scholarly journals Levantamento das causas de rejeição de amostras em laboratório de patologia clínica de hospital veterinário em Teresina, Piauí / Survey of the causes of rejection of samples in the clinical pathology laboratory of a veterinary hospital in Teresina, Piauí

2021 ◽  
Vol 7 (12) ◽  
pp. 117014-117022
Author(s):  
Kátia Regina Ferreira Sousa ◽  
Janaína de Fátima Saraiva Cardoso ◽  
Dalvan Fortaleza Alencar ◽  
Nathália Castelo Branco Barros ◽  
Wanderson Fiares De Carvalho ◽  
...  
Keyword(s):  
Clinical Pathology ◽  
Pathology Laboratory ◽  
Veterinary Hospital

scholarly journals Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis

2021 ◽  
Vol 51 (3) ◽  
Author(s):  
Ariana de Castro Tavares da Silva ◽  
José Rômulo Soares dos Santos ◽  
Rosangela Maria Nunes da Silva ◽  
Vanessa Lira de Santana ◽  
Francisco Sávio de Moura Martins ◽  
...  
Keyword(s):  
Serum Proteins ◽  
Hematological Parameters ◽  
Small Animal ◽  
Clinical Pathology ◽  
Hematological Parameter ◽  
Similar Response ◽  
Pathology Laboratory ◽  
Beneficial Effects ◽  
Reactive Protein ◽  
Veterinary Hospital

ABSTRACT: The objective of the present study was to assess the treatment of dogs with ehrlichiosis (tropical canine pancytopenia (TCP)) with doxycycline hydrochloride associated or not with prednisolone on the hematological profile and serum proteins. Ten dogs with TCP were selected in the Small Animal Medical Clinic Veterinary Hospital, Federal University of Campina Grande-UFCG-PB, Brazil. The diagnosis was obtained by clinical examination, hemogram and immunochromatographic test (with anti Ehrlichia canis antibodies). Samples were distributed randomly in two experimental groups of five animals each (n = 5), named GD and GDP. The GD group was treated with doxycycline (5 mg/kg, VO, BID for 28 days) and the GDP group was treated with doxycycline at the same dose and duration and prednisolone (2 mg/kg, VO, BID, for five days). Four blood collections were made during the treatment period: a base collection (M0), one at 10 days (M10), a second at 21 days (M21) and another at the end of the treatment (M28). These samples were used for the tests erythrogram, leucogram, plateletgram and proteinogram (dose of total proteins, pre-albumin, albumin, albumin, α-1 globulin, α-2 globulin, ß-globulin, ɣ-globulin and C- reactive protein) in the Clinical Pathology Laboratory, Veterinary Hospital-UFCG-PB. Results, that presented normal distribution, was submitted to the Tukey test (P<0.05). Comparison of treatments GD and GDP showed that both promoted discreet and similar response in the hematological parameters at different times. Results obtained allowed the conclusion that both therapeutic protocols resulted in clinical, hematological parameter and proteinogram improvement, but the use of prednisolone at the dose administered during the first five days of treatment did not show more beneficial effects than isolated administration of doxycycline.

scholarly journals Indispensability of Clinical Bioinformatics for Effective Implementation of Genomic Medicine in Pathology Laboratories

ACI Open ◽  
2020 ◽  
Vol 04 (02) ◽  
pp. e167-e172
Author(s):  
Srikar Chamala ◽  
Siddardha Majety ◽  
Shesh Nath Mishra ◽  
Kimberly J. Newsom ◽  
Shaileshbhai Revabhai Gothi ◽  
...  
Keyword(s):  
Patient Care ◽  
Clinical Laboratory ◽  
Clinical Care ◽  
Genomic Medicine ◽  
Clinical Pathology ◽  
Genetic Mutation ◽  
Genomic Research ◽  
Pathology Laboratory ◽  
Clinical Bioinformatics ◽  
Effective Implementation

