scholarly journals Extramedullary Plasmacytomas of the Oral Cavity: A Case Report and Review of the Literature

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Roxanne Bavarian ◽  
Nathaniel Treister
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Soft Tissue ◽  
Oral Cavity ◽  
Hematologic Malignancy ◽  
The Body ◽  
Radiographic Examination ◽  
Hematogenous Spread ◽  
Attached Gingiva ◽  
Extramedullary Plasmacytomas

Abstract Introduction: Multiple myeloma is a hematologic malignancy characterized by the proliferation of plasma cells and typically presents with lesions in bone, known as plasmacytomas. Through hematogenous spread, extramedullary plasmacytomas can develop in soft tissue in any location of the body. This case report describes a patient with multiple myeloma who presented with an extramedullary plasmacytoma on his maxillary gingiva and provides an updated review on the classification and characterization of extramedullary plasmacytomas of the oral cavity.  Case description: A 53-year-old male with a known diagnosis of multiple myeloma was referred to our clinic for evaluation of a gingival nodule, which was tender to palpation and had been present for a month. Clinical examination revealed a 1.5 cm violaceous, red nodule of the maxillary buccal attached gingiva, which did not blanch on palpation. He had a similar 1 cm, smooth, red nodule of his cutaneous skin on his left arm. Radiographic examination with within normal limits without evidence of dental or bony pathology. An incisional biopsy revealed the diagnosis of plasmacytoma, indicating relapse and progression of the patient’s multiple myeloma.Practical implications: Multiple myeloma can present in the oral cavity either as intra-bony plasmacytomas, paraskeletal plasmacytomas, or extramedullary plasmacytomas in the soft tissue. Extramedullary disease representative of hematogenous spread is concerning for high-risk disease with a poor risk prognosis.

scholarly journals Fourth mandibular molar in a pediatric patient – Case report

2015 ◽  
Vol 5 (20) ◽  
pp. 229-231
Author(s):  
Atanas Vlaykov ◽  
Dian Sharlanov ◽  
Dilyana Vicheva
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Treatment Modality ◽  
Treatment Plan ◽  
Female Child ◽  
Permanent Teeth ◽  
Radiographic Examination ◽  
Supernumerary Teeth ◽  
Patient Case ◽  
Mandibular Molar

Abstract Background. Supernumerary teeth are described as an excess of the normal teeth number of 20 deciduous and 32 permanent teeth and can occur in any dental region. Material and methods. The authors present the case of a 12-year-old female child with a paramolar in the maxilla, discovered accidentally during an orthopantomogram, emphasising the treatment modality and the complications that can appear. Conclusion. Supernumerary teeth can be present in any region of the oral cavity. Both practitioners and clinicians should be aware of the various types of paramolars and make a treatment plan after an accurate clinical and radiographic examination.

scholarly journals Rhabdomyosarcoma of the Oral Cavity: A Case Report

2011 ◽  
Vol 05 (03) ◽  
pp. 340-343 ◽  
Author(s):  
Ozkan Miloglu ◽  
Sare Sipal Altas ◽  
Mustafa Cemil Buyukkurt ◽  
Burak Erdemci ◽  
Oguzhan Altun
Keyword(s):  
Skeletal Muscle ◽  
Case Report ◽  
Soft Tissue ◽  
Oral Cavity ◽  
Head And Neck ◽  
Soft Tissues ◽  
Neck Region ◽  
Childhood And Adolescence ◽  
Head And Neck Region ◽  
The Common

ABSTRACTRhabdomyosarcoma (RMS), a tumor of skeletal muscle origin, is the most common soft tissue sarcoma encountered in childhood and adolescence. The common sites of occurrence are the head and neck region, genitourinary tract, retroperitonium, and, to a lesser extent, the extremities. In the head and neck region, the most commonly affected sites are the orbit, paranasal sinuses, soft tissues of the cheek, and the neck. RMS is relatively uncommon in the oral cavity, and the involvement of the jaws is extremely rare. Here, we report a case of oral RMS in a 13-year-old child and describe the clinical, radiological, histopathological, and immunohistochemical findings. (Eur J Dent 2011;5:340-343)

Oral Tissue Irritants in Toothpaste: A Case Report

2013 ◽  
Vol 38 (1) ◽  
pp. 75-78 ◽  
Author(s):  
LM Lawrence ◽  
A Farquharson ◽  
RS Brown ◽  
HO Vatanka
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Oral Cavity ◽  
Adolescent Patient ◽  
Oral Tissue ◽  
Rule Out

In this case, an adolescent patient presented with multiple, asymptomatic ulcerated lesions- resembling aphthous ulcerations- located in the oral cavity. The etiology of these lesions appeared to be associated with soft tissue irritants found in the patient's toothpaste. This report highlights the need to rule out known oral irritants in dentifrices for patients who present with oral ulcerations.

