scholarly journals Recent synthesis of thietanes

2020 ◽  
Vol 16 ◽  
pp. 1357-1410
Author(s):  
Jiaxi Xu
Keyword(s):  
Organic Synthesis ◽  
Synthetic Methods ◽  
Structural Motifs ◽  
Ring Expansions ◽  
Biological Compounds ◽  
New Strategies ◽  
Recent Synthesis

Thietanes are important aliphatic four-membered thiaheterocycles that are found in the pharmaceutical core and structural motifs of some biological compounds. They are also useful intermediates in organic synthesis. Various synthetic methods of thietanes have been developed, including inter- and intramolecular nucleophilic thioetherifications, photochemical [2 + 2] cycloadditions, ring expansions and contractions, nucleophilic cyclizations, and some miscellaneous methods. The recently developed methods provide some new strategies for the efficient preparation of thietanes and their derivatives. This review focuses on the synthetic methods to construct thietane backbones developed during 1966 to 2019.

New Strategies for Activation of Phosphonates/Phosphates to Forge Functional Phosphorus Compounds

Synlett ◽  
2019 ◽  
Vol 30 (06) ◽  
pp. 635-641 ◽  
Author(s):  
Jun Kang ◽  
Hai Huang
Keyword(s):  
Natural Products ◽  
Late Stage ◽  
Natural Compounds ◽  
Synthetic Methods ◽  
Phosphorus Compounds ◽  
Reaction Conditions ◽  
Structural Motifs ◽  
Bioactive Natural Products ◽  
Potential Applications ◽  
New Strategies

Organophosphonate analogues are important structural motifs that are present in bioactive natural products, pharmaceuticals, and agrochemicals. Because they are useful in a broad range of applications, much effort has focused on developing efficient synthetic methods that enable access to organophosphonates and their derivatives. However, currently available synthetic procedures rely on harsh reaction conditions and are limited to a narrow substrate scope. Our lab has recently made important advances in leveraging inert phosphonates/phosphates into functional phosphorus compounds such as mixed phosphonates, phosphates, and mixed aryl phosphate derivatives. Presented herein is an overview of recent achievements in the synthesis of phosphonate/phosphate derivatives and a summary of our recent accomplishments in Tf2O-promoted activating strategy of phosphonate analogues.1 Introduction2 Direct Activating Strategy of Phosphonate Analogues3 Late-stage Phosphonylation of Natural Compounds4 Potential Applications5 Summary

Sēra dioksīda fizikāli ķīmisko īpašību pielietojums jaunu organiskās sintēzes metožu izstrādē / Development of New Organic Synthesis Methods Based on Physico-Chemical Properties of Sulfur Dioxide

2021 ◽  
Author(s):  
◽  
Krista Gulbe
Keyword(s):  
Organic Synthesis ◽  
Chemical Properties ◽  
Coupling Reaction ◽  
Synthetic Methods ◽  
Synthesis Methods ◽  
Chemical Transformations ◽  
Scientific Publications ◽  
Cross Coupling Reaction ◽  
Aryl Acetylenes ◽  
The Republic

The Doctoral Thesis has been prepared as a collection of thematically related scientific publications comprising five publications in the SCI journals, one patent of the Republic of Latvia, and one application for patent of the Republic of Latvia. We have carried out fundamental research on the applications of SO2 as a solvent and reagent in organic synthesis. We have developed several novel synthetic methods that represent the use of liquid SO2 as a solvent for chemical transformations that proceed via carbenium ion intermediates: a) hydration of aryl acetylenes; b) hydrohalogenation of aryl acetylenes; c) ring opening of methylenecyclopropanes with halides; d) glycosylation with glycosyl fluorides. By employing DABSO as an SO2 surrogate, we have also discovered the catalytic activity of Ru(II) complexes towards sulfonylative cross coupling reaction. This finding has been applied for the synthesis of sulfonyl derived compounds.

scholarly journals “Probe, Sample, and Instrument (PSI)”: The Hat-Trick for Fluorescence Live Cell Imaging

Chemosensors ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 40 ◽  
Author(s):  
Ludovic Galas ◽  
Thibault Gallavardin ◽  
Magalie Bénard ◽  
Arnaud Lehner ◽  
Damien Schapman ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Fluorescent Probes ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Cell Labeling ◽  
Key Points ◽  
Research Infrastructures ◽  
New Strategies ◽  
Fluorescence Live Cell Imaging

Cell Imaging Platforms (CIPs) are research infrastructures offering support to a number of scientific projects including the choice of adapted fluorescent probes for live cell imaging. What to detect in what type of sample and for how long is a major issue with fluorescent probes and, for this, the “hat-trick” “Probe–Sample–Instrument” (PSI) has to be considered. We propose here to deal with key points usually discussed in CIPs including the properties of fluorescent organic probes, the modality of cell labeling, and the best equipment to obtain appropriate spectral, spatial, and temporal resolution. New strategies in organic synthesis and click chemistry for accessing probes with enhanced photophysical characteristics and targeting abilities will also be addressed. Finally, methods for image processing will be described to optimize exploitation of fluorescence signals.

