Analysis of Serum 25– (OH) D Levels status in Subjects Suffering from Pulmonary Tuberculosis: A Teaching Hospital Based study in Western Uttar Pradesh Region

Background: This report analyses the outcomes of a case control investigation shelled in an eventual legion learning of domestic contamination (HHCs) of TB patients. Further, these data was pooled with other available probable learning of status of vitamin D and TB hazard to demeanor asingle-participant data (IPD). Subjects and Methods: In the study recently diagnosed pulmonary tuberculosis patients were involved with a total number of 28 with a male female ration of 18 : 10 and on the other side 28 healthy controls were selected with a male female ratio of 16:12 according to inclusion and elimination criterion through non-probability purposive sampling.Results: The mean age of cases with tuberculosis was 38.8±7.5years whereas the represent age of controls was 36±5.04 years. Remarkable differences were observed between the patients with tuberculosis and controls. The differences were very significant in RBC counts, Hemoglobin,and Platelet counts. Squat standard hemoglobin values were found in the majority of study subjects in common and specifically in patients with pulmonary tuberculosis.Conclusion: It has been found in the study that squat serum 25– (OH) D levels were related through amplified threat of future succession to TB disease in a dose-depending method.

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Association of Vitamin D Deficiency and Newly Diagnosed Pulmonary Tuberculosis

Pulmonary Medicine ◽

10.1155/2021/5285841 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Vijay Jaimni ◽

Barkur Ananthakrishna Shasty ◽

Sharath P. Madhyastha ◽

Ganesh V. Shetty ◽

Raviraja V. Acharya ◽

...

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Vitamin D Deficiency ◽

Immune Defense ◽

Sputum Smear ◽

Care Hospital ◽

Healthy Controls ◽

Newly Diagnosed ◽

Tuberculosis Patients ◽

Vitamin D Levels

Introduction. Vitamin D has a significant role in host immune defense against Mycobacterium tuberculosis. It has been suggested that pulmonary tuberculosis may be associated with lower levels of vitamin D. Present study was therefore undertaken to identify the association between vitamin D deficiency and pulmonary tuberculosis. Methods. A case-control study was conducted in a tertiary care hospital from 2014 to 2016, including 50 adult newly diagnosed sputum positive pulmonary tuberculosis patients as cases and 50 age and sex-matched healthy participants as control groups. All participants in the study group had undergone detailed clinical examination and routine laboratory investigations, including vitamin D, calcium, and sputum for AFB. The clinical characteristics, X-ray findings, sputum AFB, and vitamin D levels were analyzed and compared with data obtained from healthy controls. Results. In both groups, the majority were men (88%). BMI was significantly (<0.0001 ∗ ) lower in the tuberculosis group (19.40 (17.20, 22.0) vs. 24.00 (22.50, 25.47)). Serum vitamin D levels were significantly lower ( P = 0.012 ) in the tuberculosis group (19 (7.75, 27.25) ng/dl) as compared to the control group (25 (19.75, 32.00) ng/dl). Out of 50 TB patients, 27 (54%) had vitamin D deficiency, while among healthy controls, only 13 (26%) had vitamin D deficiency. Among vitamin D deficient PTB patients, 44% had 3+/hpf AFB in sputum smear examination. Conclusion. The prevalence of vitamin D deficiency in pulmonary tuberculosis cases is very high. Hypovitaminosis D was associated with more severe clinical symptoms, higher sputum smear positivity, and extensive lesions in chest radiograph among pulmonary tuberculosis patients.

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Vitamin D deficiency among smear positive pulmonary tuberculosis patients and their tuberculosis negative household contacts in Northwest Ethiopia: a case–control study

Annals of Clinical Microbiology and Antimicrobials ◽

10.1186/s12941-017-0211-3 ◽

2017 ◽

Vol 16 (1) ◽

Cited By ~ 7

Author(s):

Belay Tessema ◽

Feleke Moges ◽

Dereje Habte ◽

Nebiyu Hiruy ◽

Shewaye Yismaw ◽

...

