Tamarillo Juice (Solanum betaceum Cav) as An Alternative to Increase Hemoglobin Levels for Pregnant Women with Anemia

Introduction: World Health Organizations recommends pregnant women to consume 120-240 mg of iron (in the form of Ferrum) per day and increase the dose by 400 mg 3 times a day if the Anemia is severe. One of the herbal therapies that can increase hemoglobin levels is Tamarillo (Solanum Betacum Cav) with a vitamin C level of 25 mg, Fe 2,765 ppm. The research objective was to analyze the effect of Tamarillo juice consumption in increasing hemoglobin (HB) levels of pregnant women with Anemia. Methods: Quasi-experimental research with pre and post-test along with control group design was used to compare the HB levels of ≥ 32 weeks pregnant women who were given Tamarillo fruit juice. Subjects in this study were 34 pregnant women as the treatment group who received Tamarillo juice and blood supplement and the control group of pregnant women who only receive blood supplements. Results: The results of the T-test analysis showed that in the treatment group there was an increase in the average hemoglobin level of 0.91 g/dL in the first week and 1.75 g/dL in the second week, while in the control group there was an increase in the average hemoglobin level of 0.43 g/dL in the first week and an increase of 0.89 g/dL in the second week. Conclusion: The administration of Tamarillo juice as an alternative companion to blood supplement in the prevention and management of care for pregnant women with Anemia.

Overview of Hemoglobin Levels and Nutritional Status Based on Body Mass Index (BMI) and Upper Arm Circumference (LLA) Indicators in Foster Families in Uteunkot Village, Muara Dua District, Lhokseumawe in 2021

Hemoglobin is a protein found in red blood cells. Hemoglobin levels that are less than normal or anemia can cause complications in the form of fatigue and stress on the body's organs. Nutritional status is one of the factors that can affect hemoglobin levels. Measurement of nutritional status can be done through several methods including anthropometry and clinical laboratories. Among these methods, the most frequently used in the field is anthropometry using body mass index (BMI) and upper arm circumference (LLA). This study aims to determine the hemoglobin level and nutritional status of the assisted families located in Uteunkot Cunda Village, Lhokseumawe. This study is a descriptive study with a cross-sectional approach to determine the description of hemoglobin levels and nutritional status based on indicators of Body Mass Index and Upper Arm Circumference in the fostered family. The sampling technique used is total sampling with a total of 79 respondents. The results obtained were the average hemoglobin level of the respondents was 12.34 g/dL in the normal category. Nutritional status based on Body Mass Index, most respondents were in normal nutritional status as many as 27 respondents (34.2%). The most nutritional status based on upper arm circumference was malnutrition, namely 55 respondents (69.6%).

Hemoglobin Levels in Blood Samples

Hemoglobin is a part of erythrocytes that serves to transport oxygen and carbon dioxide in tissues. Hemoglobin levels in the blood may decrease one of which is influenced by exposure to lead from the environment. Places that are at high risk for exposure to air lead one of them is at gas stations (Public Refueling Stations). The purpose of this study is to determine hemoglobin levels in kedungrandu gas station officers, Kec. Patikraja, Banyumas. This type of research is a non-experimental observational study. The method of measuring hemoglobin levels using strip test in the form of POCT (Point Care of Testing) tool. This method uses capillary blood samples from 20 respondents with criteria of male sex and aged 21-60 years. The result of this study was as many as 6 people (30%) of the total respondents had low hemoglobin levels, while 14 people (70%) have normal hemoglobin levels. The average hemoglobin level in the blood sample of kedungrandu gas station officers, Kec. Patikraja, Banyumas is 14.41 mg/dl or normal.

Assessment of the prevalence of anemia in patients with primary hyperparathyroidism: a single-center observational study

