scholarly journals FEATURES OF DYSLIPIDEMIA AND ITS INFLUENCE ON ENDOTHELIUM FUNCTIONAL STATE IN PATIENTS WITH RHEUMATOID ARTHRITIS AND ARTERIAL HYPERTENSION

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
I. M. Fushtey ◽  
S. L. Podsevakhina ◽  
A. I. Palamarchuk ◽  
O. V. Tkachenko
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Lipid Profile ◽  
Functional State ◽  
Reactive Hyperemia ◽  
Blood Lipid ◽  
High Density Lipoproteins ◽  
Brachial Artery Diameter ◽  
Lipid Spectrum

Abstract Purpose of the study. Was to identify the features of blood lipid spectrum and endothelium functional state in patients with rheumatoid arthritis (RA) and arterial hypertension (AH). Materials and methods. 83 patients were examined (40 with RA combined with AH, 23 with RA and 20 with AH). The blood lipid spectrum and endothelial function were studied in all patients. Results. The analysis of blood serum lipid parameters demonstrated that in patients with RA, regardless of the presence of AH, there was a significant increase of proatherogenic lipid profile parameters in comparison with those in healthy subjects. It was shown, that lower concentrations of high-density lipoproteins and higher atherogenic coefficient indices was a characteristic feature of the lipid profile in RA patients both with and without AH - in contrast to the same parameters of the lipid spectrum in patients with AH without RA. In the groups of patients with RA a significant increase of the brachial artery diameter at rest and decreased indices of endothelium-dependent vasodilation and endothelium-independent vasodilation were revealed. Subjects with RA in combination with AH had significantly lower indices according to the tests with both reactive hyperemia and nitroglycerin, while in patients with RA without AH, only NG-test was significantly lower. Conclusion. Dyslipidemia of atherogenic type and endothelial dysfunction develops at the initial stages of rheumatoid process and depends on the activity of the inflammatory process, the presence of extra-articular manifestations and rheumatoid factor seropositivity. Keywords: rheumatoid arthritis, arterial hypertension, dyslipidemia, endothelial dysfunction.

Irregularity of lipid profile blood in the patients with high activity of rheumatoid arthritis

10.12737/6448 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Майорова ◽  
Yu. Mayorova
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Profile ◽  
High Activity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Low Density Lipoprotein Cholesterol ◽  
Close Relationship ◽  
Lipid Spectrum ◽  
Inflammatory Character

The author has analyzed the lipid profile blood in 30 patients with high activity of rheumatoid arthritis. The main cause of death of patients with rheumatoid arthritis is pathology of the cardiovascular system, an important role in the development of which is atherosclerosis and complications associated with its develop-ment. Currently, similarity of mechanisms of atherosclerosis and rheumatoid arthritis is proven. There are many studies demonstrating pathogenetic unity of these diseases. Both of these diseases have immuno-inflammatory character that accounts for their close relationship and opens new opportunities therapeutic. A number of studies have shown that the development and course of rheumatoid arthritis is associated with changes in the blood lipid spectrum, characterized by high atherogenicity. In this case, adequate anti-inflammatory therapy leads not only to decrease in the activity of rheumatoid arthritis, but also to reduce the coefficient of atherogenicity. The greatest contribution was made by the elevated levels of total and low-density lipoprotein cholesterol, which is associated with a high atherogenicity and increased cardiovascular risk.

scholarly journals ASSOCIATION OF THE POLYMORPHIC VARIANT RS1061622 OF THE TNFRSFB1 GENE WITH GENETIC PREDISPOSITION TO ESSENTIAL ARTERIAL HYPERTENSION AND CHANGES IN THE BLOOD LIPID PROFILE

