Prevalence of sex under the influence of drugs among young adults: a systematic review and meta-analysis protocol

Review question / Objective: The objective of this systematic review and meta-analysis is to examine the prevalence of engaging in sex under the influence of drugs among young adults. Condition being studied: The prevalence of sex under the influence of drugs in young adults. Information sources: Published and unpublished literature will be systematically searched via three electronic databases: ISI Web of Science (WoS Core Collection); Scopus; and Psychological Information (PsycInfo). A grey literature search will also be performed via the Google and Google Scholar search engines, in order to obtain other potential relevant studies. Reference lists of relevant published studies will also be examined to obtain additional eligible reports. Additionally, emails will be sent to the research groups that have published the most about SDU, with the aim of identifying unpublished studies.

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Efficacy of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of Herpes Labialis: a systematic review

Anais da Academia Brasileira de Ciências ◽

10.1590/0001-3765201520140701 ◽

2015 ◽

Vol 87 (2 suppl) ◽

pp. 1415-1420 ◽

Cited By ~ 3

Author(s):

MARIA INÊS DA ROSA ◽

SUÉLI L. SOUZA ◽

BRUNA F. DE FARIAS ◽

PATRÍCIA D.S. PIRES ◽

EDUARDO R. DONDOSSOLA ◽

...

Keyword(s):

Systematic Review ◽

Herpes Simplex ◽

Literature Search ◽

Reference Lists ◽

Web Of Science ◽

Meta Analysis ◽

Grey Literature ◽

Cochrane Central Register ◽

Herpes Labialis ◽

Central Register

We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the Cochrane Central Register of Controlled Trials, the ISI Web of Science and IBECS from 1990 to June 2014. We reported the outcomes using relative risk (RR) with 95% confidence intervals. The literature search yielded 180 potentially relevant publications. Reviews of the reference lists yielded two further citations. Among these papers, two were considered eligible for inclusion in this review. Both trials included 1,213 patients. A meta-analysis of these studies showed a RR = 0.77, (95% CI 0.70-0.86; p<0.001).This result suggests that an early episodic treatment with the combination of an antiviral and a steroid is beneficial for herpes simplex labialis treatment.

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Comparative efficacy and safety of different corticosteroids to reduce inflammatory complications after mandibular third molar surgery: a systematic review and network meta-analysis protocol

10.37766/inplasy2021.9.0023 ◽

2021 ◽

Author(s):

Joao Vitor Canellas ◽

◽

Fabio Ritto ◽

Paul Tiwana ◽

◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Third Molar ◽

Optimal Dose ◽

Third Molar Surgery ◽

Mandibular Third Molar ◽

Review Question ◽

Postoperative Inflammatory Complications ◽

Mandibular Third Molar Surgery ◽

Analysis Protocol

Review question / Objective: This systematic review aims to compare the effects of different corticosteroids to reduce postoperative inflammatory complications (pain, edema, and trismus) after mandibular third molar surgery by applying a frequentist network meta-analysis approach. To this end, the proposed study will answer the following questions: 1) Among diverse corticosteroids currently available, what is the best preoperative option to control postoperative inflammatory complications? 2) What is the optimal dose and route of administration of corticosteroids prior to mandibular third molar surgery to control the pain, edema, and trismus induced by the surgery? Condition being studied: Inflammatory complications after mandibular third molar surgery (Pain, edema, and trismus).

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The outcome of COVID-19 among the geriatric age group in African countries: protocol for a systematic review and meta-analysis

Asthma Research and Practice ◽

10.1186/s40733-020-00064-8 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Degena Bahrey Tadesse ◽

Shishay Wahdey ◽

Melaku Negash ◽

Ebud Ayele ◽

Teklehaimanot Gereziher Haile ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

