scholarly journals Obesity and the levels of liver enzymes (ALT, AST & GGT) in East Medinipur, India

2014 ◽  
Vol 6 (1) ◽  
pp. 40-42 ◽  
Author(s):  
Ajay Kumar Das ◽  
Prasanna Chandra ◽  
Akash Gupta ◽  
Naved Ahmad
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Liver Enzymes ◽  
Medical Sciences ◽  
Significant Relation ◽  
Group Iii ◽  
Common Disorder ◽  
Group I ◽  
Group Ii

Objective Obesity is a common disorder in our country. Most widely used method to gauge obesity is Body Mass Index (BMI) which is equal to weight in kilogram divided by height in meter square. The objective of our study was to find the levels of liver enzymes ALT, AST & GGT in two groups (overweight individuals and obese individuals). Methods: A total no of 156 individuals were selected for the study and they were categorized into three groups on the basis of BMI- Group I Normal, BMI 18.5 to 24.9 (n=72), Group II Overweight, BMI 25.0 to 29.9 (n=39) and Group III Obese, BMI >30 (n=45). Serum ALT, AST & GGT were estimated by Accurex AC 112 plus semi auto analyser and values were given in U/L. Results: Values of ALT, AST & GGT were with in the normal references range in all the three groups. Conclusion: No significant relation was found between ALT, AST & GGT in normal, overweight and obese individuals. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10147 Asian Journal of Medical Sciences Vol.6(1) 2015 40-42

scholarly journals The functional state of the system of immunological protection in traumatic disease in patients with an increased body mass index

2019 ◽  
Keyword(s):  
Body Mass Index ◽  
Multivariate Analysis ◽  
Body Mass ◽  
Functional State ◽  
Adaptation Mechanism ◽  
Group Iii ◽  
Functional Relationships ◽  
Group I ◽  
Group Ii ◽  
Immunological Protection

Introduction. An important reserve that provides adaptation processes in the immunoregulation system is the possibility of its various subsystems to redistribute structural and functional relationships between them. The approach from the perspective of systemic multivariate analysis will allow us to determine the main functional relationships that arise or are violated at different periods of traumatic disease in patients with an increased body mass index (IBMI) during polytrauma in the immune response as a whole. Aim. The aim of this study was to analyze the functional state of the immunological protection system for traumatic disease in patients with IBMI. Materials and methods The integral indicators of immunogenesis were determined using a systematic multivariate analysis on the basis of a dynamic study of 1344 complex immunograms in 224 patients with IBMI with polytrauma and a different initial value of BMI. Patients were divided into 3 groups: group I - 88 patients with BMI of up to 29.9 (26.1 ± 3.1); group II - 84 patients with BMI of up to 30.0 - 39.9 (35.2 ± 3.8 ), group III - 52 patients with BMI > 40.0 (46.2 ± 5.8). The study was conducted on the 1st, 3rd, 7th, 14th, 30th and 360th days from the moment of receiving a polytrauma. Results. In the functional state of the immune system as a whole, certain regularities were identified in patients with IBMI with polytrauma: impairment of immunoreactive processes was prolonged for 1 year or more from the time of polytrauma, regardless of BMI, their nature is regular and unidirectional, have periods of decline and increase in activity; the degree of damage, the ability of compensatory possibilities and the ability to restore them depending on BMI, since the initial deviations of the integral indicator are almost identical in all groups of patients; the immune mechanisms at all times are most determined by the state of the cell link and complement system for patients of I and III groups. Moreover, the development mechanism of secondary post-traumatic immunodeficiency, which is associated with the inclusion of extended T-suppression and a decrease in IgA concentration for more than 14 days, depends on BMI; a clear cooperation of cellular and humoral relationships, which is aimed at compensating for its consequences, was determined in patients of group II as well as active participation in the immune reactions of HLA-DR + lymphocytes as a delicate adaptation mechanism. The development of functional instability of the system occurred mainly due to the T-cell link a year after the case of polytrauma. Conclusion. Our analysis made it possible to prove objectively on mathematical models that traumatic disease is a long process. Clinical and pathogenetic aspects of immune disorders are beyond question and provide the basis for the application of the proposed treatment algorithms and changes in stereotypes regarding the treatment approach as a whole.

scholarly journals Association between body mass index and 1-year outcome after acute myocardial infarction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D.W Kim
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Body Mass Index ◽  
Confidence Interval ◽  
Body Mass ◽  
Cardiac Death ◽  
Funding Source ◽  
Group Iii ◽  
End Point ◽  
Group I

