scholarly journals FRACTAL ANGLE BASED DIFFERENTIATION OF TERM PREGNANCIES USING UTERINE ELECTROMYOGRAPHIC SIGNALS

2021 ◽  
Vol 57 (2) ◽  
pp. 350-355
Author(s):  
P. Vardhini ◽  
◽  
S. Ramakrishnan
Keyword(s):  
Quantitative Measure ◽  
Coefficient Of Determination ◽  
Invasive Technique ◽  
Chi Square ◽  
Uterine Contractions ◽  
Non Invasive ◽  
Short And Long Term ◽  
Abdominal Surface ◽  
Feature Values

Uterine Electromyography (uEMG) is a non-invasive technique that provides quantitative measure of uterine activity from the abdominal surface. In this work, an attempt has been made to investigate Term (gestational age > 37 weeks) uEMG signals using Adaptive Fractal Analysis (AFA). For this, the signals obtained in second and third trimesters are considered and subjected to AFA. The fluctuation function is computed and the corresponding linear scaling regions are identified based on Chi-square statistic, standard error of slope, and coefficient of determination. Angle-based features from multiple scaling regions namely, inter-fractal angle and, short- and long-term fractal angles are extracted and are used for further analysis. The obtained results demonstrates that AFA approach can characterize the Term signals during varied gestational ages. All features show significant differences (p < 0.05) in both groups. Feature values suggest that the third trimester signals possess more correlated and smoother fluctuations when compared to second trimester signals. This is attributed to the increased coordination of uterine contractions as delivery approaches. Hence, it appears that the proposed adaptive angle-based fractal features could be potential biomarkers in analyzing the muscle contractions associated with Term pregnancies.

Contemporary Treatment for Central Serous Chorioretinopathy

2021 ◽  
Author(s):  
Mitova D
Keyword(s):  
Subretinal Fluid ◽  
Functional Results ◽  
Clinical Results ◽  
Long Term Results ◽  
Nanosecond Laser ◽  
Success Rates ◽  
Invasive Treatment ◽  
Non Invasive ◽  
Short And Long Term

Aim: To study the short-and long-term results of 2RT nanosecond laser treatment for CSC. To compare clinical results with those with AntiVEGF. Methods: Nanosecond laser (2RT, Ellex) was used. Patients were followed by BCVA, FAF, OCT, Angio-OCT. Results: 90% of the patient treated with 2RT had improvement of visual acuity and contrast sensitivity. 19 % [1] patients showed no improvement. 81% of the 2RT treated patients had total resorbtion of subretinal fluid against 60% treated with AntiVEGF. Functional results correlated with the atrophy of RPE in the macula. 46% (19 patients) had resolution on the first month, 23% [2]-on the third and 12% [3]-on the sixth month. The time of resolution shows no relation to the baseline pigment epithelial atrophy. Four patients presented with a recurrency of the disease in the follow-up period. 19% [1] were non responders. 60% of AntiVEGF treated eyes were responders and 40% were non responders. Those who responded to treatment needed between 3 and 10 injections. Conclusion: 2 RT is a non-invasive treatment modality with no adverse effects and high success rates.

Abstract P101: Short and Long-Term Outcomes in Aspirin Treated PCI Patients Using NSAIDs

2011 ◽  
Vol 4 (suppl_1) ◽  
Author(s):  
Rizwan Alimohammad ◽  
Sayed Tariq ◽  
Ali Elkharbotly ◽  
Ed Timm ◽  
Mikhail Torosoff
Keyword(s):  
Myocardial Infarction ◽  
Rank Test ◽  
Long Term Outcomes ◽  
Chi Square ◽  
Low Dose Aspirin ◽  
History Of ◽  
Short And Long Term ◽  
Mortality Table ◽  
Prolonged Hospital

Background: NSAIDs may exert direct deleterious effects on CV system, while non-selective (NS) -NSAIDs may also diminish cardio-protective effect of low-dose aspirin. On another hand, NSAIDs may decrease CRP levels and ameliorate systemic inflammation. We have investigated short and long-term outcomes associated with NSAIDs use in post-PCI patients. Methods and Material: NSAID utilization, hospital and long-term outcomes of 2933 percutaneous coronary revascularizations (PCI) were collected and analyzed. Patients not on aspirin, or treated with rofecoxib and valdecoxib were excluded. ANOVA, Chi-square, Kaplan-Meyer analysis with log-rank test, and logistic regression were utilized. The study was approved by the Institutional IRB. Results: Patients treated with NS-NSAIDs, but not celecoxib, experienced longer length of stay, higher incidence of peri-procedural myocardial infarction, and mildly increased post-PCI mortality (Table). These effects were unchanged after adjustment for age (p=0.001), ejection fraction (p<0.001), and history of previous MI (p<0.001). There was a trend towards lower long-term (50+/-15 months) mortality in NS-NSAIDs (9%) and celecoxib (6.7%) treated patients, when compared to the rest of the cohort (11.3%, Table). Conclusion: Non-selective NSAIDs, but not Celecoxib, are associated with prolonged hospital stay and increased peri-procedural myocardial infarction in PCI patients. Long-term mortality does not appear to be affected by the NSAIDs use at the time of PCI. Randomized studies of this important clinical question are needed.

