scholarly journals PECULIARITIES OF TREATMENT OF PATIENTS WITH ONYCHOMYCOSIS WITH CONTRAINDICATIONS TO SYSTEMIC ANTIMYCOTICS

2021 ◽  
Vol 74 (9) ◽  
pp. 2070-2075
Author(s):  
Kseniia Suprun ◽  
Yanina Kutasevych ◽  
Iryna Oliinyk ◽  
Oleksii Bilozorov ◽  
Iryna Mashtakova ◽  
...  
Keyword(s):  
Molecular Genetic ◽  
Comorbid Conditions ◽  
Medical Sciences ◽  
Clinical Form ◽  
Group I ◽  
Genetic Examination ◽  
Group Ii ◽  
Hydrochloride Solution ◽  
Positive Results ◽  
Overall Effectiveness

The aim: To increase the effectiveness of treatment of patients with onychomycosis with contraindications to administration of systemic antifungal therapy. Materials and methods: The study involved 63 patients with onychomycosis of the toes aged 18 to 72 years under supervision at the clinic of the Institute of Dermatology and Venereology of the National Academy of Medical Sciences of Ukraine, who were divided into groups: Group I (30 patients) received naftifine hydrochloride solution and cream; Group II (33 patients) additionally used nail kit mycosan and cytoflavin 2 tablets 2 times a day for 1-1.5 months.The study implied microscopic and molecular genetic examination of nail plates before treatment and starting from the 4th week every 2 weeks. The study included patients with onychomycosis with positive results of both microscopic and PCR studies. Mycological recovery was noted in case of coincidence of results of these studies. Results: Mycological recovery in patients of Group II began in the sixth week in 6.3% and occurred in 100% of cases at the 24th week of treatment, depending on the severity and clinical form. The overall effectiveness of therapy at the 48th week reached 56.7% in Group I and 72.7% in Group II. Conclusions: The developed method of treatment, which includes the use of naftifine hydrochloride solution and cream, nail kit micozan and cytoflavin, allows to achieve clinical and mycological recovery in 72.7% of patients and is a priority in the treatment of patients with onychomycosis with comorbid conditions.

scholarly journals Effect of Fiber Rich Product on Childhood Obesity and Lipid Profile Aged 10-12 Years

2021 ◽  
Vol 9 (3) ◽  
pp. 87-90
Author(s):  
A. Jyoth ◽  
Keyword(s):  
Exercise Group ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Diet Survey ◽  
Group Ii ◽  
And Control ◽  
Experimental Group ◽  
Positive Results ◽  
Green Peas

The effect of fiber rich product on child hood obesity studied with 60 sample which were collected randomly among 10-12 years and categorized into 2 groups i.e, experimental group and control group. Experimental group further categorized into three groups i.e, supplementation with exercise (n=15), only supplementation group (n=15), only exercise group (n=15) and control group consists of (n=15).Anthropometric, and diet survey conducted as parameters. A fiber rich product was prepared and supplemented for 2 months to the selected subjects and it consists of whole Bengal gram, whole green gram, green peas, barley and jaggery. Positive results were obtained in three experimental groups. Significant decrease observed inweight, and BMI, Total cholesterol, Triglycerides, LDL, VLDL significant increase observed in HDL in group I II and III. The results were (51.60-48.26kg, 24.7-23.1, 195.2-152.3 mg/dl, 168.2-145.0 mg/dl, 52.2-54.13 mg/dl, 109.4- 69.4mg/dl, 33.6-28.7mg/dl) in group I, In group II the results are (50.3-49.86kg, 23.7-23.4, 168.6-161.0mg/dl, 145.4-129.6mg/dl, 44.2-45.2 mg/dl, 95.3-90.0mg/dl, 29.1-28.3mg/dl).In group III the tesults aere (50.7-49.6kg, 24.5-23.9, 143.2-139.3mg/dl, 139-134.5mg/dl, 38.2-38.7mg/dl 76.8-74.1 mg/dl, 25.6-28.1mg/dl) .From the results it was clear that when compared to group II and III group I has shown better results.

scholarly journals Outcome of babies admitted with hypoxic-ischemic encephalopathy in Neonatal Unit of Services Hospital, Lahore

