽

...

Keyword(s):

Skin Cancer ◽

Cancer Risk ◽

Skin Type ◽

Uv Exposure ◽

Skin Cancer Risk ◽

Non Melanoma Skin Cancer ◽

Melanoma Skin

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Lifestyle Factors Associated With Sunscreen Use Among Young Adults

American Journal of Lifestyle Medicine ◽

10.1177/1559827616661472 ◽

2016 ◽

Vol 12 (4) ◽

pp. 331-339

Author(s):

Julie Williams Merten ◽

Jessica L. King ◽

Melissa J. Vilaro ◽

Erin Largo-Wight

Keyword(s):

Young Adults ◽

Skin Cancer ◽

Well Being ◽

The United States ◽

Lifestyle Factors ◽

Self Report ◽

Convenience Sample ◽

Factors Associated ◽

Sunscreen Use ◽

The Relationship

Background. Skin cancer is the most common cancer in the United States with melanoma rates increasing. Sunscreen use is an effective way to protect the skin and reduce skin cancer risk. Limited research has been conducted examining the relationship between sunscreen use and other lifestyle factors. Interventions aimed at multiple lifestyle factors have shown promise for prevention and reduced health care costs. Objective. This study explores the relationship between sunscreen use and lifestyle factors associated with mortality and morbidity among young adults. Lifestyle factors examined included physical activity, substance abuse, smoking, sexual behavior, unintentional injury, and mental well-being. Methods. A convenience sample of 747 college students was surveyed about sunscreen use and other health risks. Data were analyzed using SPSS 19. Results. White, female students older than 21 years were more likely to use sunscreen. Texting while driving, low life satisfaction, and binge drinking were associated with inadequate sunscreen use. Limitations. Convenience sampling limits generalizability and surveys are subject to recall, self-report, and self-selection bias. Conclusions. The findings provide the framework to develop multiple risk factor interventions.

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