scholarly journals The Proportion of Latent Tuberculosis Infection in Naive Lung Cancer Patients at Persahabatan Hospital Jakarta

2019 ◽  
Vol 39 (4) ◽  
pp. 256-265
Author(s):  
Erlina Burhan ◽  
Ririen Razika Ramdhani ◽  
Jamal Zaini
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Close Contact ◽  
Cancer Prognosis ◽  
Related Factors ◽  
Cross Sectional ◽  
Lung Cancer Patients ◽  
Total Lymphocyte ◽  
Latent Tb ◽  
Latent Tb Infection

Background: Lung cancer and pulmonary tuberculosis (TB) are two major public health problems associated with significant morbidities and mortalities. The increased prevalence of active TB and latent TB reactivation in lung cancer patients and negative effect of pulmonary TB in lung cancer prognosis needed screening of lung cancer patients for latent TB infection (LTBI). This study aimed to determine the proportion of LTBI in lung cancer patients, their characteristics and the relationship between them. Methods: This study used cross-sectional design. Collecting sample used consecutive sampling of 86 newly diagnosed treatment-naive lung cancer patients from RSUP Persahabatan in 2015 to 2016. The presence of LTBI was determined by Quantiferon-TB Gold-In-Tube (QFT- GIT) after having Mycobacterium TB not detected result from Xpert MTB/RIF sputum test. Demographic characteristics and cancer-related factors associated with LTBI were investigated. Results: The results of latent TB tests were IGRA(+) 12.8%, IGRA(-) 68.6% and IGRA(I) 18.6%. Number of male patients with lung cancer with latent were 68.6%, as many as 55.8% were immunized with BCG, 4.6% had close contact with TB and 64% were using smoking. Most types of cancer were adenocarcinomas (77.9%) with advanced stage (82.6%) and general display status 2 (50%). The characteristics that show an association with IGRA results are the location of the cancer and the total lymphocyte count. Conclusion: The proportion of latent TB in lung cancer patients at the RSUP Persahabatan was 12.8%. The location of the cancer associated with the area of typical TB was related to latent TB, although it cannot be canceled. Results of IGRA(I) in lung cancer patients with low total lymphocyte counts prove IGRA sensitivity in the protection of latent TB infection in immunocompromised patients. (J Respir Indo. 2019; 39(4): 256-65)

Costs, Trends, and Related Factors in Treating Lung Cancer Patients in 67 Hospitals in Guangxi, China

2017 ◽  
Vol 35 (5) ◽  
pp. 345-357 ◽  
Author(s):  
Li-Fang Zhou ◽  
Mao-Xin Zhang ◽  
Ling-Qian Kong ◽  
Gary H. Lyman ◽  
Ke Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Related Factors ◽  
Lung Cancer Patients

scholarly journals BCG Vaccine Protection against TB Infection among Children Older than 5 Years in Close Contact with an Infectious Adult TB Case

2020 ◽  
Vol 9 (10) ◽  
pp. 3224
Author(s):  
Angeliki Syggelou ◽  
Nikolaos Spyridis ◽  
Kyriaki Benetatou ◽  
Eleni Kourkouni ◽  
Georgia Kourlaba ◽  
...  
Keyword(s):  
Index Case ◽  
Close Contact ◽  
Cross Sectional Study ◽  
Protective Role ◽  
Bcg Vaccine ◽  
Cross Sectional ◽  
History Of ◽  
Latent Tb ◽  
Latent Tb Infection ◽  
History Of Migration