2016 ◽  
Vol 12 (2) ◽  
Author(s):  
Muhammad Nasir Rana ◽  
Muhammad Yakoob Kazi ◽  
Ambreen Nasir ◽  
Muhammad Abbas
Keyword(s):  
Congenital Anomaly ◽  
Apgar Score ◽  
Descriptive Study ◽  
Neonatal Unit ◽  
Advanced Technology ◽  
Medical Sciences ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Ischemic Encephalopathy

Objectives: To determine the outcome of newborns, admitted with different stages of HIE in Neonatal Unit, Services Hospital, Lahore. Study design: Descriptive Study. Place and duration of study: Neonatology Section, Pediatrics Department, Services Institute of Medical Sciences (SIMS) / Services Hospital, Lahore. Over a period of Six months, from 1st August 2005 to 31st January 2006. Material & methods: A total of 170 newborns having Apgar score less than 7 were included in the study. Babies with any congenital anomaly were excluded. Results: 80% were males. 17.64% had weight less than 1.5 Kg, 37.06% weight between 1.5 Kg to 2.5 Kg and 45.29% had weight more than 2.5 Kg. 90.5% of our babies were delivered in Services Hospital, Lahore. 77.64% babies were full term. Babies were divided into three groups; Group-I had Apgar score 0-3, Group-II between 4 & 5 and Group-III had Apgar score 6-7. In Group-I, 65% babies died, whereas 100% had any one of the complications, in Group-II, there were 22% deaths and no baby died from Group-III. Conclusions: Despite advanced technology, a high number of babies have HIE and its complications. It is better to prevent babies from HIE, because once HIE occur, you cannot save babies completely from its complications.

scholarly journals Effect of anticoagulant and antiplatelet agents on outcome of AV Fistula made for hemodialysis access

2012 ◽  
Vol 1 (2) ◽  
pp. 93-96
Author(s):  
N Yogi ◽  
M Baxi ◽  
J Baxi ◽  
GB Acharya ◽  
NK Hazra
Keyword(s):  
Antiplatelet Agents ◽  
Complication Rates ◽  
Hemodialysis Access ◽  
Medical Sciences ◽  
Av Fistula ◽  
Group I ◽  
Analysis Of Results ◽  
Group Ii ◽  
Age And Sex

Background: Arteriovenous fistula (AVF) is the primary mode of achieving vascular access for hemodialysis in chronic renal failure (CRF). Because of high complication rates like thrombosis, maintenance of the fistula is a major challenge. Although antiplatelets and anticoagulants are emerging rapidly for improving the outcome of AVF but fear of bleeding, hematoma, subsequent compression of AV fistula and blockade restrict their use in many dialysis centers. Methods: Seventy five patients for whom AVF was created for hemodialysis access from Feb 2005-April 2009 in Manipal Teaching Hospital, Pokhara, Nepal were included in a retrospective study. Analysis of results was done in two different age and sex matched groups; Group I had patients where no anticoagulants or antiplatelets were used and Group II had patients in which antiplatelets/anticoagulants were used. Results: There were 27 patients in group I and 48 patients in group II. Both the groups were followed up till 2 years post operatively to check for the patency of the fistula. AV fistula was repeated in 16 cases altogether. In group II there were 5 (10%) cases of repeat fistula while in group I it was repeated in 11 (40%) cases. Conclusion: Judicious use of antiplatelet/anticoagulant agents in cases of AVF for hemodialysis access can be beneficial in preventing the chances of occlusion of AVF and thus helps in its long term patency. DOI: http://dx.doi.org/10.3126/njms.v1i2.6607 Nepal Journal of Medical Sciences. 2012;1(2): 93-6

Autosomal STR loci involved in exclusion during kinship expertise in the population of the Tyumen region

2021 ◽  
Vol 22 (2) ◽  
pp. 17-19
Keyword(s):  
Capillary Electrophoresis ◽  
Genetic Study ◽  
Molecular Genetic ◽  
Molecular Genetic Study ◽  
Str Loci ◽  
Autosomal Str ◽  
Group I ◽  
Group Ii ◽  
Its Polymorphism

