ESTIMATION OF HEMOGRAMS INDICES IN PERSONS OF THE ORGANIZED GROUP IN EXTREME CONDITIONS WHEN IN THE DIET INCLUDED PRODUCTS PRODUCED BY CRYOGENIC TECHNOLOGY

2019 ◽  
pp. 54-59
Author(s):  
R.S. Rakhmanov ◽  
Е.S. Bogomolova ◽  
M.V. Ashina ◽  
A.V. Tarasov ◽  
A.E. Gruzdeva ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Comparison Group ◽  
Educational Institution ◽  
Hemoglobin Concentration ◽  
The Body ◽  
Relative Width ◽  
Initial State ◽  
Cryogenic Technology ◽  
Average Hemoglobin

We estimated the hemograms indices of the schoolstudents’ blood enrolled a high military educational institution. By cryogenic technology produced products from protein-vegetable (first) or vegetable raw materials (second) were introduced into the diet of the two main groups. The comparison group was the third one. The blood samples study was performed three times: in the initial state, after taking the product and after 30 days of observation. The average red blood cell volume increased in all examined patients indicating a compensatory reaction of the body to the load, the growth one was less significant in the main groups. The average hemoglobin content in the red blood cell in the first group did not change by stages of observation, in the second and third groups it was decreased by the end of observation. The average hemoglobin concentration decreased, it was less in the main groups. We noted an increase in the number of lymphocytes by 20.7 %, (p = 0.0001) and an increase in the indicator of a mixture from monocytes, basophils, eosinophils when taking the first product. An increase in the number of lymphocytes was noted in the second and third groups only by the end of the observation. The relative lymphocytes content when taking the first product was more significant in the second and third stages of observation than in the initial state; in the second one it was by the end of the observation. The relative neutrophils content in the first group decreased by the end of reception, in the second one it was by the end of observation; in the comparison group remained unchanged. The average platelets volume have been decreased in the first and control groups by the end of the observation and in the second group by the end of taking the product. The relative width of the platelets distribution by volume and the coefficient of large platelets have been decreased in individuals of the group, which may have a positive effect on blood clotting. Thus, the influence of adaptation factors in the main groups was less significant than in the comparison group.

scholarly journals Stress-free state of the red blood cell membrane and the deformation of its skeleton

2012 ◽  
Vol 17 (2) ◽  
Author(s):  
Tjaša Švelc ◽  
Saša Svetina
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Variational Calculation ◽  
Lateral Distribution ◽  
Free State ◽  
Initial State ◽  
Proposed Model ◽  
Deformed State ◽  
Concentric Circles ◽  
Stress Free State

AbstractThe response of a red blood cell (RBC) to deformation depends on its membrane, a composite of a lipid bilayer and a skeleton, which is a closed, twodimensional network of spectrin tetramers as its bonds. The deformation of the skeleton and its lateral redistribution are studied in terms of the RBC resting state for a fixed geometry of the RBC, partially aspirated into a micropipette. The geometry of the RBC skeleton in its initial state is taken to be either two concentric circles, a references biconcave shape or a sphere. It is assumed that in its initial state the skeleton is distributed laterally in a homogeneous manner with its bonds either unstressed, presenting its stress-free state, or prestressed. The lateral distribution was calculated using a variational calculation. It was assumed that the spectrin tetramer bonds exhibit a linear elasticity. The results showed a significant effect of the initial skeleton geometry on its lateral distribution in the deformed state. The proposed model is used to analyze the measurements of skeleton extension ratios by the method of applying two modes of RBC micropipette aspiration.

scholarly journals Preliminary Study on the Clinical and Genetic Characteristics of Hereditary Spherocytosis in 15 Chinese Children

2021 ◽  
Vol 12 ◽  
Author(s):  
Chongjun Wu ◽  
Ting Xiong ◽  
Zhongjin Xu ◽  
Chunlei Zhan ◽  
Feng Chen ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Clinical Characteristics ◽  
Hemoglobin Concentration ◽  
Chinese Children ◽  
Test Results ◽  
Test Analysis ◽  
Genetic Characteristics ◽  
Significant Difference ◽  
Gene Test