Cysticercosis of the oral cavity: an often misdiagnosed entity

2007 ◽  
Vol 122 (9) ◽  
pp. 1005-1007 ◽  
Author(s):  
B Subramanian ◽  
S Krishnaraj ◽  
K Agrawal ◽  
J Soundararagavan
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Oral Cavity ◽  
Taenia Solium ◽  
Parasitic Infection ◽  
Parasitic Infections ◽  
Oral Manifestations ◽  
Lower Lip ◽  
Soft Tissue Swelling ◽  
Single Lesion

AbstractWe present a case report of a single lesion of cysticercosis cellulosae, a parasitic infection caused by the larval stage of Taenia solium (pork tapeworm), presenting as a soft tissue swelling of the lower lip. We stress the importance of knowledge about oral manifestations of parasitic infections.

scholarly journals Lipomas of Larynx: The Rare Entities

2012 ◽  
Vol 2 (2) ◽  
pp. 79-81 ◽  
Author(s):  
Somanath B Megalamani ◽  
Ravindra Gadag ◽  
A Raza ◽  
A Satish
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Spindle Cell ◽  
Anterior Commissure ◽  
The Body ◽  
Spindle Cell Lipoma ◽  
Tissue Tumor

ABSTRACT Lipoma is the commonest soft tissue tumor arising anywhere in the body, but its occurrence in the larynx is relatively rare. We present a rarest case of lipoma with cartilaginous metaplasia arising from the larynx just above the anterior commissure. The second case report is about a large spindle cell lipoma of larynx presented with stridor. How to cite this article Megalamani SB, Gadag R, Raza A, Satish A. Lipomas of Larynx: The Rare Entities. Int J Phonosurg Laryngol 2012;2(2):79-81.

scholarly journals Epidermoid Cyst of the Buccal Mucosa: An Uncommon Entity. Case report and literature review

2021 ◽  
Author(s):  
nouha dammak ◽  
abdellatif chokri ◽  
afef slim ◽  
Ahlem Bellalah ◽  
Adel Bouguezzi ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Oral Cavity ◽  
Buccal Mucosa ◽  
Epidermoid Cyst ◽  
The Body ◽  
Benign Lesions

Epidermoid, dermoid and teratoid cysts are nonodontogenic benign lesions derived from the germinative epithelium, appearing any where of the body. In the oral cavity, these are uncommon and account for less than 0.01% of all the oral cysts. These cysts often remain asymptomatic for years however can become acutely symptomatic.

scholarly journals A Case Report of a 55 Year Old Female with Epulis Granulomatosa

2018 ◽  
Vol 2 (4) ◽  
pp. 86-88
Author(s):  
Mansimranjit Kaur Uppal ◽  
Konidena Aravinda ◽  
Rajesh Gupta ◽  
Nirvana Yumnam
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Oral Cavity ◽  
Extraction Socket

Epulis is any tumor like growth present in the oral cavity. Epulis granulomatosum is an enlargement of the soft tissue originating from the extraction socket and is thought to be a post extraction sequel. It is considered to be a benign exuberation of the soft tissue in the form of a hyperplastic reaction.

scholarly journals Nasolabial hamartoma: a rare case report

2020 ◽  
Vol 6 (7) ◽  
pp. 1397
Author(s):  
D. Senthamarai Kannan ◽  
G. Soundara Rajan ◽  
Veerasigamani Narendrakumar ◽  
V. K. Sathiya
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Rare Case ◽  
Surgical Excision ◽  
The Body ◽  
Nasolabial Fold ◽  
Tissue Development ◽  
Inborn Errors ◽  
Complete Surgical Excision ◽  
Rare Case Report

