Photodynamic therapy in oncology: Present and future

2020 ◽  
pp. 15-19
Author(s):  
O. V. Korshunova ◽  
N. G. Plekhova
Keyword(s):  
Photodynamic Therapy ◽  
Photochemical Reaction ◽  
Wave Length ◽  
General Information ◽  
Literature Survey ◽  
Cancer Tissue ◽  
Promising Direction ◽  
Atypical Cells ◽  
Luminous Radiation ◽  
Cancer Clinic

There is progress in applying photodynamic therapy in cancer clinic during the last decade. The promising direction to develop this way of treatment is the use of photosensitizers with given characteristics. It is based on a local activation of a photosensitizer in a cancer tissue by using luminous radiation of an appropriate wave length to launch photochemical reaction following the atypical cells’ destruction. In spite of a successful experience of using photodynamic therapy in different areas of medicine, not all its opportunities are studied. There are general information in this literature survey about the use of photodynamic therapy and its perspectives in oncology.

Role of Exosomes in Photodynamic Anticancer Therapy

2020 ◽  
Vol 27 (40) ◽  
pp. 6815-6824 ◽  
Author(s):  
Yuan Jiang ◽  
Chuanshan Xu ◽  
Wingnang Leung ◽  
Mei Lin ◽  
Xiaowen Cai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Basic Principle ◽  
Photochemical Reaction ◽  
Cell Communication ◽  
Anticancer Therapy ◽  
Bioactive Molecules ◽  
Promising Alternative ◽  
Tumor Tissues ◽  
Significant Attention

Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting significant attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.

Evaluation of photodynamic therapy efficiency using an in vitro three-dimensional microfluidic breast cancer tissue model

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 735-744 ◽  
Author(s):  
Yamin Yang ◽  
Xiaochuan Yang ◽  
Jin Zou ◽  
Chao Jia ◽  
Yue Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Three Dimensional ◽  
Therapeutic Agents ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Tissue Model

A microfluidic-based in vitro three-dimensional (3D) breast cancer tissue model was established for determining the efficiency of photodynamic therapy (PDT) with therapeutic agents (photosensitizer and gold nanoparticles) under various irradiation conditions.

scholarly journals Photodynamic therapy

2019 ◽  
Vol 12 (2) ◽  
pp. 141-146
Author(s):  
Dmitrii Igorevich Sazhnev ◽  
Alexandr Alexeevich Andreev ◽  
Alexandr Anatol'evich Glukhov
Keyword(s):  
Cell Proliferation ◽  
Photodynamic Therapy ◽  
Laser Radiation ◽  
Photochemical Reaction ◽  
High Tech ◽  
Therapeutic Action ◽  
History Of ◽  
Laser Devices ◽  
Antimicrobial Treatments

The article presents data on the high-tech method of treatment-photodynamic therapy (PDT). An overview of the history of the use of photochemical reaction in the treatment of patients is given. The mechanisms of therapeutic action of PDT, the advantages of the method in comparison with other methods of antimicrobial action are described in detail; the indications and contraindications for this method of treatment are given. The article lists used for PDT photosensitizers of different generations and laser devices capable of emitting laser radiation of the required wavelength. The overview contains information about the efficiency of the method of PDT with certain diseases. Based on the literature review, it is concluded that PDT is a modern and promising method of treatment that can significantly improve the quality of care for patients with various diseases, which are based on cell proliferation. The proven effectiveness of the method of photodynamic therapy and its advantage over other antimicrobial treatments demonstrate the relevance of its wider introduction into clinical practice.

scholarly journals Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1982961
Author(s):  
Christina M Huang ◽  
Lauren Lam ◽  
Robert Gniadecki
Keyword(s):  
Photodynamic Therapy ◽  
Photochemical Reaction ◽  
Therapeutic Option ◽  
Cost Effective ◽  
Oxygen Species ◽  
Type Ii ◽  
Effective Therapeutic Option ◽  
Methyl Aminolevulinate ◽  
Prospective Trials ◽  
The Brain

Primary cutaneous amyloidosis is characterized by polymerization of extracellular amyloid precursors in β-pleated sheet conformation into larger fibrillar aggregates. Observation in models of Alzheimer’s disease have noted that amyloid polymerization in the brain is blocked by reactive oxygen species. Singlet oxygen is formed in the skin during methyl aminolevulinate photodynamic therapy. Therefore, we speculate that type II photochemical reaction is responsible for the observed therapeutic activity of methyl aminolevulinate photodynamic therapy in our patient with primary cutaneous amyloidosis. Our case is the first report demonstrating the efficacy of daylight photodynamic therapy in primary cutaneous amyloidosis. Daylight photodynamic therapy may provide a convenient and cost-effective therapeutic option in primary cutaneous amyloidosis, and its efficacy should be further confirmed in prospective trials.