BACKGROUND: The combination of primary hyperparathyroidism (PHPT) with anemia was first described in 1931. It remains unclear whether PHPT is the direct cause of anemia, or it develops due to PHPT’s complications. The frequency of PHPT-­associated anemia in the Russian population is unknown.AIM: To assess the prevalence of anemia in patients with PHPT admitted to the Department of Parathyroid Glands Pathology in the Endocrinology Research Centre from January 2017 to August 2020.MATERIALS AND METHODS: The study included patients with PHPT over 18 years old. A single-center observational one-stage one-sample uncontrolled study was carried out. We analyzed laboratory and instrumental data obtained during inpatient examination in accordance with the standards of medical care. Statistical analysis was performed using Statistica 13 (StatSoft, USA) and SPSS (IBM, USA) software packages.RESULTS: The study included 327 patients with PHPT, 28 (9%) men and 299 (91%) women. The median age was 59 years [51; 66]. 26 patients (8%) with anemia were identified. Statistically significant differences between patients with and without anemia were found only in the GFR. Comparison of patients with and without anemia didn’t reveal any significant differences in the incidence of PHPT’s complications.Significant differences in serum hemoglobin concentration and average hemoglobin concentration in erythrocytes were revealed between patients with and without vertebrae fractures. In the group of patients without compression fractures these parameters were higher.In the subgroup of patients with total calcium concentration above 3 mmol/L and PTH above 3 normal values, the incidence of anemia reached 21% (95% CI: 10%; 35%). Within this group we revealed tendencies to higher levels of PTH, ionized calcium and osteocalcin in patients with anemia.CONCLUSION: In general, there was no correlation between hypercalcemia, the degree of PTH elevation and the presence of anemia in patients with PHPT. However, in the subgroup of patients with severe hypercalcemia, there was a relationship between the concentration of PTH, ionized calcium and the presence of anemia. In patients with PHPT and vertebral fractures, significantly lower concentrations of blood hemoglobin and hemoglobin in erythrocytes were observed.

Investigating Erythrocytosis: Changing Practice Patterns in the Era of Molecular Diagnostics

Background: Since the identification of JAK2 mutations in polycythemia vera (PV) in 2005 (Kralovics et al., NEJM 2005), molecular testing of JAK2 in patients with erythrocytosis has become part of routine clinical practice. We hypothesized that changes in the World Health Organization (WHO) diagnostic criteria for PV in 2016, which lowered the hemoglobin threshold to >165 g/L for men and >160 g/L for women, may have resulted in increased molecular testing. This study examines changing patterns of utilization of molecular diagnostics in patients referred for erythrocytosis at a tertiary care center. Methods: We examined all patients with erythrocytosis who underwent JAK2 testing, which included testing for JAK2 V617F with PCR between 2015 and 2017, and JAK2 V617F and exon 12 mutations with Next-Generation Sequencing (NGS) between 2018 and 2020 at London Health Sciences Centre in Ontario, Canada. We performed a retrospective chart review to extract laboratory and clinical data, including information on medical comorbidities and medications, with a focus on known secondary causes of erythrocytosis. Results: A total of 668 patients with erythrocytosis underwent JAK2 testing at our institution between August 1, 2015 and December 31, 2020. There was an overall increase in testing over the five-year study period, with a decline in the positive detection rate: 8/29 (28%) in 2015, 15/94 (16%) in 2016, 15/100 (15%) in 2017, 19/136 (14%) in 2018, 17/162 (10%) in 2019, and 14/147 (10%) in 2020 (Figure 1). The average hemoglobin levels in patients with erythrocytosis who underwent testing remained similar across all years (range 170-173 g/L for women, 179-181 g/L for men). In our cohort, there was a high proportion of patients with known or suspected secondary causes of erythrocytosis who underwent molecular testing. Between 2018 and 2020, 324/445 (73%) of patients who underwent molecular testing had either chronic obstructive pulmonary disease, obstructive sleep apnea, other hypoxic lung disease, smoking history, erythropoietin-secreting tumor, or potential drug-induced erythrocytosis. Specifically, we observed an increase in proportion of patients who underwent molecular testing on sodium-glucose cotransporter-2 (SGLT-2) inhibitors, a known secondary cause of erythrocytosis, with 15/136 (11%) in 2018, 17/162 (10%) in 2019, and 25/147 (17%) in 2020. In contrast, the proportion of patients on testosterone was relatively constant at 15/136 (11%) in 2018, 11/162 (6.8%) in 2019, and 11/147 (7.5%) in 2020. Conclusion: This study revealed that a high proportion of patients with known or suspected secondary causes of erythrocytosis underwent JAK2 testing, resulting in increase in molecular testing over time and a decline in positive detection rate. In particular, we observed a number of patients on SGLT-2 inhibitors who had investigation, suggesting that this class of medications may be an underrecognized cause of drug-induced erythrocytosis (Chin-Yee et al., CMAJ 2020). Our findings underscore the importance of careful medical history and medication review to support more judicious use of molecular testing. Similarity in average hemoglobin levels across the five-year study period suggests that other factors, such as increased availability of 'routine' molecular testing, rather than changes in the WHO diagnostic criteria may explain increases in JAK2 testing. Our study indicates a need to develop an effective clinical prediction rule for JAK2 positivity to better risk stratify patients with suspected PV based on clinical and laboratory parameters to optimize utilization of molecular diagnostics. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

