scholarly journals GAMBARAN KADAR ASAM URAT PADA PENDERITA TUBERKULOSIS PARU YANG MENERIMA TERAPI OBAT ANTI TUBERKULOSIS DI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JULI 2014 – JUNI 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Irwanto Kondo ◽  
M. C. P. Wongkar ◽  
Jeffrey Ongkowijaya
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Uric Acid ◽  
Pulmonary Tuberculosis ◽  
Female Ratio ◽  
Intensive Phase ◽  
Antituberculosis Drugs ◽  
Tuberculosis Patients ◽  
Male Female Ratio ◽  
Amino Salicylic Acid ◽  
Using Data

Abstract: Pulmonary tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. There are 6 kinds of essential drugs which have been used: isoniazid, amino salicylic acid, streptomycin, ethambutol, rifampicin, and pyrazinamide. As reported, pyrazinamide and ethambutol can cause increased levels of uric acid. This study aimed to obtain the uric acid profile in tuberculosis patients treated with antituberculosis drugs in Prof. Dr. R. D. Kandou Hospital Manado. This was a retrospective descriptive study using data of the Medical Record Department of Prof. Dr. R. D. Kandou Hospital Manado. Of 25 tuberculosis patients treated with antituberculosis drugs, the uric acid levels were as follows: high in 15 patients (60%), normal in 9 patients (36%), and low in 1 patient (4%). The highest proportion of tuberculosis patients who had hyperuricemia after treated with antituberculosis drugs were male (73.33%) and age 46-65 years (46.67%). The increased uric acid level mainly occurred in the intensive phase of treatment (0-2 months), and in patients taking the combination of pyrazinamide and ethambutol. The most common comorbid disease was anemia (53.33%). Conclusion: Hyperuricemia was found in 60% of TB patients receiving antituberculosis drugs with a male : female ratio 2.75:1, mainly occurred in the intensive phase of treatment (0-2 months) and in patients who used a combination of pyrazinamide and ethambutol.Keywords: pulmonary tuberculosis, anti-tuberculosis drugs, uric acid Abstrak: Tuberkulosis (TB) paru adalah suatu penyakit infeksi kronik yang disebabkan Mycobacterium tuberculosis. Terdapat 6 macam obat esensial yang telah dipakai, yaitu: isoniazid (H), para amino salisilik asid, streptomisin, etambutol, rifampisin, dan pirazinamid. Pirazinamid dan etambutol dilaporkan dapat menyebabkan peningkatan kadar asam urat. Penelitian ini bertujuan untuk mendapatkan gambaran kadar asam urat pada pasien TB paru yang menerima obat antituberkulosis (OAT) di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif retrospektif dengan mengambil data sekunder di Instalasi Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Hasil pemeriksaan laboratorium dari 25 pasien TB yang menjalani terapi OAT memperlihatkan 15 pasien (60%) dengan kadar asam urat tinggi, 9 pasien (36%) normal, dan 1 pasien (4%) kadar asam urat rendah. Proporsi tertinggi pasien TB yang mengalami hiperurisemia setelah menerima OAT ialah laki-laki (73,33%), rentang umur 46-65 tahun (46,67%). Peningkatan terutama terjadi pada fase intensif pengobatan (0-2 bulan), dan pada pasien yang mengonsumsi kombinasi pirazinamid dan etambutol. Penyakit komorbid terbanyak ialah anemia (53,33%). Simpulan: Hiperurisemia ditemukan pada 60% pasien TB yang menjalani terapi OAT, jenis kelamin laki-laki lebih banyak dari perempuan (2,75:1), peningkatan terutama terjadi pada pengobatan fase intensif (0-2 bulan), dan pada pasien yang menggunakan kombinasi pirazinamid dan etambutol. Kata kunci: tuberkulosis paru, obat anti tuberkulosis, asam urat

scholarly journals Analysis of Serum 25– (OH) D Levels status in Subjects Suffering from Pulmonary Tuberculosis: A Teaching Hospital Based study in Western Uttar Pradesh Region

2020 ◽  
Vol 9 (1) ◽  
pp. PM01-PM04
Author(s):  
Shailendra Kumar Jain
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Uttar Pradesh ◽  
Case Control ◽  
The Other ◽  
Healthy Controls ◽  
Female Ratio ◽  
Tuberculosis Patients ◽  
Male Female Ratio ◽  
The Mean

Background: This report analyses the outcomes of a case control investigation shelled in an eventual legion learning of domestic contamination (HHCs) of TB patients. Further, these data was pooled with other available probable learning of status of vitamin D and TB hazard to demeanor asingle-participant data (IPD). Subjects and Methods: In the study recently diagnosed pulmonary tuberculosis patients were involved with a total number of 28 with a male female ration of 18 : 10 and on the other side  28 healthy controls were selected with a male female ratio of 16:12 according to inclusion and elimination criterion through non-probability purposive sampling.Results: The mean age of cases with tuberculosis was 38.8±7.5years whereas the represent age of controls was 36±5.04 years. Remarkable differences were observed between the patients with tuberculosis and controls. The differences were very significant in RBC counts, Hemoglobin,and Platelet counts. Squat standard hemoglobin values were found in the majority of study subjects in common and specifically in patients with pulmonary tuberculosis.Conclusion: It has been found in the study that squat serum 25– (OH) D levels were related through amplified threat of future succession to TB disease in a dose-depending method.

