scholarly journals PRIMARY HYPERPARATHYROIDISM. A CLINICAL OBSERVA

2021 ◽  
Vol 11 (1) ◽  
pp. 60-62
Author(s):  
Danila Vasiliev ◽  
Anastasia Kulish ◽  
Olga Poselyugina ◽  
Elena Andreeva
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Case ◽  
Early Stage ◽  
Relevant Literature ◽  
Diagnostic Errors ◽  
Screening Methods ◽  
Internal Organs ◽  
Blood Calcium ◽  
Slow Progression ◽  
Complicated Course

Background. Primary hyperparathyroidism is an endocrine disease resulting from a primary pathology of the parathyroid gland, characterized by increased secretion of parathyroid hormone and increased blood calcium levels. Among the endocrine diseases, primary hyperparathyroidism is the third most common after diabetes mellitus and thyroid disease. Without timely diagnosis, primary hyperparathyroidism causes systemic damage to internal organs: renal impairment, nephrolithiasis, esophageal affection, cardiovascular and nervous system and affects bones. The aim of the work was to present a clinical case of a patient with primary hyperparathyroidism and to analyze the stages of its diagnosis and treatment. Material and methods. We reviewed the relevant literature and analyzed the patient’s medical records. Results and Discussion. The patient had a complicated course of primary hyperparathyroidism of bone and visceral form. Despite of the slow progression and availability of screening methods, hyperparathyroidism was detected at the stage of complications. The efficacy of the therapy has been assessed. The underlying reasons that made it difficult to diagnose PHPT at an early stage, before the development of serious complications of internal organs were investigated. Conclusions: It can be assumed that our clinical case will increase the awareness of physicians, especially therapists, about the primary manifestations of this pathology and the challenges of its detecting and avoiding diagnostic errors.

A CLINICAL CASE OF PRIMARY HYPERPARATHYROIDISM OF THE OSTEO-VISCERAL FORM

2020 ◽  
pp. 155-161
Author(s):  
Poselyugina O.B. ◽  
Kulish A.S. ◽  
Vasiliev D.F.
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Case ◽  
Early Stage ◽  
Diagnostic Errors ◽  
Epidemiological Studies ◽  
Medical Documentation ◽  
Screening Methods ◽  
Internal Organs ◽  
Blood Calcium ◽  
Slow Development

Introduction. Primary hyperparathyroidism is an endocrine disease resulting from a primary pathology of the parathyroid gland, characterized by increased secretion of parathyroid hormone and increased blood calcium levels. Among the endocrine diseases, primary hyperparathyroidism is the third most common after diabetes mellitus and thyroid disease. In Russia, according to epidemiological studies, primary hyperparathyroidism is found in 1% of the population, women suffer 2-3 times more often than men do, and the average age of diagnosis is 54-59 years. In the absence of a timely diagnosis, primary hyperparathyroidism causes systemic damage to internal organs: renal impairment, nephrolithiasis, esophageal affection, cardiovascular and nervous system involvement, and it leads to a violation of bone tissue integrity. The aim is to demonstrate a clinical case of a patient with primary hyperparathyroidism and to analyze the stages of diagnosis of the disease and treatment. Material and methods. The review of medical literature on the problem of diagnostics and treatment of primary hyperparathyroidism was performed, as well as an analysis of the patient’s medical documentation with this pathology. Results and discussion. A variant of complicated course of primary hyperparathyroidism of bone and visceral form is considered. About 15 years passed from the moment of appearance of the first symptoms of the disease to the development of complications of renal and bone system. Despite the slow development of the disease and availability of screening methods, hyperparathyroidism was detected at the stage of complications. This article provides a detailed analysis of the primary hyperparathyroidism history, as well as analyzes the possibilities of diagnosis, treatment and prevention of this pathology. The efficacy of the therapy has been assessed, and ways of correction have been outlined. The analysis of the reasons that made it difficult to diagnose this pathology at an early stage, before the development of serious complications of internal organs, has been carried out. Conclusions: It can be assumed that the presented clinical case will increase the awareness of physicians, especially therapists, about the primary manifestations of this pathology and the peculiarities of its detection and routing the patient, which will allow avoiding many diagnostic errors.

scholarly journals Primary Hyperparathyroidism Due to Parathyroid Adenoma: Clinical Case

