Novel Topical Drug Delivery Approaches for the Management of Psoriasis

2020 ◽  
Vol 13 (5) ◽  
pp. 5062-5068
Author(s):  
Bhumika Kumar ◽  
Monika Targhotra ◽  
Rohan Aggarwal ◽  
Sahoo P.K
Keyword(s):  
Drug Delivery ◽  
Life Quality ◽  
Skin Area ◽  
Treatment Approaches ◽  
Treatment Regimens ◽  
Skin Cell ◽  
Conventional Drug ◽  
Severity Of The Disease ◽  
Novel Drug ◽  
Disease Location

Psoriasis is one of the most stern and persistent autoimmune disease which affects about 1-3% population around the globe.  It influences an individual’s life quality by hindering them physically, socially and emotionally. The hyperproliferation of keratinocytes leads to excessive growth of skin cell which causes scaling and formation of plaques. Psoriasis can be mild moderate or severe depending on the percentage of skin area affected. Based on severity of the disease, location and the type of psoriasis, the treatment approaches can vary. Treatment regimens for psoriasis include topical therapies, systemic therapies and phototherapy. Conventional drug delivery approaches face various disadvantages therefore a need for better novel drug delivery system is required. The review paper focuses at providing a broad aspect of psoriasis and the novel treatment approaches which can help in tackling the disease.  

Nanoparticulate Drug Delivery Systems: An update

2021 ◽  
pp. 312-316
Author(s):  
Pandey Swarnima ◽  
Sushant Kumar
Keyword(s):  
Drug Delivery ◽  
Carrying Capacity ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
Classification Methods ◽  
Hydrophobic Drug ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Novel Drug

The paper is aimed to provide a comprehensive review on nanoparticles, methods of preparation, applications in drug delivery. In recent years, there has been an exponential interest within the development of novel drug delivery systems using nanoparticles. Nanoparticles offers significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in several route of administration and therefore the capability to deliver both hydrophilic and hydrophobic drug molecules. This review focuses on classification, methods of preparation, characterization, application, advantages of nanoparticles and health perspectives.

An Overview of Nanoparticles: Current Scenario

2021 ◽  
pp. 239-246
Author(s):  
Seema U. Shinde ◽  
Nikita D. Gidde ◽  
Pradnya P. Shinde ◽  
Akshay B. Kadam
Keyword(s):  
Drug Delivery ◽  
High Stability ◽  
Hydrophobic Drug ◽  
Preparation Methods ◽  
Routes Of Administration ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Current Scenario ◽  
Release Potential ◽  
Novel Drug

The simplest type of structures with sizes in the nm range will be nanoparticles. Any atom mean that is associated by intensity with other atoms within a 'limited' distance may be claimed to be a nanoparticle in principle. The creation of novel drug delivery systems using nanoparticles has seen an exponential interest in recent years. In terms of high stability, high precision, high drug carrying capability, managed release potential, the possibility of use in various routes of administration and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles may offer significant advantages over conventional drug delivery. The emphasis of this study is on classification, types, synthesis, preparation methods, characterization, use, nanoparticle advantages, and health perspectives.

Novel Drug Delivery System of Phytopharmaceuticals: A Review

2021 ◽  
Vol 07 ◽  
Author(s):  
Sumit Aroraa ◽  
Veerendra Dhoke ◽  
Keshav Moharir ◽  
Subhash Yende ◽  
Sapan Shah
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Distribution ◽  
Delivery Systems ◽  
Research Activity ◽  
Innovative Drug ◽  
Preparation Methods ◽  
Conventional Drug ◽  
Sites Of Action ◽  
Novel Drug

: Herbal extracts and isolated bioactives from plants have proven their therapeutic activities as evidenced by preclinical and clinical research. However, there seems some disconnect in their clinical utility as marked by lack of proper delivery mechanism at desired sites of action. This glitch nowadays is a task for global research activity and being addressed in the form of novel drug delivery systems. A steady progress is observed in integrating novel techniques of drug delivery with successful incorporation of phytochemicals marked by scores of advantages. Limitations of conventional drug delivery systems are overcome to considerable extent by innovative drug delivery methods which show improvement in targeted drug delivery, drug distribution, and protection of active substance, prolonged action and stability. The perspective of this review thus focuses on the progress in novel drug delivery systems with spotlight on nanocarriers for herbal active agents, their preparation methods with types, examples of active ingredients incorporated and biomedical applications.

scholarly journals Novel Drug Delivery Systems for Rheumatoid Arthritis: An Approach to Better Patient Compliance

2019 ◽  
Vol 12 (1) ◽  
pp. 157-170 ◽  
Author(s):  
Sangeeta Mohanty ◽  
Sthitapragnya Panda ◽  
Aslesha Bhanja ◽  
Abhisek Pal ◽  
Si Sudam Chandra
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Human Life ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Future Perspectives ◽  
Conventional Drug ◽  
Potential Applications ◽  
Novel Drug

