scholarly journals Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets

2019 ◽  
Vol 70 (2) ◽  
pp. 475-482
Author(s):  
Cristian Catalin Gavat ◽  
Leonard Vasile Vasilescu ◽  
Afrodita Doina Marculescu
Keyword(s):  
Detection Limit ◽  
Active Substance ◽  
Spectrophotometric Analysis ◽  
Visible Range ◽  
Analysis Method ◽  
Method Detection Limit ◽  
Percentage Content ◽  
Average Percentage ◽  
Quantitation Limit ◽  
Average Percentage Deviation

The aim of this research was to exactly quantify pure sodium metamizole from tablets , using a spectrophotometric analysis in Visible range. The method applied has been subjected to a validation protocal which consisted in analyzing the following parameters: linearity of the method, detection limit (LD) , quantitation limit (LQ), Sandell�s sensitivity, interference of excipients, stability of prepared solutions, method and system precision, accuracy of the method. Following actual dosing, pure sodium metamizole amount in tablet of pharmaceutical was found to be 477.477 mg assigned to a percentage content of 95.495 %, very close to official declared amount (500 mg), with an maximum average percentage deviation of only 4.505 % from the official declared active substance content. This value was situated below the maximum admissible percentage deviation from stated active substance content (� 5%), established by Romanian Pharmacopoeia, X-th Edition rules.

scholarly journals Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets

2019 ◽  
Vol 70 (1) ◽  
pp. 259-262
Author(s):  
Afrodita Doina Marculescu ◽  
Cristian-Catalin Gavat ◽  
Aurel Nechita ◽  
Gabi Topor ◽  
Leonard Vasile Vasilescu ◽  
...  
Keyword(s):  
Detection Limit ◽  
Active Substance ◽  
Spectrophotometric Analysis ◽  
Visible Range ◽  
Method Detection Limit ◽  
Percentage Content ◽  
Average Percentage ◽  
Pharmaceutical Tablets ◽  
Quantitation Limit ◽  
Average Percentage Deviation

The aim of this research was to exactly quantify pure sodium metamizole from tablets , using a spectrophotometric analysis in Visible range. The method applied has been subjected to a validation protocal which consisted in analyzing the following parameters: linearity of the method, detection limit (LD) , quantitation limit (LQ). Following actual dosing, pure sodium metamizole amount in tablet of pharmaceutical was found to be 477.477 mg assigned to a percentage content of 95.495 %, very close to official declared amount (500 mg), with an maximum average percentage deviation of only 4.505 % from the official declared active substance content. This value was situated below the maximum admissible percentage deviation from stated active substance content (� 5%), established by Romanian Pharmacopoeia, X-th Edition rules.

scholarly journals VALIDATION OF CYCLAMATE ANALYSIS METHOD WITH SPECTROPHOTOMETRY AND TURBIDIMETRY

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Regina Tutik Padmaningrum ◽  
Siti Marwati
Keyword(s):  
Detection Limit ◽  
Spectrophotometric Method ◽  
Limit Of Detection ◽  
Spectrophotometric Analysis ◽  
Linear Range ◽  
Uv Spectrophotometry ◽  
Good Precision ◽  
Analysis Method ◽  
Limit Of Quantitation ◽  
Precision And Accuracy

This research aims to validate methods of analysis by spectrophotometry and turbidimetry cyclamate in the sample drink mango-flavored jelly drink  by spectrophotometry with hypochlorite reagent, ultraviolet spectrophotometry (without reagent) and turbidimetry. The object of research was the validity parameters spectrophotometric method were linearity, linear range, the limit of detection, limit of quantitation, precision, and accuracy. The calibration curve of standard solution of sodium cyclamate in the spectrophotometric method with hypochlorite reagent, UV spectrophotometry (without reagent), and turbidimetry are linear. Linear range each method respectively at a concentration were (211.36-747.08); (16.000-146.434); and (1.8521-6.1717) ppm. The detection limit of each method successively were 53.6028; 0.5833; and 0.2723 ppm. Limit of quantitation each method successively were 66.9948; 1.9443; and 0.8068 ppm. Spectrophotometric analysis method cyclamate with hypochlorite reagent had good precision and accuracy. Ultra violet  spectrophotometric analysis method of cyclamate have a good precision but the accuracy was not good. Turbidimetric methods  analysis of cyclamate had  precision and accuracy were not good.Keywords:   method validation, spectrophotometry, turbidimetry, cyclamate

