A PECULIAR CASE OF ISOLATED METASTATIC INGUINAL LYMPHADENOPATHY IN A YOUNG LADY – A CASE REPORT

2021 ◽  
pp. 59-60
Author(s):  
Anil Kumar MS ◽  
Pankaja SS ◽  
Kavuru Pavan Rajesh
Keyword(s):  
Lymph Nodes ◽  
Head And Neck ◽  
Fungal Infections ◽  
Nasopharyngeal Cancer ◽  
Concurrent Chemotherapy ◽  
Young Lady ◽  
Pelvic Malignancies ◽  
Regional Metastases ◽  
Inguinal Lymphadenopathy ◽  
Peculiar Case

Lymphadenopathy refers to the swelling of lymph nodes which can be secondary to bacterial, viral or fungal infections, autoimmune disease and malignancy. Lymphadenopathy can be localized or diffuse. About 75% of most lymphadenopathies are localized, and about 50% of those occur in the head and neck regions . Inguinal lymphadenopathy (3) occurs at the groin region and most common causes include infections of leg or foot, STDs, non Hodgkin's lymphoma, tuberculosis and pelvic malignancies. One of the rare causes includes distant metastasis of nasopharyngeal carcinoma (NPC) which is present in our case. Nasopharyngeal cancer is an uncommon squamous cell carcinoma in the head and neck region, in most parts of the world. It has a high propensity for lymphatic spread and is known for regional metastases with occult primary at presentation . The incidence of distant (1) metastasis at presentation ranges from 4.4 to 6%. The most common sites of metastasis are bone (70%–80%) followed by liver (30%), lungs (18%) and distant lymph nodes (axillary, mediastinal, pelvic and inguinal, in that order) . About 98% of them are discovered within 3 (2) years of treatment. As it is a highly chemo and radio-sensitive tumor, radiotherapy with concurrent chemotherapy is the mainstay in the management of local and advanced diseases. Here we are presenting a peculiar case of previously treated NPC presenting as isolated left inguinal metastatic lymphadenopathy in a young lady

Nasopharyngeal carcinoma with secondaries at the porta hepatis presenting as obstructive jaundice

1990 ◽  
Vol 104 (1) ◽  
pp. 41-42 ◽  
Author(s):  
S. Elango ◽  
C. R. Jayakumar
Keyword(s):  
Head And Neck Cancer ◽  
Nasopharyngeal Carcinoma ◽  
Obstructive Jaundice ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Nasopharyngeal Cancer ◽  
Distant Metastases ◽  
Porta Hepatis ◽  
Cervical Lymph Nodes ◽  
The Common

AbstractRecent reports have dispelled the previously held concept that head and neck cancer rarely metastases beyond the cervical lymph nodes. Nasopharyngeal cancer has been reported to have a higher incidence of distant metastases compared to other head and neck cancers, the common sites being bone, lung and liver. A case of nasopharyngeal carcinoma presenting as obstructive jaundice because of secondaries at the porta hepatis is presented here.

scholarly journals Guidelines for safe and optimum neck dissection: a review article

2021 ◽  
Author(s):  
Sheetal A. Murchite ◽  
Thakut Gowtham ◽  
Abhinandan Milind Kadiyal ◽  
Vaishali Vinayak Gaikwad ◽  
Ashutosh Tiwari
Keyword(s):  
Lymph Nodes ◽  
Head And Neck ◽  
Neck Dissection ◽  
Early Stage ◽  
Neck Surgery ◽  
Head And Neck Surgery ◽  
Regional Lymph Nodes ◽  
Cervical Lymph Nodes ◽  
Early Stage Disease ◽  
Regional Metastases

Head and neck cancer is the sixth most common cancer worldwide. The single most important factor affecting prognosis for squamous cell carcinoma is the status of the cervical lymph nodes. Metastasis to the regional lymph nodes reduces the 5-year survival rate by 50% compared with that of patients with early-stage disease. The American cancer society reports that 40% of patients with squamous carcinoma of the oral cavity and pharynx present with regional metastases to the cervical lymph nodes. This activity presents the steps for safe and optimum neck dissection. Objectives of the study were to identify the anatomical structures in neck dissection, review the complications of head and neck surgery and summarize the importance of care coordination and to improve outcomes for patients undergoing head and neck surgery.