World Health ◽

Age Group ◽

African Countries ◽

Unpublished Studies ◽

Registration Number ◽

Review Protocol ◽

Health Organization ◽

Analysis Protocol

Abstract Background According to the World Health Organization (WHO), the outbreak of coronavirus disease in 2019 (COVID-19) has been declared as a pandemic and public health emergency that infected more than 5 million people worldwide at the time of writing this protocol. Strong evidence for the outcome of COVID-19 among the geriatric age group has not been published in Africa. Therefore, this protocol will be served as a guideline to conduct a systematic review and meta-analysis of the outcome of COVID-19 among the geriatric age group in Africa. Methods Published and unpublished studies on the outcome of COVID-19 among the geriatric age group in Africa and written in any language will be included. Databases (PubMed / MEDLINE, Google Scholar, Google, EMBASE, Web of Science, Microsoft Academic, WHO COVID-19 database, Cochran Library, Africa Wide Knowledge, and Africa Index Medicus) from March to August 2020 will be searched. Two independent reviewers will select, screen, extract data, and assess the risk of bias. The proportion will be measured using a random-effects model. Subgroup analysis will be conducted to manage heterogeneity. The presence of publication bias will be assessed using Egger’s test and visual inspection of the funnel plots. This systematic and meta-analysis review protocol will be reported per the PRISMA-P guidelines. Conclusion This systematic review and meta-analysis protocol will be expected to quantify the outcome of COVID-19 among the geriatric age group in Africa. Systematic review registration This protocol was submitted for registration with the International Prospective Register of Systematic Reviews (PROSPERO) in April 2020 and accepted with the registration number: (https://www.crd.york.ac.uk/PROSPERO). CRD42020180600.

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Acupoint stimulation-related therapies for the management of insomnia disorder: A systematic review and meta-analysis protocol

10.37766/inplasy2021.12.0137 ◽

2021 ◽

Author(s):

Mingmin Xu ◽

◽

Pei Guo ◽

Min’an Chen ◽

Qingyu Ma ◽

...

Keyword(s):

Systematic Review ◽

Treatment Duration ◽

Meta Analysis ◽

Patient Characteristics ◽

Insomnia Disorder ◽

Subgroup Analyses ◽

Review Question ◽

Stimulation Method ◽

Acupoint Stimulation ◽

Analysis Protocol

Review question / Objective: This meta-analysis will not only summarize all the ASRTs reported in clinical trials but also evaluate their effect on objective and subjective indices related to insomnia disorder. We will also perform subgroup analyses to identify possible confounders of the effects of ASRTs including treatment characteristics (e.g., acupoint selection, stimulation method, treatment duration) and patient characteristics (e.g., age, comorbidities, severity, and course of insomnia disorder). In doing so, we will endeavor to answer questions about whether efficacy varies according to the aspect of sleep targeted and whether the effects differ according to different modes of acupoint stimulation, acupoints applied, or specific types of insomnia, thereby providing the evidence to develop specific recommendations on prescribing ASRTs for insomnia disorder.

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Panel of COVID-19 phenotypes: systematic review protocol

10.21203/rs.3.rs-713005/v1 ◽

2021 ◽

Author(s):

Luciana Carvalho Silveira ◽

Yanca Carollynne Souza Moraes ◽

Rodrigo da Silva Santos ◽

Angela Adamski da Silva Reis

Keyword(s):

Systematic Review ◽

Human Subjects ◽

Meta Analysis ◽

Grey Literature ◽

World Health ◽

Unpublished Studies ◽

Real Risk ◽

Mechanical Ventilation Support ◽

Severity Of The Disease ◽

Health Organization

Abstract Background The pandemic caused by the SARS-CoV-2 virus, called coronavirus disease 2019 (COVID-19), had an unexpected impact on much of the world, especially Brazil. People diagnosed with the virus manifest different levels of respiratory symptoms, ranging from mild to severe, and may need mechanical ventilation support. The interaction different factors lead to the development of a spectrum of time-related diseases in different phenotypes. Methods This review will consider observational studies published from December 2019 to July 2021, without language restrictions. Studies involving human subjects, adult participants (18 years and older), with subjects who have received a COVID-19 diagnosis using the reverse transcriptase polymerase chain reaction (RT-PCR) test as a reference for the detection of the SARS- CoV-2 virus, according to World Health Organization (WHO) guidance. The databases to be searched will include PubMed/MEDLINE, EMBASE, and CINAHL. The grey literature will also be searched for published research and unpublished studies, using Google Scholar. wo reviewers will independently screen all citations, full-text articles and abstract data. Potential conflicts will be resolved through discussion. Findings will be reported using a narrative synthesis of the results will be carried out around the prevalence, severity of the disease, mortality and risk among the different phenotypes of COVID-19. The I 2 statistic will be used to examine the heterogeneity between the studies, if possible, the meta-analysis will be conducted using the RStudio® statistical software package, and the data will be displayed using forest graphics. Discussion This review will disclose a panel of the different manifestations of the disease COVID-19, and to identify the real risk factor for the most serious phenotypes. Systematic review registration This protocol has been registered within the International Prospective Register of Systematic Reviews (PROSPERO)(CRD42020211439)

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Comparing Urinary and Sexual Complications of Robot-Assisted Radical Prostatectomy and Laparoscopic Radical Prostatectomy in Prostate Cancer: a Systematic Review and Meta-Analysis Protocol

10.37766/inplasy2021.10.0068 ◽

2021 ◽

Author(s):

Afshin Heidari ◽

◽

Aida Kazemi ◽

Parisa Najjari ◽

Kamran Dalvandi ◽

...