The Bacille Calmette–Guérin (BCG) vaccine has been shown to provide considerable protection against miliary or meningeal tuberculosis (TB), but whether it prevents other forms of disease remains controversial. Recent evidence has shown that the BCG vaccine also provides protection against latent TB infection (LTBI). The aim of the current study was to examine whether BCG has a protective role against LTBI among children in close contact with an adult index case in a low TB endemicity setting with the use of the QuantiFERON-TB Gold In-Tube test (QFT-GIT). A cross-sectional study was conducted over a 10-year period among children referred to our outpatient TB clinic with a history of close contact with an adult with pulmonary TB. All subjects had a QFT-GIT performed. In total, 207 children > 5 to 16 years of age with known recent exposure were enrolled. BCG-vaccinated subjects had a 59% lower risk of presenting with LTBI after close contact with an adult index case compared with unvaccinated subjects (OR = 0.41, 95% CI: 0.23–0.73, p = 0.002). After adjustment for possible confounders, the protective effect of prior BCG immunization was estimated at 68% (OR = 0.32, 95% CI: 0.15–0.66, p = 0.002). Other risk factors for LTBI included a history of migration (OR = 2.27, 95% CI: 1.13–4.53, p = 0.021) and transmission of infection to other exposed child contacts (OR = 4.62, 95% CI: 2.27–9.39, p = 0.001). We were able to determine a strong protective role of BCG vaccination among children older than 5 years, immunized at school entry, who had close contact with an adult infectious TB case.

scholarly journals Prevalence and Correlates of Complementary and Alternative Medicine Use among Patients with Lung Cancer: A Cross-Sectional Study in Beirut, Lebanon

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Farah Naja ◽  
Bilal Anouti ◽  
Hibeh Shatila ◽  
Reem Akel ◽  
Yolla Haibe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Cancer Patients ◽  
Well Being ◽  
Open Communication ◽  
Cross Sectional ◽  
Lung Cancer Patients ◽  
Cam Use ◽  
Complementary And Alternative

Patients with lung cancer are increasingly seeking complementary and alternative medicine (CAM) to improve their physiological and psychological well-being. This study aimed to assess CAM use among lung cancer patients in Lebanon. Using a cross-sectional design, 150 lung cancer patients attending the Basile Cancer Institute at the American University of Beirut Medical Center were interviewed. Participants completed a questionnaire addressing sociodemographic characteristics, lung cancer condition, and use of CAM. The main outcome of interest was “use of any CAM therapy since diagnosis.” Prevalence of CAM use was 41%. The most commonly used CAM modality among study participants was “dietary supplements/special foods.” Results of the multiple logistic regression analyses showed that CAM use was positively associated with Lebanese nationality and paying for treatment out of pocket and was negatively associated with unemployment and having other chronic diseases. About 10% of patients used CAM on an alternative base, 58% did not disclose CAM use to their physician, and only 2% cited health professionals as influencing their choice of CAM. This study revealed a prevalent CAM use among lung cancer patients in Lebanon, with a marginal role for physicians in guiding this use. Promoting an open-communication and a patient-centered approach regarding CAM use is warranted.

The effect of gender on health-related quality of life and related factors in post-lobectomy lung-cancer patients

2015 ◽  
Vol 19 (3) ◽  
pp. 292-300 ◽  
Author(s):  
Nai-Wen Chang ◽  
Kuan- Chia Lin ◽  
Wen-Hu Hsu ◽  
Shih-Chun Lee ◽  
James Yi-Hsin Chan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Health Related Quality ◽  
Related Factors ◽  
Lung Cancer Patients ◽  
Related Quality ◽  
Health Related

scholarly journals A study to assess prevalence of treatment default among lung cancer patients registered at a tertiary care hospital

2018 ◽  
Vol 6 (7) ◽  
pp. 2499
Author(s):  
Lokendra Dave ◽  
Vikas Mishra ◽  
Rakesh C. Gupta ◽  
Neeraj Gour ◽  
Nishant Shrivastava ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Tertiary Care ◽  
Primary Lung Cancer ◽  
Drop Out ◽  
Primary Data ◽  
Care Hospital ◽  
Cross Sectional ◽  
Lung Cancer Patients ◽  
Treatment Default

Background: Lung cancer is among the five main types of cancer leading to overall cancer mortality contributing about 1.3 million deaths/year globally. Completion of treatment among lung cancer patients is one of key factor for the survival and longevity of patients. So, we have tried to find out prevalence of treatment default through this study.Methods: This is a cross-sectional descriptive study (including retrospective secondary and prospective primary data) using data base of patients of primary lung cancer diagnosed between 1st January 2006 to 31st December 2012 in indoor and outdoor of department of Respiratory Medicine, J.L.N. Medical College, Ajmer, a tertiary level hospital and teaching center.Results: Incidence of lung cancer is significantly higher among young female (10.23%) as compared to young male (8.74 %). Whereas in older group number of male suffering from lung cancer than female. Total 269 (20.7%) patients defaulted from planned treatment and most of them ultimately drop-out from chemotherapy cycles. Intercycle delay of 2 weeks-1m commonly seen.Conclusions: It provides future implication to researchers to explore reasons of these defaults and drop outs so that more evidences can be generated in this direction for the ultimate betterment of lung cancer patients.

