scholarly journals Peri-Aortic Fat Tissue Thickness in Peritoneal Dialysis Patients

2013 ◽  
Vol 33 (3) ◽  
pp. 316-324 ◽  
Author(s):  
Kultigin Turkmen ◽  
Orhan Ozbek ◽  
Mehmet Kayrak ◽  
Cigdem Samur ◽  
Ibrahim Guler ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Coronary Artery ◽  
Healthy Subjects ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Control Group ◽  
Fat Tissue ◽  
Cross Sectional ◽  
Fat Deposits ◽  
Artery Disease

BackgroundThoracic peri-aortic fat tissue (PFT) and epicardial adipose tissue (EAT) are metabolically active visceral fat deposits surrounding the thoracic aorta and the heart, respectively. Various studies have demonstrated a positive predictive value of both PFT and EAT for coronary artery disease in the general population. In the present study, we aimed to investigate PFT thickness and the independent predictors of PFT in peritoneal dialysis (PD) patients.MethodsOur cross-sectional study enrolled 35 PD patients (10 women, 25 men) and 30 age-and-sex-matched healthy subjects (15 women, 15 men). We measured PFT, thoracic artery calcification (TAC), EAT, and coronary artery calcification (CAC) by electrocardiogram-gated 64–multi-detector computed tomography.ResultsThe measured PFT, EAT, CAC, and TAC were significantly higher in the PD group than in the healthy subjects ( p < 0.05 each). In the PD group, PFT and TAC were significantly correlated ( r = 0.33, p = 0.007). Also, PFT measurements were positively correlated with EAT and total CAC in the PD and the control group alike ( r = 0.58, p = 0.001 and r = 0.54, p = 0.01 respectively). A stepwise linear regression analysis revealed that age, duration of hypertension, and being a PD patient were independent predictors of PFT.ConclusionsMeasured PFT was higher in PD patients than in healthy subjects and, in the PD population, was also shown to be related to calcification scores and EAT.

scholarly journals Association of coronary dominance with the severity of coronary artery disease: a cross-sectional study in Shaanxi Province, China

BMJ Open ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. e021292 ◽  
Author(s):  
Bin Yan ◽  
Jian Yang ◽  
Yajuan Fan ◽  
Binbin Zhao ◽  
Qingyan Ma ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Shaanxi Province ◽  
Sectional Study ◽  
Cross Sectional ◽  
Artery Disease ◽  
Coronary Dominance

ObjectiveTo investigate whether coronary artery dominance is associated with the severity of coronary artery disease (CAD).DesignCross-sectional study.SettingSingle-centre.ParticipantsBetween July 2015 and February 2017, 1654 patients who underwent coronary angiography (CAG) were recruited into this cross-sectional study.Measurement and methodsAccording to coronary dominance, patients were classified into left dominance (LD), right dominance (RD) and codominance (CD) based on the CAG results. Multiple linear regression analysis was performed to test the association between severity of CAD and coronary dominance.ResultsThe total Gensini score was significantly higher in the RD group than in the left-CD group (42.3±33.6 vs 36.3±29.8; p=0.033). After adjusting for potential confounding factors, the results of multivariate linear regression showed that RD was associated with the severity of CAD (β=6.699, 95% CI 1.193 to 12.205, p=0.017).ConclusionsThe results suggest that right coronary dominance was associated with the severity of CAD.

scholarly journals Frequency of MTHFR G1793A polymorphism in individuals with early coronary artery disease: cross-sectional study

2013 ◽  
Vol 131 (5) ◽  
pp. 296-300 ◽  
Author(s):  
Antonio Ivo Moritz Neto ◽  
Joel Rolim de Moura Junior ◽  
Darlene Camati Persuhn
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Risk ◽  
Test Group ◽  
Cross Sectional Study ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Artery Disease