scholarly journals Admission test cardiotocography in labour as a predictor of foetal outcome in high risk pregnancies

2019 ◽  
Vol 8 (4) ◽  
pp. 1331 ◽  
Author(s):  
Anvesha Kumar ◽  
Purshottam Bantaklal Jaju
Keyword(s):  
High Risk ◽  
Fetal Distress ◽  
Chi Square ◽  
Uterine Contractions ◽  
Non Invasive ◽  
Chi Square Test ◽  
Risk Patients ◽  
Foetal Outcome ◽  
Nicu Admission

Background: Continuous fetal heart monitoring in all pregnant women in labour has gained prominence in obstetric practice in the recent years. The aim of this study was to emphasize on the role of admission cardiotocography (CTG) in labour as a predictor of foetal outcome in high risk pregnancies.Methods: This was a prospective observational study done on 340 high risk patients admitted in labour with a period of gestation of ≥37 weeks. An admission CTG which consists of a 20-minute recording of FHR and uterine contractions was taken and the foetal outcome was correlated with it. The non-parametric Chi-square test was used for statistical calculations and a p valve of <0.05 was considered to designate statistical significance.Results: The admission CTG was reactive in 69.4% of all patients, equivocal in 22.2% and pathological in 8.4% of the 340 recruited patients. A total of 37.5% of the patients were post-dated followed by 20.6% of pregnancy incuded hypertensive patients. The neonatal outcomes in terms of fetal distress, meconium stained liquor, NICU admission were considerably higher in pathological test. The specificity of the test was 53.3%, and the negative predictive was    86.49%.Conclusions: Admission CTG is a simple, useful screening test and serves as a non-invasive tool in forecasting the adverse foetal outcomes in high risk pregnancies.

scholarly journals Intrathecal AAVrh10 corrects biochemical and histological hallmarks of mucopolysaccharidosis VII mice and improves behavior and survival

2019 ◽  
Vol 28 (21) ◽  
pp. 3610-3624
Author(s):  
G Pagès ◽  
L Giménez-Llort ◽  
B García-Lareu ◽  
L Ariza ◽  
M Navarro ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Intrathecal Injection ◽  
Lysosomal Storage Diseases ◽  
Invasive Technique ◽  
Lysosomal Storage ◽  
Therapy Strategy ◽  
Gene Therapy Strategy ◽  
Short And Long Term ◽  
Mps Vii

Abstract Mucopolysaccharidosis (MPS) type VII is a lysosomal storage disease caused by ß-glucuronidase deficiency, prompting glycosaminoglycan accumulation in enlarged vesicles, leading to peripheral and neuronal dysfunction. Here, we present a gene therapy strategy using lumbar puncture of AAVrh10 encoding human β-glucuronidase (AAVrh10-GUSB) to adult MPS VII mice. This minimally invasive technique efficiently delivers the recombinant vector to the cerebrospinal fluid (CSF) with a single intrathecal injection. We show that AAVrh10 delivery to the CSF allows global, stable transduction of CNS structures. In addition, drainage of AAVrh10-GUSB from the CSF to the bloodstream resulted in the transduction of somatic organs such as liver, which provided a systemic β-glucuronidase source sufficient to achieve serum enzyme activity comparable to wild type mice. ß-glucuronidase levels were enough to correct biochemical and histopathological hallmarks of the disease in the CNS and somatic organs at short and long term. Moreover, the progression of the bone pathology was also reduced. Importantly, the biochemical correction led to a significant improvement in the physical, cognitive and emotional characteristics of MPS VII mice, and doubling their life span. Our strategy may have implications for gene therapy in patients with lysosomal storage diseases.

scholarly journals Intensive care and non-invasive mechanical ventilation in kyphoscoliosis: are new perspectives still needed?

2013 ◽  
Vol 8 ◽  
Author(s):  
Antonio M. Esquinas ◽  
Yoshinori Matsuoka ◽  
Nalan Adıgüzel ◽  
Zuhal Karakurt
Keyword(s):  
Vital Capacity ◽  
Total Lung Capacity ◽  
Invasive Mechanical Ventilation ◽  
Long Term Outcomes ◽  
Non Invasive ◽  
Lung Capacity ◽  
Non Invasive Ventilation ◽  
Important Study ◽  
Short And Long Term

Non-invasive ventilation (NIV) assists breathing and thus improves oxygenation in patients with Kyphoscoliosis. The benefits of short- and long-term intermittent nocturnal in such patients have been reported previously (improvement of vital capacity, total lung capacity, muscle strength, daytime oxygenation, exercise capacity, and pulmonary hypertension). We review this important study reporting patients with kyphoscoliosis and acute respiratory failure along with their long-term outcomes. We believe that this letter may provide important information regarding the prognosis and efficacy of NIV.

