scholarly journals Comparison of ten biochemical laboratory tests before and after treatment by statins

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Tatiana Ďurčeková ◽  
Ján Mocák ◽  
Ján Balla ◽  
Gabriela Gromanová ◽  
Katarína Boronová
Keyword(s):  
Biochemical Parameters ◽  
Laboratory Tests ◽  
Lipoprotein Metabolism ◽  
Patient Data ◽  
Biochemical Tests ◽  
Blood Samples ◽  
Biochemical Laboratory ◽  
Before And After ◽  
Statin Drug

Results of 10 biochemical tests of 172 patient data (among them 84 men data and 88 women data, resp.) before and after administration of statins were thoroughly studied. All monitored patients are characterized by disorders of lipoprotein metabolism or other kind of dislipidaemia. The calculations were performed using four chemometrical methods facilitating quantification and visualization of the statin effect upon most important biochemical parameters, mainly lipid markers, and allowing classification of the patient blood samples taking into account whether the patient has been or has not been medicated by a statin drug.

scholarly journals Relationship between administration of statins and blood serum levels of selected biochemical parameters

2021 ◽  
Vol 9 (1) ◽  
pp. 83-90
Author(s):  
Tatiana Ďurčeková ◽  
Ján Mocák ◽  
Ján Balla ◽  
Gabriela Gromanová ◽  
Katarína Boronová
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Lipoprotein Metabolism ◽  
Serum Levels ◽  
Patient Data ◽  
Biochemical Tests ◽  
Blood Samples ◽  
Software Packages ◽  
Before And After

Results of biochemical tests of 172 patient data (among them 84 men data and 88 women data, resp.) before and after administration of statins were studied. All monitored patients are characterized by lipoprotein metabolism failure or other kind of lipidaemia. The calculations were performed using several chemometrical methods pursuing visualization of most important biochemical parameters and classification of the patient blood samples by means of up-to-date software packages. The dependences of the content of most common biochemical parameters upon the treatment of patients by statins were elucidated in detail.

scholarly journals The Usefulness of Performing Biochemical Tests in the Saliva of Kickboxing Athletes in the Dynamic of Training

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Oleksandr Anatolievich Volodchenko ◽  
Leonid Vladimirovich Podrigalo ◽  
Sergii Sidorovich Iermakov ◽  
Małgorzata Teresa Żychowska ◽  
Władysław Jagiełło
Keyword(s):  
Lipid Peroxidation ◽  
Lactic Acid ◽  
Pyruvic Acid ◽  
Biochemical Parameters ◽  
Training Session ◽  
Training Experience ◽  
Biochemical Tests ◽  
Male Athletes ◽  
Correlation Matrices ◽  
Before And After

The study aimed to determine the suitability of testing the saliva of kickboxing athletes to show changes in biochemical parameters in dynamic of training. 8 elite male athletes (mean age 17.29± 0.31 years, body mass 66.82± 3.46kg, with 5.62±0.96 years of training experience) participated in the study. Indicators of lipid peroxidation and glycolysis (the concentration of lactic acid and pyruvic acid) were defined before and after a training session. Significant increases in indicators of lipid peroxidation activity indicators and the concentration of lactic acid (4-fold) were observed; analysis of correlation matrices confirms the absence of expressed changes. At the same time, significant decreases in catalase (10-fold from 3.69μkat/L to 0.39μkat/L) and pyruvic acid (from 3.92μl/l to 0.55μl/l) were observed. Our results confirm the value of using saliva to determine training load in an individual. Moreover, the study provided information on the importance of indexes reflecting a correlation of various biochemical indicators to estimate the sufficiency of training loads. The ease of sampling and informational content of saliva are reasons to use such tests in monitoring athletes’ functional state to prevent fatigue.

scholarly journals Detection of lipoprotein X (LPX) – a challenge in patients with severe hypercholesterolaemia

