scholarly journals NEUROENDOCRINE CARCINOMA AS SINONASAL MALIGNANCY

2019 ◽  
Vol VOLUME 7 (VOLUME 7 NUMBER 2 NOV 2018) ◽  
pp. 30-34
Author(s):  
Nitya Singh
Keyword(s):  
Nasal Cavity ◽  
Neuroendocrine Carcinoma ◽  
Histopathological Examination ◽  
Neuroendocrine Differentiation ◽  
Imaging Study ◽  
High Recurrence Rate ◽  
Neuroendocrine Neoplasms ◽  
Left Nasal Cavity ◽  
Intravenous Contrast ◽  
Rare Malignancy

Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. Extremely rare site for neuroendocrine carcinoma are nasal cavity and paranasal sinuses and are aggressive neoplasm with a high recurrence rate and a tendency to metastasize. A 19-year male presented to the department of Otorhinolaryngology with left nasal obstruction, persistent headache for nine months and on and off bleeding from left nasal cavity for 2 months. On examination of the nasal cavity, a gross deviation of nasal septum with a red, friable, gelatinous, polypoidal mass with a tendency to bleed was seen in the left nasal cavity. The patient underwent endoscopic excision of mass under GA. Specimen was sent for histopathological examination which exhibited the properties of Neuro-endocrine carcinoma. Sinonasal NEC is an extremely rare malignancy. CT scan with intravenous contrast is the most effectual early imaging study, additionally MRI will further make a fine description of the tumor extension. Furthermore, Immunohisto-chemistry is an important tool that can be valuable in reaching a diagnosis. There is no clear recommendation regarding the treatment of the sinonasal neuroendocrine carcinoma, but the multimodal approach with proper counselling of patient is favoured and generally accepted.

Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses

2006 ◽  
Vol 120 (4) ◽  
pp. 289-297 ◽  
Author(s):  
E Babin ◽  
V Rouleau ◽  
P O Vedrine ◽  
B Toussaint ◽  
D de Raucourt ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Neuroendocrine Carcinoma ◽  
Paranasal Sinuses ◽  
Neuron Specific Enolase ◽  
Current Treatment ◽  
Small Cell ◽  
Sinonasal Tract ◽  
Neuroendocrine Neoplasms ◽  
Hormone Production ◽  
Small Cell Neuroendocrine Carcinoma

Introduction: Small cell neuroendocrine carcinoma (SNEC) of the sinonasal tract is a rare disease.Objective: Report a descriptive study of a relatively large cohort of SNEC of the nasal cavity and paranasal sinuses.Method: The medical records of 21 patients presenting with nasal and paranasal SNEC to various French hospitals, from 1989 to 2003, were analysed to determine the clinical features and current treatment of the disease.Results: Patient data were obtained from eight French hospitals. Twelve of the patients were male and nine were female, with a mean age at presentation of 55 years (range: 27 to 79 years). Patients' staging for nasal cavity malignancy was: T1, four; T2, three; T3, one; T4, 13; N0, 18; N2, three; M0, 20; and M1, one. None of the patients suffered from SNEC of the sinonasal tract with ectopic hormone production. Immunohistochemistry proved useful for diagnosis in 20 cases. Twelve cases were positive for cytokeratin, 14 for chromogranin, eight for neuron-specific enolase and 11 for neuron-specific synaptophysin. One patient had an adenocarcinoma and an inverted papilloma associated with neuroendocrine carcinoma. Patients underwent surgery (11 cases), radiotherapy (14 cases) and chemotherapy (12 cases). Recurrence occurred in 10 cases. Five patients had visceral metastases or cervical lymph node involvement. Nine of the patients died within four years of onset of the disease.Conclusion: Small cell neuroendocrine carcinoma of the sinonasal tract is an uncommon neoplasm with aggressive clinical behaviour. Recurrence is frequent and the prognosis is poor. However, the current treatment of these neuroendocrine neoplasms varies widely.

scholarly journals Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Nagesh T. Sirsath ◽  
K. Govind Babu ◽  
Umesh Das ◽  
C. S. Premlatha
Keyword(s):  
Paranasal Sinus ◽  
Neuroendocrine Carcinoma ◽  
Neuroendocrine Tumour ◽  
Neuroendocrine Differentiation ◽  
Complete Response ◽  
The Body ◽  
Intracranial Extension ◽  
Neuroendocrine Neoplasms ◽  
Rare Site ◽  
Poorly Differentiated

Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They can arise in almost every organ of the body although they are most commonly found in the gastrointestinal tract and respiratory system. Nasal cavity and paranasal sinuses are a rare site for neuroendocrine carcinoma. In contrast to the other regions, neuroendocrine tumours of the sinuses have been reported to be recurrent and locally destructive. Very few cases of paranasal sinus neuroendocrine carcinoma have been reported till date. Difficulty in pathologic diagnosis and rarity of this malignancy have hindered the progress in understanding the clinical course and improving outcomes. We herein report a case of poorly differentiated neuroendocrine tumour of ethmoid and sphenoid sinus with invasion of orbit and intracranial extension. The patient had complete response at the end of chemoradiation and he was disease-free for 9 months duration after which he developed bone metastasis without regional recurrence.

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of pancreas: a rare entity—worth to note

2020 ◽  
Vol 13 (4) ◽  
pp. e234855 ◽  
Author(s):  
Bharti Varshney ◽  
Jyotsna Naresh Bharti ◽  
Vaibhav Kumar Varshney ◽  
Taruna Yadav
Keyword(s):  
Histopathological Examination ◽  
Neuroendocrine Tumour ◽  
Pancreatic Head ◽  
Ductal Adenocarcinoma ◽  
Neuroendocrine Neoplasms ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct ◽  
Rare Malignancy

Mixed adenocarcinoma with neuroendocrine tumour of pancreas has been reported infrequently and consists of both epithelial and neuroendocrine component. We encountered an 81-year-old male patient who presented with clinical features of painful progressive jaundice for 1 month. Contrast-enhanced CT abdomen reported a mass in the pancreatic head with dilated common bile duct and pancreatic duct. He underwent pancreatoduodenectomy and histopathological examination revealed two different tumours: ductal adenocarcinoma admixed with neuroendocrine tumour of pancreas. He received adjuvant chemotherapy, and at the end of 1-year follow-up, he has no recurrence. Here, we reported this rare malignancy of pancreas for which pancreatoduodenectomy was done and diagnosed on histopathology with immunohistochemistry.

scholarly journals Small cell neuroendocrine carcinoma: A rare second primary malignancy after treatment of nasopharyngeal carcinoma

2018 ◽  
Vol 8 (31) ◽  
pp. 187-192
Author(s):  
Krishnamoorthy Madhusudhan ◽  
Nor Eyzawiah binti Hassan ◽  
Norasnieda binti Md Shukri ◽  
Shahrul bin Hitam ◽  
Ikmal Hisyam bin Bakrin
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Histopathological Examination ◽  
Neck Region ◽  
Small Cell ◽  
Field Cancerization ◽  
High Recurrence Rate ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Primary Malignancy

Abstract Small cell neuroendocrine carcinoma (SCNEC) of the nasopharynx and nasal cavity is a rare condition. It is an aggressive malignancy with a high recurrence rate. Despite its rarity in the sinonasal region, it may occur as a second primary malignancy. Patients with cancer of the head and neck region are more prone to develop a second primary tumor due to the field cancerization phenomenon, and a higher incidence is seen in those who have previously received radiation therapy. A detailed clinical and histopathological examination is pivotal to diagnose SCNEC as a second primary malignancy. We wish to highlight such a peculiar case from our center.

scholarly journals Ossifying Fibroma in the Nasal Cavity of a 2-Year-Old Horse

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 317
Author(s):  
Bernard Turek ◽  
Kamil Górski ◽  
Olga Drewnowska ◽  
Roma Buczkowska ◽  
Natalia Kozłowska ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Large Firm ◽  
Nasal Bone ◽  
Radiographic Examination ◽  
Ossifying Fibroma ◽  
Left Nasal Cavity ◽  
Caudal Part ◽  
Maxillary Bone ◽  
Oblique Position ◽  
Firm Mass