ObjectiveTo investigate the clinical and genetic characteristics of hereditary spherocythemia (HS) in Chinese children, and to analyze the potential genotypic/phenotypic associations.MethodsThe clinical data and gene test results of children with HS were collected. All patients were diagnosed by gene test results, and the laboratory results were obtained before splenectomy. The data of red blood cell (RBC), hemoglobin (HB), mean red blood cell volume (MCV), mean red blood cell hemoglobin (MCH), mean red blood cell hemoglobin concentration (MCHC), and hematocrit (HCT) were statistically analyzed according to different mutation genes. Statistical methods for comparison between groups Mann–Whitney test analysis, two-terminal p < 0.05 was considered significant difference.ResultsA total of 15 children were enrolled in our hospital, and 14 variants were found (nine variants have not been reported before), including 10 ANK1 mutations (seven ANK1 truncated mutations) and five SPTB mutations. Patients with ANK1 mutations had more severe anemia than those with SPTB mutations (significantly lower RBC, HB, MCHC, and HCT).ConclusionThis is one of the few studies on the genetic and clinical characteristics of children with HS in China. This study identified the unique genetic and clinical characteristics of Chinese children with HS and analyzed the pathogenic genotype–phenotypic association. The results confirmed that the anemia degree of HS patients caused by ANK1 was more serious than that of patients with SPTB deficiency. However, further study of the correlation between genotype and phenotype requires a larger sample size.

scholarly journals Red Blood Cell Transfusion and the Use of Intravenous Iron in Iron Deficient Patients Presenting to the Emergency Department

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 1-2
Author(s):  
Arvand Barghi ◽  
Robert Balshaw ◽  
Emily Rimmer ◽  
Murdoch Leeies ◽  
Allan Garland ◽  
...  
Keyword(s):  
Emergency Department ◽  
Logistic Regression ◽  
Iron Deficiency ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Hemoglobin Concentration ◽  
Factors Associated ◽  
Iv Iron ◽  
Iron Parameters ◽  
Rbc Transfusion

Background: Red blood cell (RBC) transfusions are often used to treat patients with iron deficiency who present to the emergency department (ED) with symptomatic anemia. Intravenous (IV) iron is the preferred treatment in this setting, as it has been shown to increase hemoglobin concentration rapidly and durably. We aim to determine the incidence of iron deficiency anemia (IDA) and the management of these patients in the ED setting. Objectives: To evaluate the incidence of IDA, the frequency of RBC transfusion and iron supplementation, and factors associated with RBC transfusion. Study Design: Retrospective cohort study of all adult patients presenting to the St Boniface Hospital (Winnipeg, CAN) ED from January 2014 to January 2019. Methods: We used electronic data from the Emergency Department Information System (EDIS) and Laboratory Information Services (LIS) databases to identify patients presenting with IDA, defined as anemia (hemoglobin <120 g/L) with either a transferrin saturation less than 20% or ferritin less than 30 umol/L, or mean corpuscular volume (MCV) of < 75 fL. A ferritin greater than 100 umol was used to exclude IDA, regardless of MCV. We extracted patient demographics, diagnoses, markers of iron storage, RBC transfusion and use of IV iron. Multivariate logistic regression analysis was used to evaluate factors associated with RBC transfusion. Results: Of 39222 patients, 17945 (45%) were anemic. Of the anemic patients, iron parameters were ordered in 1848 (10.3%) patients, and IDA was present in 910 (5.1 %). In the IDA population, 95 patients (10.4 %) received 1 RBC unit, and 197 patients (21.6 %) received 2 or more units. Oral iron and IV iron were prescribed for 64 (7 %) and 14 (1.5 %) patients, respectively. Our logistic regression model demonstrated that hemoglobin concentration was the main determinant of whether patients received RBC transfusion. Other variables including patient age, cardiac symptoms, heart rate, blood pressure, and CTAS score were not associated with increased likelihood of receiving RBC transfusion. Conclusion: Iron parameters were infrequently ordered in the evaluation of anemia in the ED, with limited use of oral and IV iron. The decision to transfuse RBCs was primarily influenced by hemoglobin concentration, but not other surrogates of hemodynamic instability. An interventional study to improve education and access to oral and IV iron is planned to reduce unnecessary RBC transfusions and their associated risks in patients with IDA. Disclosures No relevant conflicts of interest to declare.

scholarly journals Analysis of nitric oxide donor effectiveness in resistance vessels