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Case Control ◽

Northwest Ethiopia ◽

Tuberculosis Patients ◽

Household Contacts ◽

Smear Positive Pulmonary Tuberculosis ◽

Control Study

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GAMBARAN KADAR ASAM URAT PADA PENDERITA TUBERKULOSIS PARU YANG MENERIMA TERAPI OBAT ANTI TUBERKULOSIS DI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JULI 2014 – JUNI 2015

e-CliniC ◽

10.35790/ecl.4.1.2016.10980 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Irwanto Kondo ◽

M. C. P. Wongkar ◽

Jeffrey Ongkowijaya

Keyword(s):

Mycobacterium Tuberculosis ◽

Uric Acid ◽

Pulmonary Tuberculosis ◽

Female Ratio ◽

Intensive Phase ◽

Antituberculosis Drugs ◽

Tuberculosis Patients ◽

Male Female Ratio ◽

Amino Salicylic Acid ◽

Using Data

Abstract: Pulmonary tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. There are 6 kinds of essential drugs which have been used: isoniazid, amino salicylic acid, streptomycin, ethambutol, rifampicin, and pyrazinamide. As reported, pyrazinamide and ethambutol can cause increased levels of uric acid. This study aimed to obtain the uric acid profile in tuberculosis patients treated with antituberculosis drugs in Prof. Dr. R. D. Kandou Hospital Manado. This was a retrospective descriptive study using data of the Medical Record Department of Prof. Dr. R. D. Kandou Hospital Manado. Of 25 tuberculosis patients treated with antituberculosis drugs, the uric acid levels were as follows: high in 15 patients (60%), normal in 9 patients (36%), and low in 1 patient (4%). The highest proportion of tuberculosis patients who had hyperuricemia after treated with antituberculosis drugs were male (73.33%) and age 46-65 years (46.67%). The increased uric acid level mainly occurred in the intensive phase of treatment (0-2 months), and in patients taking the combination of pyrazinamide and ethambutol. The most common comorbid disease was anemia (53.33%). Conclusion: Hyperuricemia was found in 60% of TB patients receiving antituberculosis drugs with a male : female ratio 2.75:1, mainly occurred in the intensive phase of treatment (0-2 months) and in patients who used a combination of pyrazinamide and ethambutol.Keywords: pulmonary tuberculosis, anti-tuberculosis drugs, uric acid Abstrak: Tuberkulosis (TB) paru adalah suatu penyakit infeksi kronik yang disebabkan Mycobacterium tuberculosis. Terdapat 6 macam obat esensial yang telah dipakai, yaitu: isoniazid (H), para amino salisilik asid, streptomisin, etambutol, rifampisin, dan pirazinamid. Pirazinamid dan etambutol dilaporkan dapat menyebabkan peningkatan kadar asam urat. Penelitian ini bertujuan untuk mendapatkan gambaran kadar asam urat pada pasien TB paru yang menerima obat antituberkulosis (OAT) di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif retrospektif dengan mengambil data sekunder di Instalasi Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Hasil pemeriksaan laboratorium dari 25 pasien TB yang menjalani terapi OAT memperlihatkan 15 pasien (60%) dengan kadar asam urat tinggi, 9 pasien (36%) normal, dan 1 pasien (4%) kadar asam urat rendah. Proporsi tertinggi pasien TB yang mengalami hiperurisemia setelah menerima OAT ialah laki-laki (73,33%), rentang umur 46-65 tahun (46,67%). Peningkatan terutama terjadi pada fase intensif pengobatan (0-2 bulan), dan pada pasien yang mengonsumsi kombinasi pirazinamid dan etambutol. Penyakit komorbid terbanyak ialah anemia (53,33%). Simpulan: Hiperurisemia ditemukan pada 60% pasien TB yang menjalani terapi OAT, jenis kelamin laki-laki lebih banyak dari perempuan (2,75:1), peningkatan terutama terjadi pada pengobatan fase intensif (0-2 bulan), dan pada pasien yang menggunakan kombinasi pirazinamid dan etambutol. Kata kunci: tuberkulosis paru, obat anti tuberkulosis, asam urat