Cranial neuropathy following curative chemotherapy and radiotherapy for carcinoma of the nasopharynx

2000 ◽  
Vol 114 (4) ◽  
pp. 308-310 ◽  
Author(s):  
Matt Y. Kang ◽  
John M. Holland ◽  
Kenneth R. Stevens
Keyword(s):  
Head And Neck ◽  
Cranial Nerve ◽  
Hypoglossal Nerve ◽  
Cranial Nerves ◽  
Nasopharyngeal Cancer ◽  
Concurrent Chemotherapy ◽  
Cranial Neuropathy ◽  
Tumour Control ◽  
Cranial Nerve Palsies ◽  
Head And Neck Radiotherapy

Cranial nerve damage following head and neck radiotherapy is an unusual event. Cranial neuropathy following concurrent chemotherapy and radiotherapy is unreported. The authors report a case of a 54-year-old man treated with curative chemotherapy and radiotherapy for a stage III nasopharyngeal carcinoma who developed an unilateral hypoglossal nerve palsy five years after therapy. Follow-up examination and magnetic resonance imaging (MRI) show no evidence of recurrent disease. Hypoglossal nerve injury occurring after head and neck radiotherapy is an indirect effect due to progressive soft tissue fibrosis and loss of vascularity. This process develops over years leading to nerve entrapment and permanent damage. Cranial nerve palsies, including damage to the hypoglossal nerve, can develop years after therapy with no evidence of tumour recurrence. Chemotherapy and radiotherapy have improved progression-free and overall survival in advanced nasopharyngeal cancer. As more patients achieve long-term tumour control following chemotherapy and radiotherapy, we must be cognizant of potential late injury to cranial nerves.

Advances in Chemotherapy Options for Head and Neck Cancer

2009 ◽  
Vol 05 (01) ◽  
pp. 36
Author(s):  
Cristina P Rodriguez ◽  
David J Adelstein ◽  
◽  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Clinical Investigation ◽  
Locally Advanced ◽  
Nasopharyngeal Cancer ◽  
Chemotherapeutic Agents ◽  
Concurrent Chemotherapy ◽  
Definitive Therapy

The role of chemotherapy in the management of head and neck squamous cell cancers continues to evolve. Concurrent chemotherapy and radiation represents a standard treatment option for organ preservation in larynx and hypopharynx squamous cell carcinomas, unresectable locally advanced head and neck cancer, nasopharyngeal cancer, and post-operative therapy of high-risk resected disease. Chemotherapeutic agents and their combinations have known activity in metastatic disease and are frequently used for palliation. Emerging therapeutic approaches have been fueled by the observed shift in the pattern of disease recurrence after definitive therapy and the development of molecular targeted agents with disease activity. The recognition of human papillomavirus-associated oropharyngeal squamous cell carcinoma as a distinct clinical entity among head and neck cancers will influence the design of future clinical investigation.

Pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck

2005 ◽  
Vol 132 (6) ◽  
pp. 852-856 ◽  
Author(s):  
Geva Barzilai ◽  
Elhanan Greenberg ◽  
Raanan Cohen-Kerem ◽  
Ilana Doweck
Keyword(s):  
Parotid Gland ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Retrospective Chart Review ◽  
Academic Center ◽  
Level Ii ◽  
Regional Metastases ◽  
Neck Metastases ◽  
High Incidence ◽  
Occult Disease

OBJECTIVE: To assess the pattern of regional metastases from SCC of the skin of the head and neck as a prognostic factor. STUDY DESIGN AND SETTING: A retrospective chart review of 22 patients treated in a tertiary academic center. RESULTS: Metastases could be assessed clinically in the parotid gland and the neck in 50% and 59% of the patients, respectively. Histologic examination showed metastases in the parotid gland and the neck in 68% and 45.5%, respectively. Occult disease was 36% and 20% in the parotid gland and neck, respectively. The 1st echelon for metastasis was the parotid gland lymph nodes, whereas level II lymph nodes were the 1st echelon in the neck. Metastases to both the parotid gland and neck decreased the overall survival to 0, compared with 60% for metastases to the parotid gland and 100% for the neck. CONCLUSIONS: SCC of the skin of the head and neck with regional metastases has a high incidence of occult metastases in the parotid gland and the neck. Patients with metastases in both sites have a poor prognosis.

scholarly journals B-helper Neutrophils in Regional Lymph Nodes Correlate with Improved Prognosis in Patients with Head and Neck Cancer

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3092
Author(s):  
Ekaterina Pylaeva ◽  
Irem Ozel ◽  
Anthony Squire ◽  
Ilona Spyra ◽  
Charlotte Wallner ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Nodes ◽  
B Cell ◽  
Head And Neck ◽  
Neck Cancer ◽  
Patient Survival ◽  
Helper Cell ◽  
Cell Phenotype ◽  
Regional Lymph Nodes ◽  
Patient Prognosis

