scholarly journals Polyfunctional antiallergic potencies of Д-antihistamine levocetirizine

2014 ◽  
Vol 11 (2) ◽  
pp. 11-24
Author(s):  
I S Gushchin
Keyword(s):  
Public Health ◽  
Allergic Rhinitis ◽  
Public Health Problem ◽  
Receptor Occupancy ◽  
Allergic Diseases ◽  
Therapeutic Benefit ◽  
Efficacy And Safety ◽  
Adults And Children ◽  
Anti Inflammatory

The burden of allergic diseases worldwide is such that it represents a serious public health problem that attracts considerable efforts to identify effective and safe therapies. Antihistamines are an important part of the therapeutic options for allergic diseases. Levocetirizine is the R-enantiomer of cetirizine with pharmacokinetically and pharmacodynamically favourable characteristics. It is a potent inverse agonist of H 1-receptors with anti-inflammatory/anti-allergic properties. It appears to have grater in vivo H 1-receptor occupancy comparatively with other 2 nd generation H 1-antihistamines. This may confer an advantageous efficacy and safety profile. clinical trials indicate that it is safe and effective for the treatment of allergic rhinitis, chronic urticaria and some other allergic conditions in adults and children with a minimal number of untoward reactions. It is also becoming clearer that, in addition to its being a potent antihistamine, levocetirizine has several anti-inflammatory/anti-allergic effects that are observed at clinically relevant concentrations that may enhance its therapeutic benefit.

scholarly journals ASCIA-P33: TH2 NEUTRALIZATION AND IN VIVO ANTI-INFLAMMATORY ACTION OF PENTOSAN POLYSUPHATE SODIUM (PPS) IN AN ALLERGIC RHINITIS MODEL

2016 ◽  
Vol 46 ◽  
pp. 15-15
Author(s):  
Michiko Mori ◽  
Prajakta Jogdand ◽  
Caroline Sanden ◽  
Jimmie Jönsson ◽  
Ravi Krishnan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Anti Inflammatory ◽  
Inflammatory Action

scholarly journals Anti-Inflammatory Activities of Pentaherbs formula and Its Influence on Gut Microbiota in Allergic Asthma

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2776 ◽  
Author(s):  
Miranda Tsang ◽  
Sau-Wan Cheng ◽  
Jing Zhu ◽  
Karam Atli ◽  
Ben Chan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Allergic Asthma ◽  
Herbal Medicines ◽  
Oral Intake ◽  
Allergic Diseases ◽  
Short Chain Fatty Acids ◽  
Mice Model ◽  
Anti Inflammatory

Allergic asthma is a highly prevalent airway inflammatory disease, which involves the interaction between the immune system, environmental and genetic factors. Co-relation between allergic asthma and gut microbiota upon the change of diet have been widely reported, implicating that oral intake of alternative medicines possess a potential in the management of allergic asthma. Previous clinical, in vivo, and in vitro studies have shown that the Pentaherbs formula (PHF) comprising five traditional Chinese herbal medicines Lonicerae Flos, Menthae Herba, Phellodendri Cortex, Moutan Cortex, and Atractylodis Rhizoma possesses an anti-allergic and anti-inflammatory potential through suppressing various immune effector cells. In the present study, to further investigate the anti-inflammatory activities of PHF in allergic asthma, intragastrical administration of PHF was found to reduce airway hyperresponsiveness, airway wall remodeling and goblet cells hyperplasia in an ovalbumin (OVA)-induced allergic asthma mice model. PHF also significantly suppressed pulmonary eosinophilia and asthma-related cytokines IL-4 and IL-33 in bronchoalveolar lavage (BAL) fluid. In addition, PHF modulated the splenic regulatory T cells population, up-regulated regulatory interleukin (IL)-10 in serum, altered the microbial community structure and the short chain fatty acids content in the gut of the asthmatic mice. This study sheds light on the anti-inflammatory activities of PHF on allergic asthma. It also provides novel in vivo evidence that herbal medicines can ameliorate symptoms of allergic diseases may potentially prevent the development of subsequent atopic disorder such as allergic asthma through the influence of the gut microbiota.