Aim. To conduct an analysis of STR-loci in cases of exclusion during the paternity expertise, analyze the distribution of their frequencies. Materials and methods. 364 paternity expertises (non-exclusion and exclusion) were studied, in which a molecular genetic study of the blood of all participants was carried out by the method of capillary electrophoresis. Results. Paternity was excluded out of 364 examinations in 72 cases. Of these, in 68 cases, samples for research were taken from the mother, the alleged father and the child. Groups I and II were formed. Group I included examinations in which both the mother and the child were born in the Tyumen region (53 cases). Group II included examinations in which either the mother or the child was born outside the Tyumen region (15 cases). The frequency of distribution of the loci involved in exclusion and the most frequent alleles among those found were determined. Conclusion. It was found that the role of a locus in exclusion cases does not directly depend on its polymorphism and / or frequency of mutations. Establishing the loci most often involved in excluding kinship allows the use of predominantly such more informative loci or panels containing such loci when investigating kinship in a particular geographic locality.

scholarly journals Obesity and the levels of liver enzymes (ALT, AST & GGT) in East Medinipur, India

2014 ◽  
Vol 6 (1) ◽  
pp. 40-42 ◽  
Author(s):  
Ajay Kumar Das ◽  
Prasanna Chandra ◽  
Akash Gupta ◽  
Naved Ahmad
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Liver Enzymes ◽  
Medical Sciences ◽  
Significant Relation ◽  
Group Iii ◽  
Common Disorder ◽  
Group I ◽  
Group Ii

Objective Obesity is a common disorder in our country. Most widely used method to gauge obesity is Body Mass Index (BMI) which is equal to weight in kilogram divided by height in meter square. The objective of our study was to find the levels of liver enzymes ALT, AST & GGT in two groups (overweight individuals and obese individuals). Methods: A total no of 156 individuals were selected for the study and they were categorized into three groups on the basis of BMI- Group I Normal, BMI 18.5 to 24.9 (n=72), Group II Overweight, BMI 25.0 to 29.9 (n=39) and Group III Obese, BMI >30 (n=45). Serum ALT, AST & GGT were estimated by Accurex AC 112 plus semi auto analyser and values were given in U/L. Results: Values of ALT, AST & GGT were with in the normal references range in all the three groups. Conclusion: No significant relation was found between ALT, AST & GGT in normal, overweight and obese individuals. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10147 Asian Journal of Medical Sciences Vol.6(1) 2015 40-42

scholarly journals Evaluation of accuracy of transvaginal ultrasound in lower uterine segment caesarean scar integrity and histomorphometric analysis of scar tissue: a prospective study

2020 ◽  
Vol 9 (12) ◽  
pp. 4874
Author(s):  
Simmi Salim ◽  
Biju Parameswaran ◽  
Deepthi Balakrishnan
Keyword(s):  
Transvaginal Ultrasound ◽  
Scar Tissue ◽  
Lower Uterine Segment ◽  
Transvaginal Sonography ◽  
Histomorphometric Analysis ◽  
Medical Sciences ◽  
Caesarean Scar ◽  
Group I ◽  
Group Ii ◽  
A Prospective Study

Background: Caesarean section is the most common method of delivery in the present conditions. The present study conducted to evaluate the accuracy of transvaginal ultrasound in lower uterine segment caesarean scar integrity and histomorphometric analysis of scar tissue.Methods: The study was conducted in the department of OBG, SUT academy of medical sciences, Vattapara, Trivandrum, Kerala. Based on the inclusion and exclusion criteria a total of 144 patients were included in the study. All patients explained study procedure and informed consent was obtained. They were subjected to transvaginal ultrasound examination after that small piece of scar tissue was taken and used for histomorphic analysis. The data was analysed by SPSS (16.0) version used.Results: In group-I 31.11% showed 40 and above fibrosis and group-II 85.0% had fibrosis 40 and above. 8 in group-I showed 0-19% of fibrosis and 17 in group-II. 0-19% whereas vicryl had a range of 0-40% and above and the rate of fibrosis compared to transvaginal sonography not showed significant difference.Conclusions: Histomorphological analysis of scar tissue gave accurate results and it was similar to transvaginal ultrasonography results.

scholarly journals A comparative study between amoxicillin + clavulanic acid and levofloxacin in the management of acute maxillary sinusitis at RIMS, Ranchi