scholarly journals The Dual Effect of CD28 on The Prognosis of Lung Cancer Based On Nomograms: A Comprehensive Analysis of The Tumor Immune Microenvironment

2020 ◽  
Author(s):  
dantong sun ◽  
Lu Tian ◽  
Tiantian Bian ◽  
Han Zhao ◽  
Junyan Tao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Multivariate Analyses ◽  
Cancer Prognosis ◽  
Immune Microenvironment ◽  
Dual Effect ◽  
Internal Validation ◽  
Lung Cancer Patients ◽  
Tumor Immune Microenvironment

Abstract Background Lung cancer has ranked first in China in recent years, and TIME-related molecules may serve as biomarkers for the prognosis of lung cancer. Nomograms are widely used tools for the evaluation of prognosis in malignancies. We performed this study to construct nomograms based on TIME for predicting the prognosis of lung cancer. Methods Univariate and multivariate analyses were performed to estimate prognosis. TIME-related variables and basic clinical characteristics were included in the nomograms. Discrimination and calibration were used for the internal validation of the nomograms. Patients in our center and in the TCGA database were involved in the construction of the nomograms. Results Both LUAD and lung cancer patients with a higher expression of CD28 had a shorter DFS (P = 0.0011; P = 0.0001) but a longer OS (P = 0.0001; P = 0.0282). Nomograms for the DFS of young LUAD patients and the OS of LUAD and lung cancer patients were constructed. The established nomograms provide an easy way to estimate prognosis. Patients may obtain not only probabilities for disease progression and 1-year, 3-year or 5-year survival but also a precise and individualized follow-up regimen. Conclusion TIME-related variables are closely associated with the prognosis of lung cancer patients, especially young LUAD patients. CD28, which has a dual effect on lung cancer prognosis, may be a novel biomarker for not only the prognosis of lung cancer but also sensitivity to immunotherapy. Nomograms based on TIME may be a novel way to predict the prognosis of lung cancer.

scholarly journals Clinical Impact of Association Between Diabets and Lung Cancer

2019 ◽  
Vol 70 (4) ◽  
pp. 1149-1151 ◽  
Author(s):  
Laura Mazilu ◽  
Dana Lucia Stanculeanu ◽  
Andreea Daniela Gheorghe ◽  
Adrian Paul Suceveanu ◽  
Irinel Raluca Parepa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Negative Impact ◽  
Cancer Prognosis ◽  
Lung Cancer Patients ◽  
High Prevalence ◽  
Cancer Outcome ◽  
The Impact

The main objective of this analysis is to evaluate the impact of lung cancer and diabetes association on cancer treatment and outcome of lung cancer patients. Lung cancer, as well as diabetes mellitus, are two diseases with very high prevalence. Lung cancer, despite the improvement in diagnosis and therapeutic methods, is still the 1st cause of cancer-related deaths. The influence of diabetes on cancer patients survival is well established among patients with hepatic, pancreatic or breast cancer. Diabetes implication on lung cancer outcome is not well known. Several studies reported a negative impact, whereas other studies reported a better prognosis for these patients. Our study took place in the Oncology Department of the Clinical Emergency Hospital of Constanta, Romania. 80 patients with diagnosis of non-small cell lung cancer were elected to participate in this study; 29 patients had also diabetes. Selected patients were divided in 2 groups, one group of lung cancer and diabetes, and one group without diabetes. Features of the patients among both groups were analyzed. Our study showed that preexisting diabetes is an unfavorable factor, and has influence on lung cancer prognosis, treatment adhesion and quality of life. To amend the outcome of patients with lung cancer, a better evaluation of patients� co-morbidities, including diabetes mellitus, is required.

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