AN OBSERVATIONAL RETROSPECTIVE STUDY TO EVALUATE THE NON-RESPIRATORY PROTEAN MANIFESTATIONS OF COVID-19 PATIENTS -EXPERIENCE OF A DEDICATED CORONA TERTIARY CARE CENTRE IN NORTHWESTERN INDIA

2021 ◽  
pp. 11-13
Author(s):  
Aradhana singh ◽  
H.L. Saini ◽  
Khushboo Khushboo ◽  
Abishek Yadav ◽  
C.L. Nawal

INTRODUCTION - COVID-19 was primarily considered as a respiratory disease and pulmonary manifestations were the most common presentation. However, as the months passed after the declaration of covid -19 as pandemic, our knowledge regarding the symptomatology become wiser and it was found that SARS-CoV-2 infection is not limited to the respiratory system alone and other organs are also being affected. This study is aimed to characterize the non-respiratory symptomatology and the unusual manifestations of covid-19 in patients with laboratory conrmed SARS-CoV-2 infection admitted to SMS hospital Jaipur, so that Covid-19 can be diagnosed early to prevent complications arising out of misdiagnosis or delayed diagnosis. METHODOLOGY- The presented study was designed at a single center as an observational study done retrospectively in around 200 patients chosen randomly, being admitted during lockdown period from March 2020 to May 2020 in our dedicated covid hospital, Jaipur, Rajasthan after applying inclusion and exclusion criteria. Their clinical prole and symptomatology were noted and analyzed. RESULTS- In our study out of 200 patients recruited, obesity was the most common comorbidity (14.5%) and the most common protean manifestations were due to gastrointestinal involvement (17%). CONCLUSION- SARS-CoV-2 not only affect the respiratory tract, but can affect any system without involving respiratory system at all and it should always be kept as differential diagnosis while evaluating a patient with a short history in this covid era.

Author(s):  
Rangaraj Murugaiyan

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Childhood vitiligo is a special subtype and is seen in significant proportion of vitiligo patients. There are only a few clinical studies in the past which address the clinical spectrum of vitiligo in children. This study on eighty cases of childhood vitiligo will cover the epidemiology and clinical spectrum.</span></p><p class="abstract"><strong>Methods:</strong> To study the epidemiology, clinical spectrum and associations in childhood vitiligo. Inclusion criteria: all new cases of vitiligo in children under 12 years attending the outpatient department of Dermatology, exclusion criteria: old treated cases of vitiligo and age more than 12 years. Statistical analysis was done using mean and percentage of means.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Most common age group affected includes 4-6 years. Most common site of initial lesion was head and neck followed by upper limb, lower limb and trunk. Most common clinical type was vitiligo vulgaris followed by focal type then segmental. Lip tip type was least common type. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Childhood vitiligo is a serious issue and the knowledge of its various patterns and associations needs to be updated at regular intervals.</span></p>


Author(s):  
Saurabh Daseda ◽  
Gaurav Runwal

Method: This study was done at Department Of Medicine. All patients admitted with malaria in tertiary care Centre during the study period August 2017 to July 2018 were taken for the study after considering the inclusion and exclusion criteria. Our study is a clinical, prospective, observational and open study. Result: Fever occurred in all patients, and it was intermittent in 72.5% of the cases, continuous in 17.5% of the cases and remittent in the remaining 10%. Intermittent fever is the commonest. All 100% patients had chills and rigors. Most of the Patients (65%) had presented with acute illness of 2- 10 days duration of fever. Bifrontal dull aching to throbbing headache associated with fever was presenting clinical symptoms in 92% of patients. Most of the patients complained of generalized weakness, malaise and myalgia. Cerebral manifestation is seen in 10% of patients. Spleenomegaly was predominant in 64% of patients and 40% patient had hepatomegaly. Patient with mixed infection had more propensity to develop systemic complication. Conclusion: Malaria is an age-old disease of mankind, caused by protozoal plasmodium and transmitted by anopheles mosquito. It is prevalent throughout most tropical countries. Both species are commonly presented with symptoms of intermittent Fever, chills, Bi-frontal headache, vomiting and commonly clinical feature is splenomegaly. Severe complication like anemia, thrombocytopenia jaundice, acute renal failure and sometimes life threatening cerebral malaria are need to address promptly to avoid adverse outcome. Keywords: Clinical, Malaria, WHO & Presentation.