<p class="abstract">Nasolabial cysts are rare, nonodontogenic soft tissue developmental cysts occur in the maxillary lip and nasal alar regions. Patients usually presents with an asymptomatic soft swelling with obliteration of the nasolabial fold. Due to it's origin from entrapped epithelium in an embryonic fusion plane developmentally, this cyst is considered to be a Hamartoma. Hamartomas are non-neoplastic malformations, or inborn errors of tissue development. They are characterized by an abnormal mixture of tissues indigenous to that area of the body. Complete surgical excision is the accepted method of treatment. This report aimed to present a case of nasolabial cyst hamartoma, which is rare in presentation.</p>

scholarly journals Efficacy of Novel Agents on Soft-Tissue Plasmacytomas in Patients with Relapsed Multiple Myeloma

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5709-5709
Author(s):  
Raquel Jiménez-Segura ◽  
Carlos Fernández De Larrea ◽  
Maite Cibeira ◽  
Natalia Tovar ◽  
Esther Bladé ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Soft Tissue ◽  
Response Rate ◽  
Early Death ◽  
Median Number ◽  
Novel Agents ◽  
Serological Response ◽  
Novel Drugs ◽  
Number Of Cycles ◽  
Extramedullary Plasmacytomas

Abstract Introduction: the frequency of soft-tissue plasmacytomas (EMPs) is high in patients with relapsed multiple myeloma (MM). There are two types of plasmacytomas: 1) paraskeletal: originating from focal bone involvement (vertebrae, ribs, sternum, skull) and 2) extramedullary: originating from hematogenous spread (skin, liver, CNS). The reported incidence in relapsed patients is 3-34% for paraskeletal and 3-10% for extramedullary plasmacytomas. The presence of soft-tissue masses is associated with poor prognosis and the efficacy of novel agents is not well established. There are some reports about the lack of efficacy of thalidomide (Bladé et al, Br J Haematol 2001; 113: 422-24) while some efficacy has been reported with bortezomib (Rosiñol et al, Eur J Haematol 2006;76:405-08) and pomalidomide (Detweiler et al, Leukemia 2011, 25; 906-908). Aim: to analyze the effectiveness of novel drugs (thalidomide, bortezomib, lenalidomide, pomalidomide, carfilzomib) in patients with relapsed MM and EMPs. Patients and Methods: patients with EMPs (paraskeletal or extramedullary) at the time of first or subsequent relapses from our database from Hospital Clínic of Barcelona who were treated with novel agents were analyzed. Only patients receiving the novel drugs in monotherapy or in combination with corticosteroids were included in the analysis. Patients receiving combination therapy including two novel drugs (i.e. VTD, VRD) were excluded. Results: 29 patients (median age 61, M 17/F 12) with relapsed myeloma and EMPs were treated with bortezomib. The median number of previous therapies was one. 22 patients had paraskeletal and 7 extramedullary plasmacytomas. The median number of cycles received was 4. The serological response rate was: 4% CR, 27% PR, 7% MR, 24% SD, 17% PD, 7% early death, 14% non evaluable. The response of the plasmacytomas were: 14% CR, 17% PR, 10% SD, 41% PD, 4% early death, 14% non evaluable. The median PFS from the initiation of bortezomib was 3.9 months. Sixteen patients (median age 49 years, M 6/F 10) were treated with lenalidomide. 13 patients had paraskeletal and 3 extramedullary plasmacytomas. The median number of previous therapies was two. The median number of cycles was 5.5. Serological response was: 38% PR, 12% MR, 19% SD, 19% PD, 12% non evaluable. The plasmacytoma response was: 25% PR, 19% SD, 44% PD, 12% non evaluable. The median PFS from initiantion of lenalidomide was 8.4 months. Nine patients (median age 61 years, 3M/6F) were treated with pomalidomide at relapse. The median number of previous therapies was 4. Two patients had paraskeletal and 7 extramedullary plasmacytomas. The median number of cycles was 2. Serological response rate was: 44% PR, 11% SD, 23% PD, 11% non evaluable. However, none of the patients showed response of the plasmacytomas (11% SD, 77% PD, 11% early death). The median PFS was 1.3 months. 8 patients (median age 49 years, 6M/2F) were treated with thalidomide at relapse. The median number of previous therapies was one. Six patients had paraskeletal and 2 extramedullary plasmacytomas. The median number of cycles of thalidomide received was one. None of the patients showed serological response (25% stable disease (SD), 50% progressive disease (PD), 25% early death) or reduction in the size of the plasmacytomas (50% SD, 50% PD). The median progressive free survival (PFS) from initiation of treatment with thalidomide was 1.6 months. Four patients (median age 62, 2M, 2F) were treated with carfilzomib. The median number of previous therapies was 3. The EMPs type was paraskeletal (1) and extramedullary (3). The median number of cycles administered was one. None patient responded to carfilzomib: serological response rate: 75% SD, 25% PD; plasmacytomas response: 100% PD. The median PFS was 0.7 months. The median survival in the overall series of patients with soft tissues masses at relapse treated with novel agents was 15.2 months. Conclusions: The efficacy of novel drugs in the treatment of EMPs is limited, being the most effective bortezomib and lenalidomide. None of the patients treated with thalidomide, pomalidomide or carfilzomib showed any response of the soft-tissue involvement (paraskeletal or extramedullary). Finally, the presence of plasmacytomas at relapse is associated with poor OS even in the era of novel agents. However, the efficacy of these novel agents as part of front-line therapy is unknown. Disclosures No relevant conflicts of interest to declare.