Abstract Background Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as “Body Mass Index (BMI) paradox”. However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year major cardiocerebrovascular events (MACCE) after AMI. Methods and findings Among 13,104 AMI patients registered in an Institute of Health in Korea between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group I; <22 kg/m2, 22 ≤ Group II <26 kg/m2, Group III; ≥26 kg/m2). The primary end point was a composite of cardiac death (CD), myocardial infarction (MI), target vessel revascularization (TVR), and cerebrovascular events at 1 year. Over the median follow-up of 12 months, the composite of primary end point occurred more frequently in the Group I patients than in the Group III patients (primary endpoint: adjusted hazard ratio [aHR], 1.290; 95% confidence interval [CI] 1.024 to 1.625, p=0.031). Especially, cardiac death in MACCE components played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p=0.007). Conclusions Higher BMI appeared to be good prognostic factor on 1-year MACCE after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the life-quality after AMI. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Research of Korea Centers for Disease Control and Prevention and the Korea Health Technology R&D Project, Ministry of Health & Welfare (HI13C1527), Republic of Korea.

scholarly journals Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome

2016 ◽  
Vol 94 (4) ◽  
pp. 359-362 ◽  
Author(s):  
Fatma H. Rizk ◽  
Samah A. Elshweikh ◽  
Amira Y. Abd El-Naby
Keyword(s):  
Metabolic Syndrome ◽  
Liver Enzymes ◽  
Resistance Index ◽  
Control Group ◽  
Model Assessment ◽  
Group Iii ◽  
Group I ◽  
Elevated Liver Enzymes ◽  
Liver Functions ◽  
Group Ii

Irisin is a new myokine that is suspected to influence metabolic syndrome (MetS). However, there is a great controversy with respect to its level in cases of MetS and its correlation with different metabolic parameters. The present study assesses irisin levels in MetS patients and studies its relationship to metabolic and liver functions to evaluate the possible role of the liver in regulation of this level. Sixty subjects were included in this experiment, who were divided into 3 groups: group I (normal control), group II (MetS patients with normal liver enzymes), and group III (MetS with elevated liver enzymes and fatty liver disease). Serum irisin levels showed significant increases in groups II and III compared with group I, and significant increases in group III compared with group II. Also, irisin levels were positively correlated with body mass index, serum triglycerides, homeostatic model assessment of insulin resistance index (HOMA-IR), and liver enzymes. We concluded that serum irisin levels increased in patients with MetS, especially those with elevated liver enzymes, and had a positive correlation with parameters of lipid metabolism and glucose homeostasis with the possibility of hepatic clearance to irisin.

scholarly journals Outcome of babies admitted with hypoxic-ischemic encephalopathy in Neonatal Unit of Services Hospital, Lahore

2016 ◽  
Vol 12 (2) ◽  
Author(s):  
Muhammad Nasir Rana ◽  
Muhammad Yakoob Kazi ◽  
Ambreen Nasir ◽  
Muhammad Abbas
Keyword(s):  
Congenital Anomaly ◽  
Apgar Score ◽  
Descriptive Study ◽  
Neonatal Unit ◽  
Advanced Technology ◽  
Medical Sciences ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Ischemic Encephalopathy

Objectives: To determine the outcome of newborns, admitted with different stages of HIE in Neonatal Unit, Services Hospital, Lahore. Study design: Descriptive Study. Place and duration of study: Neonatology Section, Pediatrics Department, Services Institute of Medical Sciences (SIMS) / Services Hospital, Lahore. Over a period of Six months, from 1st August 2005 to 31st January 2006. Material & methods: A total of 170 newborns having Apgar score less than 7 were included in the study. Babies with any congenital anomaly were excluded. Results: 80% were males. 17.64% had weight less than 1.5 Kg, 37.06% weight between 1.5 Kg to 2.5 Kg and 45.29% had weight more than 2.5 Kg. 90.5% of our babies were delivered in Services Hospital, Lahore. 77.64% babies were full term. Babies were divided into three groups; Group-I had Apgar score 0-3, Group-II between 4 & 5 and Group-III had Apgar score 6-7. In Group-I, 65% babies died, whereas 100% had any one of the complications, in Group-II, there were 22% deaths and no baby died from Group-III. Conclusions: Despite advanced technology, a high number of babies have HIE and its complications. It is better to prevent babies from HIE, because once HIE occur, you cannot save babies completely from its complications.