Author(s):  
N. S. Jayanthi ◽  
V. Anandan ◽  
S. Kopika

<p class="abstract"><strong>Background:</strong> Cutaneous tuberculosis is a rare manifestation of tuberculosis accounting for about 1.5% of all the extra pulmonary manifestations, though the prevalence of pulmonary tuberculosis is high in India. The aim of the study was to prospectively analyze the various clinical presentations of cutaneous TB and their age and sex distribution among the OPD attending patients over a period of one year.</p><p class="abstract"><strong>Methods:</strong> Prospective study, conducted during July 2016 to June 2017. Clinically suspected cases of cutaneous tuberculosis were subjected to lesional biopsy and the results obtained were analyzed.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 36 clinically suspected cases, 24 turned out to be cutaneous tuberculosis and apart from these, 5 cases were referred from other departments as cutaneous tuberculosis. The predominant presentation was lupus vulgaris in 12 patients, followed by tuberculous verrucosa cutis in 8 cases, tuberculous ulcers in 3 cases and the remaining 2 cases were erythema induratum of Bazin. Among them, 13 were men accounting to about 52% and 7 were children which accounted for 28% and the remaining 5 were women which added to 20%.</p><p class="abstract"><strong>Conclusions:</strong> Though the cutaneous manifestations of tuberculosis is very rare, the recent years have shown a rising incidence especially among children and therefore requires a high index of suspicion in them since India has very high prevalence of tuberculosis as such.</p>


Author(s):  
Suresh Chaudhary ◽  
Mukul Dixit ◽  
Anjana Verma ◽  
Hemlata Mittal ◽  
Medha Mathur

Background: Scrub typhus is an acute febrile bacterial zoonoses, caused by Orientia tsutsugamushi and is associated with a range of complications, including sepsis, Acute respiratory distress syndrome (ARDS), pre-renal azotemia and Multiorgan dysfunction syndrome (MODS). The objective of this study was to study the demographic variables and clinical profile of the patients diagnosed with scrub typhus. admitted in a tertiary care hospital in Udaipur, Rajasthan.Methods: It was a longitudinal, observational study, conducted in a tertiary care centre in Udaipur, Rajasthan from January 2020-June 2021. All patients, diagnosed (positive for antibody IgM) with scrub typhus in the hospital during the study period were included in the study. Information about the patients was collected using a pre-tested questionnaire and clinical examination, after taking the informed consent from the study participants.Results: Mean age of the patients was 36.4±19 years. Majority (69.4%) of the patients were from rural area and fever was the most common (83.9%) symptom experienced. Eschar was found in only 1.6% of patients. About 87.1% of the patients had complications, with MODS, being the most common affecting about 34% of the total patients. The patients from rural areas were found to have significantly higher odds (OR=1.61) of having complications as compared to urban area patients (CI=1.09-4.3).  Conclusions: This article draws attention to the fact that scrub typhus is quite on rise and most of the cases are associated with complications. There is a need to develop effective strategies and interventions to stop this rampant rise of the cases in India. 


Author(s):  
Angela C. Rutledge ◽  
Yun-Hee Choi ◽  
Igor Karp ◽  
Vipin Bhayana ◽  
Ivan Stevic

Author(s):  
Supriya Maheshwari ◽  
Sumit Mehndiratta ◽  
. Amitabh

Introduction: Corona Virus Disease 2019 (COVID-19) pandemic has resulted in disruption of essential healthcare services. Children with cancer are very vulnerable group and delay in seeking treatment or defaulting scheduled medications adversely affects the outcome. Aim: To obtain insight into barriers and to evaluate concerns, outlook and challenges faced by parents of children suffering with malignancy in accessing the healthcare services during lockdown imposed due to COVID-19 pandemic. Materials and Methods: A questionnaire-based survey was conducted from parents of children newly diagnosed (during lockdown restrictions) with malignancy and previously diagnosed and under treatment at Paediatric Haematology Oncology unit in a Tertiary care centre. The responses were recorded in predesigned proforma during 15 days period after restrictions were relaxed. Results: Fifty-five responses were recorded and analysed. Father was the respondent in most cases. Acute Leukaemia (n=37) and Lymphoma (n=14) patients comprised majority of the patients. Major challenges faced were transportation (98.2%), financial burden (96.4%) and loss of job (65.4%). Fear of contracting COVID-19 infection was a primary barrier in seeking treatment for most respondents. Conclusion: The success and outcome of children with malignancy has been suboptimal in low-income and middle-income countries due to effect of lack of timely access of healthcare services, delayed diagnosis, treatment abandonment, poor compliance and financial constraints. The COVID-19 pandemic and associated setbacks have accentuated these factors and may have long term impact in final outcome for such patients.


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