scholarly journals A Comparison between Type-2 Diabetics and Non-Diabetics in Terms of Papillary Bleeding Index (PBI)

2022 ◽  
Vol 9 (1) ◽  
pp. 28-32
Author(s):  
Sara Mariyum ◽  
Nazma Saleem ◽  
Amjad Iqbal ◽  
Shama Iqbal ◽  
Munazza Khattak ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tertiary Care ◽  
P Value ◽  
Max Planck ◽  
Good Glycemic Control ◽  
Diabetes Group ◽  
Once Daily ◽  
Type 2 Diabetics ◽  
Significant Difference

OBJECTIVES: The purpose of this study was to compare the Type 2 diabetes mellitus patients and non-diabetics in terms of Papillary bleeding index (PBI) of periodontal disease. METHODOLOGY: This comparative cross-sectional study was conducted during the period of November 2020 to February 2021 in three (3) tertiary care hospitals of Peshawar. The sampling technique was purposive sampling. The sample comprised 105 individuals, 56 participants in Type–2 diabetes group and 49 in non-diabetes group. Male and females, having age between 40-65 years were recruited. Each diabetic and non-diabetic were clinically examined for periodontitis. Age and sex-matched participants suffering from periodontitis without a history of diabetes as well as with good glycemic control (HbA1c) were considered as controls subjects. Glycated hemoglobulin (HbA1c) was carried out for all the participants free of cost by using Human Gmbh-Max-Planck-Ring 21-65205 Wiesbaden-Germany kit. The study was approved by the ethical committee of the Peshawar Medical College. Data was analyzed using software package SPSS version 20. RESULTS: Out of 56  diabetics, 24 subjects brushed once daily, 15  brushed twice daily, 11 brushed occasionally and 6  didn’t brush  whereas in 49 non diabetics, 20 subjects brushed once daily, 13 brushed twice daily, 11  brushed occasionally and 5 didn’t brush. The clinical parameter mean (PBI) was recorded in our study. Score was 2.09 (±0.82) in diabetics and 1.02 (±0.47) in non-diabetics. P-value measured by the chi square test was significant. Spearman correlation test was performed to explore the association between the type 2 diabetes and Papillary bleeding index (PBI). CONCLUSION: We concluded that a significant difference exists between the mean PBI scores of Type 2 diabetics and non-diabetics.

scholarly journals A Randomized Study to Compare the Effects of Once-Weekly Dulaglutide Injection and Once-Daily Glimepiride on Glucose Fluctuation of Type 2 Diabetes Mellitus Patients: A 26-Week Follow-Up

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Huiqin Li ◽  
Xiaohua Xu ◽  
Jie Wang ◽  
Xiaocen Kong ◽  
Maoyuan Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin ◽  
Oxidation Stress ◽  
Once Daily ◽  
Glucose Fluctuation ◽  
Significant Difference

Objective. To evaluate the effects of once-weekly dulaglutide injection and once-daily glimepiride on glucose fluctuation in patients with type 2 diabetes mellitus (T2DM) using the Continuous Glucose Monitoring System (CGMS). Methods. A total of 23 patients with T2DM were randomly assigned into two groups for 26 weeks: the dulaglutide group (n=13) and the glimepiride group (n=10). 72-hour CGMS was applied to all patients: before and after the treatment. General clinical data were collected and measured, such as fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), tumor necrosis factor-α (TNF-α), 8-iso-prostaglandin F2α (8-iso-PGF2α), and interleukin-6 (IL-6). Results. HbA1c of the dulaglutide group was reduced from 8.38±0.93% to 6.68±0.73% after the treatment (P<0.05); similarly, it was reduced from 7.91±0.98% to 6.67±0.74% (P<0.05) in the glimepiride group. The levels of serum 8-iso-PGF2α, TNF-α, and IL-6 all decreased significantly in both groups after treatment, and there was no significant difference found between the two groups (P>0.05). The Mean Blood Glucose (MBG) of the two groups declined significantly after therapy (P<0.05). However, the Standard Deviation of Blood Glucose (SDBG) decreased significantly only in the dulaglutide group (from 2.57±0.74 mmol/L to 1.98±0.74 mmol/L, P<0.05). There were no significant changes of Mean Amplitude of Glycemic Excursion (MAGE) and Absolute Means of Daily Difference (MODD) after treatment in both groups. Furthermore, no statistically significant difference was found between the two groups in MBG, SDBG, MAGE, and MODD (P>0.05). The percentage time (PT) (>10 mmol/L and 3.9-10 mmol/L) of the two groups was significantly changed after the treatment (P<0.05). However, this was not seen in the PT<3.9 mmol/L after the treatment (P>0.05). Conclusion. Once-weekly dulaglutide injection has the same effectiveness as daily glimepiride on lowering blood glucose and decreasing oxidation stress and inflammation and is more effective in controlling glucose fluctuation as compared with glimepiride. This trial is registered with ClinicalTrials.gov NCT01644500.

