The effect of Diabetes mellitus (DM) induction on the Structure of Skeletal Muscle in experimental rats and the protective role of arginine on (DM) complications (Ultrastructural Study )

Abstract Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin–angiotensin system (RAS), ACE2 cleaves angiotensin II (Ang II) into angiotensin 1-7 (Ang 1-7), which is considered to exert cellular responses to counteract the activation of the RAS primarily through a receptor, Mas, in multiple organs including skeletal muscle. Previous studies have provided abundant evidence suggesting that Ang 1-7 modulates multiple signalling pathways leading to protection from pathological muscle remodelling and muscle insulin resistance. In contrast, there is relatively little evidence to support the protective role of ACE2 in skeletal muscle. The potential contribution of endogenous ACE2 to the regulation of Ang 1-7-mediated protection of these muscle pathologies is discussed in this review. Recent studies have suggested that ACE2 protects against ageing-associated muscle wasting (sarcopenia) through its function to modulate molecules outside of the RAS. Thus, the potential association of sarcopenia with ACE2 and the associated molecules outside of RAS is also presented herein. Further, we introduce the transcriptional regulation of muscle ACE2 by drugs or exercise, and briefly discuss the potential role of ACE2 in the development of COVID-19.

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The Effect of Induced Diabetes Mellitus on the Cerebellar Cortex of Adult Male Rat and the Possible Protective Role of Oxymatrine: A Histological, Immunohistochemical and Biochemical Study

10.21203/rs.3.rs-300672/v1 ◽

2021 ◽

Author(s):

Amany Mohamed Shalaby ◽

Adel Mohamed Aboregela ◽

Mohamed Ali Alabiad ◽

Mona Tayssir Sadek

Keyword(s):

Diabetes Mellitus ◽

Purkinje Cells ◽

Cerebellar Cortex ◽

Adult Male ◽

Protective Role ◽

Diabetic Rats ◽

Male Rats ◽

Group I ◽

Group Ii

Abstract Diabetes mellitus (DM) represents a widespread metabolic disease with a well-known neurotoxicity in both central and peripheral nervous systems. Oxymatrine is a traditional Chinese herbal medicine that has various pharmacological activities including; anti-oxidant, anti-apoptotic and anti-inflammatory potentials. The present work aimed to study the impact of diabetes mellitus on the cerebellar cortex of adult male albino rat and to evaluate the potential protective role of oxymatrine using different histological methods. Fifty-five adult male rats were randomly divided into three groups: group I served as control, group II was given oxymatrine (80 mg/kg/day) orally for 8 weeks and group III was given a single dose of streptozotocin (50mg/kg) intaperitoneally to induce diabetes. Then diabetic rats were subdivided into two subgroups: subgroup IIIa that received no additional treatment and subgroup IIIb that received oxymatrine similar to group II. The diabetic group revealed numerous changes in the Purkinje cell layer in the form of multilayer arrangement of Purkinje cells, shrunken cells with deeply stained nuclei as well as focal loss of the Purkinje cells. A significant increment in GFAP and synaptophysin expression was reported. Transmission electron microscopy showed irregularity and splitting of myelin sheaths in the molecular layer, dark shrunken Purkinje cells with ill-defined nuclei, dilated Golgi saccules and dense granule cells with irregular nuclear outlines in the granular layer. In contrast, these changes were less evident in diabetic rats that received oxymatrine. In conclusion, Oxymatrine could protect the cerebellar cortex against changes induced by DM.

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Protective role of calcium ion against stress-induced osmotic fragility of red blood cells in patients with type 2 diabetes mellitus

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-2012-1546 ◽

2013 ◽

Vol 53 (3) ◽

pp. 239-245 ◽

Cited By ~ 1

Author(s):

Ebrahim Mostafavi ◽

Manouchehr Nakhjavani ◽

Zaniar Ghazizadeh ◽

Hassan Barakati ◽

Hossein Mirmiranpour ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Red Blood Cells ◽

Calcium Ion ◽

Blood Cells ◽

Osmotic Fragility ◽

Protective Role

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Protective Role of CTRP3 and CTRP9 in the Development of Gestational Diabetes Mellitus

Clinical Laboratory ◽

10.7754/clin.lab.2020.200247 ◽

2020 ◽

Vol 66 (11/2020) ◽

Author(s):

Ling Xia ◽

Huijuan Zhang ◽

Qiang Shi ◽

Xueling Zhang ◽

Chongqiang Wang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Protective Role

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Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.78.2.8106637 ◽

1994 ◽

Vol 78 (2) ◽

pp. 471-477

Author(s):

J J Nolan ◽

G Freidenberg ◽

R Henry ◽

D Reichart ◽

J M Olefsky

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Skeletal Muscle ◽

Insulin Receptor ◽

Human Skeletal Muscle ◽

Dependent Diabetes Mellitus ◽

Receptor Kinase ◽

Insulin Receptor Kinase

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Protective Role of Polysaccharides from Gynostemma pentaphyllum Makino Supplementation against Exhaustive Swimming Exercise-Induced Oxidative Stress in Liver and Skeletal Muscle of Mice

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.962-965.1231 ◽

2014 ◽

Vol 962-965 ◽

pp. 1231-1234

Author(s):

Hui Huang ◽

Bo Qi

Keyword(s):

Oxidative Stress ◽

Skeletal Muscle ◽

Protective Role ◽

Swimming Exercise ◽

Control Group ◽

High Dose ◽

Gynostemma Pentaphyllum ◽

Exercise Induced ◽

Different Doses

The objective of this study was to investigate the protective role of polysaccharide fromGynostemma pentaphyllumMakino (PGP) supplementation against exhaustive swimming exercise-induced oxidative stress. A total of 48 mice were randomly divided into four groups: control, low-dose, medium-dose, and high-dose PGP supplementation groups. The control group received distilled water and the supplementation groups received different doses of PGP (50, 100 and 200 mg/kg body weight) by gavage once a day for 28 consecutive days. After 28 days, the mice performed an exhaustive swimming exercise, and some biochemical parameters related to oxidative stress, including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and malondialdehyde (MDA), were measured. The results showed that PGP supplementation could increase SOD, GPx and CAT contents, as well as decrease MDA contents in the liver and skeletal muscle of mice, which suggests that PGP supplementation has a protective role against exhaustive swimming exercise-induced oxidative stress.

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