2017 ◽  
Vol 4 (1) ◽  
pp. 185
Author(s):  
Sandeep Kumar ◽  
Abha Kumari
Keyword(s):  
Clavulanic Acid ◽  
Maxillary Sinusitis ◽  
Medical Sciences ◽  
Oral Amoxicillin ◽  
Group I ◽  
Amoxicillin Clavulanate ◽  
Amoxicillin Clavulanic Acid ◽  
The Mean ◽  
Group Ii ◽  
And Gender

<p class="abstract"><strong>Background:</strong> Acute rhinosinusitis is an acute viral or bacterial in which there is inflammation of the mucosa of the nose and paranasal sinuses. The aim of study was to compare the efficacy of oral amoxicillin-clavulanate with levofloxacin in the management of acute maxillary sinusitis.</p><p class="abstract"><strong>Methods:</strong> The present prospective study was conducted in the Department of ENT, Rajendra Institute of Medical Sciences, Ranchi during a period of 8 months i.e. from July 2016 to June 2017. In Group I patients 1 gm of amox­icillin-clavulanate was given two times a day and in Group II, 500 mg of Levo­floxicin was given once a day for a period of 10 days. Patient’s complete demographic details were recorded including name, age and gender. Xylometazoline nasal spray and steam inhalations were given to all the patients.  </p><p class="abstract"><strong>Results:</strong> The mean age of the subjects was 36.43±6.43 years. In both the groups, majority of the subjects were between 36-45 years of age. There were 34.7% (52) in Group I and 38.7% (n=58) in Group II who belonged to this age group. Least number of subjects was those aged more than 48 years. There were 88% subjects (n=132) in group I and 86% (n=129) subjects in Group II in whom complete resolution of symptoms was seen.</p><p><strong>Conclusions:</strong> From the above study we can conclude that both amoxicillin–clavulanic acid and levofloxacin are equally efficacious in managing cases of acute sinusitis. In this study there was no difference in the rate and duration of resolution amongst both the groups.</p>

scholarly journals A Study of Management of Primary Chalazion in Adults by Intralesional Injection of Triamcinolone Acetonide

2022 ◽  
Vol 9 (3) ◽  
pp. 22-25
Author(s):  
Idris Akbani
Keyword(s):  
Triamcinolone Acetonide ◽  
Intralesional Injection ◽  
Repeated Injection ◽  
Medical Sciences ◽  
Group I ◽  
Meibomian Glands ◽  
Group Ii ◽  
Considerable Size

Abstract Introduction A chalazion is a common non-effective granuloma of the meibomian glands of eyelids. They are commonly found on the tarsal conjunctival surface and the eyelid margins. It may be ignored by the patients until it reaches a considerable size. Recently the use of intralesional corticosteroids has shown promising results. We in the present study tried to evaluate the outcomes of intralesional triamcinolone acetonide injection in the management of Chalazion. Methods The current study was carried on Patients with chalazion attending Ophthalmology OPD of Rajiv Gandhi Institute of Medical Sciences, [RIMS], Adilabad. Successive patients with small multiple marginal chalazia were included. Patients were selected based on the amenability of treatment with intralesional triamcinolone acetonide injections. A chalazion is a common non-infective granuloma of the meibomian glands of eyelids. They are commonly found on the tarsal conjunctival surface and the eyelid margins. It may be ignored by the patients until it reaches a considerable size. Recently the use of intralesional corticosteroids has shown promising results. We in the present study tried to evaluate the outcomes of intralesional triamcinolone acetonide injection in the management of Chalazion. Results Group I with very small-sized chalazia< 5 mm out of n=22 included in Group I resolution after one week following treatment was found in 72.72%. Resolution following repeated injection after one week was found in 18.18%. In group II (chalazia size 5-7 mm) out of n=28 cases, 46.24% resolved after first injection and 39.28% cases resolved after the second injection and no resolution was found in 14.28% cases after one month. Conclusion Patients with small chalazia who are not amenable to incision and curettage intralesional triamcinolone acetonide injection appear to be a better option. Intralesional triamcinolone acetonide injections were found to be effective in resolving acute and sub-acute chalazia of soft to firm consistency irrespective of their duration.

