scholarly journals Drug delivery systems for Intra⁃articular injection in the Osteoarthritis treatment

2020 ◽  
Keyword(s):  
Drug Delivery ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Toxic Effect ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Development ◽  
Osteoarthritis Treatment

Intra⁃articular injection is one of the most important treatment for osteoarthritis (OA) drug administration. It would improve the pharmacotherapy efficacy and reduce the adverse drug reaction and toxic effect of drugs. In the last decades, the microspheres, nanoparticles, hydrogels, and other drug delivery systems have been extensively studied in OA therapy. This paper reviews the late research development on OA treated via IA drug delivery systems.

scholarly journals MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEMS CONTAINING POLYSACCHARIDES

2020 ◽  
Vol 54 (9-10) ◽  
pp. 889-902
Author(s):  
IRINA M. PELIN ◽  
DANA M. SUFLET
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Enzymatic Degradation ◽  
Low Cost ◽  
Hepatic Metabolism ◽  
Drug Action ◽  
Delivery Systems ◽  
Buccal Drug Delivery ◽  
Systemic Drug

The buccal mucosa is an attractive site for drug administration as it allows avoiding the enzymatic degradation of the drug in the gastrointestinal tract and its hepatic metabolism. For buccal administration, different drug delivery systems with controlled mucoadhesion have been developed and some of them are available on the market. Mucoadhesion makes it possible to obtain prolonged, local or systemic drug action, and this process is highly influenced by several factors, among which, the reactivity of macromolecules from the formulations is very important. Polysaccharides are increasingly studied due to their abundance in natural resources, low-cost availability and easy chemical modification, but also due to their biocompatibility, biodegradability and non-toxicity properties. This review briefly describes the advantages of using the buccal route of drug administration, the influencing factors that are taken into account for obtaining mucoadhesive dosage forms, and the main polysaccharides and their derivatives used for fabrication of buccal drug delivery systems.

Application of Smart Nanomaterials in Rheumatism Drug Delivery Systems

2014 ◽  
Vol 893 ◽  
pp. 141-144
Author(s):  
Guo Peng
Keyword(s):  
Drug Delivery ◽  
Drug Reaction ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Drug Efficacy ◽  
Delivery Systems ◽  
Current Development ◽  
Redox Responsive ◽  
Targeted Drug ◽  
Design And Construction

At present, more novel smart nanomaterials offering special responses towards some environmental stimuli have been used in the design and construction of rheumatism drug delivery systems to achieve a targeted drug release, thereby improving rheumatism drug efficacy and decreasing adverse rheumatism drug reaction. The current development of the application of pH, photo, thermo, enzyme and redox-responsive smart nanomaterials in rheumatism drug delivery systems was classifiedly reviewed.

Liposomes as Vancomycin Hydrochloride Delivery System

2021 ◽  
Vol 903 ◽  
pp. 3-8
Author(s):  
Mārīte Skrinda ◽  
Arita Dubnika ◽  
Janis Locs
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Encapsulation Efficiency ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Free Drug ◽  
Hydrophobic Drugs ◽  
Vancomycin Hydrochloride

Liposomes are being used as unique drug delivery systems due to their ability to encapsulate both hydrophilic and hydrophobic drugs, as well as for the fact that they improve the disadvantages of free drug administration. However, liposomes have a significant disadvantage - low encapsulation efficiency. In the research carried out, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol (Chol), in the ratio (n/n) of 2:1, 3:1 and 4:1 respectively, were used to prepare the liposomes. Blank liposomes (LIP) and vancomycin hydrochloride (VANKA) containing liposomes (VANKA-LIP) were prepared for each of the DSPC and Chol compositions. The aim of our study was to evaluate the effect of liposome composition on the VANKA encapsulation efficiency and release kinetics.

scholarly journals Oral controlled release drug delivery system and Characterization of oral tablets; A review

2016 ◽  
Vol 2 (1) ◽  
pp. 67 ◽  
Author(s):  
Muhammad Zaman ◽  
Junaid Qureshi ◽  
Hira Ejaz ◽  
Rai Muhammad Sarfraz ◽  
Hafeez Ullah Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Drug Administration ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Control Release ◽  
Controlled Drug Delivery ◽  
Oral Route ◽  
Delivery Systems ◽  
Release Drug