New strategies in using macromolecular catalysts in organic synthesis

1992 ◽  
Vol 74 (1-3) ◽  
pp. 409-419 ◽  
Author(s):  
David E. Bergbreiter ◽  
Bushi Chen ◽  
David Weatherford
Keyword(s):  
Organic Synthesis ◽  
New Strategies

scholarly journals 2-Azadienes as Enamine Umpolung Synthons for the Preparation of Chiral Amines

Synlett ◽  
2019 ◽  
Vol 30 (11) ◽  
pp. 1253-1268 ◽  
Author(s):  
Steven J. Malcolmson ◽  
Kangnan Li ◽  
Xinxin Shao
Keyword(s):  
Organic Synthesis ◽  
Metal Species ◽  
Chiral Amines ◽  
Chiral Amine ◽  
Tertiary Alcohols ◽  
Reductive Couplings ◽  
Benzylic Amines ◽  
Important Objective ◽  
New Strategies

The development of new strategies for the preparation of chiral amines is an important objective in organic synthesis. In this Synpacts, we summarize our approach for catalytically accessing nucleophilic aminoalkyl metal species from 2-azadienes, and its application in generating a number of important but elusive chiral amine scaffolds. Reductive couplings with ketones and imines afford 1,2-amino tertiary alcohols and 1,2-diamines, respectively, whereas fluoroarylations of gem-difluoro-2-azadienes deliver α-trifluoromethylated benzylic amines.1 Introduction2 Background: Umpolung Strategies for Preparing Chiral Amines3 Background: 2-Azadienes4 Reductive Couplings of 2-Azadienes5 Fluoroarylations of gem-Difluoro-2-azadienes6 Summary and Outlook

Development of a Hydrazine-Catalyzed Carbonyl-Olefin Metathesis Reaction

Synlett ◽  
2019 ◽  
Vol 30 (17) ◽  
pp. 1954-1965 ◽  
Author(s):  
Tristan H. Lambert
Keyword(s):  
Double Bond ◽  
Organic Synthesis ◽  
Olefin Metathesis ◽  
Type I ◽  
Type Ii ◽  
Metathesis Reaction ◽  
Alternative Strategies ◽  
Potential Applications ◽  
Acid Catalyzed ◽  
New Strategies

Carbonyl-olefin metathesis is a potentially powerful yet underexplored reaction in organic synthesis. In recent years, however, this situation has begun to change, most notably with the introduction of several different catalytic technologies. The development of one of those new strategies, based on hydrazine catalysts and a novel [3+2] paradigm for double bond metathesis, is discussed herein. First, the stage is set with a description of some potential applications of carbonyl-olefin metathesis and a discussion of alternative strategies for this intriguing reaction.1 Introduction2 Potential Applications of Carbonyl-Olefin Metathesis3 Carbonyl-Olefin Metathesis Strategies4 Direct (Type I): Non-Catalytic5 Direct (Type I): Acid-Catalyzed6 Indirect (Type II): Metal Alkylidenes7 Indirect (Type III): Hydrazine-Catalyzed8 Conclusion

scholarly journals Revisiting the Structure and Chemistry of 3(5)-Substituted Pyrazoles

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 42 ◽  
Author(s):  
Alina Secrieru ◽  
Paul Michael O’Neill ◽  
Maria Lurdes Santos Cristiano
Keyword(s):  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Positive Impact ◽  
Biological Activities ◽  
Experimental Methods ◽  
Synthetic Methods ◽  
Conformational Preferences ◽  
Substituted Pyrazoles ◽  
Present Subject

Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field. Pyrazoles are also interesting compounds from a structural viewpoint, mainly because they exhibit tautomerism. This phenomenon may influence their reactivity, with possible impact on the synthetic strategies where pyrazoles take part, as well as on the biological activities of targets bearing a pyrazole moiety, since a change in structure translates into changes in properties. Investigations of the structure of pyrazoles that unravel the tautomeric and conformational preferences are therefore of upmost relevance. 3(5)-Aminopyrazoles are largely explored as precursors in the synthesis of condensed heterocyclic systems, namely pyrazolo[1,5-a]pyrimidines. However, the information available in the literature concerning the structure and chemistry of 3(5)-aminopyrazoles is scarce and disperse. We provide a revision of data on the present subject, based on investigations using theoretical and experimental methods, together with the applications of the compounds in synthesis. It is expected that the combined information will contribute to a deeper understanding of structure/reactivity relationships in this class of heterocycles, with a positive impact in the design of synthetic methods, where they take part.

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