C–C (alkynylation) vs C–O (ether) bond formation under Pd/C–Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines
2011 ◽
Vol 7
◽
pp. 338-345
◽
Keyword(s):
The Pd/C–CuI–PPh3 catalytic system facilitated C–C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C–O bond formation between the chloro compounds and methanol. A variety of novel 4-alkynylthieno[2,3- d]pyrimidines were prepared via alkynylation of 4-chlorothieno[2,3-d]pyrimidines in good to excellent yields. Some of the compounds synthesized were tested for cytotoxic activity in vitro.
2013 ◽
Vol 10
(8)
◽
pp. 555-561
◽
Keyword(s):
Keyword(s):
1974 ◽
Vol 249
(17)
◽
pp. 5633-5641
Keyword(s):