Resistance Rates of Antituberculosis Drugs in Pulmonary Tuberculosis Patients Producing Mycobacterium Tuberculosis

2011 ◽  
Vol 12 (3) ◽  
pp. 111-113
Author(s):  
Gokhan Perincek ◽  
Erhan Tabakoglu ◽  
Metin Otkun ◽  
Levent Ozdemir ◽  
Burcu Ozdemir
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Antituberculosis Drugs ◽  
Tuberculosis Patients ◽  
Resistance Rates

scholarly journals Gambaran Pasien Tuberkulosis Paru Usia Produktif di RSUP Prof. Dr. R. D. Kandou Manado Periode Tahun 2014-2015

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Johanes F. N. Kesek ◽  
Cerelia E. C. Sugeng ◽  
Efata B. I. Polii
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Observational Study ◽  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Acid Fast Bacillus ◽  
Age Group ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Using Data ◽  
Global Health Problem

Abstract: Pulmonary tuberculosis (pulmonary TB) is caused by Mycobacterium tuberculosis, an acid-fast bacillus (AFB). This disease is characterized by pulmonary infiltrates and caseous granuloma formation, fibrosis, as well as cavities. To date, this disease is still a global health problem. The highest incidence of pulmonary TB is usually in productive age between 15 and 44 years. This study was aimed to obtain the profile of pulmonary tuberculosis patients in productive age at RSUP Prof. Dr. R. D. Kandou Manado during years 2014 to 2015. This was a descriptive observational study using data of medical records. The result showed that there were 178 pulmonary TB patients in the age group of 15-44 years. Based on sex, there were 94 males (52.8%) and 84 females (47.2%). TB patients with positive acid-fast bacilli (AFB) in sputum were found in 117 patients (65.7%) and those with negative AFB in 61 patients (34.3%). In conclusion, pulmonary TB patients at productive age (15-44 years) were predominant in males with positive sputum of Mycobacterium tuberculosis.Keyword: pulmonary tuberculosis, productive age Abstrak: Tuberkulosis (TB) paru adalah infeksi paru yang disebabkan oleh Mycobacterium tuberculosis, yaitu sejenis basil tahan asam (BTA). Penyakit ini ditandai oleh adanya infiltrat paru dan pembentukan granuloma kaseosa, fibrosis, dan kavitas. Penyakit TB paru masih merupakan masalah global dengan insidensi tertinggi biasanya mengenai usia produktif, antara 15–44 tahun. Penelitian ini bertujuan untuk mengetahui gambaran pasien tuberkulosis paru usia produktif di RSUP Prof. Dr. R. D. Kandou Manado periode tahun 2014-2015. Jenis penelitian ialah deskriptif observasional menggunakan data rekam medis. Hasil penelitian mendapatkan 178 pasien TB paru pada golongan usia 15-44 tahun. Berdasarkan jenis kelamin didapatkan 94 orang laki-laki (52,8%) dan 84 orang perempuan (47,2%). Pasien TB dengan hasil pemeriksaan sputum BTA (+) sebanyak 117 orang (65,7%) dan pasien dengan hasil pemeriksaan sputum BTA (-) sebanyak 61 orang (34,3%). Simpulan penelitian ini ialah penderita TB paru pada usia produktif (15-44 tahun) lebih sering didapatkan pada jenis kelamin laki-laki dan dengan hasil pemeriksaan sputum BTA (+).Kata kunci: tuberkulosis paru, usia produktif

Detection of Mycobacterium tuberculosis in smear negative sputum by PCR

2012 ◽  
Vol 6 (2) ◽  
pp. 2-6 ◽  
Author(s):  
Mohammad Jobayer ◽  
SM Shamsuzzaman ◽  
Kazi Zulfiquer Mamun
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Accurate Method ◽  
Major Health Problem ◽  
Major Health ◽  
Tuberculosis Patients ◽  
Diagnostic Potential ◽  
Total Death ◽  
Smear Negative ◽  
Negative Sputum

Pulmonary tuberculosis is a major health problem in Bangladesh that is responsible for about 7% of total death in a year. This study was conducted to isolate and identify Mycobacterium tuberculosis from sputum and to evaluate the efficacy of PCR as a modern diagnostic tool, for diagnosis of pulmonary tuberculosis, especially in the smear negative cases. One hundred and fifty suspected pulmonary TB patients (male/ female: 97/53) were included in this study. Single morning sputum was collected from each patient and diagnostic potential of PCR was compared with staining and culture. Twenty five (16.7%) sputum were positive by ZN stained smear. Among 125 smear negative samples, 13 (10.4%) yielded growth in culture in LJ media and 21 (16.8%) samples were positive by PCR. The sensitivity and specificity of PCR in smear negative cases was 100% and 92.9% respectively. Mean detection time in PCR was 24 hours. PCR detected M. tuberculosis in 21 smear negative and 9 culture negative samples. For diagnosis of tuberculosis in smear negative cases, PCR directly from sputum was a very sensitive and accurate method. In conclusion, PCR may be done, especially in clinically suspected pulmonary tuberculosis patients who remain negative by conventional methods.DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19368 Bangladesh J Med Microbiol 2012; 06(02): 2-6

