CLINICAL AND MORPHOLOGICAL FEATURES OF MERKEL’S CARCINOMA IN ELDERLY PATIENTS (LITERATURE REVIEW)

2020 ◽  
pp. 569-575
Author(s):  
В. В. Ермилов ◽  
В. Б. Барканов ◽  
Г. Ф. Микаилзаде ◽  
В. В. Маркелов
Keyword(s):  
Elderly Patients ◽  
Somatic Mutations ◽  
Skin Tumor ◽  
High Rate ◽  
Direct Connection ◽  
Malignant Growth ◽  
Age Related ◽  
Aging Mechanisms ◽  
Local Metastasis

Карцинома Меркеля (КМ) - редкая агрессивная нейроэндокринная опухоль кожи с высокой частотой рецидивирования и местного метастазирования. Средний возраст, при котором диагностируют КМ, составляет 75 лет. Выявление роли соматических мутаций и репараций ДНК в механизмах старения ставит вопрос об их непосредственной связи с процессами дифференцировки, возрастных особенностей иммунитета, программированной клеточной гибели и злокачественного роста. В этой связи сохраняется необходимость в проведении исследований, направленных на усовершенствование ранней диагностики и патогенетического лечения пожилых пациентов с КМ. Merkels cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor with a high rate of recurrence and local metastasis. The average age at which MCC is diagnosed is 75 years. The identification of the role of somatic mutations and DNA repair in aging mechanisms raises the question of their direct connection with the processes of differentiation, age-related characteristics of the immune system, programmed cell death and malignant growth. In this regard, there remains a need for research aimed at improving the early diagnosis and pathogenetic treatment of elderly patients.

scholarly journals The Emerging Role of Senescence in Ocular Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-19 ◽  
Author(s):  
Parameswaran G. Sreekumar ◽  
David R. Hinton ◽  
Ram Kannan
Keyword(s):  
Cellular Senescence ◽  
Age Related Macular Degeneration ◽  
Bioactive Molecules ◽  
Surrounding Tissue ◽  
New Members ◽  
Age Related ◽  
Reasonable Evidence ◽  
Aging Mechanisms ◽  
Cellular Stresses

Cellular senescence is a state of irreversible cell cycle arrest in response to an array of cellular stresses. An important role for senescence has been shown for a number of pathophysiological conditions that include cardiovascular disease, pulmonary fibrosis, and diseases of the skin. However, whether senescence contributes to the progression of age-related macular degeneration (AMD) has not been studied in detail so far and the present review describes the recent research on this topic. We present an overview of the types of senescence, pathways of senescence, senescence-associated secretory phenotype (SASP), the role of mitochondria, and their functional implications along with antisenescent therapies. As a central mechanism, senescent cells can impact the surrounding tissue microenvironment via the secretion of a pool of bioactive molecules, termed the SASP. An updated summary of a number of new members of the ever-growing SASP family is presented. Further, we introduce the significance of mechanisms by which mitochondria may participate in the development of cellular senescence. Emerging evidence shows that extracellular vesicles (EVs) are important mediators of the effects of senescent cells on their microenvironment. Based on recent studies, there is reasonable evidence that senescence could be a modifiable factor, and hence, it may be possible to delay age-related diseases by modulating basic aging mechanisms using SASP inhibitors/senolytic drugs. Thus, antisenescent therapies in aging and age-related diseases appear to have a promising potential.

scholarly journals T Cell Aging in Patients with Colorectal Cancer—What Do We Know So Far?