A 2-year-old mare of an unknown breed was referred to the clinic due to undetermined breathing difficulties. Physical examination revealed painless swelling rostral to the nasoincisive notch and a large, firm mass protruding from the left nostril. Radiographic examination of the head revealed a mass occupying the left nasal cavity and a displaced and hypoplastic last premolar of the left maxilla. The CT scan showed a well-demarcated heterogeneous mass measuring 22 × 9 × 5 cm (length × height × width) in the left nasal cavity attached to the roots of the displaced tooth and conchae. The surgery was performed on the standing horse. Firstly, due to the oblique position of the displaced tooth, the extraction was performed extra-orally through the trephination and repulsion of the maxillary bone. In the next step, a direct surgical approach was chosen for the caudal part of the mass via the osteotomy of the left nasal bone. The mass was bluntly separated from the conchae and removed through the nostril using Fergusson forceps. The histopathological characteristics of the mass led to the diagnosis of ossifying fibroma. The horse recovered completely in seven months, without recurrence after two years.

scholarly journals A Case of Incidental Schwannoma Mimicking Necrotic Metastatic Lymph Node from Bladder Cancer

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 728
Author(s):  
Jeong-Hyouk Choi ◽  
Koo-Han Yoo ◽  
Dong-Gi Lee ◽  
Gyeong-Eun Min ◽  
Gou-Young Kim ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Metastatic Lymph Node ◽  
Imaging Study ◽  
Surgical Excision ◽  
The Body ◽  
Pathological Examination ◽  
Cystic Tumor ◽  
Complete Surgical Excision ◽  
Ultrasound Computed Tomography ◽  
Retroperitoneal Schwannoma

Background and Objectives: Retroperitoneal schwannoma is a very rare case of schwannoma which commonly occurs in the other part of the body. However, it is difficult to distinguish schwannoma from other tumors before pathological examination because they do not show specific characteristics on imaging study such as ultrasound, computed tomography (CT), and magnetic resonance image (MRI). Case summary: A 60-year-old male showed a retroperitoneal cystic tumor which is found incidentally during evaluation of coexisted bladder tumor. Neurogenic tumor was suspicious for the retroperitoneal tumor through pre-operative imaging study. Finally, a schwannoma was diagnosed by immunohistochemical examination after complete surgical excision laparoscopically. Conclusion: As imaging technology is developed, there may be more chances to differentiate schwannoma from other neoplasm. However, still surgical resection and histopathological examination is feasible for diagnosis of schwannoma.

scholarly journals A Rare Cause of the Cough: Primary Small Cell Carcinoma of Esophagus—Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Erdal Yekeler ◽  
Timur Koca ◽  
Semra Vural
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Histopathological Examination ◽  
Hepatic Metastases ◽  
Endoscopic Examination ◽  
Small Cell ◽  
Carcinoma Of The Esophagus ◽  
Carcinoma Of Esophagus ◽  
Chest X Ray ◽  
Rare Malignancy

Primary small cell carcinoma of the esophagus is a relatively rare malignancy. It is highly progressive and poorly prognostic in untreated conditions. In the western populations, the rate of primary small cell carcinoma in all esophageal cancer types is between 0.05% and 2.4%, while it is endemically increasing up to 7.6% in the eastern populations. Most of the cases are in extensive stage at the time of diagnosis. Surgery is the treatment of choice in limited stages, but treatment must be multimodal in primary small cell carcinoma of the esophagus. A 47-year-old woman was referred to our clinic with gradually increasing severe dry cough and slight difficulty in swallowing for 20 days. Chest X-ray graphy was normal, and computed tomography of the chest showed multiple mediastinal lymph nodes and hepatic metastases. Her endoscopic examination revealed an endoluminal vegetative mass between 20 cm and 23 cm of her esophagus. The case was reported as small cell carcinoma of the esophagus on histopathological examination. The case was assumed inoperable, and chemotherapy and radiotherapy were planned. We presented a rare cause of the cough and primary esophageal small cell carcinoma in this paper.