AbstractPatient care is rapidly evolving toward the inclusion of precision genomic medicine when genomic tests are used by clinicians to determine disease predisposition, prognosis, diagnosis, and improve therapeutic decision-making. However, unlike other clinical pathology laboratory tests, the development, deployment, and delivery of genomic tests and results are an intricate process. Genomic technologies are diverse, fast changing, and generate massive data. Implementation of these technologies in a Clinical Laboratory Improvement Amendments-certified and College of American Pathologists-accredited pathology laboratory often require custom clinical grade computational data analysis and management workflows. Additionally, accurate classification and reporting of clinically actionable genetic mutation requires well-curated disease/application-specific knowledgebases and expertise. Moreover, lack of “out of the box” technical features in electronic health record systems necessitates custom solutions for communicating genetic information to clinicians and patients. Genomic data generated as part of clinical care easily adds great value for translational research. In this article, we discuss current and future innovative clinical bioinformatics solutions and workflows developed at our institution for effective implementation of precision genomic medicine across molecular pathology, patient care, and translational genomic research.

Use of cost-effective technologies for a routine clinical pathology laboratory

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Mercedes Vazquez ◽  
L. Anfossi ◽  
Hader Ben-Yoav ◽  
Lorena Diéguez ◽  
Thomas Karopka ◽  
...  
Keyword(s):  
Developing Countries ◽  
Clinical Pathology ◽  
Cost Effective ◽  
Limiting Factor ◽  
Economic Costs ◽  
Pathology Laboratory

Classically, the need for highly sophisticated instruments with important economic costs has been a major limiting factor for clinical pathology laboratories, especially in developing countries. With the aim of making...

scholarly journals ANALISIS BEBAN KERJA DI INSTALASI LABORATORIUM

2016 ◽  
Vol 20 (1) ◽  
pp. 64
Author(s):  
Amiroh Kurniati ◽  
Tahono Tahono
Keyword(s):  
Clinical Pathology ◽  
Work Load ◽  
Accurate Method ◽  
Development Planning ◽  
Smear Microscopy ◽  
Pathology Laboratory ◽  
Laboratory Installation ◽  
Laboratory Service ◽  
Laboratory Staff ◽  
Manpower Needs

Human resources (HR) planning is associated with an institution’s strategic plan, so the study of the required number of support personnel is in line with the direction of business development planning of the Laboratory Installation Unit. WISN (work load indicator staff need) method is a calculation based on the analysis of health manpower needs of the workload (work load analysis) and is considered as the most accurate method to calculate labour requirements in short-term. Based on the results of the analysis of manpower needs at the Laboratory Installation of Lung Health of the Community Hall Surakarta, it is known that there is still a lack of a number of five (5) persons of the health laboratory staff. The persons still lacking consist of: one (1) laboratory person related to clinical pathology laboratory, one (1) laboratory person for smear microscopy laboratory, and still three (3) microbiology laboratory persons. These persons are needed to be able to carry out the activities for a good laboratory service, and quality which is in accordance with the related applicable standards.

Selection of Hormonal Reference Values for Undescended Testicle Case in 8-Year-Old Boy with Abnormal Chromosome

2021 ◽  
Vol 28 (1) ◽  
pp. 91
Author(s):  
Vina Corry ◽  
Merci M. Pasaribu
Keyword(s):  
Reference Values ◽  
Clinical Pathology ◽  
Tanner Stage ◽  
Chromosome Analysis ◽  
Reference Intervals ◽  
Undescended Testicle ◽  
Pediatric Endocrinology ◽  
Pathology Laboratory ◽  
Testosterone Levels ◽  
And Gender