Recent advances in science and technology radically changed the way we detect, treat and prevent different diseases in all aspects of human life. Rheumatoid arthritis (RA) is a chronic, systemic, progressive, autoimmune disease in which the body’s immune system whose major role is to protect the health by attacking foreign bacteria and viruses are mistakenly, attacking the joints resulting in thickened synovium, pannus formation, & destruction of bone, cartilage. Still now researchers are unable to know the exact cause of this disease. However, it is believed that genes and environmental factors play a role in development of RA. In this review, we discuss the Pathophysiology, predictors, & factors involved in pathogenesis of RA. We also discuss the Conventional therapeutic agents for Rheumatoid Arthritis. More importantly, we extensively discuss the emerging novel drug delivery systems (NDDS) like nanoparticles, dendrimers, micelles, microspheres, liposomes, and so on as these are the promising tools having successful applications in overcoming the limitations associated with conventional drug delivery systems. Although several NDDS have been used for various purposes, liposomes have been focused on due to its potential applications in RA diagnosis and therapy. In addition, we discuss the therapeutic effectiveness and challenges for RA by using these novel drug delivery systems. Finally, we conclude by discussing the future perspectives.

Niosomes: The Current and Future perspectives in Drug Delivery System

2021 ◽  
pp. 3961-3966
Author(s):  
Bhupendra Singh ◽  
Pooja Sharma ◽  
Sujit Bose ◽  
Jyoti Thakur ◽  
Geetanjali Saini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Ionic Surfactants ◽  
Future Perspectives ◽  
Conventional Drug ◽  
Dosing Frequency ◽  
Novel Drug Delivery System ◽  
Novel Drug

There are many problems with the conventional dosage form of various drugs and one of them is dosing frequency in which patients have to take the drug again and again throughout the day which is very difficult mainly for the elder patient. So, to overcome this problem the approach of a novel drug delivery system (NDDS) is used to replace the conventional drug delivery system. NDDS mainly deals with sustained release of drugs which is effective to reduce the dosing frequency. Niosome is one of the best approaches of a novel drug delivery system, in which the drug in solution form is enclosed in vesicle which is made up of non-ionic surfactants. In the case of liposome which is another part of NDDS vesicles is made up of phospholipids. Niosome formulation is a powerful tool to resolve the issue of insolubility and the low bioavailability of drugs. This paper overviews the various methods of preparation of Niosome along with its pharmaceutical applications.

Establishment of Innovative Approaches of Nanofluids

2021 ◽  
pp. 997-1002
Author(s):  
Ranajit Nath ◽  
Ratna Roy ◽  
Ambika Mandal ◽  
Rajesh Ghosh ◽  
Writormi Chatterjee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tissue Level ◽  
Widespread Application ◽  
Novel Technique ◽  
Therapeutic Benefits ◽  
Significant Fluctuation ◽  
Conventional Drug ◽  
New Challenges ◽  
Novel Drug

The main objective of therapy for many medications is to obtain a therapeutically effective and non-toxic steady-state blood or tissue level for a sustained length of time. Conventional drug delivery system not only achieves but also maintains the drug concentration within the therapeutically effective range only when taken several times a day depending upon the dosage regimen. This result shows significant fluctuation in drug levels. An approach to overcome such fluctuations conventional led to the development of several novel drug delivery systems (NDDS) that could revolutionize formulation methods and provide a number of therapeutic benefits. The chapter is divided into two sections: the first deals with nanofluids, and the second discusses their use in medicine. Nanotechnology is a novel technique that comprises materials and equipment capable of regulating a substance's physical as well as chemical characteristics at subatomic scales. This invention has the potential to remove some of the obvious boundaries between biology, physics, and chemistry, as well as influence our current perceptions and understanding. As a result of the widespread application of nanotechnology throughout time, a slew of new challenges and bearings may develop in education, research, and diagnostics. Nanofluids are known as emulsions or suspensions of nanoparticles (NPs) in fluids. At low nanoparticle concentrations, they demonstrate a significant improvement in their characteristics.