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The study of correlation between vitamin D and tuberculosis in newly detected tuberculosis - pulmonary and extra pulmonary patients attending to K R hospital, Mysuru, Karnataka, India

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20195622 ◽

2019 ◽

Vol 7 (1) ◽

pp. 34 ◽

Cited By ~ 1

Author(s):

Vandana Balgi ◽

Sanjana J. M. ◽

Suneetha D. K. ◽

Amrudha Surendran ◽

Chandrashekar G. S.

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Extrapulmonary Tuberculosis ◽

P Value ◽

Host Immune System ◽

Tuberculosis Patients ◽

Pulmonary Tb ◽

Vitamin D Levels ◽

The Mean ◽

Extra Pulmonary

Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has posed a constant challenge to mankind in its treatment due to increasing resistance and longer duration of treatment. The newer approach is to look towards strengthening host immune system along with suppressing the organism. Aim of the study was to assess the existence of Vitamin D deficiency in TB patients and aid in the strategies and development of newer improvised approaches in the treatment of TB. Objectives of the study was to estimate vitamin D levels in Tuberculosis (pulmonary and extrapulmonary) patients, assess Correlation between vitamin D and pulmonary tuberculosis and to assess correlation between Vitamin D and extrapulmonary Tuberculosis.Methods: This is a descriptive cross-sectional study. The study consisted of 80 tuberculosis patients both extrapulmonary and pulmonary. Blood samples was analysed for Vitamin D levels and results were compared with age and sex matched controls. Results was analysed using SPSS software.Results: The cases included patient in the age group of 18-60 year with the mean age being 42.34±14.65 year. Of the 80 tuberculosis patients 42 were diagnosed with pulmonary tuberculosis and 38 constituted extrapulmonary tuberculosis. The mean Vitamin D in cases was 24.82±12.33 and controls was 34.41±6.19. Among the cases 25 (31.3%) subjects had Vitamin D levels <20 pg/ml and none of the controls had levels <20 pg/ml. The mean Vitamin D level in pulmonary Tb patients was found to be 24.29±11.86 pg/ml and Extra-pulmonary Tb was 25.40±12.96 pg/ml. The unpaired t-test was statistically significant with p value of 0.005.Conclusions: This study has emphasized on the presence of nutritional deficiency in TB patients and necessity to correct them to achieve a better cure rate.

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Determination some Immunological Aspects in Pulmonary Tuberculosis Patients in Qadisiyah Province

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.v9i2.13632 ◽

2018 ◽

Vol 9 (2) ◽

Author(s):

Syoof Khowman Alramahy ◽

Akram Hadi Hamza

Keyword(s):

Mycobacterium Tuberculosis ◽

Pulmonary Tuberculosis ◽

Statistical Difference ◽

Positive Culture ◽

Control Group ◽

Tuberculosis Patients ◽

Significant Difference ◽

Lowenstein Jensen ◽

The Mean ◽

Igg Level

This study was carried out to study of some immunological aspects among the pulmonary Tuberculosis patients infected with causative agent, Mycobacterium tuberculosis. A Total of 200 sputum samples were collected from patients attending the consultant Clinic for Chest and Respiratory disease center, Diwaniya. Control group (No=15) also included. According to acid fast stain of sputum, the patients were classified as positive (No=91,45.5%) and negative (No=109,54.5, Lowenstein Jensen medium used for the cultivation of samples, on which 70% of sputum samples where positive culture for this microorganism. The grown microorganism were identified as M. tuberculosis, based on positive A.F.B, Niacin producers ,negative for catlase at 68c. The mean IgG level was l184.053±76.684 mg/100 ml in tuberculosis group compared with 1016.533 ± 44.882 mg/100ml in control group, rendering the statistical difference significant. For IgA and IgM levels, they were at mean of 315.880±38.552 mg/100 ml and 119.527±8.464 mg/100 ml in control group compared with 396.358±38.776 mg/100 ml and 134.207±11.696 mg/100 ml in patients group respectively with significant difference