Establishing the diagnosis of undescended testicles requires appropriate hormonal laboratory reference values basedon age and gender. An 8-year-old boy with an undescended testicle, mental retardation, and stunting had a blood test thatwas carried out at the Clinical Pathology Laboratory, dr. Cipto Mangunkusumo (RSCM) Hospital on February 6, 2020, withtestosterone levels of 0.69 nmol/L (N male: 4.94-32.01 nmol/L) indicating decreased testosterone levels. The patient wasconsulted from urological surgery to pediatric endocrinology to determine the presence or rudiment of the patient'stesticles. Using the reference range of testosterone values assists clinicians in determining the diagnosis, monitoringtherapy, and prognosis of a disease. There are some testosterone reference values, which are currently available, includingCanadian Laboratory Initiative on Pediatric Reference Intervals Database (CALIPER) and the Tanner stage reference value.Later is more applicable because it is based on chronological age and secondary sexual development in assessing pubertydevelopment. A case of an 8-year-old boy with a clinical diagnosis of an undescended testicle, the laboratory test resultsshowed normal-low testosterone levels using the CALIPER and Tanner stage ranges according to the patient's age. Noincrease of testosterone levels after the second HCG stimulation test might be due to differences in the HCG administrationprotocol; therefore, the diagnosis of anorchia had not been established, and chromosome abnormalities of 46 XY, +6 Mar,17 dmin on chromosome analysis suggested the suspected syndrome. These findings were consistent with the suspicion ofprimary hypogonadism in children with suspected syndrome caused by bilateral cryptorchidism with a suspectedseminiferous tubular defect.

scholarly journals Use of the GeneReader NGS System in a clinical pathology laboratory: a comparative study

2017 ◽  
Vol 70 (8) ◽  
pp. 725-728 ◽  
Author(s):  
Ulrike Koitzsch ◽  
Carina Heydt ◽  
Hans Attig ◽  
Isabelle Immerschitt ◽  
Sabine Merkelbach-Bruse ◽  
...  
Keyword(s):  
Comparative Study ◽  
Clinical Pathology ◽  
Pathology Laboratory

scholarly journals Frequency of dermatophytes in the metropolitan area of Porto Alegre, RS, Brazil

1998 ◽  
Vol 40 (2) ◽  
pp. 71-76 ◽  
Author(s):  
Adelina MEZZARI
Keyword(s):  
Metropolitan Area ◽  
Low Income ◽  
Clinical Pathology ◽  
Rio Grande ◽  
The State ◽  
Rio Grande Do Sul ◽  
Porto Alegre ◽  
Pathology Laboratory ◽  
Prevalence Data ◽  
The City

In order to evaluate the distribution of dermatophytes in Porto Alegre, the capital of the state of Rio Grande do Sul, Brazil, they were isolated from the skin, hairs and nails samples and retrospectively analyzed from June 1981 to June 1995, in two different institutions in the city of Porto Alegre: (i) the Serviço de Micologia do Instituto de Pesquisas Biológicas Jandyr Maya Faillace, da Secretaria de Saúde e Meio Ambiente do Rio Grande do Sul which attends the low income population (low and middle classes) and, (ii) Laboratório Weinmann, a clinical pathology laboratory which attends predominantly the higher income population (middle and upper classes), both which attend in the metropolitan area of Porto Alegre. The dermatophyte predominance of Trichophyton rubrum was confirmed (55.33%) followed by T. mentagrophytes (21.46%). The data obtained were compared with the existing prevalence data which were collected in the interior of the state over a period of 32 years (1960-1992). T. verrucosum, T. simii, Microsporum persicolor, T. schöenleinii, M. nanum and M. cookei were isolated in the interior and have not been found in the capital so far. On the other side, T. violaceum was, isolated in the capital and has not been found in the interior so far.

Feline cryptococcosis: a retrospective evaluation

1997 ◽  
Vol 33 (2) ◽  
pp. 118-122 ◽  
Author(s):  
S Gerds-Grogan ◽  
B Dayrell-Hart
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cryptococcus Neoformans ◽  
Clinical Pathology ◽  
Fungal Disease ◽  
University Of Pennsylvania ◽  
Retrospective Evaluation ◽  
Cns Involvement ◽  
The University ◽  
Veterinary Hospital

Cryptococcus neoformans causes the most common form of feline systemic fungal disease. Nineteen cats with cryptococcosis were seen at the Veterinary Hospital of the University of Pennsylvania between April 1986 and May 1995. Compared to other studies, these 19 cases showed increased neurological and ophthalmological involvement. Males were affected more often than females. Season and environment appeared to influence time of onset or presentation to the hospital. Clinical pathology did not show typical changes. It is possible that the organism was present frequently in the urine but was mistaken for fat droplets. Treatment with ketoconazole was unrewarding in cases with central nervous system (CNS) involvement.

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