Colorimetric Determination of Fluoride in Drinking Groundwater using a Polymeric Zirconium Complex of 5-(2-Carboxyphenylazo)-8-Hydroxyquinoline

2013 ◽  
Vol 12 (7) ◽  
pp. 460-465
Author(s):  
Sameer Amereih ◽  
Zaher Barghouthi ◽  
Lamees Majjiad
Keyword(s):  
Drinking Water ◽  
Detection Limit ◽  
Complex Formation ◽  
Molar Absorptivity ◽  
Colorimetric Determination ◽  
Zirconium Complex ◽  
Reliable Determination ◽  
Percentage Recovery ◽  
Quantitation Limit

A sensitive colorimetric determination of fluoride in drinking water has been developed using a polymeric zirconium complex of 5-(2-Carboxyphenylazo)-8-Hydroxyquinoline as fluoride reagents. The method allowed a reliable determination of fluoride in range of (0.0-1.5) mg L-1. The molar absorptivity of the complex formation is 7695 ± 27 L mol-1 cm-1 at 460 nm. The sensitivity, detection limit, quantitation limit, and percentage recovery for 1.0 mg L-1 fluoride for the proposed method were found to be 0.353 ± 0.013 μg mL-1, 0.1 mg L-1, 0.3 mg L-1, and 101.7 ± 4.1, respectively.

scholarly journals Comparison of Factors Affecting Crash Severities in Hit-and-Run and Non-Hit-and-Run Crashes

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Bei Zhou ◽  
Zongzhi Li ◽  
Shengrui Zhang
Keyword(s):  
Comparison Group ◽  
Reference Group ◽  
Multinomial Logistic Regression ◽  
Crash Severity ◽  
Property Damage ◽  
Average Percentage ◽  
Crash Data ◽  
Hit And Run ◽  
The Impact ◽  
Average Percentage Deviation

A hit-and-run (HR) crash occurs when the driver of the offending vehicle flees the crash scene without reporting it or aiding the victims. The current study aimed at contributing to existing literatures by comparing factors which might affect the crash severity in HR and non-hit-and-run (NHR) crashes. The data was extracted from the police-reported crash data from September 2017 to August 2018 within the City of Chicago. Two multinomial logistic regression models were established for the HR and NHR crash data, respectively. The odds ratio (OR) of each variable was used to quantify the impact of this variable on the crash severity. In both models, the property damage only (PDO) crash was selected as the reference group, and the injury and fatal crash were chosen as the comparison group. When the injury crash was taken as the comparison group, it was found that 12 variables contributed to the crash severities in both HR and NHR model. The average percentage deviation of OR for these 12 variables was 34%, indicating that compared with property damage, HR crashes were 34% more likely to result in injuries than NHR crashes on average. When fatal crashes were chosen as the comparison group, 2 variables were found to be statistically significant in both the HR and the NHR model. The average percentage deviation of OR for these 2 variables was 127%, indicating that compared with property damage, HR crashes were 127% more likely to result in fatalities than NHR crashes on average.

scholarly journals RISIKO KESEHATAN PAJANAN BENZENA, TOLUENA DAN XYLENA PETUGAS PINTU TOL

2016 ◽  
Vol 11 (2) ◽  
pp. 188 ◽  
Author(s):  
Bambang Wispriyono ◽  
Eko Handoyo
Keyword(s):  
Detection Limit ◽  
Health Risks ◽  
Risk Groups ◽  
Health Impacts ◽  
Method Detection Limit ◽  
Cross Sectional ◽  
Risk Management System ◽  
Environmental Health Risk ◽  
Benzene Concentration ◽  
Benzene Toluene