Efficacy and safety of the antileukotriene drugs: relevant data. RAACI experts conclusion

2020 ◽  
Vol 17 (3) ◽  
pp. 121-129
Author(s):  
Natalya I. Il`ina ◽  
Oksana M. Kurbacheva ◽  
Natalya M. Nenasheva ◽  
Natalya G. Astafieva ◽  
Evgenij K. Beltyukov ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Adverse Events ◽  
Bronchial Asthma ◽  
Drug Administration ◽  
Expert Opinion ◽  
Adverse Reactions ◽  
Efficacy And Safety ◽  
The World ◽  
Adults And Children ◽  
Expert Commission

In many countries of the world and in Russia, in particular, the pharmacological use of antagonists of cysteinyl receptors LT1 (CysLTR) is a long-proven and well-proven pharmacotherapy of bronchial asthma (BA) and allergic rhinitis (AR) in adults and children. Among antileukotriene drugs the most commonly used medication for the treatment of these diseases is the original montelukast, which is considered a safe drug associated with the appearance of only a few adverse reactions, usually not differing in type and frequency from those that occur with placebo. Currently, there are a large number of generics of montelukast, therefore, practitioners have many questions regarding the benefits and risks of montelukast therapy for patients with BA and AR. In 2020 FDA (Food and Drug Administration USA) analyzed the risk of adverse events during Montelukast treatment and indicated them on the packaging of the drug (original montelukast and its generics). This contributed to the creation of an expert commission to study this issue and form an expert opinion, which is demonstrated in our publication.

Emergency department patients’ perceptions of the efficacy and safety of opioid analgesics

2020 ◽  
Vol 16 (4) ◽  
pp. 239-246
Author(s):  
Maryann Mazer-Amirshahi, PharmD, MD, MPH, PhD ◽  
Christie Sun, MD ◽  
Lydia Koroshetz, BS ◽  
Rui W. Soares Jr, BS ◽  
Anagha Kumar, MS, MA, MBA ◽  
...  
Keyword(s):  
Public Health ◽  
Emergency Department ◽  
Prescription Drug ◽  
Health Problem ◽  
Media Coverage ◽  
Public Health Problem ◽  
Prescription Opioid ◽  
Efficacy And Safety ◽  
Cross Sectional ◽  
Convenience Sample

Introduction: Emergency department (ED) providers are on the forefront of the prescription drug crisis and understanding patient’s perceptions of opioids may allow physicians to better address misconceptions. The aim was to determine the perceptions of ED patients regarding the efficacy and safety of opioid analgesics.Methods: Cross-sectional study of a convenience sample of adults at a single urban academic ED. Patients completed a tablet-based survey regarding the efficacy and safety of opioid analgesics.Results: Of the 715 subjects, the sample was predominantly black (80.4 percent), female (59.2 percent), and aged 18-59 years (76.8 percent). The majority (70.1 percent) of respondents reported pain as the reason for visit. Seventy-two percent had previously taken an opioid primarily for acute pain, found them effective for pain (88.2 percent), and would be willing to do so again (62.7 percent). Adverse effects made patients less likely to use them again (OR 0.703, [0.659-0.751]). Gender and age did not affect perceptions of efficacy and safety, but certain racial groups did (OR 1.08, [1.02 to 1.14], p 0.05). Knowing someone who used opioids in a nonmedical manner did not impact willingness to use opioids. Many (54 percent) believed opioids to be as safe as nonopioid alternatives. The majority (78 percent) considered prescription opioid abuse a public health problem, however underestimated the number of annual opioid-related deaths.Conclusion: The majority of ED patients had used opioids and considered the prescription drug crisis a public health problem. Through personal use or media coverage, the majority of participants considered opioids safe, even compared to nonopioid alternatives. Better understanding these viewpoints may improve patient–physician communication about analgesic treatment.

scholarly journals A comparative study to assess the efficacy and safety of bepotastine and cetirizine in allergic rhinitis

2019 ◽  
Vol 8 (10) ◽  
pp. 2304
Author(s):  
A. T. Priyanka ◽  
K. R. Mamatha ◽  
G. M. Puttamadaiah
Keyword(s):  
Allergic Rhinitis ◽  
Symptom Score ◽  
Therapeutic Benefit ◽  
Efficacy And Safety ◽  
Open Label ◽  
Effective Treatment Option ◽  
Over The Counter ◽  
Once Daily ◽  
Group A ◽  
Group B