2018 ◽  
pp. 59
Author(s):  
Людмила Владимировна Топчиева ◽  
Виктория Алексеевна Корнева ◽  
Ирина Валерьевна Курбатова ◽  
Lyudmila Topchieva ◽  
Viktoria Korneva ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Lipid Profile ◽  
Genetic Predisposition ◽  
Blood Lipid ◽  
Polymorphic Variant ◽  
Blood Lipid Profile ◽  
Essential Arterial Hypertension

scholarly journals Influence of Meldonium on Blood Lipid Spectrum and Echocardiography Parameters in Patients with Coronary Heart Disease and or Withoutconcomitant Arterial Hypertension

2021 ◽  
Vol 2-3 (35-36) ◽  
pp. 50-57
Author(s):  
D. Volynskyi ◽  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Arterial Hypertension ◽  
Total Cholesterol ◽  
Stable Angina ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Positive Effect ◽  
Lipid Spectrum ◽  
Concomitant Hypertension

Introduction. Coronary heart disease (CHD) is one of the main causes of high mortality, disability and reduced quality of life for patients in both Europe and Ukraine. Modern drug therapy of coronary heart disease in combination with arterial hypertension (AH) does not always achieve a satisfactory therapeutic effect. The use of meldonium, which has antioxidant properties, has a positive effect on NO release and has a lipid-lowering effect is promising for patients with AH. The aim of the study. To evaluate the influence of meldonium on lipid metabolism and echocardiography parameters in combination therapy in patients with CHD with stable angina and concomitant AH. Materials and methods. We examined 66 patients with CHD, stable angina pectoris II-III functional class, 40 of them with concomitant AH stage II-III. Patients were divided into 2 groups of 40 and 26 patients, respectively. The first group included patients with CHD and concomitant AH, the second - without pre-existing hypertension. Each of the groups was further divided into 2 subgroups: 1) Patients who were prescribed meldonium at a dose of 750.0 mg/d for 6 months in addition to the basic therapy of the underlying disease (n = 20 for CHD + AH and n = 14 for CHD without hypertension). 2) Patients who continued basic antianginal, disaggregating, hypolipidemic therapy (n = 20 for CHD + AH and n = 12 for CHD without hypertension). Serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol were assessed. Indicators of cardiac hemodynamics were determined by echocardiography with assessment of left ventricular end systolic and diastolic volumes and diameters (LVESV, LVEDV, LVESD, LVEDD respectively), the thickness of the interventricular septum and posterior wall of the left ventricle (IVST, LVPWT respectively), pulmonary artery pressure (PAP), LV myocardial mass (LVM) and LV myocardial mass index (LVMI). Results. The use of meldonium for 6 months in patients with CHD and concomitant AH led to a decrease in the concentration of total cholesterol from 5.07 to 4.34 mmol/l and LDL from 2.07 to 1.70 mmol/l. In the group of patients without concomitant hypertension there was a decrease in the concentration of total cholesterol from 4.80 to 3.93 mmol/l, LDL from 1.62 to 1.18 mmol/l and an increase in HDL from 1.18 to 1.37 mmol/l. At 6-month administration of meldonium as a part of combination therapy of patients with CHD with concomitant AH, there is a decrease in LVM from 216.90 g to 181.50 g and LVMI from 109.10 g/m2 up to 91.20 g/m2. In patients without concomitant hypertension, a decrease in LVM from 232,20 g to 183.90 g and LVMI from 121.50 g/m2 to 96.40 g/m2 was observed. Conclusions. Our study showed that meldonium has a positive effect on lipid metabolism and echocardiography. In the group of patients with coronary heart disease and concomitant hypertension on the background of additional use of meldonium for six months, we registered a decrease in TC, LDL and AI. LVPWT, PAP, LVM and LVMI also significantly decreased. In the group of patients with coronary heart disease without concomitant hypertension, we registered a decrease in TC, LDL, AI and an increase in HDL. LVM and LVMI also decreased significantly. Therefore, we consider it appropriate to use meldonium in the complex treatment of patients with coronary heart disease with stable angina and concomitant hypertension. Keywords: coronary heart disease, arterial hypertension, meldonium, echocardiography, blood lipid spectrum.