Ultrastructural Lesions Produced by Alcohol and Sucrose in the Heart and Liver of C57BL Mice

1970 ◽  
Vol 28 ◽  
pp. 208-209
Author(s):  
K.K. SEKHRI ◽  
C.S. ALEXANDER ◽  
H.T. NAGASAWA
Keyword(s):  
Osmium Tetroxide ◽  
Male Mice ◽  
Alcohol Group ◽  
Group Iii ◽  
Group I ◽  
C57bl Mice ◽  
Group Ii

C57BL male mice (Jackson Lab., Bar Harbor, Maine) weighing about 18 gms were randomly divided into three groups: group I was fed sweetened liquid alcohol diet (modified Schenkl) in which 36% of the calories were derived from alcohol; group II was maintained on a similar diet but alcohol was isocalorically substituted by sucrose; group III was fed regular mouse chow ad lib for five months. Liver and heart tissues were fixed in 2.5% cacodylate buffered glutaraldehyde, post-fixed in 2% osmium tetroxide and embedded in Epon-araldite.

Heterogeneity and Immunochemical Properties of Anti-β2-glycoprotein I Autoantibodies

1998 ◽  
Vol 80 (09) ◽  
pp. 393-398 ◽  
Author(s):  
V. Regnault ◽  
E. Hachulla ◽  
L. Darnige ◽  
B. Roussel ◽  
J. C. Bensa ◽  
...  
Keyword(s):  
Fluid Phase ◽  
Anticardiolipin Antibodies ◽  
Dual Reactivity ◽  
Group Iii ◽  
Important Group ◽  
Epitope Specificity ◽  
Glycoprotein I ◽  
Group I ◽  
Group Ii ◽  
Sufficient Concentration

SummaryMost anticardiolipin antibodies (ACA) associated with antiphospholipid syndrome (APS) are directed against epitopes expressed on β2-glycoprotein I (β2GPI). Despite a good correlation between standard ACA assays and those using purified human β2GPI as the sole antigen, some sera from APS patients only react in the latter. This is indicative of heterogeneity in anti-β2GPI antibodies. To characterize their reactivity profiles, human and bovine β2GPI were immobilized on γ-irradiated plates (β2GPI-ELISA), plain polystyrene precoated with increasing cardiolipin concentrations (CL/β2GPI-ELISA), and affinity columns. Fluid-phase inhibition experiments were also carried out with both proteins. Of 56 selected sera, restricted recognition of bovine or human β2GPI occurred respectively in 10/29 IgA-positive and 9/22 IgM-positive samples, and most of the latter (8/9) were missed by the standard ACA assay, as expected from a previous study. Based on species specificity and ACA results, IgG-positive samples (53/56) were categorized into three groups: antibodies reactive to bovine β2GPI only (group I) or to bovine and human β2GPI, group II being ACA-negative, and group III being ACA-positive. The most important group, group III (n = 33) was characterized by (i) binding when β2GPI was immobilized on γ-irradiated polystyrene or cardiolipin at sufficient concentration (regardless of β2GPI density, as assessed using 125I-β2GPI); (ii) and low avidity binding to fluid-phase β2GPI (Kd in the range 10–5 M). In contrast, all six group II samples showed (i) ability to bind human and bovine β2GPI immobilized on non-irradiated plates; (ii) concentration-dependent blockade of binding by cardiolipin, suggesting epitope location in the vicinity of the phospholipid binding site on native β2GPI; (iii) and relative avidities approximately 100-fold higher than in group III. Group I patients were heterogeneous with respect to CL/β2GPI-ELISA and ACA results (6/14 scored negative), possibly reflecting antibody differences in terms of avidity and epitope specificity. Affinity fractionation of 23 sera showed the existence, in individual patients, of various combinations of antibody subsets solely reactive to human or bovine β2GPI, together with cross-species reactive subsets present in all samples with dual reactivity namely groups III and II, although the latter antibodies were poorly purified on either column. Therefore, the mode of presentation of β2GPI greatly influences its recognition by anti-β2GPI antibodies with marked inter-individual heterogeneity, in relation to ACA quantitation and, possibly, disease presentation and pathogenesis.

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