scholarly journals Application Of The Preparation Floxal In Treatment Of Acute And Chronic Diseases Of The Lid And Conjunctives

2021 ◽  
Vol 03 (06) ◽  
pp. 122-126
Author(s):  
Kakharova Dildora Maribzhanovna ◽  
◽  
Shadmanov Mirzamakhmud Alisherovich ◽  
Khoshimova Dilrabo Khoshimovna ◽  
Abdurkhmanova Mukhayyo Abdurakhimovna ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Allergic Conjunctivitis ◽  
Inflammatory Diseases ◽  
Anterior Segment ◽  
Ophthalmic Ointment ◽  
Subjective Discomfort

The problem of treating inflammatory diseases of the anterior segment of the eye, in particular chronic allergic conjunctivitis, blepharoconjunctivitis , continues to be relevant. In addition to the pronounced subjective discomfort, cosmetic defect, these diseases pose a danger to the cornea. Our study was aimed at studying the effectiveness of Floxal antibacterial ophthalmic ointment - in the treatment of acute and chronic diseases of the eyelids and conjunctiva.

Exploiting Anti-Inflammation Effects of Flavonoids in Chronic Inflammatory Diseases

2020 ◽  
Vol 26 (22) ◽  
pp. 2610-2619 ◽  
Author(s):  
Tarique Hussain ◽  
Ghulam Murtaza ◽  
Huansheng Yang ◽  
Muhammad S. Kalhoro ◽  
Dildar H. Kalhoro
Keyword(s):  
Oxidative Stress ◽  
Chronic Diseases ◽  
Inflammatory Diseases ◽  
Therapeutic Option ◽  
Cellular Level ◽  
Antiinflammatory Drugs ◽  
Suitable Alternative ◽  
Chronic Inflammatory Diseases

Background: Inflammation is a complex response of the host defense system to different internal and external stimuli. It is believed that persistent inflammation may lead to chronic inflammatory diseases such as, inflammatory bowel disease, neurological and cardiovascular diseases. Oxidative stress is the main factor responsible for the augmentation of inflammation via various molecular pathways. Therefore, alleviating oxidative stress is effective a therapeutic option against chronic inflammatory diseases. Methods: This review article extends the knowledge of the regulatory mechanisms of flavonoids targeting inflammatory pathways in chronic diseases, which would be the best approach for the development of suitable therapeutic agents against chronic diseases. Results: Since the inflammatory response is initiated by numerous signaling molecules like NF-κB, MAPK, and Arachidonic acid pathways, their encountering function can be evaluated with the activation of Nrf2 pathway, a promising approach to inhibit/prevent chronic inflammatory diseases by flavonoids. Over the last few decades, flavonoids drew much attention as a potent alternative therapeutic agent. Recent clinical evidence has shown significant impacts of flavonoids on chronic diseases in different in-vivo and in-vitro models. Conclusion: Flavonoid compounds can interact with chronic inflammatory diseases at the cellular level and modulate the response of protein pathways. A promising approach is needed to overlook suitable alternative compounds providing more therapeutic efficacy and exerting fewer side effects than commercially available antiinflammatory drugs.

scholarly journals Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4426 ◽  
Author(s):  
Ming-Shun Wu ◽  
Levent Bless B. Aquino ◽  
Marjette Ylreb U. Barbaza ◽  
Chieh-Lun Hsieh ◽  
Kathlia A. De Castro-Cruz ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
Sesamum Indicum ◽  
The Body ◽  
Anticancer Activities ◽  
Anticancer Properties ◽  
Pharmacological Significance ◽  
Anti Inflammatory ◽  
Natural Medicines

The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

scholarly journals COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence?

2021 ◽  
Author(s):  
Arash Maleki ◽  
Sydney Look-Why ◽  
Ambika Manhapra ◽  
Charles Stephen Foster
Keyword(s):  
Inflammatory Diseases ◽  
Case Reports ◽  
Anterior Segment ◽  
Posterior Segment ◽  
Ischemic Optic Neuropathy ◽  
Temporal Artery Biopsy ◽  
Dexamethasone Implant ◽  
Intravitreal Dexamethasone Implant ◽  
The Right ◽  
Intravitreal Dexamethasone