Comparison between transcranial Doppler and Coulter counter for detection of lipid micro embolization from mediastinal shed blood reinfusion during cardiac surgery

Perfusion ◽  
2011 ◽  
Vol 26 (6) ◽  
pp. 519-523
Author(s):  
A Eyjolfsson ◽  
F Al-Rashidi ◽  
M Dencker ◽  
S Scicluna ◽  
B Brondén ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Transcranial Doppler ◽  
Bypass Surgery ◽  
Coulter Counter ◽  
Shed Blood ◽  
Non Invasive ◽  
Cardiopulmonary Bypass Surgery ◽  
Short And Long Term

Introduction: Lipid micro embolization (LME) from re-transfused shed blood has been postulated to be a potential reason for short- and long-term cognitive dysfunction after cardiac surgery. The purpose of this investigation was to evaluate if transcranial Doppler (TCD) has the capacity to detect LME. Methods: Thirteen patients undergoing cardiopulmonary bypass surgery were investigated. Each patient’s cerebral circulation was monitored with transcranial Doppler during the first two minutes after re-transfusion of shed blood and blood was simultaneously sampled and characterised by a Coulter counter. Results: Strong correlation was found between embolic loads, as measured by transcranial Doppler and Coulter counter (r=0.79, P<0.005). Conclusions: This pilot study shows that non-invasive monitoring by transcranial Doppler could be a potential tool to monitor LME during cardiopulmonary bypass surgery.

scholarly journals The Effect of Dexpanthenol on the Treatment of Nipple Injuries in Breastfeeding Mothers: A Randomized Control Trial

2019 ◽  
Vol 8 (2) ◽  
pp. 80-84
Author(s):  
Kazhal Masoudin ◽  
Mahnaz Shahnazi ◽  
Mahin Kamalifard ◽  
Shakiba Pourasad Shahrak ◽  
Fariba Esmaeili
Keyword(s):  
Randomized Control Trial ◽  
Intervention Group ◽  
Invasive Technique ◽  
Chi Square ◽  
Non Invasive ◽  
Randomized Control ◽  
Double Blinded ◽  
Postpartum Mothers ◽  
And Control ◽  
Trauma Scores

Background: Considering the importance of treatment of sour nipples in breastfeeding mothers, the aim of this study was to evaluate the effect of dexpanthenol creams on the treatment of traumatic nipples. Materials and Methods: This study was a double-blinded, randomized, control trial, in which 82 postpartum mothers with nipple injuries who had attended health centers and Children’s Hospital of Sanandaj, Iran, participated. The participants were randomly divided into two groups of dexpanthenol and control. Nipple pain and trauma was measured using Storr and Champion scale. Analysis was done through chi-square and ANOVA tests using SPSS software version 13.0. P value less than 0.05 was considered significant. Results: The results of this study demonstrated that the mean score of pain and trauma in third, seventh, and fourteenth days of study in intervention group was decreased. In addition, there was significant differences in pain and trauma scores between dexpanthenol and control groups. Conclusion: Dexpanthenol is advised as an effective, simple, and non-invasive technique with no side effects for the treatment of nipple fissures and pain.

scholarly journals Relationship of Advanced Paternal Age and Onset of Schizophrenia

2019 ◽  
Vol 2 (1) ◽  
pp. 22-27
Author(s):  
Arsusy Widyastuty ◽  
Dapot P Gultom ◽  
Muhammad Surya Husada
Keyword(s):  
De Novo ◽  
Paternal Age ◽  
De Novo Mutations ◽  
Chi Square ◽  
Cross Sectional ◽  
Gene Group ◽  
Increased Risk ◽  
Short And Long Term ◽  
Relationship Of

Background: Increased paternal age has been associated with an increased risk of spontaneous abortion, premature birth, infant mortality, congenital malformations, childhood cancer, epilepsy, autism, bipolar and schizophrenia in offspring. The biological mechanisms behind this relationship are not known but may be associated with de novo mutations and epigenetic changes in male cells with short and long term health consequences for their offspring. Males are responsible for most of the new mutations in the gene group, to the permanent distribution of reproductive cells and the number of mutations increases significantly with age. Objective: The aim of the study to determine the correlation between paternal age and onset of schizophrenia. Method: This study was correlation analysis with cross sectional approach with The subject is 92 schizophrenia patient. Analysis of the data  using statistical test that is chi-square. Result: the study findings showed there was significant correlation between paternal age with schizophrenic aged onset of 0.001 (p <0.05).

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