scholarly journals Long-term indapamide retard therapy in adolescents with Stage I arterial hypertension

2011 ◽  
Vol 10 (2) ◽  
pp. 6-12
Author(s):  
I. V. Logacheva ◽  
E. A. Gunicheva
Keyword(s):  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Reactive Hyperemia ◽  
Intima Media Thickness ◽  
Term Treatment ◽  
Stage I ◽  
Control Group ◽  
Large Artery ◽  
Long Term Treatment

Aim. To study the dynamics of office blood pressure (BP) levels, autonomic balance, endothelial dysfunction, and vascular remodelling in adolescents with Stage I arterial hypertension (AH), treated with indapamide retard (IR). Material and methods. In total, the study included 41 adolescent boys, aged 16-18 years, with Stage I AH (main group, MG), and 27 healthy adolescents (control group, CG). The MG participants received, IR (1,5 mg/day) for 6 months. At baseline and in the end of the study, all participants underwent office BP measurement, echocardiography, veloergometry, and the assessment of heart rate variability (HRV), endothelial dysfunction (reactive hyperemia test, endotelin-1 levels), microalbuminuria (MAU), and vascular parameters, such as large artery rigidity and intima-media thickness. Results. Target BP levels were achieved in all MG patients by Week 4 of the treatment, with normal BP values registered throughout the follow-up period. Indapamide therapy was associated with decreased hemodynamic cardiovascular load, normalized endothelial function, and MAU disappearance. IR monotherapy had beneficial effects on HRV, due to moderate parasympathetic stimulation. Conclusion. IR is an effective and safe medication for long-term treatment of adolescents with Stage I AH.

scholarly journals THU0160 FEATURES OF LIPID PROFILE INDICATORS IN PATIENTS WITH RHEUMATOID ARTHRITIS IN CONNECTION WITH ARTERIAL HYPERTENSION

2019 ◽  
Author(s):  
Roman Yatsyshyn ◽  
Oleksandr Shtefiuk ◽  
Bohdana Doskaliuk ◽  
Oleksandra Hotsaniuk ◽  
Irina Mykhaloiko
Keyword(s):  
Rheumatoid Arthritis ◽  
Arterial Hypertension ◽  
Lipid Profile

scholarly journals Blood lipid profile of female and male rats in case of toxic cardiomyopathy, due to the introduction of sodium nitrite

2017 ◽  
Author(s):  
I. Ya. Krynytska ◽  
M. I. Marushchak ◽  
I. O. Stahurska ◽  
I. R. Bekus ◽  
M. V. Kyryliv ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Lipid Profile ◽  
Sodium Nitrite ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Male Rats ◽  
Cholesterol Concentration ◽  
High Density Lipoproteins ◽  
Blood Lipid Profile

The indices of the blood plasma lipid profile of female and male rats in case of toxic cardiomyopathy, due to the introduction of sodium nitrite were sudied. It was determined the increasing of cholesterol concentration in the blood plasma and its redistribution between lipoproteins due to reduction in high density lipoproteins and an increase in low-density lipoprotein, which have proatherogenic properties in animals of both sexes. In gender comparison of changes in blood lipid profile in case of sodium nitrite intoxication their significant prevalence in male rats was found. 

scholarly journals Ischemic and hemorrhagic stroke: a comparative evaluation of lipid profile

2021 ◽  
Vol 8 (2) ◽  
pp. 121
Author(s):  
Nipun Saproo ◽  
Roma Singh
Keyword(s):  
Ischemic Stroke ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Hemorrhagic Stroke ◽  
Total Cholesterol Level ◽  
Strong Association ◽  
Blood Lipid ◽  
Significant Rise ◽  
High Density Lipoproteins ◽  
Mean Values

