scholarly journals PRIMARY SPLENIC LYMPHOMA: CAN TRUCUT BIOPSY AND R-CHOP SUPERSEDE SPLENECTOMY?

2020 ◽  
pp. 1-2
Author(s):  
Aanchal Sawhney ◽  
Mridusmita Khataniar ◽  
Roopal Verma
Keyword(s):  
Unknown Origin ◽  
Rare Type ◽  
Chop Regimen ◽  
Organ Systems ◽  
Pet Ct ◽  
Splenic Lymphoma ◽  
Trucut Biopsy ◽  
High Index Of Suspicion ◽  
Primary Splenic Lymphoma

Primary Splenic lymphoma is a rare type of Non Hodgkin’s lymphoma of the spleen with or without splenic hilar lymph nodes with preservation of other organ systems. In this case, we encountered a patient who presented with fever of unknown origin since 25 days and was diagnosed with Primary splenic lymphoma based on a tru cut biopsy which was then confirmed by immunohistochemistry. Patient was treated with Chemotherapy alone and showed no recurrence after 6 months of follow up. The aim of reporting this case is to have a high index of suspicion for rare malignancies like PSL in cases of FUO. Contrary to the current guidelines, use of trucut biopsy can be used as a promising investigation to diagnose PSL and treatment with chemotherapy with R-CHOP regimen alone prevented recurrence of the tumour. Investigations like PET-CT which have 100% accuracy in diagnosing PSL can reduce the number of operative procedures like splenectomy used for its diagnosis and treatment.

scholarly journals 18F-FDG-PET/CT in staging, recurrence detection and response evaluation of primary splenic lymphoma with eight years follow up

2015 ◽  
Vol 18 (1) ◽  
pp. 37-38 ◽  
Author(s):  
Sellam Karunanithi ◽  
Shambo Guha Roy ◽  
Vijaya Murugan ◽  
Chandrasekhar Bal ◽  
Rakesh Kumar
Keyword(s):  
Fdg Pet ◽  
Response Evaluation ◽  
Pet Ct ◽  
Splenic Lymphoma ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Primary Splenic Lymphoma

Use of 18F-FDG PET/CT Imaging for Evaluation of Patients With Primary Splenic Lymphoma

2014 ◽  
Vol 39 (9) ◽  
pp. 772-776 ◽  
Author(s):  
Sellam Karunanithi ◽  
Punit Sharma ◽  
Shambo Guha Roy ◽  
Beth Vettiyil ◽  
Atul Sharma ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Pet Ct ◽  
Splenic Lymphoma ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Primary Splenic Lymphoma

scholarly journals Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases

2021 ◽  
Vol 11 (1) ◽  
pp. 32
Author(s):  
Suzanne Béra ◽  
Yvan Jamilloux ◽  
Mathieu Gerfaud-Valentin ◽  
Stéphane Durupt ◽  
Raphaèle Nove-Josserand ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Hematological Malignancies ◽  
Inflammatory Diseases ◽  
Unknown Origin ◽  
Final Diagnosis ◽  
Diagnostic Value ◽  
Empirical Treatment ◽  
Pet Ct ◽  
Fdg Pet Ct

(1) Background: there are few studies on the inflammation of unknown origin (IUO). We sought to determine the etiologies and prognosis of IUO, as well as the contribution of complementary examinations. (2) Methods: this retrospective study analyzed patients meeting the Vanderschueren’s criteria in the Hospices Civils de Lyon from 2005 to 2020. (3) Results: a total of 57 patients (mean age: 67 years; interquartile range: 55–79) were included. Final diagnoses were made for 26 (46%) patients. Non-infectious inflammatory diseases were the most common diagnoses (13/26, 50%), followed by neoplasms (10/26, 38%; 8/10 hematological malignancies), infections (2/26, 8%), and miscellaneous causes (1/26, 4%). Moreover, 18-FDG-PET/CT was contributory in 12/42 cases. Anti-neutrophil cytoplasmic antibodies, serology, temporal biopsies, and bone marrow aspirates were contributory in 3/41, 1/57, 5/23, and 3/19 cases, respectively. At last follow-up (mean follow-up duration: 48 months), 8/31 undiagnosed patients were cured (five received an empirical treatment), and 5/31 died (one death was related to the empirical treatment). (4) Conclusion: more than half of the IUO remained undiagnosed. Non-infectious inflammatory diseases and hematological malignancies were the most common etiologies. Moreover, 18-FDG-PET/CT had the highest diagnostic value. Most IUO without final diagnosis persisted. The role of empirical treatments remains to be explored.