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AB0287 HEMATOLOGICAL SIDE EFFECTS OF BIOLOGICAL THERAPY IN RHEUMATOLOGY: DATA FROM THE TUNISIAN REGISTER

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.6251 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1442.2-1442

Author(s):

H. Bettaieb ◽

S. Boussaid ◽

S. Jemmali ◽

S. Rekik ◽

E. Cheour ◽

...

Keyword(s):

Side Effects ◽

Biological Treatment ◽

Blood Count ◽

Biological Therapy ◽

National Registry ◽

Close Monitoring ◽

Female Ratio ◽

Therapy Initiation ◽

Male Female Ratio ◽

The Mean

Background:During the last decade, the treatment of chronic inflammatory rheumatism (CIR) has been greatly improved with the advent of biotherapy.However, the use of biological treatment can lead to a number of side effects including abnormalities in the blood count.Objectives:The aim of this study was to assess the different hematological side effects of biological treatment in patients with rheumatoid arthritis (RA) and spondyloarthitis (SA).Methods:This study included patients with RA (ACR/EULAR 2010) and SA (ASAS 2009) registred with the Tunisian Biologic National Registry (BINAR).Patients were followed and treated with biologics for 2 years of less. Clinical data relative to biological treatment, including haematological side effects, have been collected.Results:Two hundred and ninety-eight patients (178 women and 111 men) were included in the study.The mean age was 49.2 ± 14.1 years. The male/female ratio was 0.6. The mean diseases durations for RA and SA were respectively 6.7 ± 3.5 years and 6.5 ±3.6 years.Anti-TNFα agents were prescribed in 87.9% of patients (n = 263) with respectively: Infliximab (20.4%) Etanercept (23.1%), Adalimumab (24.6%) and Certolizumab (26.5%).Tocilizumab and Rituximab were prescribed in 10.4% and 5% of the patients, respectively.Blood count abnormalities were noted in 15.4 % of patients (n=46).Neutropenia was the most frequently anomaly met on the hemogram (9.1%) followed by anemia (3.4%) and thrombocytopenia (3%). Pancytopenia was found in 11.4% of patients (n=34).The median time between biological therapy initiation and the onset of hematologic manifestations was 4.8 months [1-12]. Biological treatment was interrupted in two patients.In the other cases, the biological treatment was maintained with close monitoring of blood cell count. No case of death related to these hematological disturbances has been reported.Conclusion:In our registry, hematological side effects of biological treatment were found in 15.4% of cases and were noted with a median delay of 4.8 [1-12] months after the treatment initiation. Further studies are needed to confirm our preliminary results.Disclosure of Interests:None declared

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Diabetes mellitus and its influence on sputum smear positivity at the 2nd month of treatment among pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: A case control study

International Journal of Mycobacteriology ◽

10.1016/j.ijmyco.2015.09.003 ◽

2015 ◽

Vol 4 (4) ◽

pp. 323-329 ◽

Cited By ~ 14

Author(s):

Noorsuzana Mohd Shariff ◽

Nazarudin Safian

Keyword(s):

Diabetes Mellitus ◽

Pulmonary Tuberculosis ◽

Case Control Study ◽

Case Control ◽

Sputum Smear ◽

Kuala Lumpur ◽

Tuberculosis Patients ◽

Control Study

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Laryngopharyngeal Reflux: Is It the Real Culprit in Patients with Laryngeal Complaints?