Keyword(s):

Prostate Cancer ◽

Systematic Review ◽

Radical Prostatectomy ◽

Meta Analysis ◽

Prostate Gland ◽

Laparoscopic Radical Prostatectomy ◽

Robot Assisted ◽

Conventional Laparoscopic ◽

Review Question ◽

Analysis Protocol

Review question / Objective: The aims of this study are: 1. To compare urinary complications of robot-assisted radical prostatectomy(RARP) and laparoscopic radical prostatectomy(LRP) in patients with prostate cancer; 2. To compare sexual complications of RARP and LRP in patients with prostate cancer. Condition being studied: Prostate cancer is one of the most prevalent types of cancer; according to 2018 statistics, prostate cancer was responsible for 7.1% of all cancer in men. The primary intervention in such patients is radical prostatectomy surgery (RP), which could be performed in different methods in patients that cancer has not spread beyond the prostate gland or has not spread much. One of the most common types of RP is laparoscopic radical prostatectomy. There are several techniques for performing RP; two are Conventional Laparoscopic Radical Prostatectomy (LRP) and Robot-Assisted Radical Prostatectomy (RARP). Sexual and urinary difficulties can occur in prostate cancer patients due to cancer itself or the treatment. Like any treatment option and surgery, radical prostatectomy can carry risks, like urinary(e.g., incontinency) and sexual complications(e.g., Impotence). In this review, we compared urinary and sexual complications of LRP and RARP.

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The efficacy of kinesio taping in the treatment of ankle sprain: Systematic review and meta-analysis

10.37766/inplasy2021.12.0059 ◽

2021 ◽

Author(s):

Haoan Zhu ◽

◽

Wenbin Li ◽

Yitong Lin ◽

Hao Wu

Keyword(s):

Systematic Review ◽

Physical Therapy ◽

Ankle Sprain ◽

Information Sources ◽

Web Of Science ◽

Meta Analysis ◽

Ankle Sprains ◽

Kinesio Tape ◽

Relieve Pain ◽

Review Question

Review question / Objective: The purpose of this systematic review is to accurately evaluate the efficacy of kinesio tape for ankle sprains. Condition being studied: Ankle sprain may cause a series of problems, such as pain, swelling, and various dysfunctions. As a physical therapy method that has attracted much attention in recent years, kinesio tape has been proven to relieve pain, reduce swelling and promote functional recovery for some diseases. In this way, we can provide a reference for clinical physical therapy. Information sources: PubMed, Cochrane, Scopus, Web of Science, Embase, CNKI, Wanfang Data, Technological periodical database, SinoMed.

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Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis

Current Medicinal Chemistry ◽

10.2174/0929867326666190918120209 ◽

2020 ◽

Vol 27 (37) ◽

pp. 6373-6383 ◽

Cited By ~ 1

Author(s):

Leila Jouybari ◽

Faezeh Kiani ◽

Farhad Islami ◽

Akram Sanagoo ◽

Fatemeh Sayehmiri ◽

...