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Agnieszka Ćwiklińska ◽  
Agnieszka Mickiewicz ◽  
Robert Kowalski ◽  
Barbara Kortas-Stempak ◽  
Agnieszka Kuchta ◽  
...  
Keyword(s):  
Laboratory Tests ◽  
Free Cholesterol ◽  
Liver Enzymes ◽  
Cholestatic Liver Disease ◽  
Cholesteryl Esters ◽  
Routine Laboratory ◽  
Laboratory Practice ◽  
Biochemical Tests ◽  
Liver Insufficiency ◽  
Biochemical Laboratory

Summary Background Lipoprotein X (LpX) is an abnormal lipoprotein fraction, which can be detected in patients with severe hypercholesterolaemia and cholestatic liver disease. LpX is composed largely of phospholipid and free cholesterol, with small amounts of triglyceride, cholesteryl ester and protein. There are no widely available methods for direct measurement of LpX in routine laboratory practice. We present the heterogeneity of clinical and laboratory manifestations of the presence of LpX, a phenomenon which hinders LpX detection. Methods The study was conducted on a 26-year-old female after liver transplantation (LTx) with severely elevated total cholesterol (TC) of 38 mmol/L and increased cholestatic liver enzymes. TC, free cholesterol (FC), cholesteryl esters (CE), triglycerides, phospholipids, HDL-C, LDL-C, and apolipoproteins AI and B were measured. TC/apoB and FC:CE ratios were calculated. Lipoprotein electrophoresis was performed using a commercially available kit and laboratory-prepared agarose gel. Results Commercially available electrophoresis failed to demonstrate the presence of LpX. Laboratory-prepared gel clearly revealed the presence of lipoproteins with γ mobility, characteristic of LpX. The TC/apoB ratio was elevated and the CE level was reduced, confirming the presence of LpX. Regular lipoprotein apheresis was applied as the method of choice in LpX disease and a bridge to reLTx due to chronic liver insufficiency. Conclusions The detection of LpX is crucial as it may influence the method of treatment. As routinely available biochemical laboratory tests do not always indicate the presence of LpX, in severe hypercholesterolaemia with cholestasis, any discrepancy between electrophoresis and biochemical tests should raise suspicions of LpX disease.

Dietary Changes in Fasting Levels of Factor VII Coagulant Activity (FVII: C) Are Accompanied by Changes in Factor VII Protein and other Vitamin K-dependent Proteins

1995 ◽  
Vol 73 (02) ◽  
pp. 239-242 ◽  
Author(s):  
E M Bladbjerg ◽  
T Tholstrup ◽  
P Marckmann ◽  
B Sandström ◽  
J Jespersen
Keyword(s):  
Fatty Acids ◽  
Vitamin K ◽  
Protein C ◽  
Saturated Fatty Acids ◽  
Factor Vii ◽  
Dietary Regimen ◽  
Blood Samples ◽  
Dietary Changes ◽  
Coagulant Activity ◽  
Before And After

SummaryThe mechanisms behind dietary effects on fasting coagulant activity of factor VII (FVII: C) are not clarified. In the present study of 15 young volunteers, two experimental diets differing in composition of saturated fatty acids (C18:0 [diet S] or C12:0 + C14:0 [diet ML]) were served for 3 weeks each. Fasting blood samples were collected before and after the dietary regimen and analysed for triglycerides, FVII:C, and protein concentrations of FVII, FII, FX, protein C, CRP, albumin, fibrinogen, and F1+2. FVII:C was significantly reduced on diet S compared with diet ML. This was accompanied by a decrease in FVII protein, F1+2 and the vitamin K-dependent proteins FII, FX, and protein C. In contrast, no changes were observed in triglycerides, FVII:C/FVII: Ag, albumin and CRP. Fibrinogen was increased on diet S compared with diet ML. Our findings suggest that the change in fasting FVII:C was part of a general change in concentrations of vitamin K-dependent proteins.