2005 ◽  
Vol 288 (5) ◽  
pp. H2390-H2399 ◽  
Author(s):  
Daniel R. Hyduke ◽  
James C. Liao
Keyword(s):  
Nitric Oxide ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Interstitial Space ◽  
The Body ◽  
Nitric Oxide Donor ◽  
Free Zone ◽  
Pathological Conditions ◽  
Resistance Vessels ◽  
No Bioavailability

Decreased nitric oxide (NO) bioavailability is associated with a number of pathological conditions. Administration of a supplemental source of NO can counter the pathological effects arising from decreased NO bioavailability. A class of NO-nucleophile adducts that spontaneously release NO (NONOates) has been developed, and its members show promise as therapeutic sources of NO. Because the NONOates release NO spontaneously, a significant portion of the NO may be consumed by the myriad of NO reactive species present in the body. Here we develop a model to analyze the efficacy of NO delivery, by membrane-impermeable NONOates, in the resistance arterioles. Our model identifies three features of blood vessels that will enhance NONOate efficacy: 1) the amount of NO delivered to the abluminal region increases with lumen radius; 2) the presence of a flow-induced red blood cell-free zone will augment NO delivery; and 3) extravasation of the NONOate into the interstitial space will increase abluminal NO delivery. These results suggest that NONOates may be more effective in larger vessels and that NONOate efficacy can be altered by modifying permeability to the interstitial space.

scholarly journals Constraints on vertebrate athleticism: The temperature dependence of red blood cell volume

2013 ◽  
Author(s):  
James JF Gillooly ◽  
Rosana Zenil-Ferguson
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Red Blood Cell ◽  
Oxygen Supply ◽  
The Body ◽  
Whole Body ◽  
Activity Levels ◽  
Aerobic Activity ◽  
Highly Active ◽  
Athletic Ability

The ability to perform at high levels of aerobic activity (i.e. athletic ability) increases with temperature among vertebrates. These differences in species’ activity levels, from highly active to sedentary, are reflected in their ecology and behavior. Yet, the changes in the cardiovascular system that allow for greater oxygen supply rates at higher temperatures, and thus greater activity levels, remain unclear. Here we show that vertebrates provide more oxygen to tissues at higher temperatures in part by increasing the total volume of red blood cells in the body. Across 60 species of vertebrates (fishes,amphibians, reptiles, birds and mammals), whole-body red blood cell volume increases exponentially with temperature after controlling for effects of body size and taxonomy. These changes are accompanied by increases in relative heart mass, an indicator of athletic ability. The results help explain how temperature-dependent changes in cardiovascular design allow species to overcome the constraints of passive diffusion on oxygen supply.

scholarly journals Red Blood Cell Variables in Children and Adolescents regarding the Age and Sex

2019 ◽  
Author(s):  
Jasmina PLUNCEVIC GLIGOROSKA ◽  
Serjoza GONTAREV ◽  
Beti DEJANOVA ◽  
Lidija TODOROVSKA ◽  
Daniela SHUKOVA STOJMANOVA ◽  
...  
Keyword(s):  
Blood Cell ◽  
Children And Adolescents ◽  
Red Blood Cell ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Female Group ◽  
Distribution Width ◽  
Hematological Indices ◽  
Significant Difference ◽  
Age And Sex

Background: This study aimed to assess the basic red blood cell variables and hematological indices in children and adolescents and analyze the differences regarding age and sex. Methods: Overall, 320 young participants, age 8 to 18 yr, were enrolled at Laboratory of Sport’s Medicine, Medical Faculty, Skopje, Macedonia in 2016. Capillary blood samples were drawn and following hematologic parameters were measured: the red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit level (Hct) and hematological indexes: mean corpuscular volume (MCV), mean hemoglobin concentration (MCH), mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW). Results: RBC variables in male group showed high statistical level of significance between age different groups (P=0.001) for all studied parameters except MCHC (P=0.423) and RDW (P=0.174). ANOVA test and multivariate tests in female group showed that there was no significant difference for all hematological parameters between age different groups. Regarding the sex differences, male participants had significantly higher red blood count (P<0.001), hemoglobin content (P<0.001) and hematocrit (P<0.001). Conclusion: Hematological parameters in adolescent as inhomogeneous population are not quantified sufficiently, especially hematological indices. RBC variables, regardless of the age, differ very much between male and female examinees, in favor of the male examinees. Hematological indices were insignificantly higher in males. Regarding the age of examinees, RBC variables showed significant inter-groups differences only within male adolescents. While with girls, ages span 8 to 18 yr, we did not find significant differences for most of the hematological variables.