Purpose: To report two cases; bilateral arteritic anterior ischemic optic neuropathy (AAION) and bilateral acute zonal occult outer retinopathy (AZOOR) after COVID-19 mRNA vaccination. Case Reports: The first patient was a 79-year-old female was presented to us 35 days after a sudden bilateral loss of vision, which occurred two days after receiving the second recombinant mRNA vaccine (Pfizer) injection. Temporal artery biopsy was compatible with AAION. At presentation, the best-corrected visual acuity was 20/1250 and 20/40 in the right and left eyes on the Snellen acuity chart, respectively. There was 3+ afferent pupillary defect in the right eye. The anterior segment and posterior segment exams were normal except for pallor of the optic nerve head in both eyes. Intraocular pressure was normal in both eyes. She was diagnosed with bilateral AAION and Subcutaneous tocilizumab 162 mg weekly was recommended with monitoring her ESR, CRP, and IL-6. The second patient was a 33-year-old healthy female who was referred to us for a progressive nasal field defect in her left eye, and for flashes in both eyes. Her symptoms started 10 days after receiving the second recombinant mRNA vaccine (Moderna) injection. Complete bloodwork performed by a uveitis specialist demonstrated high ESR (25) and CRP (19) levels. As a result, she was diagnosed with unilateral AZOOR in her left eye and was subsequently treated with an intravitreal dexamethasone implant in the same eye. At presentation, vision was20/20 in both eyes. The anterior segment and posterior segment exams were completely normal except for the presence of abnormal white reflex in the temporal macula of her left eye. We diagnosed her with bilateral AZOOR. Since she was nursing, intravitreal dexamethasone implant was recommended for the right eye. Conclusion: There may be a correlation between ocular inflammatory diseases with autoimmune mechanism and the mRNA COVID-19 vaccination.

Local antibiotic therapy of bacterial infectious and inflammatory diseases of the anterior segment of the eye (literature review)

2021 ◽  
pp. 89-93
Author(s):  
A.E. Babushkin ◽  
Keyword(s):  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
High Efficiency ◽  
Inflammatory Diseases ◽  
Anterior Segment ◽  
Eye Diseases ◽  
Good Tolerability ◽  
Wide Range ◽  
Local Antibiotic ◽  
Topical Antimicrobial

Inflammatory eye diseases are one of the most important problems of ophthalmology. They can be caused by various pathogens of the infection, which is still more often bacterial. Therapy of bacterial inflammatory diseases of the eye involves the use of antibacterial drugs (sulfonamides, antiseptics, nitrofurans, etc.), among which antibiotics are of primary importance. Of this group of drugs, in this review article, special attention is paid to quinolones, mainly synthetic fluoroquinolones, which are distinguished by a wide range of bactericidal action, fairly high efficiency, low level of resistance of microorganisms to it and the frequency of side effects, as well as good tolerability by patients, i.e. they best meet the requirements for modern topical antimicrobial agents. In certain clinical situations and indications, it is advisable to use ophthalmic antiseptics and combined preparations containing several antibiotics of different effects at once, or an antibiotic and a corticosteroid. Key words: infectious and inflammatory eye diseases, antibacterial agents, antibiotics, combined preparations, antiseptics.

The objective criteria of chronic diseases of digestive system in children (literature review)

10.12737/7593 ◽  
2015 ◽  
Vol 9 (1) ◽  
pp. 0-0
Author(s):  
Сапожников ◽  
Vladimir Sapozhnikov ◽  
Воробьева ◽  
A. Vorobeva
Keyword(s):  
Chronic Diseases ◽  
Digestive System ◽  
Anterior Abdominal Wall ◽  
Inflammatory Diseases ◽  
Medical Problem ◽  
Pathological Process ◽  
Logical Relation ◽  
Number Of Children ◽  
Co Morbidity ◽  
Instrumental Methods

Recently, in Russia the number of children with chronic inflammatory diseases of the digestive system grows steadily. Chronic diseases of the digestive system in children often begin in pre-school and school age. This article discusses the objective criteria of the chronic diseases of the digestive system in children. This pathology is an important social and medical problem among children. Today, there are many children with digestive pathology. The leading is gastro-duodenal pathology. Analysis of the above data shows the high complexity of the diagnostic evaluation of different symptoms that can only be detected on palpation of the anterior abdominal wall in children with combined pathology of the organs of the gastro-duodenal zone. This is due to the co-morbidity of development of pathological process. On the other part, however, the authors observed a logical relation in the frequency of occurrence of these or other symptoms depending on the extent and nature of the lesion of the stomach, duodenum, biliary system, pancreas in children. This again underlines the importance of improving instrumental methods in children with disorders of the digestive system.

scholarly journals Is copper a new target to counteract the progression of chronic diseases?

Metallomics ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1712-1722 ◽  
Author(s):  
Clara Balsano ◽  
Cristiana Porcu ◽  
Silvia Sideri
Keyword(s):  
Chronic Diseases ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases

In this review, we highlight the importance of a Cu imbalance in the pathogenesis of several chronic inflammatory diseases.

scholarly journals The concurrence of chronic diseases among unemployed and employed persons: a register-based study

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
B Yildiz ◽  
M Schuring ◽  
M G Knoef ◽  
L van Zoonen ◽  
A Burdorf
Keyword(s):  
Chronic Diseases ◽  
Employment Status ◽  
Older Persons ◽  
Large Scale ◽  
Middle Age ◽  
Inflammatory Diseases ◽  
Psychological Disorders ◽  
Respiratory Illness ◽  
Sociodemographic Characteristics ◽  
Objective Data