CONTEXT AND OBJECTIVE: Atherosclerotic disease is the leading cause of death in Brazil. It is a complex disease and its prevention involves identification and control of risk factors. Moderately increased plasma homocysteine concentration (hyperhomocysteinemia) has been considered to be a risk factor for several vascular diseases. Mutations in the methylenetetrahydrofolate reductase (MTHFR) enzyme, which is involved in homocysteine metabolism, have been investigated as potential vascular disease risk factors. G1793A polymorphism was described in 2002 and there are few studies analyzing its involvement in diseases. The objective of this study was to investigate the prevalence of G1793A polymorphism in subjects with early coronary artery disease (CAD). DESIGN AND SETTING: Cross-sectional study with control group conducted at a private cardiology clinic and a molecular biology laboratory (Universidade do Vale do Itajaí). METHODS: We studied 74 early-onset CAD+ patients and 40 CAD- individuals with normal angiography results. DNA was extracted from blood samples. Molecular data were obtained via PCR/RFLP and agarose gel electrophoresis. RESULTS: The occurrence of G1793A heterozygotes was similar in the control (5%) and test (6.25%) groups, thus showing that in the population studied there was no correlation between the marker and occurrences of early CAD. There was also no association between the polymorphism and the risk factors for atherosclerosis. CONCLUSIONS: The frequency of the 1793A allele in the test group (3.4%) was similar to what was found in the control individuals (2.5%). There was no correlation between G1793A polymorphism and occurrences of early CAD in this population.

scholarly journals Association of Chlamydia pneumoniae Infection With Atherosclerotic Plaque Formation

2015 ◽  
Vol 8 (4) ◽  
pp. 260 ◽  
Author(s):  
Omid Assar ◽  
Azim Nejatizadeh ◽  
Farzaneh Dehghan ◽  
Mohammad Kargar ◽  
Nader Zolghadri
Keyword(s):  
Coronary Artery ◽  
Atherosclerotic Plaque ◽  
Chlamydia Pneumoniae ◽  
Artery Bypass ◽  
Cross Sectional Study ◽  
Control Group ◽  
Atherosclerotic Plaques ◽  
Nested Polymerase Chain Reaction ◽  
Cross Sectional ◽  
Artery Disease

<p>Atherosclerosis is a complex multifactorial disorder. Studies show that infectious microbial agents may play an important role in the development of atherosclerosis; however, these findings are conflicting. This study investigated the presence of <em>Chlamydia pneumoniae</em> DNA in atherosclerotic plaques of patients suffering from coronary artery disease. In a cross-sectional study, 85 patients (43 females and 42 males with mean age of 61±9.5, range 42-82 years) referred for coronary artery bypass grafting (CABG) and thoracic biopsy as the control groups were enrolled for this study. Standard questionnaires, including demographic and clinical evaluation were administered. Obtained specimens were processed and then nested polymerase chain reaction with primers for <em>Pst1</em> fragment was carried out to detect <em>Chlamydia pneumoniae</em> DNA. Statistical analysis was done using the SPSS software. Of note,<em> </em>in 25 out of the 85 patients (29.4%), <em>C. pneumoniae</em> was detected within atherosclerotic plaques, whereas, 5 out of the 85 thoracic biopsy (5.9%) were positive for the presence of the mentioned bacteria in internal thoracic artery. There was a statistically significant association between atherosclerotic plaque (study group) and thoracic biopsy (control group) in terms of <em>C. pneumoniae</em> positivity (P= 0.0001). The findings of this study support the hypothesis that <em>C. pneumoniae</em> is associated with atherosclerosis.</p>

scholarly journals Hypertension But Not Heart Failure or Coronary Artery Disease is Associated with Mental Disorders

2020 ◽  
Author(s):  
Hossein Namdar ◽  
Fatemeh Jamshidi ◽  
Davoud Ezzati ◽  
raana Zakeri ◽  
Seyyed-Reza Sadat-Ebrahimi
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Psychological Disorders ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Control Group ◽  
Depression Anxiety Stress Scale ◽  
Cross Sectional ◽  
Artery Disease

Abstract Background: Previous studies have emphasized the significant association between depression, anxiety, and stress and hypertension (HTN), heart failure (HF), and coronary artery disease (CAD). However, among included patients with HF or CAD in those studies, there were considerable proportions of patients with concomitant HTN and vice versa leading to some possible bias in final estimations. Therefore, we aimed to exclude those patients with concomitant diseases and reassess the association between these three prevalent cardiovascular diseases with three important psychological disorders. Methods: In this cross-sectional study, 300 patients were evaluated, including 100 with HTN (without a history or concomitant HF or CAD), 100 with HF (without HTN or CAD), and 100 with CAD (without HTN or HF). Moreover, 100 healthy volunteers were considered as the control group. Depression Anxiety Stress Scale 21 was used to measure the magnitude of depression, anxiety, and stress. Result: The average scores of 4.6, 9.1, 3.7, and 4.4 for depression, 3.9, 11.1, 4.1, and 3.6 for anxiety and 6.5, 13.6, 5.2, and 5.4 for stress were detected in control, HTN, CAD, and HF groups, respectively. The depression, anxiety, and stress scores of HTN group were significantly higher than the control (p<0.05), CAD (p<0.05) and HF (p<0.05) groups; this is while these scores were not significantly different between other study groups (p>0.05).Conclusion: Our study demonstrated a significantly higher magnitude of psychological disorders in patients with HTN. However, their magnitude in patients with HF and CAD without concomitant HTN were similar to those in healthy participants.