Light intensity effect on the mechanisms of tumor damage photosensitized by a substituted Zn(II)-naphthalocyanine

2001 ◽  
Vol 05 (11) ◽  
pp. 798-802 ◽  
Author(s):  
M. SHOPOVA ◽  
M. PEEVA ◽  
N. STOICHKOVA ◽  
G. JORI ◽  
D. WÖHRLE ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Intensity ◽  
Photochemical Reaction ◽  
Optimal Conditions ◽  
Lewis Lung ◽  
Intensity Effect ◽  
Photo Oxidation ◽  
Cell Culture Systems ◽  
Tumor Reduction

Cytotoxicity induced by photodynamic therapy (PDT) is connected with the phenomena of photo-oxidation. Generation of singlet oxygen and free radicals (superoxide or hydroxide) is accepted as a mechanism for the photo-oxidation action of PDT. Very little is however known about the validity of metabolitic and biochemical events observed in cell culture systems to in vivo tumor shrinkage following PDT. In the present work using the well-studied tetrabenzamido-substituted zinc (II)-naphthalocyanine ( ZnNc ) including towards pigmented melanoma, we accessed its efficacy for apoptotic processes during PDT of Lewis lung carcinoma (LLC) in mice in dependence on light intensity. Early photodynamic therapy responses were examined at 1, 3, 6, 10 and 24 h after coherent 774 nm illumination of the tumors applied 24 h after intraperitoneal (i.p.) injection of dipalmitoylphosphatidylcholine (DPPC)-liposome-incorporated 0.5 mg kg-1 b.w. ZnNc . Fluence rates of 260, 380 and 500 mW cm-2 at a fluence of 360 J cm-2 were used. Macroscopic observations showed that tumor reduction (and its eventual elimination) depends on optimal conditions for the occurring of photochemical reaction during PDT. At the same time, electron microscopy (EM) assays demonstrated strongly expressed dependence of apoptotic processes on the applied light intensities. Features of apoptotic processes were most clearly expressed at the highest used fluence rate.

scholarly journals Present-Day Glaciers in the U.S.S.R. and Some Data on their Mass Balance

1969 ◽  
Vol 8 (52) ◽  
pp. 9-22 ◽  
Author(s):  
M. G. Grosval’d ◽  
V. M. Kotlyakov
Keyword(s):  
Mass Balance ◽  
Wave Length ◽  
Phase Relationship ◽  
General Information ◽  
Tien Shan ◽  
Swiss Alps ◽  
Equilibrium Line ◽  
Mountain Glacier ◽  
Polar Urals ◽  
The Polar Urals

There are four major glacier regions in the U.S.S.R.: the Atlantic-Arctic, Atlantic-Eurasian, East Siberian and Pacific-Asian, which can be divided into 19 separate glacier areas. The total area of the glaciers in the country amounts to 81 900 km2, and the volume of water stored in them to 13 750 km3.The main characteristic features of glacier regime, such as the elevation of the equilibrium line, the value of the total accumulation at the equilibrium line, the vertical gradients of net balance, the “glacier ratios”. etc., are estimated for the majority of the glacier areas. The data on mass balance of the glaciers in the Polar Urals and Tien Shan which were obtained by direct measurement during the last decade are tabulated and compared. It has been found that the glacier balance changes in the two areas are nonsynchronous.A comparison of the variations in mass balance of the Lednik IGAN in the Polar Urals, and the Grosser Aletschgletscher in the Swiss Alps, over a period of several decades suggests a cyclic trend of the variations in both regions (with a wave-length of about 22 years), and the direct opposition in their phase. The analogy of 22-year cycles of the balance variations with the cyclic fluctuations of the same wave-length in solar activity seems to be quite evident, whereas the atmospheric circulation appears to be one of the main intermediate variables in the chain sun-glaciers responsible for the out-of-phase relationship in glacier variations of certain areas.In conclusion, some data on the present changes in glacier regime are given, as well as general information on glaciological studies carried on in the U.S.S.R. within the framework of the I.H.D. programmes. The latter include the compilation of the Soviet Union inventory of perennial snow and ice masses, the continuous measurement of glacier variations, and the research on combined heat, mass and water balances at selected mountain glacier basins.

scholarly journals Present-Day Glaciers in the U.S.S.R. and Some Data on their Mass Balance

