scholarly journals Preliminary Results of the Research of Anthropological Material from Tomb I of an Aisleless Quarter Church at Eski-Kermen Plateau

2021 ◽  
pp. 184-204
Author(s):  
Vladimir Yu. Radochin
Keyword(s):  
Research Centre ◽  
Traumatic Lesion ◽  
Locomotor Apparatus ◽  
Age Related ◽  
Physical Burden ◽  
Iron Deficient ◽  
The Crimea ◽  
Inflammatory Processes ◽  
Residential Quarter ◽  
New Material

In 2018, the joint expedition of the Institute of Archaeology of the Crimea of the Russian Academy of Sciences and the History and Archaeology of the Crimea Research Centre of the V. I. Vernadsky Crimean Federal University continued the long-term systematic excavations of a residential quarter of the mediaeval town located atop of Eski-Kermen plateau. The regular research uncovered new rooms in the previously excavated mediaeval buildings with adjacent areas of the main and streets and a wall of a previously unknown church with tomb I annexed to it. The researchers of Crimean medieval Christian monuments have paid attention to a great variety of burial traditions connected with constructions of burials and the ways of using them. As a rule, the majority of mediaeval burial constructions at Eski-Kermen plateau were continuously used throughout a long period. The given paper examines the material obtained from tomb I annexed to the wall of an aisleless church. In the tomb under study, there are skeletons of some of the buried persons laying in anatomic order. All the bones of the individuals buried in the tomb occurred within this burial construction. The preservation of bone remains can be evaluated as satisfactory. In the course of work, quantitative and sex-age-related characteristics of the buried persons have been determined; the analysis of palaeopathological conditions has been made; a number of non-metric features has been documented. Epigenetic features more often appeared on the cranium bones; it is possibly connected with the preservation of the bones of postcranial skeletons. Among pathological developments, diseases related with teeth-maxillary apparatus are most common. Diseases of locomotor apparatus have been documented on the bones of vertebral column and big joints of long bones of arms and legs of all sexually mature individuals. Some changes typical of the Forestier disease have been recorded at the backbone of one of the buried male individuals. Pathological changes caused by iron-deficient conditions, inflammatory processes, and changes of osseous tissues connected with physical overexertion of osseous apparatus caused by extreme physical burden have been recorded among those who were buried in tomb 1. Only one traumatic lesion has been documented at the new material.

scholarly journals Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

Life ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 337
Author(s):  
Ravindra Kolhe ◽  
Virgenal Owens ◽  
Ashok Sharma ◽  
Tae Jin Lee ◽  
Wenbo Zhi ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Protein Content ◽  
Extracellular Vesicle ◽  
Specific Protein ◽  
Paracrine Signaling ◽  
Age Related ◽  
Specific Manner ◽  
Inflammatory Processes ◽  
Novel Biomarkers ◽  
Cellular Pathways

Women are at a significantly higher risk of developing osteoarthritis (OA) compared to males. The pathogenesis of osteoarthritis (OA) in women is poorly understood. Extracellular vesicles (EVs) have been shown to play an essential role in numerous signaling processes during the pathogenesis of age-related diseases via paracrine signaling. Molecular profiling of the synovial fluid-derived EVs cargo in women may help in the discovery of novel biomarkers and therapeutics for the treatment of OA in women. Previously, we reported that synovial fluid-derived EV miRNA cargo differs in a sex-specific manner. This study aims to characterize synovial fluid-derived EV protein cargo in OA patients. Our data showed sex-specific EVs protein content in OA. We found haptoglobin, orosomucoid, and ceruloplasmin significantly up-regulated, whereas apolipoprotein down-regulated in female OA EVs. In males, we discovered β-2-glycoprotein, and complement component 5 proteins significantly up-regulated and Spt-Ada-Gcn5 acetyltransferase (SAGA)-associated factor 29 down-regulated in male OA EVs. Database for Annotation, Visualization, and Integrated Discovery (DAVID) and QuickGO analysis revealed OA-specific protein involvement in several biological, molecular, and cellular pathways, specifically in inflammatory processes. In conclusion, synovial fluid EV protein content is altered in a sex-specific manner with OA, explaining the increased prevalence and severity of OA in women.

