scholarly journals The Pedagogy of the Imagination

2009 ◽  
Vol 2 (2) ◽  
pp. 43-57
Author(s):  
Michael Armstrong
Keyword(s):  
Curriculum Design ◽  
Teaching Method ◽  
Educational Assessment ◽  
Italo Calvino ◽  
Close Reading ◽  
Educational Implications ◽  
Critical Scrutiny ◽  
First Time

The author takes an essay on the imagination by Italo Calvino as the cue for a reconsideration of the role of imagination in children’s thought and action and its educational implications. He emphasizes the value of interpretation, or critical scrutiny, as foremost among a teacher’s skills and central to curriculum design, teaching method and educational assessment, demonstrating the quality of children’s imaginative work, and how to value it, by means of a close reading of an eight year old’s brief med- itation on coming to school for the first time.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

scholarly journals Changes in Plasma Phospholipid Metabolism Are Associated with Clinical Manifestations of Systemic Sclerosis

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2116
Author(s):  
Marija Geroldinger-Simić ◽  
Thomas Bögl ◽  
Markus Himmelsbach ◽  
Norbert Sepp ◽  
Wolfgang Buchberger
Keyword(s):  
Systemic Sclerosis ◽  
High Performance ◽  
Clinical Manifestations ◽  
Plasma Phospholipid ◽  
Phospholipid Metabolism ◽  
Internal Organs ◽  
New Biomarkers ◽  
First Time

Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and/or internal organs, causing a decrease in quality of life and survival. There is no causative therapy, and the pathophysiology of the SSc remains unclear. Studies showed that lipid metabolism was relevant for autoimmune diseases, but little is known about the role of lipids in SSc. In the present study, we sought to explore the phospholipid profile of SSc by using the lipidomics approach. We also aimed to analyze lipidomics results for different clinical manifestations of SSc. Experiments were performed using high-performance liquid chromatography coupled to mass spectrometry for the lipidomic profiling of plasma samples from patients with SSc. Our study showed, for the first time, significant changes in the level of phospholipids such as plasmalogens and sphingomyelins from the plasma of SSc patients as compared to controls. Phosphatidylcholine plasmalogens species and sphingomyelins were significantly increased in SSc patients as compared to controls. Our results also demonstrated a significant association of changes in the metabolism of phospholipids (phosphatidylcholine and phosphatidylethanolamine plasmalogens species and sphingomyelins) with different clinical manifestations of SSc. Further lipidomic studies might lead to the detection of lipids as new biomarkers or therapeutic targets of SSc.

scholarly journals To Kill a Mockingbird and Legal Ethics: On the Role of Atticus Finch’s Attic Rhetoric in Fulfillment of Duties to Client, to Court, to Society, and to Self

2019 ◽  
Vol 8 (2) ◽  
pp. 289-325
Author(s):  
Michelle Kundmueller
Keyword(s):  
Ethical Conduct ◽  
Professional Conduct ◽  
Legal Ethics ◽  
To Kill A Mockingbird ◽  
Public Citizen ◽  
First Time ◽  
Special Responsibility

Abstract Atticus Finch, protagonist of Harper Lee’s To Kill a Mockingbird and longtime hero of the American bar, is well known, but he is not well understood. This article unlocks the secret to his status as the most admired of fictional attorneys by demonstrating the role that his rhetoric plays in his exemplary fulfillment of the duties of an attorney to zealously represent clients, to serve as an officer of the court, and to act as a public citizen with a special responsibility for the quality of justice. Always using the simplest accurate wording, focusing on reason over emotion, and speaking in the same manner whether in private or in public, Atticus’s rhetoric exemplifies the ancient Roman style known by students of rhetoric as “Attic.” Using this style to navigate the potential for conflict among his duties, Atticus reveals the power, the elegance, and the ethical necessity of Attic rhetoric. Connecting Atticus’s name to the Attic style of rhetoric for the first time, this article advances several scholarly debates by demonstrating the mutual compatibility of the duties imposed by the Model Rules of Professional Conduct and proffering a powerful tool to attorneys seeking to practice or to teach improved ethical conduct.

scholarly journals PENDAMPINGAN & PELATIHAN BERWIRAUSAHA IBU-IBU PETANI JAGUNG

2020 ◽  
Vol 3 (1) ◽  
pp. 1-9
Author(s):  
Usman Usman ◽  
Veneranda Rini Hapsari
Keyword(s):  
Teaching Method ◽  
Market Price ◽  
Corn Flour ◽  
Entrepreneurship Training ◽  
Pests And Diseases ◽  
Interview Method ◽  
Industrial Material ◽  
Corn Prices