scholarly journals Pulmonary Function Test of Forced Vital Capacity and Slow Vital Capacity Using Spirometry in Young Adults With Respect to Body Mass Index: A Normative Study

2020 ◽  
Vol 5 (8) ◽  
pp. 1094-1111
Author(s):  
Jyothy Anthraper ◽  
Dr. Reeny Roy
Keyword(s):  
Body Mass Index ◽  
Pulmonary Function ◽  
Body Mass ◽  
Lung Volume ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Management Tool ◽  
I 18 ◽  
Group I ◽  
Group Ii

Objectives: To determine the effect of Age, Gender and its correlation on pulmonary functions of Forced Vital Capacity and Slow Vital Capacity in Group I (18-24 years) and Group II (25-30 years) with respect to Body Mass Index.  Methodology: Sixty healthy adults between 18-30 years were included in the study. Participants were subdivided into Group I (18 to 24 years) and Group II (25 to 30 years) each group having 15 males and 15 females. The parameters considered were expiratory reserve volume, tidal volume, inspiratory capacity, forced vital capacity and slow vital capacity. Spirometer RMS HELIOS 401 was used. Procedures were explained to each participant; best values from 3 maneuvers were documented and were subjected to analysis.  Results: It is noticed a significant difference in various parameters of pulmonary function. As age increases there was an increase in body mass index and the lung volume also increased. Overall males had higher pulmonary function compared to females, males in Group II (25-30 years) was better compared to males in Group I (18-24 years). With an increase in body mass index, pulmonary function was increased in males compared to females. Age, gender, age, and gender interaction effect with respect to Body Mass Index was seen.  Conclusion: Values obtained can be used as reference standard for estimation of lung volume for age group 18-30 years. In future, Spirometry can be used as a clinical assessment and management tool in the field of speech language pathology, by modifying respiratory patterns to control lung volumes, phonations and the flow of speech.

scholarly journals Study on the relationship between menopausal age, body mass index and total number of teeth

2021 ◽  
Vol 67 (1) ◽  
pp. 29-34
Author(s):  
Ioana Madalina Lescai ◽  
◽  
Laurenta Lelia Mihai ◽  
Monica Mihaela Cirstoiu ◽  
◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
The Body ◽  
Entire Group ◽  
Number Of Teeth ◽  
Group I ◽  
Average Body Mass ◽  
Group Ii ◽  
The Relationship ◽  
Average Body

Objectives. The objective of this study is to assess the state of oral health, from the perspective of the number of teeth present, according to the body mass index as a representative element of health. Materials and methods. This study consists of 180 patients from a private dental practice. All 180 patient records were reviewed for an assessment of the number of teeth present and the body mass index at menopausal age. The cohort of patients was divided into two groups, a group of women aged 40 to 54.9 years and the second group, which included women aged 55 and over. The 2 groups were divided based on premenopausal (group I) and postmenopausal (group II) age. Results. The average number of present teeth (based on radiographs) for the entire population of 180 patients is 22.02 teeth. In group I, for the 109 women in the premenopausal group, the average number of teeth is 23.94. The total number of teeth for the 71 women in the postmenopausal group is 19.07. The average BMI for the entire group of patients is 27.24 kg/m2, with a lower value in group I, 26.25 kg/m2, compared to group II, 28.78 kg/m2. Discussions. The average number of teeth in the premenopausal group is higher than in the postmenopausal group. The average body mass index places the whole series of patients in the overweight category. Conclusions. This study shows that the relationship between BMI and the number of lost teeth is positive and proportional, BMI increases with increasing number of teeth lost at premenopausal age.

Impact of Body Mass Index on In-Hospital Outcomes after Percutaneous Coronary Interventions

2017 ◽  
Vol 10 (1) ◽  
pp. 31-39
Author(s):  
Mohammad Khalilur Rahman Siddiqui ◽  
STM Abu Azam ◽  
Pradip Kumar Karmakar ◽  
Shaila Nabi ◽  
Pranob Karmaker ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Left Ventricular ◽  
Adverse Outcomes ◽  
Obese People ◽  
Hospital Outcomes ◽  
Hospital Outcome ◽  
Group I ◽  
Percutaneous Coronary ◽  
Group Ii