Complement Activation and Inflammatory Processes in Drusen Formation and Age Related Macular Degeneration

2001 ◽  
Vol 73 (6) ◽  
pp. 887-896 ◽  
Author(s):  
Lincoln V Johnson ◽  
William P Leitner ◽  
Michelle K Staples ◽  
Don H Anderson
Keyword(s):  
Macular Degeneration ◽  
Complement Activation ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Inflammatory Processes

scholarly journals Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models

Cytokine X ◽  
2020 ◽  
Vol 2 (3) ◽  
pp. 100031
Author(s):  
Elisabeth Richert ◽  
Claus von der Burchard ◽  
Alexa Klettner ◽  
Philipp Arnold ◽  
Ralph Lucius ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Mouse Models ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Inflammatory Processes

scholarly journals Sleep in dementia and caregiving – assessment and treatment implications: a review - CORRIGENDUM

2010 ◽  
Vol 23 (4) ◽  
pp. 679-679
Author(s):  
D. R. Lee ◽  
A. J. Thomas
Keyword(s):  
Biomedical Research ◽  
Research Centre ◽  
Related Disease ◽  
Age Related ◽  
Assessment And Treatment ◽  
Newcastle Upon Tyne

The authors wish to add the following Acknowledgment:This work was supported by an award from the U.K. NIHR Biomedical Research Centre for Ageing and Age-related Disease to the Newcastle upon Tyne Hospitals NHS Foundation Trust.

scholarly journals The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

2022 ◽  
Vol 12 ◽  
Author(s):  
Junhua Xie ◽  
Lien Van Hoecke ◽  
Roosmarijn E. Vandenbroucke
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rational Design ◽  
Neurodegenerative Disorder ◽  
Peripheral Inflammation ◽  
Comprehensive Overview ◽  
Age Related ◽  
Symptomatic Medication ◽  
Inflammatory Processes ◽  
The Impact

Alzheimer’s disease (AD) is a devastating age-related neurodegenerative disorder with an alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of which the therapeutic effect is not yet conclusively proven, only symptomatic medication that is effective for some AD patients is available. In order to be able to design more rational and effective treatments, our understanding of the mechanisms behind the pathogenesis and progression of AD urgently needs to be improved. Over the last years, it became increasingly clear that peripheral inflammation is one of the detrimental factors that can contribute to the disease. Here, we discuss the current understanding of how systemic and intestinal (referred to as the gut-brain axis) inflammatory processes may affect brain pathology, with a specific focus on AD. Moreover, we give a comprehensive overview of the different preclinical as well as clinical studies that link peripheral Inflammation to AD initiation and progression. Altogether, this review broadens our understanding of the mechanisms behind AD pathology and may help in the rational design of further research aiming to identify novel therapeutic targets.

scholarly journals Serum Iron Profile in Chronic Renal Failure Patients

2012 ◽  
Vol 2 (2) ◽  
pp. 8-13
Author(s):  
Md Helal Miah ◽  
Md Zakir Hossain ◽  
Bidhu Bhusun Das ◽  
Md Mokhlesur Rahman Sarker ◽  
Sumanta Kumar Saha ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Iron Deficiency ◽  
Renal Insufficiency ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Research Centre ◽  
Iron Deficient ◽  
Iron Profile

Background & objective: Chronic Renal Failure (CRF) is a serious condition with a worldwide impact. Anemia is a common complication of CRF leading to significant morbidity. Iron deficiency may be a contributing factor for developing anemia in CRF patients. It may be particularly problematic during erythropoietin therapy. This study was intended to find the serum iron status in CRF patients. Method: This cross sectional study was conducted on 100 consecutive patients of CRF in the Department of Medicine, Rangpur Medical College & Hospital, Rangpur and Hypertension & Research Centre, Rangpur between July 2010 to June 2012. Result: 40% of the patients were 40-59 years old, 28% were 20 - 39 years and 32% >60 years old. Males were predominant (64%) than the females (36%). None of the biochemical variables (serum creatinine, haemoglobin and serum iron profile), except total iron binding capacity (TIBC) differ by sex. TIBC was significantly higher in females than that males (p = 0.029). Of the 100 patients 40% were iron deficient; of them 12(30%) had absolute iron deficiency and 28(70%) relative iron deficiency. Iron deficiency was not influenced by sex (p = 0.519). It was not even affected by the degree of renal insufficiency (p = 0.524). However, the incidence of severe anemia increases significantly with the degree of renal insufficiency (p = 0.037). Conclusion: Serum iron profile remains normal in most of the cases of CRF patients. It should be investigated in every CRF patients before deciding for iron therapy. Ibrahim Cardiac Med J 2012; 2(2): 8-13

scholarly journals Znacaj senzorno evociranih potencijala u visinskoj leziji brahijalnog pleksusa