scholarly journals Hypertension but Not Heart Failure or Coronary Artery Disease is Associated With Mental Disorders

2020 ◽  
Author(s):  
Hossein Namdar ◽  
Fatemeh Jamshidi ◽  
Davoud Ezzati ◽  
raana Zakeri ◽  
Seyyed-Reza Sadat-Ebrahimi
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Psychological Disorders ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Control Group ◽  
Depression Anxiety Stress Scale ◽  
Cross Sectional ◽  
Artery Disease

Abstract Background Previous studies have emphasized the significant association between depression, anxiety, and stress and hypertension (HTN), heart failure (HF), and coronary artery disease (CAD). However, among included patients with HF or CAD in those studies, there were considerable proportions of patients with concomitant HTN and vice versa leading to some possible bias in final estimations. Therefore, we aimed to exclude those patients with concomitant diseases and reassess the association between these three prevalent cardiovascular diseases with three important psychological disorders. Methods In this cross-sectional study, 300 patients were evaluated, including 100 with HTN (without a history or concomitant HF or CAD), 100 with HF (without HTN or CAD), and 100 with CAD (without HTN or HF). Moreover, 100 healthy volunteers were considered as the control group. Depression Anxiety Stress Scale 21 was used to measure the magnitude of depression, anxiety, and stress. Result The average scores of 4.6, 9.1, 3.7, and 4.4 for depression, 3.9, 11.1, 4.1, and 3.6 for anxiety and 6.5, 13.6, 5.2, and 5.4 for stress were detected in control, HTN, CAD, and HF groups, respectively. The depression, anxiety, and stress scores of HTN group were significantly higher than the control (p < 0.05), CAD (p < 0.05) and HF (p < 0.05) groups; this is while these scores were not significantly different between other study groups (p > 0.05). Conclusion Our study demonstrated a significantly higher magnitude of psychological disorders in patients with HTN. However, their magnitude in patients with HF and CAD without concomitant HTN were similar to those in healthy participants.

scholarly journals The association between early vascular aging and cyclothymic affective temperament

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
M Vecsey-Nagy ◽  
B Szilveszter ◽  
M Kolossvary ◽  
X Gonda ◽  
Z Rihmer ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Linear Regression Analysis ◽  
Suspected Coronary Artery Disease ◽  
Cross Sectional Study ◽  
Vascular Aging ◽  
Cross Sectional ◽  
Entire Cohort ◽  
Affective Temperaments ◽  
Affective Temperament ◽  
Vascular Age

Abstract Funding Acknowledgements Type of funding sources: None. onbehalf Cardiovascular Imaging Research Group Background Affective temperaments (depressive, anxious, irritable, hyperthymic, cyclothymic) are regarded as the biologically stable core of personality, and accumulating data implies their relationship with cardiovascular diseases. There are currently limited data on the association of affective temperaments and early vascular aging. Purpose The aim of our study was to assess the potential relationship of affective temperaments and vascular age, as assessed by coronary CT. Methods In our current cross-sectional study, 209 patients referred to coronary computed tomography angiography (CCTA) due to suspected coronary artery disease (CAD), were included. After the evaluation of medical history and demographic parameters, all patients completed the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) and the Beck Depression Inventory (BDI). Vascular age was estimated using coronary artery calcium (CAC) score and we calculated its difference from chronological age for each patient. Linear regression analysis was applied to identify predictors of early vascular aging in the entire cohort and in male and female sub-populations, separately. Results The independent predictors of early vascular aging were female sex (B = -10.82 [95%CI: -15.30 – -6.33]), diabetes mellitus (B = 7.16 [95%CI: 1.20 – 13.12]) and dyslipidemia (B = -8.28 [95%CI: 3.94 – 12.62]). Further assessing gender differences, cyclothymic temperament score proved to be an independent predictor of early vascular aging in women (B = 0.89 [95%CI: 0.04 – 1.75]), while this association was absent in men. Conclusion Our results suggest that cyclothymic affective temperament contribute to early vascular aging in women.

scholarly journals Effect of redundant clinical trials from mainland China evaluating statins in patients with coronary artery disease: cross sectional study