TEMPE DAPAT MENINGKATKAN KADAR HEMOGLOBIN (HB) PADA IBU HAMIL

Background: Anemia is one of the indirect causes of death of pregnant women, therefore the condition of anemic pregnant women can have an impact on Low Birth Weight Babies. Efforts to prevent anemia in pregnancy can be given with pharmacological and non-pharmacological therapies. Pharmacological therapy has side effects such as stomach discomfort, nausea, difficulty in defecating, and black stools. While the non-pharmacological therapy that we can give to accelerate the increase in hemoglobin levels of pregnant women is one of them by consuming tempe (Fathonah, 2016).The purpose of the study: to determine the effect of tempeh consumption on the increase in hemoglobin levels in pregnant women with anemia at the Karta Raharja Public Health Center.Research method: This study uses a quasi-experimental or quasi-experimental method. In this study, the population was all pregnant women in the Kartaraharja Health Center in 2020, while the sample was 36 pregnant women. The sampling method of this study uses a non-probability sampling technique with purposive sampling. Intervention was carried out in the form of giving tempeh for 15 days, then after that the hemoglobin levels were checked again. Analysis of the data using the T-Dependent statistical test.Results: From the results of the research conducted, the average hemoglobin level in the intervention group before being given tempeh was 9.4278 gr%, after being given tempeh the average hemoglobin level rose to 10,7111 gr%. The average increase in hemoglobin levels of pregnant women after the intervention was 1.2833 gr%. The results of data analysis in the control group were 9.7111 gr%, while the average hemoglobin level after monitoring was 10.4333 gr%. The average increase in the control group was 0.7222 gr%.Conclusion: from this study it can be concluded that there is an effect of consuming tempeh and iron on anemic pregnant women at the Karta Raharja Tulang Bawang Barat Health Center in 2020.Suggestion: it is hoped that later it will become a place of knowledge for mothers so that they have good and right abilities and vice versa. The results of this study can be continuously improved to provide more relevant information and learning references regarding the treatment with non-pharmacological therapy of Anemia as an effort to prevent and support the achievement of Maternal Health in Tulang Bawang Barat, which is also very useful for scientific development in the future. And it is necessary to hold a program that helps handling cases of anemia, especially in Tulang Bawang Barat Regency which coordinates with other sectors such as religious leaders, community leaders, besides that health education is still provided by health workers and cadres to young women and women of childbearing age about danger of anemia. Keywords : Anemia, Hemoglobin, Tempe ABSTRAK Latar Belakang: Anemia merupakan salah satu faktor penyebab tidak langsung kematian ibu hamil, oleh karena itu kondisi ibu hamil anemia dapat berdampak pada BBLR. Upaya untuk mencegah terjadinya anemia pada kehamilan dapat diberikan dengan terapi farmakologi dan non farmakologi. Terapi farmakologi memberikan efek samping seperti perut terasa tidak enak, mual, susah buang air besar, dan feses berwarna hitam. Sedangkan terapi non farmakologi yang dapat kita berikan untuk mempercepat peningkatan kadar Hb ibu hamil salah satunya dengan konsumsi tempe (Fathonah, 2016).Tujuan penelitian: untuk mengetahui pengaruh konsumsi tempe terhadap kenaikan kadar hemoglobin pada ibu hamil yang mengalami anemia di puskesmas Karta Raharja.Metode penelitian: Penelitian ini menggunakan metode quasi eksperiment atau eksperimen semu.Dalam penelitian ini populasinya adalah seluruh ibu hamil yang ada di Puskesmas Kartaraharja tahun 2020, sampel sebanyak 36 ibu hamil. Metode sampling penelitian ini menggunakan non-probability dengan teknik sampling purposive sampling. Dilakukan intervensi berupa pemberian tempe selama 15 hari, kemudian setelah itu dilakukan pengecekan kadar Hemoglobin kembali. Analisis data menggunakan uji statistik uji T-Dependen.Hasil: Dari hasil penelitian yang dilakukan, rata-rata kadar Hemoglobin pada kelompok intervensi sebelum diberikan tempe adalah 9,4278 gr%, setelah diberikan tempe rata-rata kadar hb naik menjadi 10.7111 gr%. Peningkatan rata-rata kadar Hb ibu hamil setelah diberikan intervensi sebesar 1,2833 gr%. Hasil analisis data pada kelompok kontrol 9,7111 gr%, sedangkan rata-rata kadar Hb setelah dilakukan pemantauan sebesar 10.4333 gr%. Peningkatan rata-rata pada kelompok kontrol 0.7222 gr%.Kesimpulan: dari penelitian ini dapat disimpulkan bahwa adanya pengaruh konsumsi tempe dan Fe pada ibu hamil mengalami anemia di Puskesmas Karta Raharja Tulang Bawang Barat Tahun 2020.Saran : diharapkan nantinya menjadi wadah pengetahuan bagi ibu sehingga memiliki kemampuan yang baik dan benar begitu pula sebaliknya. Hasil penelitian ini dapat terus ditingkatkan untuk memberikan informasi dan referensi pembelajaran yang lebih relevan mengenai penanganan dengan terapi non farmakologi Anemia sebagai salah satu upaya pencegahan dan mendukung tercapainya Kesehatan Ibu di Tulang Bawang Barat, juga sangat berguna untuk pengembangan keilmuan dikemudian hari. Serta perlu diadakannya suatu program yang membantu penanganan kasus Anemia pada, khususnya di Kabupaten Tulang Bawang Barat yang berkoordinasi dengan sektor lain seperti Tokoh Agama, Tokoh Masyarakat, disamping itu pendidikan kesehatan yang tetap diberikan oleh tenaga kesehatan serta kader kepada remaja putri maupun PUS/WUS tentang bahaya Anemia.Kata Kunci : Anemia, Hemoglobin, Tempe Kata Kunci : Anemia, Hemoglobin, Tempe