scholarly journals Fever of Unknown Origin as a Sole Presentation of Subacute Thyroiditis in an Elderly Patient: A Case Report with Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Rishi Raj ◽  
Srujana Yada ◽  
Aasems Jacob ◽  
Dileep Unnikrishnan ◽  
Wael Ghali
Keyword(s):  
Elderly Patient ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Subacute Thyroiditis ◽  
Thyroid Function Tests ◽  
Laboratory Studies ◽  
High Index Of Suspicion ◽  
Very High ◽  
Rule Out

An 80-year-old Caucasian male presented with fever of 3-week duration. Outpatient workup for infectious etiologies was negative and due to persistent fever, he was hospitalized for further evaluation of fever of unknown origin (FUO). Physical examination and laboratory studies remained unremarkable; however a follow-up CT scan of chest, abdomen, and pelvis with contrast done to rule out malignancy as an underlying cause of FUO revealed heterogeneous thyroid gland with surrounding hazy changes suggestive of thyroiditis. Thyroid function tests confirmed the diagnosis of subacute thyroiditis. The patient was started on prednisone with good response in his symptoms and was eventually discharged to home. The importance of our case lies in the fact that diagnosing subacute thyroiditis in the absence of classical symptoms of neck pain can be challenging and a physician should have a very high index of suspicion especially in an elderly patient where FUO can be the sole presentation.

Comparison of Fluorine(18)-fluorodeoxyglucose and Gallium(68)-citrate PET/CT in patients with tuberculosis

2019 ◽  
Vol 58 (05) ◽  
pp. 371-378
Author(s):  
Alfred O. Ankrah ◽  
Ismaheel O. Lawal ◽  
Tebatso M.G. Boshomane ◽  
Hans C. Klein ◽  
Thomas Ebenhan ◽  
...  
Keyword(s):  
Tracer Uptake ◽  
Pet Ct ◽  
The Mean ◽  
18F Fdg ◽  
Definition Of ◽  
Gallium 68 ◽  
Attending Physician ◽  
Pet Scans ◽  
The Brain

Abstract 18F-FDG and 68Ga-citrate PET/CT have both been shown to be useful in the management of tuberculosis (TB). We compared the abnormal PET findings of 18F-FDG- and 68Ga-citrate-PET/CT in patients with TB. Methods Patients with TB on anti-TB therapy were included. Patients had a set of PET scans consisting of both 18F-FDG and 68Ga-citrate. Abnormal lesions were identified, and the two sets of scans were compared. The scan findings were correlated to the clinical data as provided by the attending physician. Results 46 PET/CT scans were performed in 18 patients, 11 (61 %) were female, and the mean age was 35.7 ± 13.5 years. Five patients also had both studies for follow-up reasons during the use of anti-TB therapy. Thirteen patients were co-infected with HIV. 18F-FDG detected more lesions than 68Ga-citrate (261 vs. 166, p < 0.0001). 68Ga-citrate showed a better definition of intracerebral lesions due to the absence of tracer uptake in the brain. The mean SUVmax was higher for 18F-FDG compared to 68Ga-citrate (5.73 vs. 3.01, p < 0.0001). We found a significant correlation between the SUVmax of lesions that were determined by both tracers (r = 0.4968, p < 0.0001). Conclusion Preliminary data shows 18F-FDG-PET detects more abnormal lesions in TB compared to 68Ga-citrate. However, 68Ga-citrate has better lesion definition in the brain and is therefore especially useful when intracranial TB is suspected.