1969 ◽  
Vol 8 (52) ◽  
pp. 9-22 ◽  
Author(s):  
M. G. Grosval’d ◽  
V. M. Kotlyakov
Keyword(s):  
Mass Balance ◽  
Wave Length ◽  
Phase Relationship ◽  
General Information ◽  
Tien Shan ◽  
Swiss Alps ◽  
Equilibrium Line ◽  
Mountain Glacier ◽  
Polar Urals ◽  
The Polar Urals

There are four major glacier regions in the U.S.S.R.: the Atlantic-Arctic, Atlantic-Eurasian, East Siberian and Pacific-Asian, which can be divided into 19 separate glacier areas. The total area of the glaciers in the country amounts to 81 900 km2, and the volume of water stored in them to 13 750 km3. The main characteristic features of glacier regime, such as the elevation of the equilibrium line, the value of the total accumulation at the equilibrium line, the vertical gradients of net balance, the “glacier ratios”. etc., are estimated for the majority of the glacier areas. The data on mass balance of the glaciers in the Polar Urals and Tien Shan which were obtained by direct measurement during the last decade are tabulated and compared. It has been found that the glacier balance changes in the two areas are nonsynchronous. A comparison of the variations in mass balance of the Lednik IGAN in the Polar Urals, and the Grosser Aletschgletscher in the Swiss Alps, over a period of several decades suggests a cyclic trend of the variations in both regions (with a wave-length of about 22 years), and the direct opposition in their phase. The analogy of 22-year cycles of the balance variations with the cyclic fluctuations of the same wave-length in solar activity seems to be quite evident, whereas the atmospheric circulation appears to be one of the main intermediate variables in the chain sun-glaciers responsible for the out-of-phase relationship in glacier variations of certain areas. In conclusion, some data on the present changes in glacier regime are given, as well as general information on glaciological studies carried on in the U.S.S.R. within the framework of the I.H.D. programmes. The latter include the compilation of the Soviet Union inventory of perennial snow and ice masses, the continuous measurement of glacier variations, and the research on combined heat, mass and water balances at selected mountain glacier basins.

scholarly journals The effective in vivo mitochondrial-targeting nanocarrier combined with a π-extended porphyrin-type photosensitizer

2021 ◽  
Author(s):  
Satrialdi . ◽  
Yuta Takano ◽  
Eri Hirata ◽  
Natsumi Ushijima ◽  
H. Harashima ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Molecular Oxygen ◽  
Photochemical Reaction ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Targeting

A photochemical reaction mediated by light-activated molecules (photosensitizers) in photodynamic therapy (PDT) causes molecular oxygen to be converted into highly reactive oxygen species (ROS) that is beneficial for cancer therapy....

scholarly journals Antimicrobial photodynamic therapy and its applicability in aquaculture systems and aquatic animal health management: An overview

2016 ◽  
Vol 8 (1) ◽  
pp. 506-514 ◽  
Author(s):  
Pooja Kanyal ◽  
Rameez Roshan P.M. ◽  
Mohd Danish ◽  
Anita Anita ◽  
Akansha Khati ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Health Management ◽  
Animal Health ◽  
Wave Length ◽  
Microbial Pathogens ◽  
Control Fish ◽  
Aquatic Animal ◽  
Antimicrobial Photodynamic Therapy ◽  
Food Fish

Global aquaculture production in 2012 touched new high of 90.4 million tonnes including 66.6 million tonnes of food fish and 23.8 million tonnes of aquatic algae providing 19.2 kg per capita food fish suppy. Aquaculture is reported to suffer heavy production and financial losses due to fish infections caused by microbial pathogens. Therefore in order to make aquaculture industry more sustainable, effective strategies to control fish infections are urgently needed. Antimicrobial Photodynamic Therapy (aPDT) is an emerging, low-cost anti-microbial approach to the treatment of locally occurring infections and also for the treatment of aquaculture water and waste waters. Already proven effective in various medical and clinical applications, it utilizes three vital components: a photosensitizing agent (PS), a light source of an appropriate wave length and oxygen. aPDT has got a potential of being a preferred choice over antibiotics in aquaculture systems because of its non-target specificity, few side effects, lack of the pathogenicity reversal and re-growth of the micro-organism after treatment and the lack of development of resistance mechanisms. The technique has been proved effective in vitro against bacteria (including drug-resistant strains), yeasts, fungi, viruses, parasites and even the stubborn biofilms. Although preliminary results indicate that this technology has a high potential to disinfect waters in aquaculture system and also in hatcheries and seed production units, but it clearly needs more deep knowledge and multi-dimenstional approach.

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