Background: Pharmacotherapy is the mainstay of allergic rhinitis and many caregivers use over-the-counter antihistamines. Bepotastine is a novel oral second generation non-sedative antihistamine and an effective treatment option for allergic rhinitis. The objectives of the present study were to evaluate the efficacy and safety of bepotastine versus cetirizine an over the counter drug.Methods: A prospective, randomized, open-label, parallel-group study was conducted among 60 patients fulfilling the inclusion and exclusion criteria. Group A (n=30) received tablet cetirizine 10 mg once daily and Group B (n=30) received tablet bepotastine 10 mg once daily. Efficacy was assessed by mean change in total symptom score (TSS) which is the sum of total nasal symptom score and total ocular symptom score at the end of two weeks from baseline.Results: At the end of two weeks of treatment, both groups showed statistically significant (p<0.005) improvements from their baseline TSS. Mean TSS was reduced from12.36±2.12 to 4.2±1.66 in group A and from 13.33±3.039 to 3.033±1.40 in Group B. Significant statistical difference in TSS was seen more in Group B than Group A (p<0.005).Conclusions: Both the groups showed a substantial therapeutic benefit in patients with allergic rhinitis, however bepotastine is more effective. 

scholarly journals Sublingual immunotherapy in allergic rhinitis: indications, efficacy and safety

2013 ◽  
Vol 51 (1) ◽  
pp. 9-17
Author(s):  
H.H. Kariyawasam ◽  
G. Rotiroti ◽  
D.S. Robinson
Keyword(s):  
Allergic Rhinitis ◽  
Medical Treatment ◽  
Clinical Efficacy ◽  
Systematic Reviews ◽  
Sublingual Immunotherapy ◽  
Therapeutic Benefit ◽  
Recent Analysis ◽  
Efficacy And Safety ◽  
Attractive Option ◽  
Established Treatment

Sublingual immunotherapy (SLIT) is now an established treatment for allergic rhinitis. Whilst several systematic reviews have now confirmed clinical efficacy and safety, recent analysis also confirms that therapeutic benefit persists for several years after the com- pletion of SLIT. Such findings, along with the obvious ease of administration of sublingual preparations, have clearly promoted SLIT as an attractive option for treatment of allergic rhinitis resistant to medical treatment. This article reviews the development, efficacy and safety of SLIT in allergic rhinitis and the current indications for its use.

scholarly journals Prevalence of Overweight and Obesity in 6–7-Year-Old Children—A Result of 9-Year Analysis of Big City Population in Poland

2020 ◽  
Vol 17 (10) ◽  
pp. 3480 ◽  
Author(s):  
Joanna Szczyrska ◽  
Agnieszka Jankowska ◽  
Michał Brzeziński ◽  
Marek Jankowski ◽  
Paulina Metelska ◽  
...  
Keyword(s):  
Public Health ◽  
Body Weight ◽  
Public Health Problem ◽  
Overweight And Obesity ◽  
Excess Body Weight ◽  
Anthropometric Parameters ◽  
Regular Screening ◽  
City Population ◽  
Big City ◽  
Adults And Children

Excess body weight is a serious public health problem, which affects both adults and children. Unfortunately, the prevalence of excess body weight in children in Poland is not subject to any regular screening. The aim of this study was to analyze the prevalence of overweight and obesity in 6–7-year-old children in the municipality of Gdańsk in the years 2008–2016. The anthropometric parameters of 12,330 children (49.55% girls and 50.45% boys) with a mean age of 6.53 ± 0.38 years were analyzed. The prevalence of overweight was 7.49% (7.91% girls and 7.07% boys) and obesity 4.24% (4.47% girls and 3.99% of boys). There was no difference in the prevalence of neither overweight nor obesity between boys and girls (p = 0.076). However, the prevalence of overweight and obesity combined is higher in girls (12.38% vs. 11.06%, p = 0.023). There were no statistically significant differences in the prevalence of overweight and obesity neither in the group of girls nor in the group of boys in children aged 6–7 years in yearly cohorts examined between 2008 and 2016. The prevalence of excess body weight in this population is at a stable level.

scholarly journals Inhibition of Angiogenic Factor Productions by Quercetin In Vitro and In Vivo

