Role of Polymers in Exploring Modified and Sustained Release for Intradermal Drug Delivery

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

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The Fundamental of Novel Drug Delivery System; Methodology, Role of Nanotechnology; Nanoparticles in Pharmaceutical Research.

SSRN Electronic Journal ◽

10.2139/ssrn.3557341 ◽

2019 ◽

Author(s):

Kushwah Nilesh ◽

Yezdani Umama ◽

mohammad gayoor khan ◽

Manish Kushwah ◽

AYUSH KUMAR

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Pharmaceutical Research ◽

Novel Drug Delivery System ◽

Novel Drug ◽

System Methodology

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Emerging Role of Colloidal Drug Delivery Systems (CDDS) in NSAID Topical Administration

Current Medicinal Chemistry ◽

10.2174/0929867311320140004 ◽

2013 ◽

Vol 20 (14) ◽

pp. 1847-1857 ◽

Cited By ~ 8

Author(s):

Carmelo Puglia ◽

Giorgia Tirendi ◽

Francesco Bonina

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Topical Administration ◽

Delivery Systems

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The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery

Current Pharmaceutical Design ◽

10.2174/1381612822666151216151856 ◽

2016 ◽

Vol 22 (9) ◽

pp. 1259-1273 ◽

Cited By ~ 8

Author(s):

Carolyn Jordan ◽

Vladimir V. Shuvaev ◽

Mark Bailey ◽

Vladimir R. Muzykantov ◽

Thomas D. Dziubla

Keyword(s):

Drug Delivery ◽

Biological Barriers

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Monocyte as an Emerging Tool for Targeted Drug Delivery: A Review

Current Pharmaceutical Design ◽

10.2174/1381612825666190102104642 ◽

2019 ◽

Vol 24 (44) ◽

pp. 5296-5312 ◽

Cited By ~ 5

Author(s):

Fakhara Sabir ◽

Rai K. Farooq ◽

Asim.ur.Rehman ◽

Naveed Ahmed

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

The Body ◽

Carrier System ◽

Bone Marrow Precursor ◽

Extensive Introduction ◽

Cancer Inflammation ◽

Targeted Drug ◽

Cluster Of Differentiation

Monocytes are leading component of the mononuclear phagocytic system that play a key role in phagocytosis and removal of several kinds of microbes from the body. Monocytes are bone marrow precursor cells that stay in the blood for a few days and migrate towards tissues where they differentiate into macrophages. Monocytes can be used as a carrier for delivery of active agents into tissues, where other carriers have no significant access. Targeting monocytes is possible both through passive and active targeting, the former one is simply achieved by enhanced permeation and retention effect while the later one by attachment of ligands on the surface of the lipid-based particulate system. Monocytes have many receptors e.g., mannose, scavenger, integrins, cluster of differentiation 14 (CD14) and cluster of differentiation 36 (CD36). The ligands used against these receptors are peptides, lectins, antibodies, glycolipids, and glycoproteins. This review encloses extensive introduction of monocytes as a suitable carrier system for drug delivery, the design of lipid-based carrier system, possible ways for delivery of therapeutics to monocytes, and the role of monocytes in the treatment of life compromising diseases such as cancer, inflammation, stroke, etc.

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