Oral route of drug administration is considered as the safest and easiest route of drug administration. Control release drug delivery system is the emerging trend in the pharmaceuticals and the oral route is most suitable for such kind of drug delivery system. Oral route is more convenient for It all age group including both pediatric and geriatrics. There are various systems which are adopted to deliver drug in a controlled manner to different target sites through oral route. It includes diffusion controlled drug delivery systems; dissolution controlled drug delivery systems, osmotically controlled drug delivery systems, ion-exchange controlled drug delivery systems, hydrodynamically balanced systems, multi-Particulate drug delivery systems and microencapsulated drug delivery system. The systems are formulated using different natural, semi-synthetic and synthetic polymers. The purpose of the review is to provide information about the orally controlled drug delivery system, polymers which are used to formulate these systems and characterizations of one of the most convenient dosage form which is the tablets. 

scholarly journals Non-Invasive Drug Delivery Systems

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 611
Author(s):  
Driton Vllasaliu
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Non Invasive ◽  
Biological Barriers ◽  
Mucosal Surfaces ◽  
Administration Methods

Non-invasive drug delivery generally refers to painless drug administration methods involving drug delivery across the biological barriers of the mucosal surfaces or the skin [...]

Ternary supramolecular nanocomplexes for superior anticancer efficacy of natural medicine

Nanoscale ◽  
2021 ◽  
Author(s):  
Jie Yang ◽  
Chunshu Fang ◽  
Hongming Liu ◽  
Mingjun Wu ◽  
Shaolin Tao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Efficacy ◽  
Anticancer Drug Delivery ◽  
Natural Medicine

Discovery of effective anticancer drug delivery systems and elucidation of mechanism are enormous challenges. Using two drug administration-approved biomaterials, we constructed a natural medicine (NM)-loaded ternary supramolecule nanocomplex (TSN) suitable...

Nanotechnology-based drug delivery systems as potential for skin application: a review

2020 ◽  
Vol 27 ◽  
Author(s):  
Franciele Garcia Baveloni ◽  
Bruno Vincenzo Fiod Riccio ◽  
Leonardo Delello Di Filippo ◽  
Mariza Aires Fernandes ◽  
Andréia Bagliotti Meneguin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Large Body ◽  
Delivery Systems ◽  
Multiple Drug ◽  
Promising Alternative ◽  
Administration Routes ◽  
Main Barrier

: Administration of substances through the skin represents a promising alternative, in relation to others drug administration routes, due to its large body surface area, in order to offer ideal and multiple sites for drug administration. In addition, the administration of drugs through the skin avoids first-pass metabolism, allowing an increase in the bioavailability of drugs, as well as reducing their side effects. However, the stratum corneum (SC) comprises the main barrier of protection against external agents, mainly due to its structure, composition and physicochemical properties, becoming the main limitation for the administration of substances through the skin. In view of the above, pharmaceutical technology has allowed the development of multiple drug delivery systems (DDS), which include liquid crystals (LC), cubosomes, liposomes, polymeric nanoparticles (PNP), nanoemulsions (NE), as well as cyclodextrins (CD) and dendrimers (DND). It appears that the DDS circumvents the problems of drug absorption through the SC layer of the skin, ensuring the release of the drug, as well as optimizing the therapeutic effect local. This review aims to highlight the DDS that include LC, cubosomes, lipid systems, PNP, as well as CD and DND, to optimize topical skin therapies.

Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: A concise overview

2013 ◽  
Vol 65 (10) ◽  
pp. 1316-1330 ◽  
Author(s):  
Serge Mignani ◽  
Saïd El Kazzouli ◽  
Mosto Bousmina ◽  
Jean-Pierre Majoral
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Concise Overview

scholarly journals Intra-Articular Drug Delivery for Osteoarthritis Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2166
Author(s):  
Yifeng Cao ◽  
Yifeng Ma ◽  
Yi Tao ◽  
Weifeng Lin ◽  
Ping Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Degenerative Joint Disease ◽  
Delivery Systems ◽  
Nano Particles ◽  
Joint Disease ◽  
High Concentration ◽  
Efficient Treatment ◽  
Osteoarthritis Treatment ◽  
Prolonged Retention

Osteoarthritis (OA) is the most prevalent degenerative joint disease affecting millions of people worldwide. Currently, clinical nonsurgical treatments of OA are only limited to pain relief, anti-inflammation, and viscosupplementation. Developing disease-modifying OA drugs (DMOADs) is highly demanded for the efficient treatment of OA. As OA is a local disease, intra-articular (IA) injection directly delivers drugs to synovial joints, resulting in high-concentration drugs in the joint and reduced side effects, accompanied with traditional oral or topical administrations. However, the injected drugs are rapidly cleaved. By properly designing the drug delivery systems, prolonged retention time and targeting could be obtained. In this review, we summarize the drugs investigated for OA treatment and recent advances in the IA drug delivery systems, including micro- and nano-particles, liposomes, and hydrogels, hoping to provide some information for designing the IA injected formulations.

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