ADRENAL 17-HYDROXYCORTICOSTEROID SECRETION IN THE DOG IN RESPONSE TO ETHANOL

1972 ◽  
Vol 70 (4) ◽  
pp. 736-740 ◽  
Author(s):  
T. Suzuki ◽  
R. Higashi ◽  
T. Hirose ◽  
H. Ikeda ◽  
K. Tamura
Keyword(s):  
Venous Blood ◽  
Secretion Rate ◽  
Conscious Dogs ◽  
Blood Samples ◽  
Before And After

ABSTRACT Conscious dogs were infused intravenously with ethanol in doses of 0.7 and 1.0 g/kg. The adrenal venous blood samples were collected before and after the infusion of ethanol and analysed for 17-hydroxycorticosteroids (17-OHCS). After the infusion of 0.7 g/kg (subanaesthetic dose) of ethanol the adrenal 17-OHCS secretion rate showed either a slight increase or no change. After the infusion of 1.0 g/kg (anaesthetic dose) of ethanol the adrenal 17-OHCS secretion rate increased markedly and reached 1.21±0.15 (mean±sem) μg/kg/min, while it was 0.09±0.023 μg/kg/min before the infusion.

scholarly journals Evaluation of Clinical, Biochemical and Microbiological Markers Related to Dental Caries

2021 ◽  
Vol 18 (11) ◽  
pp. 6049
Author(s):  
Maria D Ferrer ◽  
Salvadora Pérez ◽  
Aránzazu López Lopez ◽  
José Luis Sanz ◽  
Maria Melo ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Oral Health ◽  
Dental Caries ◽  
Biochemical Parameters ◽  
Salivary Flow ◽  
Low Ph ◽  
Tooth Brushing ◽  
Sugar Solution ◽  
Before And After ◽  
Caries Lesions

Our aim was to evaluate clinical, biochemical and microbiological markers related to dental caries in adults. A sample that consisted of 75 volunteers was utilized. The presence of caries and the presence of plaque and gingival indices were determined. Unstimulated salivary flow, pH, lactate, Streptococcus mutans and Streptococcus dentisani were measured in the participants’ plaque and saliva samples before and after rinsing with a sugar solution. Lactate in plaque was found to be significantly related to age, gender, tooth-brushing frequency, the presence of cavitated caries lesions and plaque and gingival indices (p < 0.05). The levels of S. dentisani in plaque increased significantly with tooth-brushing frequency (p = 0.03). Normalized plaque S. dentisani values and the percentage of S. dentisani were slightly higher in patients with basal lactic acid levels ≤ 50 mg/L. After rinsing with a sugary solution, the percentage of S. mutans levels in plaque were higher in patients with lactic acid levels > 350 mg/L (p = 0.03). Tooth-brushing frequency was the factor which was most associated with oral health. Women reflected better clinical and biochemical parameters than men. Low pH and high lactic acid levels tended to be associated with high caries rates. No association was found between bacteria levels and caries indices.

INFLUENCE OF PHOTOPERIOD ON THYROTROPIN RELEASING HORMONE-INDUCED PROLACTIN RELEASE IN EWES

1983 ◽  
Vol 63 (1) ◽  
pp. 67-73 ◽  
Author(s):  
B. E. HOWLAND ◽  
D. SONYA ◽  
L. M. SANFORD ◽  
W. M. PALMER
Keyword(s):  
Thyrotropin Releasing Hormone ◽  
Day Length ◽  
Constant Light ◽  
Serum Prolactin ◽  
Prolactin Release ◽  
Blood Samples ◽  
Releasing Hormone ◽  
Before And After ◽  
Release Curve ◽  
Short Days