Background: Obesity, measured on the basis of body mass index (BMI), is an independent cardiovascular risk factor. However, some studies have reported the “obesity paradox” after percutaneous coronary intervention (PCI). The relationship between BMI and clinical outcomes after PCI has not been thoroughly investigated, especially in Bangladesh.Method: This cross sectional observational study was conducted at National Institute of Cardiovascular Diseases, on total 100 patients who underwent PCI with two equally divided groups on the basis of BMI of Asian ethnicity: Group I (BMI < 23 kg/m2) and Group II (BMI e” 23.0 kg/m2). In-hospital outcomes were observed and recorded after PCI.Results: The mean BMI of study population was 23.9 ± 1.9 kg/m2. The sum of occurrence of adverse in-hospital outcomes was 14.0%. Complications were significantly (p < 0.01) higher in Group I than Group II. Among all adverse in-hospital outcomes, only acute left ventricular failure was found to be statistically significant between groups (p < 0.01). The difference of mean duration of hospital stay after PCI was higher in Group-I which was statistically significant (p < 0.01). Diabetes mellitus and dyslipidemia were found to be the independent predictors for developing adverse in-hospital outcome (OR= 1.68 and 1.46; 95% CI = 1.25 – 2.24 and 1.16 – 1.83; p = 0.018 and 0.040, respectively). BMI was inversely associated with adverse in-hospital outcome after PCI (OR = 0.95; 95% CI = 0.91 – 0.98; p = 0.007).Conclusion: BMI is inversely associated with adverse in-hospital outcomes after PCI. The underweight and normal weight people are at greater risk to experience in-hospital adverse outcomes than overweight and obese people following PCI.Cardiovasc. j. 2017; 10(1): 31-39

True insulin and intact proinsulin levels in acromegalic patients

1996 ◽  
Vol 134 (5) ◽  
pp. 549-553 ◽  
Author(s):  
Edelweiss F Tavares ◽  
Ivaldir S Dalbosco ◽  
Julio Abucham ◽  
Ewaldo MK Russo
Keyword(s):  
Body Mass Index ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Body Mass ◽  
Control Group ◽  
Immunoreactive Insulin ◽  
Oral Glucose ◽  
Group I ◽  
Active Acromegaly ◽  
Group Ii

Tavares EF, Dalbosco IS, Abucham J, Russo EMK. True insulin and intact proinsulin levels in acromegalic patients. Eur J Endocrinol 1996;134:549–53. ISSN 0804–4643 To determine whether proinsulin (PI) contributes significantly to the immunoreactive insulin (IRI) concentrations in acromegalics, we measure PI, "true insulin" and IRI in a group of acromegalics compared with a control group. Serum PI was determined by the immunofluroimetric assay (IFMA). Insulin was also determined by an IFMA that measures true insulin and by a radioimmunoassay (RIA). We performed an oral glucose tolerance test (OGTT) in a total group of 46 subjects: 10 controls with normal OGTT and body mass index <25 kg/m2 (control group I), 10 controls with normal OGTT and body mass index > 25 kg/m2 (control group II), 15 patients with active acromegaly and normal OGTT and 11 patients with active acromegaly and IGT. Plasma glucose, serum GH, insulin and proinsulin were measured in all OGTT samples. Basal levels of insulin-like growth factor I (IGF-I) were measured in acromegalics. Mean body mass index in acromegalics with normal and impaired glucose tolerance were significantly higher compared with control group I and similar when compared with control group II. Proinsulin increased during OGTT in acromegalics with impaired glucose tolerance compared to control group I, and only fasting proinsulin compared to control group II. In normal OGTT acromegalics, only fasting proinsulin was increased. The RIA insulin during OGTT was significantly higher for both acromegalic groups compared to control group I and only at fasting when compared with control group II. This difference was not evident when insulin was measured by IFMA. These results suggest that in acromegalics, hyperinsulinism measured by RIA was at least in part due to hyperproinsulinism. Ewaldo MK Russo, PO Box 20266, CEP 04034-970, Sáo Paulo, SP, Brazil

scholarly journals The dynamics of coagulation hemostasis markers in patients with an increased body mass index with polytrauma

2019 ◽  
Vol 23 (1) ◽  
pp. 138-142
Author(s):  
V.V. Kucheriavchenko ◽  
Yu.V. Volkova ◽  
K.Yu. Sharlai
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Antithrombin Iii ◽  
Early Period ◽  
Fast Response ◽  
The Body ◽  
Group Iii ◽  
Group I ◽  
Student’S T ◽  
Immunological Protection