BMJ ◽  
2021 ◽  
pp. n48
Author(s):  
Yuanxi Jia ◽  
Jiajun Wen ◽  
Riaz Qureshi ◽  
Stephan Ehrhardt ◽  
David D Celentano ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Clinical Trials ◽  
Coronary Artery ◽  
Confidence Interval ◽  
Randomized Clinical Trials ◽  
Mainland China ◽  
Statin Treatment ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Artery Disease

Abstract Objective To identify redundant clinical trials evaluating statin treatment in patients with coronary artery disease from mainland China, and to estimate the number of extra major adverse cardiac events (MACEs) experienced by participants not treated with statins in those trials. Design Cross sectional study. Setting 2577 randomized clinical trials comparing statin treatment with placebo or no treatment in patients with coronary artery disease from mainland China, searched from bibliographic databases to December 2019. Participants 250 810 patients with any type of coronary artery disease who were enrolled in the 2577 randomized clinical trials. Main outcome measures Redundant clinical trials were defined as randomized clinical trials that initiated or continued recruiting after 2008 (ie, one year after statin treatment was strongly recommended by clinical practice guidelines). The primary outcome is the number of extra MACEs that were attributable to the deprivation of statins among patients in the control groups of redundant clinical trials—that is, the number of extra MACEs that could have been prevented if patients were given statins. Cumulative meta-analyses were also conducted to establish the time points when statins were shown to have a statistically significant effect on coronary artery disease. Results 2045 redundant clinical trials were identified published between 2008 and 2019, comprising 101 486 patients in the control groups not treated with statins for 24 638 person years. 3470 (95% confidence interval 3230 to 3619) extra MACEs were reported, including 559 (95% confidence interval 506 to 612) deaths, 973 (95% confidence interval 897 to 1052) patients with new or recurrent myocardial infarction, 161 (132 to 190) patients with stroke, 83 (58 to 105) patients requiring revascularization, 398 (352 to 448) patients with heart failure, 1197 (1110 to 1282) patients with recurrent or deteriorated angina pectoris, and 99 (95% confidence interval 69 to 129) unspecified MACEs. Conclusions Of more than 2000 redundant clinical trials on statins in patients with coronary artery disease identified from mainland China, an extra 3000 MACEs, including nearly 600 deaths, were experienced by participants not treated with statins in these trials. The scale of redundancy necessitates urgent reform to protect patients.

Abstract P354: Circulating Interleukin 17 A In Patients With Acute And Chronic Coronary Syndrome

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Dinaldo C Oliveira ◽  
Edivaldo Mendes Filho ◽  
Mariana Barros ◽  
Carolina Oliveira ◽  
Joao Vitor Cabral ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Volunteers ◽  
Clinical Characteristics ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Interleukin 17 ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Artery Disease

Introduction: Interleukin L-17 is produced by Th 17 cells and other cells. There is a debate if IL 17 is atherogenic or atheroprotective. The true role of this interleukin during the development and progression of the coronary artery disease is not known. Objective: To evaluate if there are differences between the IL17 A serum levels according to clinical presentation of the coronary artery disease. Methods: This is a cross sectional study which enrolled 101 patients with acute coronary syndrome (ACS), 100 patients with chronic coronary syndrome (CCS) and 100 healthy volunteers. Blood samples were taken from patients ( at admission) and controls to analysis the level of IL17A. Clinical characteristics were collected through questionnaires. This research was approved by ethical committee. Results: Comparisons of the clinical characteristics between patients with ACS and CCS revealed: mean age ( 62 ± 12.4 vs 63.3 ± 9.8, p = 0.4 ), male (63.4% vs 58%, p = 0.4) hypertension (85.1% vs 79%, p = 0.1) , disyipidemia (48% vs 31%, p =0.01), Diabetes Mellitus (47.5% vs 41%, p = 0.3), previous myocardial infarction (57.4% vs 40%, p = 0,01), smoking (29.7% vs 38%, p = 1). The peripheral concentrations of IL17A according to ACS, CCS and controls were: 5.36 ± 8.83 vs 6.69 ± 17.92 vs 6.26 ± 11.13, p = 0.6. Besides, the comparison between ACS and CCS showed: 5.36 ± 8.83 vs 6.69 ± 17.92, p = 0.3. Conclusion: The main finding os this study was that the circulating IL 17 concentrations were similar in patients with ACS, CCS and healthy volunteers). Besides, there was no difference between patients with ACS and CCS. Therefore, our hypothesis is that in patients with ACS and CCS the circulating IL 17 A concentrations are low or undetectable.

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