Nanotechnology: Revolutionizing the Science of Drug Delivery

2019 ◽  
Vol 24 (43) ◽  
pp. 5086-5107 ◽  
Author(s):  
Mohini Mishra ◽  
Pramod Kumar ◽  
Jitendra Singh Rajawat ◽  
Ruchi Malik ◽  
Gitanjali Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Structural Features ◽  
Delivery Systems ◽  
The Novel ◽  
Drug Delivery Vehicles ◽  
Conventional Drug ◽  
Diagnostic Agents ◽  
Pros And Cons ◽  
Novel Drug

Growing interest in the field of nanotechnology has led to its emergence in the field of medicine too. Nanomedicines encompass the various medical tools, diagnostic agents and the drug delivery vehicles being evolved with the advancements in the aura of nanotechnology. This review emphasizes on providing a cursory literature on the past events that led to the procession of nanomedicines, various novel drug delivery systems describing their structural features along with the pros and cons associated with them and the nanodrugs that made a move to the clinical practice. It also focuses on the need of the novel drug delivery systems and the challenges faced by the conventional drug delivery systems.

scholarly journals CRYPTOSOMES: A REVOLUTIONARY BREAKTHROUGH IN NOVEL DRUG DELIVERY

2019 ◽  
Vol 11 (1) ◽  
pp. 7 ◽  
Author(s):  
Aiswarya M. U. ◽  
Keerthana Raju ◽  
Revathy B. Menon ◽  
Lakshmi V. S. ◽  
Sreeja C. Nair
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Phosphatidyl Ethanolamine ◽  
Delivery Systems ◽  
The Body ◽  
Solid Lipid ◽  
Conventional Drug ◽  
Novel Drug

The vesicular drug delivery systems are promising approaches to overthrown the problems of drugs having lesser bioavailability and rapid elimination from the body. The four type of lipid based drug delivery systems are: solid-lipid particulate system, emulsion based system, solid lipid tablet and vesicular system. Cryptosomes, a novel emerging vesicular drug delivery system which can overcome the disadvantages associated with conventional drug delivery systems like high stability, increased bioavailability, sustained release, decreased elimination of rapidly metabolizable drugs etc. The word Cryptosome was orginated from Greek word ‘’Crypto’’ means hidden and ‘’Soma’’ means body. It is formed from the mixture of phospholipids like distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG) with distearoylphosphatidylcholine. These entire information regarding its origin and formation is explained in Dinesh Kumar et al. Vesicular systems symbolizes the use of vesicles in the different fields as carrier system or additives. This review disclose various vesicular drug delivery system and point out the advancement of cryptosome in the world of drug delivery.This review would help researchers involved in the field of vesicular drug delivery.

Magnetic Drug Targeting: Drug Delivery in Large Vasculature

2008 ◽  
Author(s):  
Jaime Schmieg ◽  
Alicia Williams ◽  
Pavlos Vlachos
Keyword(s):  
Drug Delivery ◽  
Drug Targeting ◽  
Current Treatment ◽  
The Body ◽  
Magnetic Drug Targeting ◽  
Delivery Methods ◽  
Treatment Practices ◽  
Conventional Drug ◽  
Novel Drug

Magnetic drug targeting (MDT) is a novel drug delivery method with potential to dramatically revolutionize clinical approaches of the treatment of many diseases. In fact, MDT has been proposed for ailments ranging from vascular disease to cancer [1, 2]. Conventional drug delivery methods utilize large doses of medication to account for the dispersion of the drug throughout the body in the hope that a sufficient concentration of medicine arrives at the diseased site. Unfortunately, many medications can have caustic effects on healthy systems leaving patients with discomfort, weakened immunity or lowered quality of life. Alternatively, MDT aims to reduce potentially harmful global dosage levels by localizing medication at the diseased site. Additionally, magnetic drug targeting not only reduces chemicals seen by healthy areas of the body, it may provide a higher concentration of drug capable of remaining at the damaged location for a longer duration than typically seen for current treatment practices. Possibly the most important advantage of MDT is the method’s ability to enhance delivery while providing no additional invasive procedures.

scholarly journals Novel Drug Delivery Systems and its Future Prospects

2022 ◽  
Vol 24 (1) ◽  
pp. 48-60
Author(s):  
Avani K. Shewale ◽  
◽  
Akshay R. Yadav ◽  
Ashwini S. Jadhav ◽  
◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Level ◽  
Delivery Systems ◽  
The Body ◽  
Conventional Drug ◽  
Novel Drug Delivery System ◽  
Novel Drug

Most common methods of delivery include the preferred topical (skin), transmucosal (nasal, buccal, sublingual, vaginal, ocular and rectal) and inhalation routes. The conventional dosage forms provide drug release immediately and it causes fluctuation of drug level in blood depending upon dosage form. Therefore to maintain the drug concentration within therapeutically effective range needs novel drug delivery system. In the past few decades, considerable attention has been focused on the development of novel drug delivery system (NDDS). The NDDS should ideally fulfill two prerequisites. Firstly, it should deliver the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it should channel the active entity to the site of action. In conventional drug delivery systems, there is little or no control over release of the drug and effective concentration at the target site can be achieved by irregular administration of grossly excessive doses. At present, no available drug delivery system behaves ideally, but sincere attempts have been made to achieve them through various novel approaches in drug delivery.

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