Effect of a moustache on nasal Staphylococcus aureus colonisation and nasal cytology results in men

2015 ◽  
Vol 129 (2) ◽  
pp. 155-158 ◽  
Author(s):  
E Soylu ◽  
I Orhan ◽  
A Cakir ◽  
A Istanbullu ◽  
G Altin ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Control Group ◽  
Study Group ◽  
Left Nasal Cavity ◽  
Adult Men ◽  
Nasal Cytology ◽  
Non Allergic Rhinitis

AbstractObjective:This study compared the results of nasal Staphylococcus aureus carriage and nasal cytology in men with and without a moustache.Methods:The study group comprised 118 adult men with a moustache, and the control group consisted of 123 adult men without a moustache. Samples were taken from the participants' right nasal cavity for cytology and from the left nasal cavity for microbiology.Results:The results for S aureus were positive in 19.5 per cent (n = 23) of participants with a moustache and in 20.3 per cent (n = 25) of men without a moustache. This difference was not significant (p > 0.05). However, nasal cytology revealed rich eosinophil clusters in participants with a moustache.Conclusion:The presence or absence of a moustache had no effect on nasal S aureus colonisation. However, further research is needed to understand whether the presence of a moustache increases the risk of allergic or non-allergic rhinitis.

Primary nasal cavity Ewing’s sarcoma in pediatric practice: A clinical case

2021 ◽  
Vol 59 (1) ◽  
pp. 39-42
Author(s):  
А. Bekisheva ◽  
A. Makhneva ◽  
E. Satbaeva ◽  
G. Abyov ◽  
M. Remkulova
Keyword(s):  
Nasal Cavity ◽  
Clinical Case ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Histopathological Examination ◽  
Neck Region ◽  
Diagnostic Techniques ◽  
Tumor Type ◽  
Head And Neck Region ◽  
Tumor Remission

Ewing’s sarcoma is an aggressive tumor rarely found in the head and neck region and extremely rare in the nasal cavity or paranasal sinuses (2-3% of all Ewing’s sarcomas). Purpose: The article presents a clinical diagnostic case of nasal cavity Ewing’s sarcoma finally verified only by IHC test. Results: The presented clinical case describes Ewing’s sarcoma of the nasal cavity in a 14-year-old girl and presents the clinical picture, the results of MRI and CT examination of the sinuses, histopathological and IHC tests. Adequate diagnostical tools made it possible to establish a diagnosis. Timely determined treatment tactics, taking into account the tumor localization and possible postoperative complications, led to tumor remission. At present, the patient is under dynamic observation. Conclusion: The presented clinical case confirms that a primary nasal cavity Ewing’s sarcoma diagnostic largely depends on histopathological examination since visual diagnostic techniques do not provide reliable information on the tumor type.

Histopathological Study of Lesions of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in a Tertiary Care Centre, Visakhapatnam over a Period of 2 Years

2021 ◽  
Vol 8 (33) ◽  
pp. 3054-3059
Author(s):  
Rajendra Prasad Jagannadham ◽  
Lakshmi Latchupatula ◽  
Sravani Ponnada ◽  
Neelima Lalam ◽  
Raghunadhababu Gudipudi ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Malignant Tumours ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Male Predominance

BACKGROUND A variety of non - neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasopharynx and these are very common lesions encountered in clinical practice. Histopathological examination of these lesions is the gold standard for diagnosis because management and prognosis vary among different lesions. The aim of the present study was to evaluate the histopathological study of the lesions of the nasal cavity, paranasal sinuses and nasopharynx in relation to their incidence, age, gender and site wise distribution and to compare the results with the available data. METHODS A study of 88 cases was conducted for a period of 2 years from August 2017 to July 2019. After fixation, Processing and Haematoxylin and Eosin staining and special stains histopathological diagnosis was made. RESULTS Among 88 total cases, 58 were males and 30 were females. A male predominance was observed with a male to female ratio of 1.93 : 1. They were more common in third, fourth and fifth decade of life. Malignant nasal lesions were seen after fourth decade of life. Nasal lesions were more common in nasal cavity (67.05 %), followed by paranasal sinuses (18.18 %) and nasopharynx (14.75). Out of 88 total cases, 39 (44.32 %) were non - neoplastic, 30 (34.09 %) were benign and 19 (21.59 %) were malignant nasal lesions. CONCLUSIONS Sinonasal lesions and nasopharyngeal lesions can have various differential diagnoses. A complete clinical, radiological and histopathological correlation helps to categorize these sinonasal lesions into various non - neoplastic and neoplastic types. But histopathological examination remains the mainstay of definitive diagnosis. KEYWORDS Nasal Cavity, Paranasal Sinuses, Nasopharynx, Benign Tumours, Malignant Tumours, Histopathological Examination

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