International Journal of Phonosurgery & Laryngology ◽

10.5005/jp-journals-10023-1132 ◽

2017 ◽

Vol 7 (1) ◽

pp. 6-9 ◽

Cited By ~ 1

Author(s):

Rajesh Vishwakarma ◽

Ruta V Shah

Keyword(s):

Laryngopharyngeal Reflux ◽

Reflux Symptom Index ◽

Symptom Index ◽

Female Ratio ◽

The Real ◽

Body Sensation ◽

Male Female Ratio ◽

The Mean ◽

Nose And Throat

ABSTRACT Aim The aim of this study is to evaluate the role of laryngopharyngeal reflux (LPR) in patients with laryngeal complaints and study the correlation between reflux symptom index (RSI) and reflux finding score (RFS). Materials and methods This is a study of 104 patients, who presented in the ear, nose, and throat outpatient department at the Civil Hospital, Ahmedabad, India, from April 2015 to April 2016, with complaints like change of voice, chronic cough, foreign body sensation, throat clearing, difficulty swallowing, and regurgitation. All the patients were examined with 90° endoscope by a single examiner, and an RSI ≥13 was considered as indicative of reflux. Observation and discussion The mean age of the 104 patients was 47.2 years. The male-female ratio was 1:1.8. The RSI ranged from 5 to 44, with a mean of 22.99 and standard deviation (SD) of 7.43. The RFS ranged from 4 to 22, with a mean of 11.04 and SD of 3.07. Both the parameters showed high correlation (correlation coefficient 0.98). Conclusion The LPR plays an important contributory role in patients with laryngeal complaints. The RFS and RSI can be used as routine parameters in establishing the diagnosis of reflux. How to cite this article Shah RV, Vishwakarma R. Laryngopharyngeal Reflux: Is It the Real Culprit in Patients with Laryngeal Complaints? Int J Phonosurg Laryngol 2017; 7(1):6-9.

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Anaesthesia and Perioperative Care in Remote Health Camps- Patients’ Concerns

Journal of Nepal Medical Association ◽

10.31729/jnma.87 ◽

2010 ◽

Vol 49 (179) ◽

Author(s):

Balkrishna Bhattarai ◽

A Ghimire ◽

BK Baral ◽

A Shrestha ◽

Y Dhungana

Keyword(s):

Observational Study ◽

Perioperative Care ◽

Local Anaesthesia ◽

Prospective Observational Study ◽

Main Concern ◽

Surgical Experience ◽

Female Ratio ◽

Male Female Ratio ◽

The Mean ◽

Remote Health

INTRODUCTION:Identifying patients' concerns and expectations regarding anaesthesia and perioperative care in mobile surgical camps is relevant for the camp workers. This prospective observational study was conducted to assess knowledge, concerns, and expectations about anaesthesia and perioperative care in patients undergoing surgery in mobile surgical camps in remote mountainous districts of Eastern Nepal.METHODS:A questionnaire with seven items related to anaesthesia and perioperative care was used for interviewing 80 individuals of age > or = 12 years, 20 from each camp at Solukhumbu, Sankhuwasabha, Khotang and Bhojpur districts.RESULTS:Data of two patients were lost leaving only 78 individuals for analysis. The mean age of the subjects was 30.5 (+/- 14.6) years with the male: female ratio of 43: 35. Fifty-eight (74.4%) patients had some gross idea about the modality of administration of anaesthetics. Twenty-six (33.3%) individuals preferred GA over local anaesthesia, whereas 22 (28.2%) were happy either way if there was no pain. Pain was the main concern for 73.1% of the patients. Of the 25 patients expressing fear of GA, death or not being able to wake up anymore was the main concern for 60.0%. Increasing age was associated with lower fear of GA (p < 0.05). Surgical experience was distressing for 17 (21.8%) patients. The overall experience of the anaesthesia and surgery was worse than expected for 25.6% of the patients.CONCLUSIONS:Patients presenting to these health camps have limited knowledge regarding anaesthesia and perioperative care but have valid concerns and expectations in respect of their safety, comfort and outcome.

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