scholarly journals Impact of aliskiren treatment on urinary aldosterone levels in patients with type 2 diabetes and nephropathy: an AVOID substudy

2011 ◽  
Vol 13 (1) ◽  
pp. 118-121 ◽  
Author(s):  
Frederik Persson ◽  
Julia B Lewis ◽  
Edmund J Lewis ◽  
Peter Rossing ◽  
Norman K Hollenberg ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Antihypertensive Therapy ◽  
Plasma Renin ◽  
Diabetic Patients ◽  
Once Daily ◽  
Significant Difference ◽  
Renin Inhibition ◽  
Aldosterone Breakthrough ◽  
Aldosterone Blockade

Introduction: Aldosterone blockade reduces albuminuria in diabetic patients with chronic kidney disease (CKD), and improves prognosis in chronic heart failure. This study assessed the effects of direct renin inhibition with aliskiren in combination with losartan and optimal antihypertensive therapy on urinary aldosterone, plasma renin activity (PRA) and plasma renin concentration (PRC). Materials and methods: In the AVOID study, 599 patients with type 2 diabetes, hypertension and nephropathy received 6 months aliskiren (150 mg force titrated to 300 mg once daily after 3 months) or placebo added to losartan 100 mg and optimal antihypertensive therapy. Urinary aldosterone excretion, PRA and PRC were measured at baseline and after 24 weeks in a prespecified subset of 133 patients. Results: Aliskiren added to losartan provided reductions from baseline in urinary aldosterone compared with adding placebo (−24% vs. −4%, p = 0.017) at week 24. There was no significant difference between the aliskiren and placebo groups in the proportion of patients with aldosterone breakthrough (aliskiren 35%, placebo 46%, p = 0.199). Aliskiren treatment reduced PRA by 90% at 24 weeks and increased PRC by 328%. Conclusions: Adding aliskiren to recommended renoprotective treatment with losartan and optimal antihypertensive therapy provided significant reductions in urinary aldosterone excretion which may attenuate decline in kidney function.

scholarly journals Pengaruh Propolis Terhadap Il-6 Pada Diabetes Melitus Tipe 2: A Literature Review

2021 ◽  
Vol 4 (3) ◽  
pp. 57
Author(s):  
Nazula Rahma Shafriani
Keyword(s):  
Type 2 Diabetes ◽  
Literature Review ◽  
Pancreatic Beta Cells ◽  
Diabetes Type 2 ◽  
Active Components ◽  
Plant Resources ◽  
Diabetes Group ◽  
Significant Difference ◽  
Anti Inflammatory

Type-2 diabetes is a metabolic disease characterized by an increase in blood sugar levels due to decreased insulin secretion by pancreatic beta cells, or inappropriate insulin action. The pathophysiology of type-2 diabetes is related to inflammatory mechanisms caused by an increase in proinflammatory cytokines such as IL-6. Propolis has an anti-inflammatory role that can influence type 2 diabetes. To determine the effect of propolis as an anti-inflammatory to the IL-6 cytokines in type 2 Diabetes Mellitus A Literature review by searching electronic databases on Pubmed, ProQuest, and Google Scholar with the keywords "propolis or bee propolis and IL-6 levels or interleukin-6 levels and diabetes type-2 or type-2 diabetes" published in 2010-2020. Based on the search results, 9 journals were found. These articles consist of 5 experimental articles and 4 RCT articles. Five databases reported a decrease in IL-6 levels and three journals stated that there was an increase in IL-6 levels in the type-2 diabetes group after being given propolis. One journal reported no significant difference. Variations in propolis administration and time in IL-6 measurements affected the tendency to decrease IL-6 levels in type 2 diabetes patients. The active components in propolis were influenced by differences in plant resources, collection season, bee species, and solvents used in the extraction. IL-6 levels in the type-2 diabetes group tended to decrease after propolis administration compared to the type-2 diabetes group without propolis administration. IL-6 levels in the type-2 diabetes group increased after propolis administration because IL-6 helps improve chronic inflammation associated with type-2 diabetes.