2021 ◽  
Vol 11 (1) ◽  
pp. 76-80
Author(s):  
A. E. Shklyaev ◽  
A. M. Khisamutdinova ◽  
A. G. Bessonov ◽  
O. V. Muravtseva ◽  
A. V. Kobelev ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Phosphorus Metabolism ◽  
Elevated Blood ◽  
Blood Calcium ◽  
Endocrine Disease ◽  
Calcium Phosphorus ◽  
Excessive Secretion ◽  
Indication For Surgical Treatment

Primary hyperparathyroidism (PGPT) is an endocrine disease characterized by excessive secretion of parathyroid hormone (PTH) in upper — normal or elevated blood calcium levels due to primary parathyroid gland pathology (osch). Primary hyperparathyrosis, depending on the clinical manifestations, can occur in the normocalcemic, mild and manifest form. This article presents a clinical case of the development of the manifest form by the type of visceral disorders. Which appeared in the form of pathology of the gastrointestinal tract. This form of the disease is an indication for surgical treatment and further correction of calcium-phosphorus metabolism.

Molecular Processes Involved in Pancreatic Cancer and Therapeutics

2020 ◽  
Vol 14 ◽  
Author(s):  
Subhajit Makar ◽  
Abhrajyoti Ghosh ◽  
Divya ◽  
Shalini Shivhare ◽  
Ashok Kumar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Molecular Mechanisms ◽  
Early Stage ◽  
Locally Advanced ◽  
Therapeutic Strategies ◽  
Screening Methods ◽  
Pancreatic Cancer Cells ◽  
Systemic Treatments ◽  
Cancer Initiation ◽  
Novel Therapeutic Strategies

: Despite advances in the development of cytotoxic and targeted therapies, pancreatic adenocarcinoma (PAC) remains a significant cause of cancer mortality worldwide. It is also difficult to detect it at an early stage due to numbers of factors. Most of the patients are present with locally advanced or metastatic disease, which precludes curative resection. In the absence of effective screening methods, considerable efforts have been made to identify better systemic treatments during the past decade. This review describes the recent advances in molecular mechanisms involved in pancreatic cancer initiation, progression, and metastasis. Additionally, the importance of deregulated cellular signalling pathways and various cellular proteins as potential targets for developing novel therapeutic strategies against incurable forms of pancreatic cancer is reported. The emphasis is on the critical functions associated with growth factors and their receptors viz. c-MET/HGF, CTHRC1, TGF-β, JAK-STAT, cyclooxygenase pathway, WNT, CCK, MAPK-RAS-RAF, PI3K-AKT, Notch, src, IGF-1R, CDK2NA and chromatin regulation for the sustained growth, survival, and metastasis of pancreatic cancer cells. It also includes various therapeutic strategies viz. immunotherapy, surgical therapy, radiation therapy and chemotherapy.

scholarly journals Narushenie purinovogo obmena u patsienta s pervichnym giperparatireozom i sakharnym diabetom 2 tipa

2010 ◽  
Vol 7 (3) ◽  
pp. 43-48
Author(s):  
N G Mokrysheva ◽  
A Yu Tokmakova ◽  
I A Voronkova ◽  
L Ya Rozhinskaya ◽  
A I Bukhman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Primary Hyperparathyroidism ◽  
Diabetes Mellitus Type 2 ◽  
Clinical Case ◽  
Diabetes Mellitus Type ◽  
The Relationship

In this article we describe a clinical case of primary hyperparathyroidism, gout tophus and diabetes mellitus type 2. The relationship between hyperuricemia and hypercalcemia linked to primary hyperparathyroidism is discussed.

scholarly journals NATAL INJURIES OF VISCERAL ORGANS

2018 ◽  
Vol 63 (5) ◽  
pp. 197-201
Author(s):  
V. I. Morozov ◽  
A. A. Podshivalin ◽  
G. E. Chigvintsev ◽  
G. A. Yulmetov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Organ Failure ◽  
Clinical Case ◽  
Perinatal Period ◽  
Internal Organs ◽  
Visceral Organs ◽  
Multi Organ Failure

The article describes surgical diseases of newborns after a trauma of central nervous system in the perinatal period. There is a detailed diagnostic and therapeutic tactics for injuries of internal organs. There is a clinical case of natal injury, leading to severe multi-organ failure and death.

scholarly journals Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy

2020 ◽  
Vol 146 (12) ◽  
pp. 3111-3122
Author(s):  
Shuyu Huang ◽  
Sander M. J. van Duijnhoven ◽  
Alice J. A. M. Sijts ◽  
Andrea van Elsas
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Clinical Evaluation ◽  
Immune Cell ◽  
Early Stage ◽  
Relevant Literature ◽  
Hematologic Malignancies ◽  
Bispecific Antibodies ◽  
Tumor Associated Antigens ◽  
Tumor Selectivity