The influence of photoperiod on serum prolactin levels and prolactin release induced by thyrotropin releasing hormone (TRH) was determined in ewes maintained under the following lighting regimes: Room 1, lighting mimicked natural changes in photoperiod; Room 2, annual photoperiod changes condensed into 6 mo with short days in June; Room 3, same as Room 2 except photoperiod changed abruptly from 16.5 to 8.0 h on 21 Mar. and back to 16.5 h on 21 June; Room 4, constant light. Weekly blood samples were obtained from February to August. Additionally, blood samples were collected before and after treatment with 10 μg TRH on 19 May, 13 June, 27 June and 19 July. Prolactin levels were elevated in ewes exposed to long days or constant light. The mean of all pre-TRH samples was significantly correlated with stress-induced elevations in prolactin (highest pre-TRH value) (r = 0.72) and area under the TRH-induced release curve (r = 0.56). The prolactin release in response to TRH was greatest in ewes exposed to long days or constant light. Abrupt increase of day length elevated pretreatment prolactin levels (P < 0.01) and increased area under the response curve (P < 0.05). Key words: Photoperiod, TRH, prolactin, ewes

Detection of Vigil And Fatigue States During The Execution of Laparoscopic Tasks Based On EEG Patterns

2021 ◽  
Author(s):  
Yeremi Pérez ◽  
Roberto Borboa-Gastelum ◽  
Luz Maria Alonso-Valerdi ◽  
David I. Ibarra-Zarate ◽  
Eduardo A. Flores-Villalba ◽  
...  
Keyword(s):  
Medical Students ◽  
Individual Component ◽  
Support Vector ◽  
Patient Death ◽  
Professional Activities ◽  
Health Area ◽  
Before And After ◽  
Lack Of Sleep ◽  
Eeg Signal Processing

Abstract Fatigue decreases performance in several professional activities. Fatigue can lead to commit technical mistakes which consequences might be lethal, such as in health area, where a surgical error due to the absence of rest can provoke the patient death. Therefore, this study aims to detect vigil and fatigue (due to lack of sleep) states in medical students through the classification of electroencephalographic (EEG) patterns. The EEG signals of 18 physician students were analyzed within theta band (4 - 8 Hz) over front-central recording sites, and alpha band (8 - 13 Hz) rhythms over temporal and parieto-occipital recording sites during the execution of laparoscopic tasks before and after their medical duties. The EEG signal processing pipeline consisted in pre-processing based on individual component analysis, absolute band power estimates, and Support Vector Machine classification. The F-score to differ between vigil and fatigue states was 90.89%, where the first class was slightly more identifiable reaching a sensitivity of 90.18%. Based on this outcome, the detection of fatigue in medical students while their laparoscopic training seems achievable and feasible to diminish technical mistakes that could be lethal in health area. For this purpose, EEG recording are provided.

Study on Effect of Spheroidization on Hazardous Classification of ADN

2021 ◽  
Vol 881 ◽  
pp. 71-76
Author(s):  
Jian Yang ◽  
Hong Bin Li ◽  
Song Tao Ren ◽  
Peng Gang Jin ◽  
Zan Gao
Keyword(s):  
Temperature Stability ◽  
Impact Sensitivity ◽  
Classification Method ◽  
Ammonium Dinitramide ◽  
Classification Procedure ◽  
Research Results ◽  
Before And After ◽  
Hazard Classification ◽  
Friction Sensitivity

In order to determine the influence of spheroidization process of Ammonium dinitramide’s hazard grade, the hazardous division of Ammonium dinitramide before and after spheroidization is studied by using hazard classification procedure for combustible and explosive substances and articles standard (WJ20405) and hazard classification method and criterion for combusitible and explosive substances and articles standard (WJ20404). The research results show that spheroidization process can significantly improve the temperature stability of Ammonium dinitramide and significantly reduce friction sensitivity and impact sensitivity of Ammonium dinitramide. So spheroidization process can reduce the hazardous of Ammonium dinitramide and improve the safe character of Ammonium dinitramide.

Classification of Brain Signal Activities Before and After Consuming Soy Peptide Using Fuzzy Logic

2021 ◽  
Author(s):  
Arjon Turnip ◽  
Gilbert F. Y. Sihombing ◽  
Giraldo F. J. Sihombing ◽  
George Michael Tampubolon ◽  
Peri Turnip ◽  
...  
Keyword(s):  
Fuzzy Logic ◽  
Before And After
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