scholarly journals MICROALBUMINURIA;

2017 ◽  
Vol 24 (02) ◽  
pp. 221-227
Author(s):  
Ghazanfar Ali Sandhu ◽  
Ghulam Abbas Tahir ◽  
Zaheer Ahmad ◽  
Aqeel Maqsood Anjum
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
T Test ◽  
Losartan Potassium ◽  
P Value ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Significant Difference

Diabetes Mellitus is a rapidly increasing problem which is contributing tochronic illnesses like Cerebrovascular, Cardiovascular, Diabetic Retinopathy and End StageKidney Disease. These dreaded complications can be prevented if treated early. In patientswith diabetes mellitus type 2, microalbuminuria is an independent and strong risk factor forcardiovascular mortality & morbidity and diabetic nephropathy. If diagnosed early, diabeticnephropathy can be treated at this stage. Angiotensin converting enzyme inhibitors (ACEInhibitors) and Angiotensin Receptor Blockers (ARBs) are effective in prevention and treatmentof microalbuminuria. Material & Methods: Study Design: randomized controlled trial. Setting:medical department, allied hospital, Faisalabad. Duration of study: Feb 2013 to July 2013.Sample size: 60 (30 in each group). Sampling technique: Non-probability consecutivesampling. Results: 60 patients were included in the study. 28(46.7%) were males and 32(53.3%)were females. Mean age of study population was 50.15±7.27 years. Albumin creatinine ratio(mcg/mg) at start of study was 193±67.5 in Losartan potassium group and 209.5±72.00 inlisinopril group (independent sample t-test p value=0.302). Albumin creatinine ratio (mcg/mg) at 12 weeks of study was 36.33±54.68 in Losartan potassium group and 72±83.42 inlisinopril group (independent sample t-test p value = 0.056). Paired sample t test applied toboth treatment groups and p value was found to be 0.0001 which is highly significant for bothgroups and shows that both drugs are effective in reducing microalbuminuria in both groups.Microalbuminuria was reduced significantly in 26 patients (86.7%) in Losartan potassiumgroup and 20 patients (66.7%) in lisinopril group (p-value=0.067). Conclusion: It has beenconcluded from this study that lisinopril and Losartan potassium, both significantly reducemicroalbuminuria in type 2 diabetes mellitus and there is no statistically significant difference inefficacy of these two drugs in reducing microalbuminuria in type 2 diabetes mellitus.

scholarly journals Sudut ATD sebagai Penanda Diabetes Mellitus Tipe-2 (DMT2)

BioScience ◽  
2019 ◽  
Vol 2 (1) ◽  
pp. 34
Author(s):  
Syam Syamsurizal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Research Method ◽  
Diabetes Mellitus Type 2 ◽  
P Value ◽  
Intensity Index ◽  
Pattern Type ◽  
Significant Difference

Dermatoglyphic of patterns (finger prints) could be used as genetic markers with type 2 diabetes. Analysts dermatoglyphic patterns can quantitatively through several parameters: frequency fingerprint patterns (arch, loop and whorl), the number of vines, pattern type index consists of the Dankmeijer index, Furuhata index, pattern intensity index and atd angle. Atd angle is the angle formed by connecting point triradius a, t and d on the palm area. Objective studies link dermatoglyphic characteristics (atd angle) with type 2 diabetes mellitus in Minangkabau ethnic.The research method used descriptive with 132 sample consisted of 66 patients with type-2 diabetes mellitus and 66 control. Results of research on atd angle in type 2 diabetes was 40,44± 3,34 and 40,42±3,96 in controls. The results of t-test and α = 5% p value = 0.75. It can be concluded that there was no significant difference in the average of atd angle in diabetes mellitus type 2 Minangkabau ethnic.

scholarly journals The Association Between Serum Magnesium Level and Microalbuminuria in Type 2 Diabetes Mellitus Patients

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Masoud Mohebbi ◽  
Katayoun Samadi ◽  
Nazafarin Navari ◽  
Melika Ziafati-fahmideh-sani ◽  
Golshid Nourihosseini ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Magnesium ◽  
P Value ◽  
Albumin Concentration ◽  
Cross Sectional ◽  
Urine Albumin ◽  
Significant Difference