<p>Efek negatif dari polusi udara terhadap kesehatan manusia banyak diteliti termasuk polusi akibat sistem transportasi. Emisi kendaraan bermotor menghasilkan Benzena, Toluena dan Xylena (BTX) yang merupakan bahan kimia yang bersifat karsinogenik dan petugas pintu tol merupakan kelompok berisiko terpajan BTX. Penelitian bertujuan mengetahui risiko kesehatan akibat pajanan BTX pada petugas pintu tol. Desain penelitian adalah <em>cross-sectional</em> dengan pendekatan Analisis Risiko Kesehatan Lingkungan (ARKL) dan  faktor-faktor antropometri. Hasil penelitian menunjukkan pada pintu tol rata-rata konsentrasi (mean<span style="text-decoration: underline;">+</span>SD) benzena sebesar 0,00167<span style="text-decoration: underline;">+</span>0,000056 mg/m<sup>3</sup>, toluena sebesar 0,00124<span style="text-decoration: underline;">+</span>0.000049 mg/m<sup>3</sup> dan xylena sebesar 0,00147<span style="text-decoration: underline;">+</span>0,000063 mg/m<sup>3</sup> sedangkan pada kantor administrasi konsentrasi tidak terdeteksi oleh alat (<em>Method Detection Limit</em>). Rata-rata risiko non karsinogenik (RQ) BTX pada petugas pintu tol lebih tinggi secara signifikan dibandingkan dengan rata-rata RQ BTX petugas administrasi. Risiko kesehatan non karsinogenik dan karsinogenik belum menunjukkan adanya risiko kesehatan yang signifikan. Upaya pencegahan berupa pengelolaan manajemen risiko untuk pengendalian risiko bahan berbahaya di lingkungan perlu ditingkatkan.</p><p> </p><p><strong>Kata Kunci:</strong> Pintu Tol, Benzena, Toulena, Xylena</p><p> </p><p>The researches of BTX (Benzene, Toluene and Xylene) related to the health impacts have been done and published in any publications. One of the risk groups is toll gate’s workers who have been exposed every day with BTX. The design of this study is cross-sectional with Environmental Health Risk Analysis to determine the magnitude of health risks of BTX on the toll gate. The results showed at the toll workers’s respondents have  benzene concentration 0.00167+0.000056 mg/m<sup>3</sup>, toluene 0.00124+0.000049 mg/m<sup>3</sup> and xylene 0.00147+0,000063 mg/m<sup>3</sup> respectively, while in the administrative office’s respondents, BTX was undetectable (Minimum Detection Limit). The average RQ of toll gate respondents was significantly higher than administrative office’s respondents. In conclusion, the risk of all workers have the RQ ≤ 1. Non carcinogenic and carcinogenic health risks to all toll gate’s workers recently have not shown any risk yet. Nevertheless, risk management system should be developed and improved.</p><p> </p><p><strong>Keywords</strong>: Toll Gate, Benzene, Toulene, Xylene</p>

scholarly journals QUANTIFICATION OF BILASTINE AND MONTELUKAST COMBINATION IN FORMULATIONS UTILIZING LIQUID CHROMATOGRAPHY: STABILITY STUDIES

2021 ◽  
pp. 210-215
Author(s):  
KANCHARLA VIJAYALAKSHMI ◽  
BETHAPUDI SAMUEL ANAND ANDREWS ◽  
BOLINENI NAGESWARA RAO
Keyword(s):  
Liquid Chromatography ◽  
Detection Limit ◽  
Mobile Phase ◽  
Tablet Formulation ◽  
Uv Detection ◽  
Stability Studies ◽  
Stability Indicating ◽  
Quantitation Limit ◽  
Rp Hplc