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Breast Tissue ◽

Reference Lists ◽

Meta Analysis ◽

Cancer Risks ◽

Hair Samples ◽

Significant Difference ◽

Mean Differences ◽

Very High

: Breast cancer is the most common neoplasm, comprising 16% of all women's cancers worldwide. Research of Copper (Cu) concentrations in various body specimens have suggested an association between Cu levels and breast cancer risks. This systematic review and meta-analysis summarize the results of published studies and examine this association. We searched the databases PubMed, Scopus, Web of Science, and Google Scholar and the reference lists of relevant publications. The Standardized Mean Differences (SMDs) between Cu levels in cancer cases and controls and corresponding Confidence Intervals (CIs), as well as I2 statistics, were calculated to examine heterogeneity. Following the specimens used in the original studies, the Cu concentrations were examined in three subgroups: serum or plasma, breast tissue, and scalp hair. We identified 1711 relevant studies published from 1984 to 2017. There was no statistically significant difference between breast cancer cases and controls for Cu levels assayed in any studied specimen; the SMD (95% CI) was -0.01 (-1.06 - 1.03; P = 0.98) for blood or serum, 0.51 (-0.70 - 1.73; P = 0.41) for breast tissue, and -0.88 (-3.42 - 1.65; P = 0.50) for hair samples. However, the heterogeneity between studies was very high (P < 0.001) in all subgroups. We did not find evidence for publication bias (P = 0.91). The results of this meta-analysis do not support an association between Cu levels and breast cancer. However, due to high heterogeneity in the results of original studies, this conclusion needs to be confirmed by well-designed prospective studies.

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Misuse of medication in adult substance misuse services: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2020-047283 ◽

2021 ◽

Vol 11 (6) ◽

pp. e047283

Author(s):

Rosalind Gittins ◽

Louise Missen ◽

Ian Maidment

Keyword(s):

Systematic Review ◽

Substance Misuse ◽

Data Extraction ◽

Meta Analysis ◽

Grey Literature ◽

Opioid Analgesics ◽

Physical And Mental Health ◽

Qualitative Synthesis ◽

Treatment Services ◽

The Impact

IntroductionThere is a growing concern about the misuse of over the counter (OTC) and prescription only medication (POM) because of the impact on physical and mental health, drug interactions, overdoses and drug-related deaths. These medicines include opioid analgesics, anxiolytics such as pregabalin and diazepam and antidepressants. This protocol outlines how a systematic review will be undertaken (during June 2021), which aims to examine the literature on the pattern of OTC and POM misuse among adults who are accessing substance misuse treatment services. It will include the types of medication being taken, prevalence and demographic characteristics of people who access treatment services.Methods and analysisAn electronic search will be conducted on the Cochrane, OVID Medline, Pubmed, Scopus and Web of Science databases as well as grey literature. Two independent reviewers will conduct the initial title and abstract screenings, using predetermined criteria for inclusion and exclusion. If selected for inclusion, full-text data extraction will be conducted using a pilot-tested data extraction form. A third reviewer will resolve disagreements if consensus cannot be reached. Quality and risk of bias assessment will be conducted for all included studies. A qualitative synthesis and summary of the data will be provided. If possible, a meta-analysis with heterogeneity calculation will be conducted; otherwise, Synthesis Without Meta-analysis will be undertaken for quantitative data. The reporting of this protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.Ethics and disseminationEthical approval is not required. Findings will be peer reviewed, published and shared verbally, electronically and in print, with interested clinicians and policymakers.PROSPERO registration numberCRD42020135216.

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Association between Oral Hygiene and Metabolic Syndrome: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm10132873 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2873

Author(s):

Cornelia Melinda Adi Santoso ◽

Fera Ketti ◽

Taufan Bramantoro ◽

Judit Zsuga ◽

Attila Nagy

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Oral Hygiene ◽

Reference Lists ◽

Meta Analysis ◽

Tooth Brushing ◽

Inclusion Criteria ◽

Poor Oral Hygiene ◽

Dental Visits ◽

Substantial Heterogeneity

Emerging evidence has linked poor oral hygiene to metabolic syndrome (MetS), but previously, no summary of evidence has been conducted on the topic. This systematic review and meta-analysis aims to evaluate the associations of oral hygiene status and care with MetS. A systematic search of the PubMed and Web of Science databases from inception to March 17, 2021, and examination of reference lists was conducted to identify eligible observational studies. A random-effects model was applied to pool the effects of oral hygiene status and care on MetS. Thirteen studies met the inclusion criteria and had sufficient methodological quality. Good oral hygiene status (OR = 0.30 (0.13–0.66); I2 = 91%), frequent tooth brushing (OR = 0.68 (0.58–0.80); I2 = 89%), and frequent interdental cleaning (OR = 0.89 (0.81–0.99); I2 = 27%) were associated with a lower risk of MetS. Only one study examined the association between dental visits and MetS (OR = 1.10 (0.77–1.55)). Our findings suggested that there might be inverse associations of oral hygiene status, tooth-brushing frequency, and interdental cleaning with MetS. However, substantial heterogeneity for tooth-brushing frequency and inconsistent results for oral hygiene status in subgroup analyses were observed. There was insufficient evidence for the association between dental visits and MetS. Further longitudinal studies are needed to investigate these associations.

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