The hemostasis system is one of the fast response systems of the body. The aim of the work was to analyze the dynamics of coagulation hemostasis markers in patients with an increased body mass index (IBMI) with polytrauma. A study of complex hemostasiograms was conducted in 224 patients with IBMI during a month of hospital stay with a diagnosis of Polytrauma and on the 360th control day of the outpatient visit. The patients were divided into 3 groups depending on the starting numbers of the BMI. The study included the study of activated partial thromboplastin time, prothrombin index, antithrombin III, plasma tolerance to heparin and fibrinogen. To process the data obtained, Student’s t test and correlation analysis were used. The condition of the coagulation situation in patients with IBMI in group I (BMI≤29.9) included a slight increase in the aggregative capacity of platelets without disturbing their number, non-intensive increases in the hemostatic potential in all coagulation tests, dysfibrinogenemia and the absence of disturbances in the system of natural anticoagulants in the early period of traumatic illness. For patients in group II (BMI 30.0–39.9) in the early stages — up to the 14th day — hyperfibrinogenemia was characteristic, with a decrease in fibrinolytic activity. For patients in group III (BMI≥40.0), it was characteristic: in the first week there was dysfibrinogenemia, a sharp — by 50% decrease in antithrombin III, and a decrease in plasma tolerance to heparin. It should be noted that a significant and growing in dynamics reduction in the amount of antithrombin III was less than 80% unfavorable for the progression of coagulation disorders. Thus, it is necessary to note the clinical and pathogenetic significance of hemostasiological disorders in traumatic disease in patients with IBMI with polytrauma, the nature, intensity, dynamics and direction of which determine the consequences and possible complications, and require specific correction. In the future we plan to study the functional state of the system of immunological protection in traumatic disease in patients with IBMI.

scholarly journals Comparison of Vitamin D Level among Vaccinated and Non Vaccinated Pregnant Women with Covid-19

2021 ◽  
Vol 15 (10) ◽  
pp. 3500-3502
Author(s):  
Saeeda Safi ◽  
Umme habiba ◽  
Shandana Mustafa Jadoon ◽  
Umbreen Idrees ◽  
Ayesha Aftab ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Gestational Age ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Group I ◽  
Group Ii

Objective: The aim of this study is to compare the vitamin D level among vaccinated and non-vaccinated pregnant women with COVID-19. Study Design: Observational/comparative study Place and Duration: The study was conducted at the department of Gynae and Obs Quaid-e-Azam International Hospital, Islamabad and Qazi Hussain Ahmad Medical Complex, Nowshera for Duration of six months from October 2020 to March 2021. Methods: Total 120pregnant women had coronavirus disease were presented. Informed written consent was taken for details demographics age, gestational age, parity and body mass index. 18-45years was the women ages. Patients were categorized into 2-groups. Group I had 60 vaccinated patients and in group II 60 non-vaccinated pregnant women. Blood sample of all the patients were taken for the level of serum 25-hydroxy vitaminD3 [25 (OH) D3]. Vitamin D deficiency was calculated and compared among both groups. Sufficient serum vitamin D level was considered >30ng/ml. SPSS 23.0 version was used to analyze complete data. Results: In group I age was 28.4±8.55 years with mean BMI 24.08±1.18 kg/m2 and in group II age was 27.41±6.37 years with mean body mass index 23.12±4.42 kg/m2. Mean gestation age in group I was 33.12±9.42 weeks and in group II mean gestational age was 34.07±5.63 weeks. Mean parity in group I was 3.88±7.27 and in group II 4.01±4.14 was mean parity. We found 28 (46.7%) primigravida cases in I-group and 30 (50%) primigravida females in II-group. In group I 51(85%) patients had vitamin D deficiency and in group II 54 (90%) had deficiency of vitamin D. Among 51 deficient women of group I, number of severe deficiency (<10ng/ml) women were 8 (13.3%), deficiency (10-20ng/ml) were 13 (21.7%) and not-sufficient (20-30ng/ml) were 30 (50%) and in group II prevalence of severity (<10ng/ml) patients were 10 (16.7%), deficient cases (10-20ng/ml) were 15 (25%) and not-sufficient cases (20-30ng/ml) were 29 (48.3%). Deficient vitamin D serum levels were 15.01±1.22 in group I and 14.34±4.12 in group II. Conclusion: In this study we concluded that prevalence of vitamin D deficiency was highly among pregnant women and most probably in non-vaccinated pregnant patients but did not find any significantly difference among both groups. Keywords: Pregnancy, COVID-19, Vitamin D, Vaccination

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