Objective: We have developed a “stability-indicating RP-HPLC” procedure for the Bilastine (BLS) and montelukast (MTL) analysis of tablets. Methods: The quantification of BLS and MTL combination was implemented utilising a Waters column (C18, 5 μm, 250 mm and 4.6 mm). Isocratic mobile phase had 60% volume KH2PO4 of 0.1M strength with pH 4.2 units and 40% volume methanol at a flow with 1.0 ml/min speed. UV detection at 232 nm was done to examine BLS and MTL. Stability experiments of BLS and MTL under distinctive environments of stress were also performed. Results: The BLS and MTL were eluted at 1.810 min and 2.551 min, respectively. The responses were found to be linear for the concentration ranges of 10-30 µg/ml (BLS) and 5-15 µg/ml (MTL). Percent comparative standard deviance for precision was 0.331% (BLS) and 0.486% (MTL). Percent assay for accuracy was 98.96% (BLS) and 99.00% (MTL). The detection limit and quantitation limit measures for BLS were 0.018 µg/ml and 0.059 µg/ml, respectively, while for MTL it was 0.024 µg/ml and 0.081 µg/ml, respectively. Robustness studies authorized that the method is robust with percent comparative standard deviance of a highest 1.950%. Conclusion: The developed “stability-indicating RP-HPLC” procedure for the BLS and MTL analysis is simple, sensitive, precise, specific and robust, making it appropriate to the assessment of BLS and MTL in a tablet formulation.

scholarly journals PENERAPAN MODEL PEMBELAJARAN TPS (THINK-PAIR-SHARE) BERBANTUAN MEDIA KARTU HURUF UNTUK MENINGKATKAN KEMAMPUAN MENGENAL HURUF

2019 ◽  
Vol 2 (3) ◽  
Author(s):  
Nurul Ilma ◽  
I Ketut Pudjawan
Keyword(s):  
Descriptive Analysis ◽  
Language Ability ◽  
Letter Recognition ◽  
Analysis Method ◽  
Learning Models ◽  
Quantitative Descriptive Analysis ◽  
First Semester ◽  
Average Percentage ◽  
Statistical Analysis Method ◽  
Elementary School Education

This research is motivated by the development of children's language, especially in letter recognition. Language development requires more optimal guidance because as a child's capital to enter elementary school education. Therefore this study aims to improve the ability to recognize the language of letters applied using Think Pair Share (TPS) learning models assisted by letter card media in the TK Kartika VII-3 Singaraja B3 group in 2018/2019. The type of research used was Classroom Action Research (CAR) which was carried out in two cycles, the subject of research was the TK Kartika Singaraja VII-3 Singaraja B3 group, which consisted of 27 children, consisting of 9 girls and 18 boys. The object of research is the child's language ability to recognize letters. Data collection in this study was conducted with observation media. The analytical method used is descriptive statistical analysis method and quantitative descriptive analysis method. The results of data analysis in this study indicate that an average increase in the percentage of language ability to recognize letters in the B3 group is 25.7%. This can be seen from the increase in the average percentage of the ability of the language to recognize child letters in the first cycle of 55.31% with low criteria being 81.01% in cycle II with high criteria. Thus, it can be concluded that the application of Think Pair Share (TPS) learning models assisted by letter card media can improve the ability of the language to recognize the letters of the children of B3 TK Kartika Singaraja group in the first semester of 2018/2019

Graphite Furnace Atomic Absorption Method for the Determination of Lead in Sugars and Syrups

1994 ◽  
Vol 77 (5) ◽  
pp. 1288-1292 ◽  
Author(s):  
Nancy J Miller-Ihli
Keyword(s):  
Detection Limit ◽  
Atomic Absorption ◽  
Graphite Furnace ◽  
Absorption Spectrometry ◽  
Magnesium Nitrate ◽  
Method Detection Limit ◽  
High Fructose ◽  
Graphite Furnace Atomic Absorption ◽  
Characteristic Mass

Abstract A method was developed for the determination of lead in sugars and syrups. Samples are wet-ashed with a nitric acid–hydrogen peroxide procedure and analyzed by graphite furnace atomic absorption spectrometry. The method involves the use of magnesium nitrate as a matrix modifier, air ashing, platform atomization, and quantitation by peak area measurements with direct calibration against aqueous standards. The instrumental detection limit (based on 3.29σ) was 10 pg, or 0.5 μg/L for a 20 μL injection, corresponding to a method detection limit of 3.3 ng/g sugar. The characteristic mass was approximately 12 pg. This method was validated by analyzing sucrose and high-fructose corn syrup samples spiked with known quantities of lead. The average recovery was 101 ± 6%.

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