Abstract The problem faced by corn farmers is that the quality of corn prices is not in accordance with the market price because they do not drain well so that prices in the market have fallen considerably. The role of corn is very important and beneficial for human and animal life. And it is the second staple food after rice. While in the world corn ranks third after wheat and rice. The advantage of corn itself is that the harvest time is faster and very resistant to pests and diseases and higher production. (Ermanita, 2004). Indonesia is a tropical climate and fertile soil and as a country known as an agrarian nation, Indonesia is a country known for its rich biodiversity which is a mainstay in the fields of food, industry and energy. As an industrial material corn can be processed into processed oils, corn flour, sugar and others. The method used in this service is a method of training and teaching that is discussion, teaching method, participants of the training are housewives in the Farmer Business group. They are given material about how to make cakes so that they can be of selling value., Using the method (Discussion Method) Trainees are given the opportunity to discuss issues related to corn, using the interview method. The trainees were given the opportunity to be interviewed how much influence the training on baking for them in developing themselves.Keywords: ASSISTANCE, ENTREPRENEURSHIP,TRAINING FOR CORN  FARMERS

scholarly journals Neuroinflammation and cognition across psychiatric conditions

CNS Spectrums ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 4-15 ◽  
Author(s):  
Célia Fourrier ◽  
Gaurav Singhal ◽  
Bernhard T. Baune
Keyword(s):  
Psychiatric Disorders ◽  
Cognitive Impairments ◽  
Kynurenine Pathway ◽  
Homeostatic Plasticity ◽  
Cytokine Levels ◽  
Inflammatory Processes ◽  
Psychiatric Conditions ◽  
First Time

Cognitive impairments reported across psychiatric conditions (ie, major depressive disorder, bipolar disorder, schizophrenia, and posttraumatic stress disorder) strongly impair the quality of life of patients and the recovery of those conditions. There is therefore a great need for consideration for cognitive dysfunction in the management of psychiatric disorders. The redundant pattern of cognitive impairments across such conditions suggests possible shared mechanisms potentially leading to their development. Here, we review for the first time the possible role of inflammation in cognitive dysfunctions across psychiatric disorders. Raised inflammatory processes (microglia activation and elevated cytokine levels) across diagnoses could therefore disrupt neurobiological mechanisms regulating cognition, including Hebbian and homeostatic plasticity, neurogenesis, neurotrophic factor, the HPA axis, and the kynurenine pathway. This redundant association between elevated inflammation and cognitive alterations across psychiatric disorders hence suggests that a cross-disorder approach using pharmacological and nonpharmacological (ie, physical activity and nutrition) anti-inflammatory/immunomodulatory strategies should be considered in the management of cognition in psychiatry.

Sound foundations: archaeology in Scotland's towns and cities and the role of the Scottish Burgh Survey

Antiquity ◽  
2002 ◽  
Vol 76 (293) ◽  
pp. 802-807 ◽  
Author(s):  
Olwyn Owen
Keyword(s):  
Total Population ◽  
Natural Heritage ◽  
1960S And 1970S ◽  
First Time

We shall not cease from explorationAnd the end of all our exploringWill be to arrive where we startedAnd know the place for the first time.T.S. ELIOTIntroductionThink of Scotland. The chances are that what springs to mind is a picture of mountains, lochs, glens and coasts — an outstanding natural heritage which uplifts the spirit and overflows the pages of the tourist brochures. Paradoxically, though, modern Scotland has an urban heart, with its people, the lifeblood of its economy and its cultural centres all concentrated in the towns and cities. Scotland is fortunate in the quantity and quality of its historic towns, with a preponderance of small and medium-sized towns, many of which escaped the insensitive 1960s and 1970s redevelopment so eloquently lamented elsewhere. Even Scotland’s cities are small by English standards; the population of Glasgow, our largest city, was about 650,000 in the 1991 census, and Dundee, the smallest (before Inverness’s elevation), only about 165,000. Today some 80% of the total population of around 5,000,000 live and work in towns and cities.

scholarly journals Non-financial corporations in Lebanon: Who governs? “The governance myopia”

2016 ◽  
Vol 14 (1) ◽  
pp. 84-95 ◽  
Author(s):  
Mireille Chidiac El Hajj ◽  
Richard Abou Moussa ◽  
Maha Akiki ◽  
Anthony Sassine
Keyword(s):  
Capital Market ◽  
Stock Exchange ◽  
Board Members ◽  
Exchange Market ◽  
Quality Of Information ◽  
Face To Face ◽  
Governance Practices ◽  
First Time