2003 ◽  
Vol 50 (1) ◽  
pp. 15-22
Author(s):  
Vladimir Bojovic ◽  
Iva Berisavac ◽  
Lukas Rasulic
Keyword(s):  
Evoked Potentials ◽  
Brachial Plexus ◽  
Direct Action ◽  
Primary Phase ◽  
Paraspinal Muscles ◽  
Traumatic Lesion ◽  
Nerve Structure ◽  
Inflammatory Processes ◽  
Muscle Groups ◽  
Bone Structures

The aim of this work is to show the highlights of electrophysiological diagnostics, i.e. its potentials in level diagnostics of traumatic dysfunction of brachial plexus (BP). In that manner we have analyzed the results of electrophysiological research, made on 53 patients with different levels and grades of traumatic lesion of brachial plexus. We have also analyzed the authors' opinions and points of view who have contributed in solving these problems. Brachilal plexus is a complex, vulnerable nerve structure that is often, in life, exposed to direct or indirect influence of mechanical force. Preserved integrity of bone structures of a shoulder protects BP from longitudinal forces, which are the most common causes of injury of this structure. Traction mechanism of the injury is always up to date in the cases of fractures and dislocation of the skeleton in this region. In the early childhood, mechanical injuries of brachial plexus are caused by distocia in the second delivery period, while in adulthood most common injuries are caused by sudden and intensive forces, which cause dysfunction of plexus by traction mechanism (dislocation of a shoulder and clavicular fracture) and by direct action (stabing and pircing injuries). Slowly progressive, expansive, degenerative and inflammatory processes of neighboring organs are causing the dysfunction of the plexus as well. Traction actions are aimed mostly at radiculars as a vulnerable structure that is placed between relatively mobile shoulder joint and rigid cervical part of vertebral column. Complex anatomical structure and mutual overlapping of radicular motor and sensitive inrevation of muscles and dermatoms, make the diagnostics of dysfunction of this periphery nerve structure very difficult and complicated. Dysfunction of neighboring bone, vascular and muscle elements as well as the nearness of vital organs, which complicates even more the diagnostics. Taking into account the general analysis of all electrophysiological results of the research on 53 patients with an PB injury, we have concluded that none of the functional methods is not sovereign, i.e. the contribution of this research is complementary also with rendgenological results. Clinical data are unavoidable, but they are not enough without good argumentation, especially for the level of lesion, pre- or postganglionary. Electromiography gives reliable results for the phase and the grade of denervation of particular muscle groups, and that way it is possible to conclude, indirectly, which part of the plexus is in difunction. Special attention should be payed to EMG of paraspinal muscles, where the signs of denervation are aleays indicating intradural lesion of the radicular. In the examined group, 52 % of the patients with radicular dysfunction had the signs of denervation in paraspinal muscles. Examination of the sensitive action potentials is another method by which we can see the dysfunction level of the plexus in an anesthetical region. In a group with preganglionary root dysfunction, 48% of the patients had preserved sNAP response. In a group with postganglionary dysfunction, 36% of the patients had no sNAP response. Somatosemsory evoked potentials are addition to EMG and ENG research and they are efficient in the primary phase, when electromyographic and electroneurograhic examinations are not offering relevant data. Checking of the early diagnostics of the pre- and postganglionary lesions with somatosensory evoked potentials wasn't possible in this group because the first examinations of these patients in our laboratory were mostly made couple of months after the injury. Difunction of the ratio amplitudes N9 and P/ N13 in the group with preganglionary lesion was found in 31%, with postganglionary in 42.2 % and with both in 10% of the patients.