<p class="abstract"><strong>Background: </strong>The scientific community often sees association of blood lipid levels with the risk of cardiovascular disease. Strong association has often been found between high levels of low density lipoproteins (LDL) and the development of atherosclerosis while elevated levels of high density lipoproteins (HDL) are understood to play protective role. This study was conducted to compare lipid profile among ischemic and hemorrhagic stroke patients.</p><p class="abstract"><strong>Methods: </strong>This observational study was conducted in Department of Neurology, Medanta, Medicity Gurugram, where 50 patients’ cases of infarct and 50 cases of hemorrhagic stroke were studied during: April 2020 to October 2020. All patients with clinically and radiologically proved cerebrovascular accident were included in the study.</p><p class="abstract"><strong>Results: </strong>Mean total cholesterol (TC) for hemorrhagic and ischemic stroke was 175.2 mg/dl and 192.4±41.6 mg/dl respectively. Deranged LDL among subjects with ischemic stroke was 32%. Deranged LDL was seen in 76% of patients reporting ischemic stroke. The mean values for triglycerides (TG) stood at 122±34.6 mg/dl and 141±43.3 mg/dl for hemorrhagic and ischemic stroke respectively. It was seen that the risk of developing ischemic stroke increased with rise in total cholesterol and LDL value. Lipid derangement thus formed an important risk factor for stroke.</p><p class="abstract"><strong>Conclusions: </strong>A significant association is found between raised LDL, abnormal HDL and ischemic stroke, however, a significant rise in total cholesterol level was found in case of both the groups. It is very apparent that patients under high risk should be regularly screened for serum lipid profile.</p>

scholarly journals Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: a monocentric cross-sectional study.

2020 ◽  
Author(s):  
Gian Luca Erre ◽  
Arduino Aleksander Mangoni ◽  
Giuseppe Passiu ◽  
Stefania Bassu ◽  
Floriana Castagna ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Reactive Hyperemia ◽  
Cross Sectional Study ◽  
Peripheral Arterial Tonometry ◽  
Cross Sectional ◽  
Bivariate Correlation ◽  
Plasma Adma ◽  
Plasma Arginine ◽  
The Relationship

Abstract Background The relationship between plasma arginine metabolites influencing vascular homeostasis and peripheral vasodilatory capacity in rheumatoid arthritis (RA) patients is not known. Methods L-arginine (Arg), monomethyl-L-arginine (MMA), L-homoarginine (hArg), asymmetric dimethyl-L-arginine (ADMA), symmetric dimethyl-L-arginine, and L-citrulline (Cit) were measured by LC-MS/MS in 164 RA patients and 100 age- and sex-matched healthy controls without previous cardiovascular events. Log-transformed reactive hyperemia index (Ln-RHI) evaluated by peripheral arterial tonometry (PAT, EndoPAT2000 device) was assessed as surrogate measure of peripheral vasodilatory capacity in RA patients. Ln-RHI values <0.51 indicated peripheral endothelial dysfunction (ED). The relationship between plasma arginine metabolite concentrations, RA descriptors and peripheral vasodilatory capacity was evaluated by bivariate correlation and regression analyses. Results Plasma ADMA concentrations were significantly higher, and plasma hArg concentrations significantly lower, in RA patients than in controls (0.53 ± 0.09 vs 0.465 ± 0.07 μmol/L and 1.50 ± 0.60 vs 1.924 ± 0.78 μmol/L, respectively; p<0.001 for both comparisons). Bivariate correlation analysis demonstrated no significant correlation between arginine metabolites and disease descriptors. In regression analysis in RA patients, higher plasma ADMA concentrations were independently associated with presence of ED [OR(95%CI) = 77.3(1.478 - 4050.005), p =0.031] and lower Ln-RHI [B coefficient(95%CI) =-0.57(-1.09 to -0.05), p =0.032]. Conclusions ADMA was significantly, albeit weakly, associated with impaired microcirculatory vasodilatory capacity and peripheral endothelial dysfunction in RA. This suggests an important pathophysiological role of this metabolite in the vascular alterations observed in this patient group.

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