Suspected osseous recurrence visualized on a 68Ga- DOTATATE PET/CT scan during the follow-up of a patient with a resected pulmonary carcinoid tumour

2011 ◽  
Vol 50 (05) ◽  
pp. N57-N59
Author(s):  
S. Geiger ◽  
S. Horster ◽  
A. R. Haug ◽  
A. Hausmann ◽  
M. Schlemmer ◽  
...  
Keyword(s):  
Ct Scan ◽  
Carcinoid Tumour ◽  
Pulmonary Carcinoid ◽  
Pet Ct ◽  
Pet Ct Scan

Prediction of lymph node metastase in NSCLC

2010 ◽  
Vol 01 (05) ◽  
pp. 219-226 ◽  
Author(s):  
F. Beyer ◽  
B. Buerke ◽  
J. Gerss ◽  
K. Scheffe ◽  
M. Puesken ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Fdg Pet ◽  
Automatic Segmentation ◽  
Correlation Coefficients ◽  
Mediastinal Lymph Nodes ◽  
Intra Class Correlation ◽  
Axial Diameter ◽  
Pet Ct ◽  
Fdg Pet Ct

SummaryPurpose: To distinguish between benign and malignant mediastinal lymph nodes in patients with NSCLC by comparing 2D and semiautomated 3D measurements in FDG-PET-CT.Patients, material, methods: FDG-PET-CT was performed in 46 patients prior to therapy. 299 mediastinal lymph-nodes were evaluated independently by two radiologists, both manually and by semi-automatic segmentation software. Longest-axial-diameter (LAD), shortest-axial-diameter (SAD), maximal-3D-diameter, elongation and volume were obtained. FDG-PET-CT and clinical/FDG-PET-CT follow up examinations and/or histology served as the reference standard. Statistical analysis encompassed intra-class-correlation-coefficients and receiver-operator-characteristics-curves (ROC). Results: The standard of reference revealed involvement in 87 (29%) of 299 lymph nodes. Manually and semi-automatically measured 2D parameters (LAD and SAD) showed a good correlation with mean

Restaging of patients with lymphoma

2008 ◽  
Vol 47 (01) ◽  
pp. 37-42 ◽  
Author(s):  
T. Pfluger ◽  
V. Schneider ◽  
M. Hacker ◽  
N. Bröckel ◽  
D. Morhard ◽  
...  
Keyword(s):  
Low Dose ◽  
Non Hodgkin Lymphoma ◽  
Contrast Enhanced ◽  
Pet Ct ◽  
Significant Difference ◽  
18F Fdg ◽  
Sensitivity Specificity ◽  
Fdg Pet Ct

SummaryAim: Assessment of the clinical benefit of i.v. contrast enhanced diagnostic CT (CE-CT) compared to low dose CT with 20 mAs (LD-CT) without contrast medium in combined [18F]-FDG PET/CT examinations in restaging of patients with lymphoma. Patients, methods: 45 patients with non-Hodgkin lymphoma (n = 35) and Hodgkin's disease (n = 10) were included into this study. PET, LD-CT and CECT were analyzed separately as well as side-by-side. Lymphoma involvement was evaluated separately for seven regions. Indeterminate diagnoses were accepted whenever there was a discrepancy between PET and CT findings. Results for combined reading were calculated by rating indeterminate diagnoses according the suggestions of either CT or PET. Each patient had a clinical follow-up evaluation for >6 months. Results: Region-based evaluation suggested a sensitivity/specificity of 66/93% for LD-CT, 87%/91% for CE-CT, 95%/96% for PET, 94%/99% for PET/LD-CT and 96%/99% for PET/CE-CT. The data for PET/CT were obtained by rating indeterminate results according to the suggestions of PET, which turned out to be superior to CT. Lymphoma staging was changed in two patients using PET/ CE-CT as compared to PET/LD-CT. Conclusion: Overall, there was no significant difference between PET/LD-CT and PET/CE-CT. However, PET/CE-CT yielded a more precise lesion delineation than PET/LD-CT. This was due to the improved image quality of CE-CT and might lead to a more accurate investigation of lymphoma.

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