The role of neutrophils during cancer formation and elimination is diverse. Here, for the first time, we investigate neutrophil helper cells (NBH), their influence on B cell activity in the regional lymph nodes (RLN) of head-and-neck cancer patients and the effect of this neutrophil/B cell interaction on patient prognosis. Circulating and RLN neutrophils of patients with stage I–IV head-and-neck squamous cell carcinoma were investigated with flow cytometry and qPCR. In addition, neutrophil/B cell co-localization in RLNs was evaluated using immunohistochemistry. B cell proliferation was assessed and correlated with the distance to neutrophils. Patient survival was evaluated. Neutrophils with the helper cell phenotype were identified in the RLN of HNC patients. B cells in close proximity to such NBH showed significantly higher proliferation rates, together with elevated activation-induced cytidine deaminase (AID) expression. Notably, patient survival was significantly higher in individuals with high NBH frequencies in the B follicles of RLNs. Neutrophils in RLN can support T cell-independent activation of the adaptive immune system through B cell stimulation, capturing helper cell phenotype character. The presence of such helper neutrophils in the RLNs of HNC patients positively correlates with patient prognosis.

scholarly journals Extranodal lymphoma of the head and neck: a pictorial essay

2019 ◽  
Vol 52 (4) ◽  
pp. 268-271
Author(s):  
Pinar Gulmez Cakmak ◽  
Gülsüm Akgün Çağlayan ◽  
Furkan Ufuk
Keyword(s):  
Lymph Nodes ◽  
Head And Neck ◽  
Neck Region ◽  
Extranodal Lymphoma ◽  
Imaging Findings ◽  
Head And Neck Region ◽  
Radiological Features ◽  
Extranodal Site ◽  
Pictorial Essay

Abstract Primary extranodal lymphoma is defined as a lymphoma at a solitary extranodal site, with or without involvement of the lymph nodes. The clinical and radiological features of extranodal lymphoma have been documented in recent studies. In this pictorial essay, we reviewed imaging findings of extranodal lymphoma in the head and neck region.

Clinical features of pharyngeal cancer: a retrospective study of 258 consecutive patients

2001 ◽  
Vol 115 (2) ◽  
pp. 112-118 ◽  
Author(s):  
A. Escribano Uzcudun ◽  
P. Bravo Fernández ◽  
J. J. Sánchez ◽  
A. García Grande ◽  
I. Rabanal Retolaza ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Head And Neck ◽  
Clinical Features ◽  
Medical Records ◽  
Performance Status ◽  
Nasopharyngeal Cancer ◽  
University Hospital ◽  
Premalignant Lesions ◽  
Pharyngeal Cancer ◽  
Presenting Symptoms

Pharyngeal cancer still presents an unsatisfactory mortality (30-40 per cent in most series, with a slightly better prognosis for nasopharyngeal cancer relative to both oropharyngeal and hypophyarngeal cancers) despite advances in treatment. Therefore, it is critical to know the clinical features of pharyngeal cancer. The purpose of this study was to investigate the most relevant clinical features of pharyngeal cancer (oropharyngeal, hypopharyngeal, and nasopharyngeal) in order to improve knowledge of this malignancy with the aim of ameliorating diagnosis and treatment.The retrospective study was based on a review of medical records from 258 consecutive patients with pharyngeal cancer (oropharyngeal, hypopharyngeal and nasopharyngeal) diagnosed at La Paz University Hospital, Madrid, Spain, between January 1 1991 and and December 31 1995. Medical records were provided by the Departments of Otorhinolaryngology, Head and Neck Surgery, Radiation Oncology, and Medical Oncology.All medical records were analysed for the following clinical variables: 1) incidence, 2) sociodemographics, 3) sites (oropharynx, hypopharynx, nasopharynx) and subsites, 4) clinical and histological staging, 5) pathlogy, 6) presenting symptoms, 7) time to diagnosis, 8) patients’ general performance status at diagnosis, 9) personal cancer history and synchronous head and neck tumours, 10) premalignant lesions, and 11) paediatric cases.Our most outstanding finding was the excessively long time that elapsed between first clinical manifestation appearance and conclusive diagnosis of pharyngeal cancer (4.7 months for pharynx, 4.5 for oropharynx, 4.4 for hypopharynx and 6.5 for nasopharynx cancers). It was found that nasopharyngeal cancer was quite different from both oropharyngeal and hypopharyngeal cancers with respect to its potential aetiology, risk factors and clinical presentation. In addition it has a better prognosis.

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