The Effect of Moringa Oleifera on Hemoglobin Level in Pregnancy

Anemia is a form of the body's compensation mechanism for decreasing hemoglobin levels. Anemia in pregnancy is a condition in which hemoglobin is below normal, which is below 11 g/dl. The most common cause of anemia in pregnancy is iron deficiency. Moringa leaves are one type of food that is rich in iron which can overcome anemia. The purpose of the study was to determine the effect of giving Moringa leaf soup on hemoglobin levels of pregnant women in the third trimester at the Oepoi Health Center, Kupang City in 2021. Quasy Experimental research design with a two group pre-test and post-test design. The study population was all pregnant women. The sampling technique is purposive sampling. The sample was 32 pregnant women. Statistical test using t-test. The location of this research was carried out at the Oepoi Health Center, Kupang City from July to August 2021. The research instrument was observation sheet and Hb measuring instrument. The results showed that the average hemoglobin of pregnant women before the intervention in the experimental group was 9.813 g/dl with a standard deviation of 0.57. The hemoglobin level of pregnant women after being given Moringa leaf soup in the experimental group was 11.494 g/dl with a standard deviation of 1.24. The average hemoglobin in pregnant women before intervention in the control group was 9.825 g/dl with a standard deviation of 0.61. The average hemoglobin in pregnant women after the intervention in the control group was 9.675 g/dl with a standard deviation of 1.28. Analysis using the t-test obtained a significance value of 0.000 <0.05. It can be concluded that there was a significant effect between giving Moringa leaf soup on hemoglobin levels in TM III pregnant women. It is hoped that in addition to consuming Fe tablets, it is also recommended to consume foods high in iron such as Moringa leaves to increase hemoglobin in pregnant women.

Pemberian Nugget Tempe terhadap Kadar Hemoglobin pada Remaja Putri

In Indonesia, 23.9 percent of adolescent girls suffer from anemia. Adolescent girls with anemia have poor memory and are less thorough in scholastic exams, resulting in inferior learning achievements. They are also more susceptible to illness, putting them at risk when they become pregnant. The goal of this study was to see how providing tempeh nuggets affected adolescent girls' hemoglobin levels at SMP Negeri in Gorontalo City. This sort of study uses a pre-experimental design with a pretestposttest research design with a single group design and a sample of 43 persons drawn by chance. Provision of tempe nuggets was the independent variable, whereas hemoglobin levels in teenage girls was the dependent variable. The average value or difference in the average hemoglobin levels of adolescent girls after being fed tempeh nuggets was 0.40 gr/dl, standard deviation was 0.42, and sig (2-tailed) = 0.000< 0.05, according to the findings of statistical test analysis with Paired T-test. Conclusion At SMP Negeri Gorontalo City, giving tempeh nuggets has an effect on hemoglobin levels in adolescent girls.