The purpose of this paper is to study governance practices in non-financial enterprises in Lebanon, and it is the first time that such enterprises are studied in the Lebanese context. Only three non-financial institutions are listed in the Beirut Stock Exchange (BSE), which constitute the whole population of this research. Built on Principles, Governance is based on transparency and on accurate, relevant, and timely information in order to support the Board members’ decision-making (OECD, 2015). Balanced between Jensen and Meckling’s (1976) agency theory and Donaldson and Davis’ (1991) Stewardship theory, the results of our Qualitative study showed that the main problems faced by the enterprises are not in the quality of information but rather in its selection and filtering, which opens doors to “Governance Myopia”. Face-to-face interviews showed that the primary conflict in our case is between the non-financial enterprises and the BSE, since the BSE is controlled by the enterprises and is not controlling them. The main reason of such practices come from the fear of the BSE of losing a potential position in the MENA Exchange Market, doubled with the fear of losing potential investors. All these reasons weigh heavily on the Administrators of the BSE in Lebanon, forcing them to choose the “Laisser passer” way. Referring to the soft Law when dealing with the companies, the BSE is playing the double role of a marketer and a controller, thus not willing to impose restrictions. A need for “harder laws”, for “Privatization” of the BSE, and a call to the Capital Market Authority (CMA) to put more restrictions on Corporations should be observed.

Anti-Mullerian hormone and its predictive value for assessing oocyte quality

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (6) ◽  
pp. 21-26
Author(s):  
Natalia V. Aleksandrova
Keyword(s):  
Ovarian Reserve ◽  
Predictive Value ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Oocyte Quality ◽  
Laboratory Markers ◽  
Diagnostic Capabilities ◽  
First Time

The article systematizes information on the diagnostic capabilities of modern clinical and laboratory markers of ovarian reserve. The diagnostic capabilities of anti-Mllerian hormone (AMH) as a marker of ovarian reserve are discussed, which make it possible to adjust the dose of hormonal drugs and predict the response of the ovary to stimulation in programs of assisted reproductive technologies. This paper discusses for the first time the role of AMH in assessing the quality of oocytes and subsequent embryos. Despite insufficient literature data, further study of AMH, as well as full-scale research in this direction, seems to be extremely promising.

scholarly journals GRP78 in lung cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Shengkai Xia ◽  
Wenzhe Duan ◽  
Wenwen Liu ◽  
Xinri Zhang ◽  
Qi Wang
Keyword(s):  
Lung Cancer ◽  
Er Stress ◽  
Potential Role ◽  
Prognostic Biomarker ◽  
Therapeutic Interventions ◽  
Comprehensive Understanding ◽  
Protein Response ◽  
First Time

AbstractGlucose-regulating protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum (ER) that promotes folding and assembly of proteins, controls the quality of proteins, and regulates ER stress signaling through Ca2+ binding to the ER. In tumors, GRP78 is often upregulated, acting as a central stress sensor that senses and adapts to changes in the tumor microenvironment, mediating ER stress of cancer cells under various stimulations of the microenvironment to trigger the folding protein response. Increasing evidence has shown that GRP78 is closely associated with the progression and poor prognosis of lung cancer, and plays an important role in the treatment of lung cancer. Herein, we reviewed for the first time the functions and mechanisms of GRP78 in the pathological processes of lung cancer, including tumorigenesis, apoptosis, autophagy, progression, and drug resistance, giving a comprehensive understanding of the function of GRP78 in lung cancer. In addition, we also discussed the potential role of GRP78 as a prognostic biomarker and therapeutic target for lung cancer, which is conducive to improving the assessment of lung cancer and the development of new therapeutic interventions.

scholarly journals The role of economics and the type of legal standards in antitrust enforcement by DGCOMP: an empirical investigation

2020 ◽  
Author(s):  
Y Katsoulacos ◽  
G Makri
Keyword(s):  
Economic Analysis ◽  
Empirical Investigation ◽  
Optimal Level ◽  
Competition Authority ◽  
Antitrust Enforcement ◽  
Legal Standards ◽  
First Time ◽  
Made In

Abstract We empirically investigate, for the first time to the best of our knowledge, the role of economics in antitrust enforcement by EC’s Competition Authority (DGCOMP), by constructing and measuring indicators capturing the extent and type of economics used in reaching infringement decisions between 1992 and 2016. This allows us to identify the legal standards (LSs) adopted in assessing different conducts and their evolution and compare these to their theoretically optimal level, thus capturing the quality of enforcement. On average, economic analysis plays a modest role in investigations, with little analysis to substantiate consumer harm or to account for efficiencies, for conducts for which effects-based would be the appropriate LS. However, there is a consistent and significant improvement over time in the quality of enforcement in abuse of dominance cases, with effects-based LSs adopted in recent years. This contrasts to earlier findings and questions recent views, by indicating that DGCOMP has been influenced by the significant progress that economic analysis of antitrust has made in recent decades. Results on how LSs adopted affect the outcome of the judicial review (the rate of decision annulment) do not support the hypothesis that this increases as LSs move closer to effects-based.

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