Abstract Background The first aim of this study was to describe the prevalence of chronic diseases and multimorbidity among employed and unemployed persons. The second aim was to investigate associations of sociodemographic characteristics with the prevalence of chronic diseases and multimorbidity. Methods Data linkage of large-scale registries on employment status, medication use and sociodemographic characteristics for all Dutch residents in 2016 was applied. In total, 5,074,227 subjects aged 18-65 years were included in the study. The prevalence of six common chronic diseases and multimorbidity was investigated among unemployed and employed persons. Multivariate logistic regression analyses were performed to examine associations of sociodemographic characteristics with the prevalence of chronic diseases and multimorbidity. Results Unemployed persons had a higher prevalence of psychological disorders (18.3% vs 5.4%), cardiovascular disease (20.1% vs 8.9%), inflammatory diseases (24.5% vs 15.8%), and respiratory illness (11.7% vs 6.5%) compared to employed persons. Unemployed persons were more likely to have one (OR 1.30, 95% CI 1.29-1.31), two (OR 1.74, 95% CI 1.73-1.76) and at least three chronic diseases (OR 2.59, 95% CI 2.56-2.61) than employed persons. Older persons, women, lower educated persons and migrants were more likely to have one, two, and at least three chronic diseases. Especially at younger ages, psychological disorders and inflammatory conditions were more prevalent but declined from middle age onwards among unemployed persons, whereas as slight increase from middle age onwards was observed among employed persons. Conclusions Using objective data, this study provided evidence for inequalities in the prevalence of chronic diseases and multimorbidity, indicating employment status to be an important determinant of health. Policy measures and health interventions should target chronic diseases and multimorbidity, especially among unemployed persons. Key messages Using objective data, this study showed that unemployed persons had a higher prevalence of chronic diseases and multimorbidity compared to employed persons. In particular older persons, women, lower educated persons and migrants were more likely to have chronic diseases and multimorbidity.

scholarly journals Curcumin's antioxidant effects on inflammatory diseases

2021 ◽  
Vol 7 (1) ◽  
pp. 45-53
Author(s):  
Halime Selen ◽  
Veysel Çomaklı
Keyword(s):  
Chronic Diseases ◽  
Inflammatory Diseases ◽  
Endocrine Diseases ◽  
The World ◽  
Antioxidant Effects

There are similar inflammatory reasons behind non-contagious chronic diseases. The prevalence of these diseases increases everyday both in our country and around the world. That's why scientists have begun looking for strong antioxidants that could help prevent and treat such inflammatory diseases. Curcumin is one of those antioxidants. Curcumin is one of the components of turmeric, which belongs to the ginger family. Many studies showed that the curcuminoids in turmeric can be used to prevent and treat cardiovascular, autoimmune and endocrine diseases, cancer as well as various inflammatory diseases. With this study, we aim to interpret these recent studies conducted with curcumin.

Characterization of lactobacilli strains isolated from baby’s feces for their potential immunobiotic application

2019 ◽  
Author(s):  
Imad Al Kassaa ◽  
Samah Mechemchani ◽  
Mazen Zaylaa ◽  
Mohamad Bachar Ismail ◽  
Khaled El Omari ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Chronic Diseases ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Antibacterial Activities ◽  
In Vivo Model ◽  
Bowel Diseases ◽  
Anti Inflammatory ◽  
Lactobacillus Spp

Background and Objectives: Several LAB species were evaluated and characterized for potential probiotic use. Besides the antimicrobial activity, probiotics showed recently a capacity to prevent and to alleviate inflammatory and chronic diseases. Immunomodulation effect is one of the modes of actions of such probiotics, called immunobiotics, which can be used in several chronic diseases such as Inflammatory Bowel Diseases (IBD). The aim of this study was to isolate, identify and char- acterize lactobacilli strains from healthy baby’s feces in order to select some strains with potential immunobiotic application especially strains which can stimulate anti-inflammatory responses. Materials and Methods: Forty-two LAB strains were isolated and identified by the MALDI-TOF / MS technique. In addi- tion, strains were subjected to several assessments such as antimicrobial activity, the capacity to form biofilm in polystyrene microplate and immunomodulation activity in a PBMC model. Results: Results showed that the majority of strains (90.4%) were identified as Lactobacillus. However, among these, only 39.4% of lactobacilli strains were not identified at the species level. All isolated lactobacilli strains showed an anti-inflam- matory effect. Moreover, 7 strains were considered as good probiotic candidates based on their characteristics such as their antibacterial activities, formation of the strongest biofilm and their ability to stimulate an anti-inflammatory response in PBMCs model. Conclusion: Two strains (Lactobacillus spp S14 and Lactobacillus spp S49) which showed the best immunobiotic char- acteristics, could be selected and evaluated more deeply in vivo model as well as in human clinical study to ensure their effectiveness in inflammatory diseases such as IBD.

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