Background: Diabetic nephropathy occurs in 20 - 30% of diabetic cases globally, and microalbuminuria (MA) is the first symptom of this disorder. Some studies have suggested that there is an association between the serum magnesium (Mg) level and MA. Objectives: Therefore, we investigated the association between the serum Mg level and MA in type 2 diabetes mellitus (T2DM) patients. Methods: We conducted a cross-sectional study on 122 subjects with T2DM. We categorized them into two groups of microalbuminuria (MA) and non-microalbuminuria (NMA) according to their urine albumin-creatinine ratio (UACR). MA was considered as a UACR of 30 to 300 mg/g. Participants were excluded if they had the following conditions: The age of under 16 years, cardiac, renal, or hepatic disorders, using corticosteroids, diuretics, Mg /calcium (Ca) supplements, and antiepileptic drugs, heavy physical activity within 24 hours before the test, pregnant and breastfeeding women, febrile patients, and patients who were unwilling to participate in the study. The analysis was performed using SPSS version 15. A P-value < 0.05 was considered significant. Results: Among the patients, 50.81% were male. Also, the mean body mass index (BMI) of the NMA group was greater than the MA group (29.84 ± 5.64 vs. 27.31 ± 3.14, P-value = 0.003). Mg levels of the MA and NMA groups showed no significant differences (2.13 ± 0.42 and 2.10 ± 0.43, respectively; P-value = 0.67). Overall, data analysis provided no significant difference between Mg level and the urine albumin concentration between the MA and NMA groups (P-value = 0.21 and 0.81, respectively.). Conclusions: Serum Mg level and MA have no significant relationship. Further prospective studies are needed to assay this issue.

scholarly journals MON-667 Prevalence and Predictors of Diabetic Retinopathy Among Type 2 Diabetes Patients at a Tertiary Care Center

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Khaled Ahmed Baagar ◽  
Fahmi Khan ◽  
Mahmoud Zirie ◽  
Sara Darwish ◽  
Ahmed K A Mohammed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Mean

Abstract Objective: Diabetic retinopathy (DR) is one of the most common microvascular complications of type 2 diabetes (T2D). The reported prevalence of DR from different populations in the last decade was 13 - 38.1%. A report from our center 17 years ago showed that DR prevalence was 43.6%. With the all accumulated evidence showing that diabetes control decreases DR risk and the introduction of new drugs that helped better T2D control, we aimed to assess the current prevalence and predictors of DR among patients with T2D attending out-patient department at our tertiary care center. Methods: We conducted a cross-sectional study involving 638 patients. We collected information about their baseline characteristics, confirmed DR with its severity and maculopathy diagnosis, age at T2D diagnosis, duration of T2D, and averages of HbA1C, blood pressure (BP), cholesterol, and vitamin D levels over the previous year. A statistical analysis was performed using the software SPSS 23.0. A multivariate logistic regression analysis examined the independent predictors of DR development. Results: The mean age of the patients was 55.8 ± 10.3 years, and 42.8% were males. The mean BMI was 32.4 ± 12.4 kg/m2 with 58% had obesity. The mean duration of T2D was 11.5 ± 7.7 years, and the mean age at T2D diagnosis was 44.0 ± 9.98 years. The mean HbA1C was 8.3 ± 1.6 % with 77% had average HbA1C above 7% and 51.3% had average HbA1c above 8%. The mean systolic and diastolic BP were 136.37 ± 15.01 mmHg and 74.12 ± 8.078 mmHg, respectively. DR was diagnosed in 223 cases (35%). Of the 638 patients, 24.5% had non-proliferative DR, 9.2% had proliferative DR, and 4.2% had maculopathy. There was no significant difference in DR prevalence between males (36%) and females (34.1%) (P = 0.59). Predictors of DR development were age above 40 years, duration of T2D more than 10 years, early age of T2D diagnosis, average HbA1C more than 8%, and hypertension. Discussion: T2D is a major health challenge to our community with its very high prevalence. The prevalence of DR in T2D patients attending our institution was significant (more than one-third, 35%) in comparison to reports from other centers. However, we showed an improvement in DR development in our patients from 43.6% to 35%, probably due to better T2D and BP control. Similar to previous reports, T2D patients with older age, long T2D duration, younger age at T2D diagnosis, uncontrolled diabetes, and uncontrolled BP were more likely to develop DR. Conclusion: Physicians treating T2D patients should ensure regular retina screening especially for those with risk factors for DR. Also, they should fix the modifiable risk factors of DR; diabetes and BP control. References: (1) Alaboud et al. Saudi Med J 2016; Vol. 37 (12): 1408–1411.doi: 10.15537/smj.2016.12.17062. (2) Lim MC et al. Ann Acad Med Singapore. 2008 Sep;37(9):753–9. (3) Hammes H-P et al. PLoS ONE 10(7): e0132492. doi:10.1371/journal. pone.0132492

scholarly journals The Role of Serum Angiopoietin-Like Protein 4 (ANGPTL-4) and its Gene in Iraq Patients with Type2 Diabetes Mellitus: Case-Control Study