Determination some Immunological Aspects in Pulmonary Tuberculosis Patients in Qadisiyah Province

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Syoof Khowman Alramahy ◽  
Akram Hadi Hamza
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Statistical Difference ◽  
Positive Culture ◽  
Control Group ◽  
Tuberculosis Patients ◽  
Significant Difference ◽  
Lowenstein Jensen ◽  
The Mean ◽  
Igg Level

This study was carried out to study of some immunological aspects among the pulmonary Tuberculosis patients infected with causative agent, Mycobacterium tuberculosis. A Total of 200 sputum samples were collected from patients attending the consultant Clinic for Chest and Respiratory disease center, Diwaniya. Control group (No=15) also included. According to acid fast stain of sputum, the patients were classified as positive (No=91,45.5%) and negative (No=109,54.5, Lowenstein Jensen medium used for the cultivation of samples, on which 70% of sputum samples where positive culture for this microorganism. The grown microorganism were identified as M. tuberculosis, based on positive A.F.B, Niacin producers ,negative for catlase at 68c. The mean IgG level was l184.053±76.684 mg/100 ml in tuberculosis group compared with 1016.533 ± 44.882 mg/100ml in control group, rendering the statistical difference significant. For IgA and IgM levels, they were at mean of 315.880±38.552 mg/100 ml and 119.527±8.464 mg/100 ml in control group compared with 396.358±38.776 mg/100 ml and 134.207±11.696 mg/100 ml in patients group respectively with significant difference

scholarly journals Gambaran leukosit urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Pingkan C. Pasuhuk ◽  
Arthur E. Mongan ◽  
Mayer Wowor
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Dipstick Test ◽  
Chemical Test ◽  
Tuberculosis Patients ◽  
Negative Results ◽  
Normal Urine ◽  
Observational Descriptive Study ◽  
Positive Results ◽  
Urine Specimens

Abstract: Tuberculosis (TB) is an infectious diseases caused by Mycobacterium Tuberculosis. Consuming the anti-tuberculosis medicine such as streptomycin and rifampicin will cause nephrotoxic effect. In kidney disfunction especially the glomeruli, the number of leukocytes in the urine increase. The most common urinalysis tests are chemical test and microscopic test, especially the leukocyte urine test. These tests can be used to detect the kidney disfunction and the urinary tract infection. In normal urine, the result of the dipstick test is negative, and the result of microscopic test is 0-5/HPF. This study was aimed to obtain the description of leukocyte urinalysis in pulmonary tuberculosis patients at Prof. Dr. R. D. Kandou Hospital Manado. This was an observational descriptive study conducted in October-November 2016 at Prof. Dr. R. D. Kandou Hospital Manado. Samples were random urine specimens that met the predefined criteria. The results showed that based on the urinalysis, of 30 patients with pulmonary tuberculosis, 27 patients had negative results and 3 patients had positive results. Conclusion: There was no relationship between urine leucocyte and pulmonary tuberculosis in adult patients.Keywords: pulmonary tuberculosis, urinalysis, urine leukocyte Abstrak: Tuberkulosis (TB) merupakan penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis. Obat anti-tuberkulosis seperti streptomisn dan rifampisin memiliki efek nefrotoksik. Kerusakan ginjal terutama glomerulus dapat menimbulkan peningkatan leukosit dalam urin. Metode urinalisis yang sering digunakan yaitu uji kimia/ carik-celup dan mikroskopik. Pemeriksaan leukosit urin dapat digunakan untuk mengetahui adanya gangguan pada ginjal dan infeksi saluran kemih. Pada urin normal hasil pemeriksaan dipstick negatif dan hasil pemeriksaan mikroskopik urin 0-5 leukosit/LPB. Penelitian ini bertujuan untuk mendapatkan gambaran leukosit urin pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif observasional dan dilakukan pada bulan Oktober-November 2016 di RSUP Prof. Dr. R. D. Kandou Manado. Sampel penelitian ialah sampel urin sewaktu dari semua pasien tuberkulosis paru yang memenuhi kriteria yang telah ditentukan. Hasil urinalisis dari 30 pasien terdiagnosis penyakit tuberkulosis paru mendapatkan 27 pasien dengan hasil negatif dan 3 pasien dengan hasil positif. Simpulan: Tidak terdapat hubungan antara leukosit urin dengan tuberkulosis paru dewasa. Kata kunci: TB paru, urinalisis, leukosit urin

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