Ontogeny of Dianthus andrzejowskianus (Zapal.) Kulcz. in the conditions of the Bashkir Pre-Ural

2020 ◽  
pp. 153-158
Author(s):  
L. Kh. Uzyanbaeva ◽  
A. A. Reut
Keyword(s):  
Root System ◽  
Botanical Garden ◽  
Research Centre ◽  
Middle Aged ◽  
The South ◽  
Federal Research ◽  
Age Related ◽  
Sympodial Growth

The article is devoted to the results of the introduction study of Dianthus andrzejowskianus (Zapal.) Kulcz. on the basis of the South-Ural Botanical Garden-Institute of Ufa Federal Research Centre of RAS. Data on the ontogenesis of this species are provided. Three age periods (latent, pregenerative and generative) and 6 ontogenetic states (seedlings, juvenile, immature, virginal, young and middle-aged generative states) are described. Indicator signs of age-related conditions are: for seedlings - the presence of a thin germ root, two oval-shaped cotyledons; for juvenile individuals - the appearance of the first true leaves; for immature individuals - the transition of plants to sympodial growth and the growth of the root system. In the virginal state, the vegetative sphere increases, the plant acquires the features of adults. Young generative plants have few reproductive shoots. The middle-aged generative state is characterized by the most powerfully developed vegetative and reproductive spheres.

Lost and found: Alopecosa krynickii (Araneae: Lycosidae) in the Crimea

Zootaxa ◽  
2018 ◽  
Vol 4394 (4) ◽  
pp. 594
Author(s):  
ANTON A. NADOLNY
Keyword(s):  
Rare Species ◽  
Wolf Spider ◽  
Original Description ◽  
Wolf Spiders ◽  
Single Male ◽  
European Species ◽  
Lost And Found ◽  
The Crimea ◽  
New Material ◽  
First Time

The wolf spider genus Alopecosa Simon, 1885 contains 152 species (WSC 2017), 30 of which are poorly described. Alopecosa krynickii (Thorell, 1875) is one of the least known European species of wolf spiders, of which the single male was collected in November, 1860 (Logunov 2013a: fig. 3). The original description of the species was made by Thorell (1875a, b), without illustrations. Since then no studies on A. krynickii based on new material have been published. Recently, Logunov (2013a) redescribed this species on the basis of its holotype. This redescription allowed me to identify A. krynickii from newly collected material from the Crimea. The aim of the present paper is to redescribe the rare species Alopecosa krynickii, based on both sexes and to describe the female for the first time. 

scholarly journals Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration

2021 ◽  
Vol 8 ◽  
Author(s):  
Alan G. Palestine ◽  
Brandie D. Wagner ◽  
Jennifer L. Patnaik ◽  
Rebecca Baldermann ◽  
Marc T. Mathias ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Plasma Concentrations ◽  
Age Related Macular Degeneration ◽  
Disease Development ◽  
Cutoff Value ◽  
Multiplex Assays ◽  
Age Related ◽  
Inflammatory Processes ◽  
History Of ◽  
The Relationship

Purpose: To determine the relationship between plasma concentrations of the C-C chemokines CCL2, CCL3, CCL4, and CCL5 and intermediate age-related macular degeneration (iAMD) patients compared with control inidividuals to further define the inflammatory pathways associated with age-related macular degeneration.Methods: The concentrations of CCL2, CCL3, CCL4, and CCL5 were measured using multiplex assays in plasma collected from 210 patients with iAMD and 102 control individuals with no macular degeneration as defined by multi-modal imaging. Non-inflammatory data included in the analysis were: age, sex, family history of AMD, history of smoking, body mass index, presence of reticular pseudo-drusen and cardiovascular disease. Median concentrations as well as a cutoff value for each chemokine were compared between the two groups.Results: The median concentrations of CCL2 and CCL4 did not differ between control and iAMD groups, however, CCL2 was elevated in iAMD when a cutoff comparison was used (p < 0.05). Median CCL3 and CCL5 concentrations were significantly decreased in the macular degeneration group compared with controls (p < 0.001) as well as when a cutoff value comparison was used. CCL3 and CCL5 were negatively correlated in cases and positively correlated in controls.Conclusions: Plasma CCL3 and CCL5 concentrations were significantly decreased and CCL2 concentrations were increased in patients with iAMD compared with controls, suggesting a role for C-C chemokines in the systemic inflammatory processes associated with disease development.

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