Medicines ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 22
Author(s):  
Takayuki Okumo ◽  
Atsuko Furuta ◽  
Tarou Kimura ◽  
Kanako Yusa ◽  
Kazuhito Asano ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Growth Factor ◽  
Mast Cells ◽  
Allergic Diseases ◽  
Angiogenic Factors ◽  
Nasal Lavage ◽  
Angiogenic Factor ◽  
Factor Secretion

Background: Angiogenesis is well known to be an important event in the tissue remodeling observed in allergic diseases. Although there is much evidence that quercetin, one of the most abundant dietary flavonoids, exerts anti-allergic effects in both human and experimental animal models of allergic diseases, the action of quercetin on angiogenesis has not been defined. Therefore, in this study, we first examined the action of quercetin on the secretion of angiogenic factors from murine mast cells in vitro. We also examined the action of quercetin on angiogenic factor secretion in the murine allergic rhinitis model in vivo. Methods: Mast cells (1 × 105 cells/mL) sensitized with ovalbumin (OVA)-specific murine IgE were stimulated with 10.0 ng/mL OVA in the presence or the absence of quercetin for 24 h. The concentrations of angiogenic factors, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), tumor necrosis factor-α, IL-6 and IL-8 in the supernatants were examined by ELISA. BALB/c male mice immunized with OVA were challenged intranasally with OVA every other day, starting seven days after the final immunization. These mice were then orally administered quercetin once a day for five days, starting seven days after the final immunization. Clinical symptoms were assessed by counting the number of sneezes and nasal rubbing behaviors during the 10 min period just after OVA nasal provocation. The angiogenic factor concentrations in the nasal lavage fluids obtained 6 h after nasal antigenic provocation were examined by ELISA. Results: Quercetin significantly inhibited the production of angiogenetic factors induced by IgE-dependent mechanisms at 5.0 µM or more. Oral administration of 25.0 mg/kg quercetin into the mice also suppressed the appearance of angiogenetic factors in nasal lavage fluids, along with the attenuation of nasal symptoms. Conclusions: These results strongly suggest that the inhibitory action of quercetin on angiogenic factor secretion may be implicated in the therapeutic action of quercetin on allergic diseases, especially allergic rhinitis.

scholarly journals In Vivo Anti-Inflammatory Effect of H1 Antihistamines in Allergic Rhinitis: A Randomized Clinical Trial

2015 ◽  
Vol 32 (4) ◽  
pp. 352-358 ◽  
Author(s):  
Corina I. Bocsan ◽  
Adriana I. Bujor ◽  
Nicolae Miron ◽  
Stefan C. Vesa ◽  
Diana Deleanu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Allergic Rhinitis ◽  
Randomized Clinical Trial ◽  
H1 Antihistamines ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Warifteine, an Alkaloid Purified fromCissampelos sympodialis, Inhibits Neutrophil MigrationIn VitroandIn Vivo

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Thaline F. A. Lima ◽  
Juliana D. B. Rocha ◽  
Anderson B. Guimarães-Costa ◽  
José M. Barbosa-Filho ◽  
Débora Decoté-Ricardo ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Neutrophil Migration ◽  
Allergic Diseases ◽  
Neutrophil Function ◽  
Intracellular Camp ◽  
Cell Adhesion And Migration ◽  
Anti Inflammatory ◽  
And Migration

Cissampelos sympodialisEichl is a plant from the Northeast and Southeast of Brazil. Its root infusion is popularly used for treatment of inflammatory and allergic diseases. We investigated whether warifteine, its main alkaloid, would have anti-inflammatory effect due to a blockage of neutrophil function.In vivowarifteine treatment inhibited casein-induced neutrophil migration to the peritoneal cavity but did not inhibit neutrophil mobilization from the bone marrow. Analysis of the direct effect of warifteine upon neutrophil adherence and migrationin vitrodemonstrated that the alkaloid decreased cell adhesion to P and E-selectin-transfected cells. In addition, fLMP-induced neutrophil migration in a transwell system was blocked by warifteine; this effect was mimicked by cAMP mimetic/inducing substances, and warifteine increased intracellular cAMP levels in neutrophils. The production of DNA extracellular traps (NETs) was also blocked by warifteine but there was no alteration on PMA-induced oxidative burst or LPS-stimulated TNFαsecretion. Taken together, our data indicate that the alkaloid warifteine is a potent anti-inflammatory substance and that it has an effect on neutrophil migration through a decrease in both cell adhesion and migration.

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