PENGARUH KONSUMSI BUAH KURMA (PHOENIX DACTYLIFERA)DAN TABLET FeTERHADAP KENAIKAN KADAR HEMOGLOBIN (Hb)PADA IBU HAMIL DENGAN ANEMIA

Background AKI cases in Lampung continue to increase, based on information from the Lampung Provincial Health Office in 2015 there were 122 AKI in Lampung. That number increased to 144 cases in 2015 and in 2016 it reached 138 cases and in 2017 it reached 142 cases. While the incidence of anemia in pregnant women in Pesawaran Regency in 2016 was 14.4%, and in 2017 it was 15.4%.The purpose of this study was to determine the effect of consuming dates and Fe tablets on the increase in hemoglobin levels in pregnant women with anemia at the Hanura Health Center, Teluk Pandan District, Pesawaran Regency in 2019.Methods Types of Quantitative Research, the research design is a quasi-experimental method with a pretest-posttest approach with a control group. The population in this study were all pregnant women in the second and third trimesters with anemia who performed Antenatal Care (ANC) at the Hanura Health Center, Teluk Pandan District, Pesawaran Regency, namely 56 pregnant women who experienced anemia. With a sample of 30 people made into 2 groups, 15 people were treated with dates and Fe tablets, and 15 people were treated with Fe tablets, with the inclusion criteria of all pregnant women with mild anemia, Respondents with full awareness, Willing to be research subjects, Respondents taking FE tablets. By using purposive sampling technique. Analysis of univariate and bivariate data with independent T-test.The results showed the average hemoglobin level before consumption of dates and Fe tablets was 9.907 g/dl., the average hemoglobin level after consumption of dates and Fe tablets was 11.320 g/dl., the average hemoglobin level before consumption of Fe tablets was 9.867. gr/dl., the average hemoglobin level after consuming Fe tablets was 10,667 gr/dl.The conclusion is that there is an influence of the consumption of dates and Fe tablets on the increase in hemoglobin levels in pregnant women with anemia at the Hanura Health Center, Teluk Pandan District, Pesawaran Regency in 2019. The t test results obtained p value 0.000 < (0.05).Suggest for health workers, especially midwives, to recommend pregnant women to consume dates as a supplement for Fe because it can increase hemoglobin levels in pregnant women. Keywords: Dates, Fe tablets, hemoglobin levels ABSTRAK Latar Belakang Kasus AKI di Lampung terus meningkat, berdasarakan keterangan Dinas Kesehatan Provinsi Lampung pada 2015 terdapat 122 AKI di Lampung. Jumlah itu meningkat menjadi 144 kasus di tahun 2015 dan tahun 2016 mencapai 138 kasus dan pada tahun 2017 mencapai 142 kasus. Sedangkan angka kejadian anemia pada ibu hamil di Kabupaten Pesawaran pada tahun 2016 sebanyak 14,4%, dan pada tahun 2017 sebanyak 15,4%.Tujuan dari penelitian iUntuk mengetahui pengaruh konsumsi buah kurma dan tablet fe terhadap kenaikan kadar hemoglobin pada ibu hamil dengan anemia di Puskesmas Hanura Kecamatan Teluk Pandan Kabupaten Pesawaran Tahun 2019.Metode Jenis Penelitian Kuantitatif, rancangan penelitian metode quasi eksperimen dengan pendekatan pretest-posttest with control group. Populasi dalam penelitian ini adalah seluruh ibu hamil trimester II dan trimester III dengan anemia yang melakukan Antenatal Care (ANC) di Puskesmas Hanura Kecamatan Teluk Pandan Kabupaten Pesawaran yaitu sebanyak 56 ibu hamil yang mengalami anemia. Dengan jumlah sampel 30 orang di buat dalam 2 kelompok yaitu 15 orang diberikan perlakuan dengan kurma dan tablet fe, dan 15 orang diberikan perlakun dengan tablet fe, dengan kriteria inklusi seluruh ibu hamil dengan anemi ringan, Responden dengan kesadaran penuh, Bersedia menjadi subjekpenelitian, Responden mengkonsumsi tablet FE. Dengan teknik sampling purposive sampling. Analisa data univariat dan bivariate dengan uji T-test independent.Hasil penelitian menunjukan rata-rata kadar hemoglobin sebelum konsumsi kurma dan tablet Fe sebesar 9,907 gr/dl.,rata-rata kadar hemoglobin setelah konsumsi kurma dan tablet Fe sebesar 11,320 gr/dl., rata-rata kadar hemoglobin sebelum konsumsi tablet Fe sebesar 9,867 gr/dl., rata-rata kadar hemoglobin setelah konsumsi tablet Fe sebesar 10,667 gr/dl.Kesimpulan diketahui ada perngaruh konsumsi buah kurma dan tablet Fe terhadap kenaikan kadar hemoglobin pada ibu hamil dengan anemia di Puskesmas Hanura Kecamatan Teluk Pandan Kabupaten Pesawaran Tahun 2019. Hasil uji t didapat p value 0,000 < α (0,05).Sarankan bagi tenaga kesehatan khususnya bidan agar menganjurkan kepada ibu hamil untuk mengkonsumsi kurma sebagai pendamping Fe karena dapat menaikan kadar hemoglobin pada ibu hamil. Kata Kunci : Kurma, Tablet Fe, Kadar hemoglobin