scholarly journals Vitamin-C Treated Haematology Assessment of Swiss Albino Mice (Mus musculus)

2020 ◽  
Vol 11 (2) ◽  
pp. 9044-9050
Keyword(s):  
Vitamin C ◽  
Blood Cell ◽  
Cell Count ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
The Body ◽  
Blood Cell Count ◽  
Swiss Albino Mice ◽  
Positive Effects ◽  
Albino Mice

Vitamin C is an essential dietary supplement that plays a vital role in battling health conditions. The antioxidant has positive effects on the functioning of the body. The purpose of this study is to investigate the outcome of varying concentrations of Vitamin C on the hematological parameters of Swiss Albino mice. Four albino mice were separated and accommodated in similar caging conditions. Three of them were orally administered with 250mg/kg, 500mg/kg, and 1000mg/kg Vitamin C powder, along with their diet. The fourth one was kept as control, in order to provide a standard value for future comparison. After 30 days of administration of the Vitamin C, the red blood cell count, the white blood cell count, the hemoglobin concentration, the platelet cell count, and the packed cell volume of the blood samples were tested.

scholarly journals Hematological, Hormonal and Fitness Indices in Youth Swimmers: Gender‐Related Comparisons

2019 ◽  
Vol 70 (1) ◽  
pp. 69-80
Author(s):  
Guang Cai ◽  
Jun Qiu ◽  
Shuai Chen ◽  
Qile Pan ◽  
Xunzhang Shen ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Anaerobic Power ◽  
Anaerobic Capacity ◽  
Hemoglobin Concentration ◽  
Erythrocyte Indices ◽  
Testosterone Levels ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Aerobic And Anaerobic

Abstract This study objective was to evaluate gender differences in hematological, hormonal and fitness variables among youth swimmers and to explore relationships between erythrocyte indices and aerobic and anaerobic capacity. 137 girls and 171 boys participated in the study and were divided into three groups based on their training experience. Blood samples were obtained to determine red blood cell counts, hemoglobin concentration, hematocrit, and plasma erythropoietin and testosterone levels. VO2max was assessed using a submaximal cycle protocol. 76 girls and 102 boys also undertook a Wingate test to determine their peak anaerobic power. Boys had higher (p < 0.05) means than girls for all hematological variables except for erythropoietin and these variables demonstrated an increase with training in boys. The average VO2max in l∙min-1 and peak anaerobic power in watts were also higher in boys (2.91 ± 0.08 and 547 ± 28, respectively) than girls (2.25 ± 0.07 and 450 ± 26, respectively). Modest but significant (p < 0.05) correlations were found between VO2max and red blood cell counts (r = 0.252), hemoglobin concentration (r = 0.345), or hematocrit (r = 0.345) and between peak anaerobic power and red blood cell counts (r = 0.304), hemoglobin concentration (r = 0.319) or hematocrit (r = 0.351). This study revealed relatively lower yet age- and gender-appropriate hematological, hormonal and fitness indices in youth swimmers. The gender-related differences in erythrocyte indices seem unrelated to erythropoietin and may be explained by the higher testosterone levels seen in boys. Given their correlation to both aerobic and anaerobic capacity, erythrocyte indices may be used as part of talent identification for sports.

scholarly journals Anemia: Considerations for the Dental Practitioner

2021 ◽  
Author(s):  
Georges Aoun ◽  
Pamela Aoun ◽  
Abbass El-Outa
Keyword(s):  
Blood Cell ◽  
Oxygen Transport ◽  
Red Blood Cell ◽  
Hemoglobin Concentration ◽  
Cell Number ◽  
Dental Practitioner ◽  
Dental Management

Anemia is a condition of decreased red blood cell number or hemoglobin concentration, or of disturbance in their function, ultimately leading to decreased oxygen transport to tissues. Many factors and diseases may lead to anemia, with wide manifestations systemically as well as orally. Therefore, a sound understanding of this syndrome is essential for the dental practitioner, with emphasis on alerting signs, dental management and proper communication with patient&rsquo;s physician.

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