An extremely rare epithelioid sarcoma arising from the infratemporal fossa: a case report and literature review

2021 ◽  
Vol 16 ◽  
Author(s):  
Weiming Ran ◽  
Wei Tang ◽  
Junyan Duan ◽  
Jiao Qing ◽  
Zhaohua Zhai
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Head And Neck ◽  
Imaging Techniques ◽  
Infratemporal Fossa ◽  
Epithelioid Sarcoma ◽  
The Body ◽  
Imaging Features ◽  
Anatomic Structure ◽  
Medical College

Introduction: Epithelioid sarcoma (ES) is a rare histopathological type of soft tissue sarcoma. They are subcutaneous soft tissue masses that tend to arise in extremity sites (the classic type, formerly referred to as distal type) or proximal midline region of the body (the proximal type), such as the perineum, genital tract, and pelvis. The head and neck regions are rarely affected by ES, but the infratemporal fossa (ITF) is extremely rare. ES involving the ITF has not been reported before in literature. In this paper, the imaging features of ES were reviewed in detail, and the anatomical structure and epidemiology of ITF were briefly introduced. Sources: We performed a systematic search from 3 databases, CNKI(China National Knowledge Internet), FMRS(Foreign Medical Literature Retrieval Service, Shenzhen METSTR Technology CO., Led. China), and PubMed, to obtain literature from January 1970 to July 2020. Epithelioid sarcoma, head and neck regions, infratemporal fossa, diagnostic imaging, anatomy, MRI, and CT were used as keywords for advanced retrieval. A study had to be found eligible for inclusion to be closely related to ES and/or ITF. A total of 129 related pieces of literature were retrieved successfully, of which 37 were closely related to this study. The case report in this article is from the Affiliated Hospital of North Sichuan Medical College. The present study was approved by the institutional review board of the Affiliated Hospital of North Sichuan Medical College and a written informed consent for the publication of the case was obtained from the patient. Case Presentation: A 33-year-old man accidentally found a slowly growing, painless mass in the left cheek more than a month ago. On plain computed tomography (CT) scan of the outpatient department, an oval slightly low-density mass with well-defined and uniform boundary in the infratemporal fossa was revealed, and on the contrast-enhanced scan, it was homogeneous and moderately enhanced. Initially, the CT appearance favored benign lesions. However, the possibility of a malignant tumor can not be excluded completely. Finally, the patient was referred to the inpatient department a tumor arose from IF and underwent a selective operation. The tumor was completely removed. Histologic findings were compatible with epithelioid sarcoma. Post-operatively, the patient received 2 cycles of radiotherapy, and there was no evidence of recurrence after 6 months follow-up. Conclusion: The imaging manifestations of ES are various. The anatomic structure of ITF is complex and the pathological types are various. It should be very careful in the qualitative diagnosis of tumors from the ITF, and advanced imaging techniques will be useful in imaging diagnosis.

Sign in / Sign up

Export Citation Format

Share Document