MO790PREDICTORS OF ERYTHROPOIETIN HIPORESPONSIVENESS IN PREVALENT PATIENTS ON PERITONEAL DIALYSIS: A CROSS-SECTIONAL STUDY

Background and Aims Anemia resistant to recombinant human erythropoietin (EPO) is a risk factor for mortality in dialyzed patients with chronic kidney disease. Identifying the causes of hyporesponsiveness may help overcome this resistance. The aim of this study was to investigate the risk factors of EPO hyporesponsiveness in a prevalent population of patients on peritoneal dialysis (PD). Method Cross-sectional study involving 50 prevalent DP patients. To evaluate the dose–response effect of EPO therapy, we used the erythropoietin resistance index (ERI), calculated as the average weekly weight-adjusted dose of EPO (U/Kg per week) divided by the average hemoglobin level (g/dL), over a 3-month period. Patients were classified in two groups according to ERI: ERI ≤ 10 and ERI &gt; 10. We compared clinical, analytical and demographic data among groups. Body composition and fluid volume were evaluated by bioimpedance using the body composition monitor (BCM). Logist regression analysis was performed to identify predictors of EPO hyporesponsiveness. Statistical analysis was executed using SPSS (Version 23 for Mac OSX). Results The average age of 50 prevalent DP patients was 52.04 ± 15.98 years, 29 (58%) were male, 29 (58%) were diabetic and 31 (64%) were treated with angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). Average hemoglobin level (Hb) was 10.99 ± 0.81g/dL and average ERI was 7.64 ± 7.25. Eleven patients (22%) had hyporesponsiveness to EPO therapy (ERI&gt;10). There was no age, gender, cause of chronic kidney disease or PD modality difference among groups. There was also no difference in the use of ACEIs or ARBs. Hyporesponsive patients had lower body mass index (BMI) (22.94 ± 2.89 vs 26.74 ± 4.53Kg/m2, p=0.01) and lower lean tissue index (LTI) (9.96 ± 1.94 vs 16.23 ± 18.51Kg/m2, p=0.02), but not fat tissue index (FTI). Weekly creatinine clearance (peritoneal plus urinary), but not Kt/V, was also significantly lower in this group (68.76 ± 37.29 vs 87.84 ± 35.35L/1.73m2, p=0.028). Hyporesponsive patients had lower urine volume (0.73 ± 0.63 vs 1.39 ± 0.67L, p=0.005) and residual kidney function (3.43 ± 3.04 vs 6.13 ± 3.69mL/min/1.73m2, p=0.044). The proportion of patients with fluid overload, defined as overhydration (OH)/extracellular water (ECW) &gt; 15%, was significantly higher in this group (p=0.04). No difference was observed in albumin, c-reactive protein, serum iron, serum ferritin, transferrin saturation index or parathormone among groups. In a logist regression analysis, BMI [(OR) 0.56 (CI: 0.364-0.849)] and LTI [(OR) 0.315 (CI: 0.130-0.767)] were predictors of hyporesponsiveness to EPO therapy. Conclusion Lower BMI and lower LTI were predictors of resistance to EPO therapy in our study. Body composition, fluid status and residual kidney function seem to be the main factors influencing the response to EPO therapy in prevalent patients on PD, emphasizing the importance of strategies oriented to preserve residual kidney function in these patients.