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6227
Author(s):  
Oana-Maria Thoma ◽  
Markus F. Neurath ◽  
Maximilian J. Waldner
Keyword(s):  
Colorectal Cancer ◽  
T Cells ◽  
T Cell ◽  
Elderly Patients ◽  
Cell Aging ◽  
Cell Dysfunction ◽  
Age Related ◽  
History Of ◽  
T Cell Dysfunction

Colorectal cancer (CRC) continues to be one of the most frequently diagnosed types of cancers in the world. CRC is considered to affect mostly elderly patients, and the number of diagnosed cases increases with age. Even though general screening improves outcomes, the overall survival and recurrence-free CRC rates in aged individuals are highly dependent on their history of comorbidities. Furthermore, aging is also known to alter the immune system, and especially the adaptive immune T cells. Many studies have emphasized the importance of T cell responses to CRC. Therefore, understanding how age-related changes affect the outcome in CRC patients is crucial. This review focuses on what is so far known about age-related T cell dysfunction in elderly patients with colorectal cancer and how aged T cells can mediate its development. Last, this study describes the advances in basic animal models that have potential to be used to elucidate the role of aged T cells in CRC.

Age-related memory deficit: Role of study time and encoding strategies

2010 ◽  
Author(s):  
Charlotte Froger ◽  
Badiaa Bouazzaoui ◽  
Laurence Taconnat
Keyword(s):  
Memory Deficit ◽  
Study Time ◽  
Age Related ◽  
Encoding Strategies

Role of anxiolysis in ophthalmosurgery in elderly patients

2019 ◽  
pp. 72-73
Author(s):  
A.F. Yusupov ◽  
◽  
M.K. Karimova ◽  
N.T. Vakhabova ◽  
R.P. Khashimov ◽  
...  
Keyword(s):  
Elderly Patients

Crucial role of physiotherapy in treating COVID-19 patients

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 967-971
Author(s):  
Poonam Thakre ◽  
Waqar M. Naqvi ◽  
Trupti Deshmukh ◽  
Nikhil Ingole ◽  
Sourabh Deshmukh
Keyword(s):  
Public Health ◽  
Distress Syndrome ◽  
Public Health Problem ◽  
Public Health Emergency ◽  
High Rate ◽  
Major Public Health Problem ◽  
Front Line ◽  
The Many ◽  
Sixth International

The emergence in China of 2019 of severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) previously provisionally names 2019-nCoV disease (COVID19) caused major global outbreak and is a major public health problem. On 30 January 2020, the WHO declared COVID19 to be the sixth international public health emergency. This present pandemic has engrossed the globe with a high rate of mortality. As a front line practitioner, physiotherapists are expected to be getting in direct contact with patients infected with the virus. That’s why it is necessary for understanding the many aspects of their role in the identification, contains, reduces and treats the symptoms of this disease. The main presentation is the involvement of respiratory system with symptoms like fever, cough, sore throat, sneezing and characteristics of pneumonia leads to ARDS(Acute respiratory distress syndrome) also land up in multiorgan dysfunction syndrome. This text describes and suggests physiotherapy management of acute COVID-19 patients. It also includes recommendations and guidelines for physiotherapy planning and management. It also covers the guidelines regarding personal care and equipment used for treatment which can be used in the treatment of acute adult patients with suspected or confirmed COVID-19.

THE ROLE OF PHOSPHATIDYLINOSITOL-3-KINASE IN CARCINOGENESIS

2017 ◽  
Vol 63 (4) ◽  
pp. 545-556
Author(s):  
Natalya Oskina ◽  
Aleksandr Shcherbakov ◽  
Maksim Filipenko ◽  
Nikolay Kushlinskiy ◽  
L. Ovchinnikova
Keyword(s):  
Genetic Disease ◽  
Intracellular Signaling ◽  
Somatic Mutations ◽  
Pi3k Pathway ◽  
Genetic Alterations ◽  
Phosphatidylinositol 3 Kinase ◽  
Intracellular Signaling Pathway ◽  
Metabolic Activities ◽  
Carcinogenic Process

Currently it is established that cancer is a genetic disease and that somatic mutations are the initiators of the carcinogenic process. The PI3K/AKT/mTOR pathway is an important intracellular signaling pathway regulating the cell growth and metabolic activities. Aberrant activation of the PI3K pathway is commonly observed in many different cancers. In this review we analyze the genetic alterations of PI3K pathway in a variety of human malignancies and discuss their possible implications for diagnosis and therapy.

Sign in / Sign up

Export Citation Format

Share Document