2021 ◽  
Vol 24 (4) ◽  
pp. 7-14
Author(s):  
Aseel Ali Abd Ali Sahib ◽  
◽  
Mohammed I. Hamzah ◽  
Mahmood Shakir Khudhair ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Case Control Study ◽  
Glycated Hemoglobin ◽  
Control Group ◽  
Diabetes Group ◽  
Significant Difference ◽  
Control Study

Background Type 2 Diabetes Mellitus is produced by cell failure of pancreatic cells and insulin resistance and is a disorder in which the amount of sugar in the blood is elevated. Angiopoietin-like protein 4 (ANGPTL4) functions as an inhibitor of lipoprotein lipase, a critical enzyme in lipid metabolism. The aim of this study was to explore if the ANGPTL4 gene's E40K variant and ANGPTL4 serum levels are related to the Body mass index, fasting glucose levels, lipid levels, and glycated hemoglobin.Method75 people were enrolled in this case-control study, 25 of whom had type 2 diabetes mellitus while the other 50 were healthy control subjects. Fasting blood glucose, Lipid profile, Glycated hemoglobin were estimated by Cobas 111 analyzer, BMI (weight, height) was calculated, angiopoietin-like protein 4by anenzyme-linked immune sorbent test kit and TaqMan genotyping-based real-time PCR was used to ascertain ANGPTL4 genotypes. The variant was linked to the risk of Type 2 Diabetes Mellitus and parameters used to quantify the variant were identified. Result Patients in the 30-50 age range with type 2 diabetes and those in the same age group who serve as controls. The control group had a lower level of angiopoietin-like protein 4 (ANGPTL4) than the diabetes group. Patients with T2DM had a substantially (p< 0.0001) greater fasting serum Angiopoietin-like protein 4 level than the control group (135.1±6.70) ng/ml and (62.35±6.4) ng/ml, respectively. The diabetes group has significantly higher fasting serum glucose, lipid profile, and glycated hemoglobin compared with non-diabetics. Serum Angiopoietin-like protein 4 was correlated positively with body mass index. (CC,CT,TT) genotypes of the rs2010871 polymorphism There was a significant difference in frequency of the control group (p =0.0477); however, there was no significant difference in its level of (diabetics, newly diagnosed type 2 diabetic before treatment)p-value (0.7066, 0.5555) respectively Conclusion Serum Angiopoietin-like protein 4 levels are negatively correlated to cholesterol, positively correlated to triglyceride, negatively correlated to HDL, positively correlated to HbA1c, negatively correlated to LDL, negatively correlated to VLDL, negatively correlated to FBS, negatively correlated to BMI. The C>T allele at the ANGPTL4 gene's rs2010871polymorphic locus was linked to a decreased prevalence of Type 2 diabetes.

scholarly journals Switching to Once-Weekly Insulin Icodec Versus Once-Daily Insulin Glargine U100 in Type 2 Diabetes Inadequately Controlled on Daily Basal Insulin: A Phase 2 Randomized Controlled Trial

2021 ◽  
Author(s):  
Harpreet S. Bajaj ◽  
Richard M. Bergenstal ◽  
Andreas Christoffersen ◽  
Melanie J. Davies ◽  
Amoolya Gowda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Glargine ◽  
Basal Insulin ◽  
Oral Glucose ◽  
Loading Dose ◽  
Phase 2 ◽  
Once Daily ◽  
Daily Insulin ◽  
Significant Difference