Abstract Purpose Bispecific antibodies (BsAbs) have emerged as a leading drug class for cancer therapy and are becoming increasingly of interest for therapeutic applications. As of April 2020, over 123 BsAbs are under clinical evaluation for use in oncology (including the two marketed BsAbs Blinatumomab and Catumaxomab). The majority (82 of 123) of BsAbs under clinical evaluation can be categorized as bispecific immune cell engager whereas a second less well-discussed subclass of BsAbs targets two tumor-associated antigens (TAAs). In this review, we summarize the clinical development of dual TAAs targeting BsAbs and provide an overview of critical considerations when designing dual TAA targeting BsAbs. Methods Herein the relevant literature and clinical trials published in English until April 1st 2020 were searched using PubMed and ClinicalTrials.gov database. BsAbs were considered to be active in clinic if their clinical trials were not terminated, withdrawn or completed before 2018 without reporting results. Data missed by searching ClinicalTrials.gov was manually curated. Results Dual TAAs targeting BsAbs offer several advantages including increased tumor selectivity, potential to concurrently modulate two functional pathways in the tumor cell and may yield improved payload delivery. Conclusions Dual TAAs targeting BsAbs represent a valuable class of biologics and early stage clinical studies have demonstrated promising anti-tumor efficacy in both hematologic malignancies and solid tumors.

scholarly journals Early Autism Screening: A Comprehensive Review

2019 ◽  
Vol 16 (18) ◽  
pp. 3502 ◽  
Author(s):  
Fadi Thabtah ◽  
David Peebles
Keyword(s):  
Autistic Spectrum Disorder ◽  
Early Stage ◽  
Screening Tools ◽  
Screening Methods ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Speed Up ◽  
Sensitivity Specificity ◽  
Further Development ◽  
Lengthy Process

Autistic spectrum disorder (ASD) refers to a neurodevelopmental condition associated with verbal and nonverbal communication, social interactions, and behavioural complications that is becoming increasingly common in many parts of the globe. Identifying individuals on the spectrum has remained a lengthy process for the past few decades due to the fact that some individuals diagnosed with ASD exhibit exceptional skills in areas such as mathematics, arts, and music among others. To improve the accuracy and reliability of autism diagnoses, many scholars have developed pre-diagnosis screening methods to help identify autistic behaviours at an early stage, speed up the clinical diagnosis referral process, and improve the understanding of ASD for the different stakeholders involved, such as parents, caregivers, teachers, and family members. However, the functionality and reliability of those screening tools vary according to different research studies and some have remained questionable. This study evaluates and critically analyses 37 different ASD screening tools in order to identify possible areas that need to be addressed through further development and innovation. More importantly, different criteria associated with existing screening tools, such as accessibility, the fulfilment of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) specifications, comprehensibility among the target audience, performance (specifically sensitivity, specificity, and accuracy), web and mobile availability, and popularity have been investigated.

scholarly journals Mild Encephalitis with a Reversible Splenial Lesion: A Clinical Benign Condition, often Underrecognized – Clinical Case and Literature Review

2017 ◽  
Vol 08 (02) ◽  
pp. 281-283 ◽  
Author(s):  
Sandro Zambito Marsala ◽  
Eleonora Antichi ◽  
Michele Pistacchi ◽  
Manuela Gioulis ◽  
Rosa Maria Candeago ◽  
...  
Keyword(s):  
Literature Review ◽  
Corpus Callosum ◽  
Clinical Case ◽  
Early Stage ◽  
Spontaneous Resolution ◽  
Electrolyte Disorders ◽  
Posterior Portion ◽  
Benign Condition ◽  
Diagnostic Panel ◽  
Reversible Lesion

ABSTRACTMild encephalitis with reversible lesion in the splenium is a clinicoradiological syndrome characterized by a variegated symptomatology with a solitary mass in the central portion of the splenium of the corpus callosum. Complete spontaneous resolution is the hallmark of this syndrome, though its pathogenesis is still unknown. We describe the clinical picture of a 51-year-old woman who developed a partial sensitive seizure, with MRI evidence of a lesion localized in the posterior portion of the corpus callosum. The patient made a full recovery thanks to the administration of antiepileptic drugs. Acquiring knowledge of this syndrome, in the wide diagnostic panel which includes vertebrobasilar diseases besides the broad range of metabolic and electrolyte disorders, is crucial to a prompt clinical diagnosis and in establishing a reliable prognosis at an early stage.

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