<b>OBJECTIVE</b><br><b></b><p><b> </b>Insulin icodec (icodec) is a novel once-weekly basal insulin analog. This trial investigated two approaches for switching to icodec versus once-daily insulin glargine U100 (IGlar U100) in people with type 2 diabetes receiving daily basal insulin and ≥1 oral glucose-lowering medication.</p> <p><b>RESEARCH DESIGN AND METHODS</b><br> This multicenter, open-label, treat-to-target phase 2 trial randomized (1:1:1) eligible basal-insulin-treated (total daily dose 10–50 U) people with type 2 diabetes (HbA<sub>1c</sub> 7.0–10.0% [53.0–13.3 mmol/mo]) to icodec with an initial 100% loading dose (where only the first dose was doubled; icodec LD), icodec with no loading dose (icodec NLD) or IGlar U100 for 16 weeks. Primary endpoint was percent time in <a>range (TIR; 3.9–10.0 mmol/L [70–180 mg/dL]) </a>during weeks 15 and 16, measured using continuous glucose monitoring. Key secondary endpoints included HbA<sub>1c</sub>,<sub> </sub>adverse events (AEs) and hypoglycemia. </p> <p><b>RESULTS</b><br> Estimated mean TIR during weeks 15 and 16 was 72.9% (icodec LD; <i>n</i> = 54), 66.0% (icodec NLD; <i>n</i> = 50) and 65.0% (IGlar U100; <i>n</i> = 50), with a statistically significant difference favoring icodec LD versus IGlar U100 (7.9%-points, 95% CI 1.8 to 13.9%). Mean HbA<sub>1c</sub> reduced from 7.9% (62.8 mmol/mol) at baseline to 7.1% ([54.4 mmol/mol] icodec LD) and 7.4% ([57.6 mmol/mol] icodec NLD and IGlar U100); incidences and rates of AEs and hypoglycemic episodes were comparable.<br> <br> </p> <p><b>CONCLUSIONS</b><br> Switching from daily basal insulin to once-weekly icodec was well tolerated and provided effective glycemic control. Loading dose use when switching to once-weekly icodec significantly increased percent TIR during weeks 15 and 16 versus once-daily IGlar U100, without increasing hypoglycemia risk.</p>

scholarly journals A Prospective Randomized Comparative Study to Evaluate the Effect of Once Daily Dose of Tadalafil (5 mg) vs. On-Demand Tadalafil (10 mg) on International Index for Erectile Function (IIEF) Score

2020 ◽  
Vol 7 (46) ◽  
pp. 2694-2699
Author(s):  
N. Imdad Ali ◽  
Paresh Sankhe ◽  
Ravishankar T.H.S
Keyword(s):  
Erectile Dysfunction ◽  
Tertiary Care ◽  
Mean Difference ◽  
P Value ◽  
Once Daily ◽  
On Demand ◽  
Tertiary Care Medical Center ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

BACKGROUND Erectile dysfunction is a common condition affecting middle and old age men throughout the world. Tadalafil is preferred by many urologists as well as patients because of its long half-life. Tadalafil on demand was compared with daily dosing in many studies. We wanted to conduct the study in south India at a tertiary care medical center to study the effect of tadalafil daily (5 mg) vs. on demand (10 mg) and check its efficacy with the IIEF scoring system. METHODS Patients were randomised into two groups using simple randomization chit box method. Allocation concealments was done by sealed enveloped method. Before starting treatment IIEF scoring was done for both groups. Group A was given once-daily 5 mg tadalafil. The group B was given 10 mg tadalafil before sexual activity. All patients under either of the two medication regimens for a period of 12 wks. and assessment done at 4 wks. and 12 wks. interval. Both the patient and the examiner was blinded to the randomisation of the subjects. Scoring scale is 1 to 30 which is divided into five groups of sever, moderate, mild to moderate, mild, and no dysfunction for score of 0 - 10, 11 - 16, 17 - 21, 22 - 25, and 26 - 30 respectively. RESULTS Tadalafil 5 mg OD has statistically significant better result when compared with IIEF score after 4 wks. with percentage improvement of 21.12 % when compared to baseline, with a P value of < 0.0001. In group II tadalafil 10 mg on demand shows statistically significant results when IIEF score baseline was compared with that after 4 wks. When group I compared with group II for mean difference of score after 4 wks. group I shows statistically significant improvement with P value 0.017 (< 0.05). When compared with score after 16 wks. with baseline both group I and II shows statistically significant improvement in IIEF score. But group I which shows mean difference in score of 5.40 (42.05 % improvement from baseline) is a statistically significant difference (p value - 0.0001) when compared to group II which shows mean difference of score at 16 wks. as 2.73 (20.71 % improvement from baseline). CONCLUSIONS Tadalafil 5 mg daily provides significant increase in IIEF score as compared to on demand 10 mg tadalafil. We need longer duration of study the side effects in each group. KEYWORDS Tadalafil, IIEF, Once a Day, On Demand, Erectile Dysfunction

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