scholarly journals The Electrical and Massage Stimulation of the Abdominal Region Altered the Body Weight of Experimental Dietary Obese Rats

2005 ◽  
Vol 55 (2) ◽  
pp. 123-132
Author(s):  
Takaaki KOJIMA ◽  
Hajime OGAWA ◽  
Takemasa SHIRAISHI
Keyword(s):  
Body Weight ◽  
The Body ◽  
Abdominal Region ◽  
Obese Rats ◽  
Stimulation Of

scholarly journals Development of Lipid and Glycide Abnormalities in Genetically Hypertensive Obese Koletsky Rats and in Their Lean Siblings

1998 ◽  
Vol 41 (4) ◽  
pp. 163-166
Author(s):  
Věroslav Golda ◽  
Jiřina Hilgertová
Keyword(s):  
Body Weight ◽  
Glucose Intolerance ◽  
Plasma Cholesterol ◽  
The Body ◽  
Total Plasma Cholesterol ◽  
Total Plasma ◽  
Plasma Triglycerides ◽  
Obese Rats ◽  
Lipid Abnormalities ◽  
Genetically Hypertensive

Experiments were performed in the genetically hypertensive Koletsky rats and in their lean siblings at the age of two and three months. In the study of development of glycide and lipid abnormalities animal represents control for itself. At the age of two months Koletsky obese rats show relative to their lean controls elevation of plasma triglycerides (males +184%, females +152%) and insulin (males +169%, females +201%). During one month plasma triglycerides elevated in lean males +9%, in lean females 0%, but in obese males +21%, in obese females +139%.Considering insulinemia similar results were obtained. Thus during one month insulin elevates in lean males +19%, in lean females +23%, but in obese males +80%, in obese females +144%. During one month glucose intolerance is elevated as well only in obese rats. Total plasma cholesterol during period of one month shows no changes in both substrains of rats.Similar picture can be found in basal glycemia.In all groups of rats no changes were registered except one, i.e., obese females show decrease.Considering the substrain differences in basal glycemia then at age of one as well as two months obese of both sexes show elevation. As to the body weight at the age of two as well as three months there is increase in obese rats. The changes of body weight during one month are expressively higher in obese rats.

scholarly journals The application of [D-Tle6,ProNHEt9]mGnRH (Lecirelin) with the dopaminergic inhibitor metoclopramide to stimulate ovulation in African catfish (Clarias gariepinus)

2011 ◽  
Vol 49 (No. 7) ◽  
pp. 297-306 ◽  
Author(s):  
E. Brzuska ◽  
J. Kouřil ◽  
J. Adamek ◽  
Z. Stupka ◽  
V. Bekh
Keyword(s):  
Body Weight ◽  
Female Body ◽  
Clarias Gariepinus ◽  
The Body ◽  
African Catfish ◽  
Average Body ◽  
Stimulation Of ◽  
Average Body Weight ◽  
Pituitary Homogenate

The results of reproduction were tested in females of the African catfish (Clarias gariepinus Burchell 1822) after stimulation of ovulation with carp pituitary (4 mg/kg body weight) or with Lecirelin (15 μg/kg) and metoclopramide (10 mg/kg). After administering the synthetic substance eggs were obtained from all females while in the group treated with pituitary homogenate 7 out of 8 hypophysed females spawned. The applied spawning agent did not significantly influence the weight of eggs expressed in grams, but in the case of females treated with carp pituitary homogenate a significantly higher weight of eggs expressed as the percentage of body weight of fish was recorded. The applied stimulators of ovulation did not affect any trait reflecting the quality of eggs. Females used as an experimental material belonged to two categories in respect of body weight: lighter females with average body weight of 2.63 ± 0.36 kg and heavier females with average body weight of 3.91 ± 0.48 kg. It was proved that the weight of eggs expressed either in grams or as a percentage of a female’s weight was significantly related to the body weight of a female (P ≤ 0.01 and P ≤ 0.05, respectively), as well as the percentage of fertilised eggs and the percentage of living embryos after 28 hours of incubation (P ≤ 0.05 and P ≤ 0.05, respectively). The interaction between the stimulator of ovulation and the female body weight was significant only for traits reflecting the weight of obtained eggs (P ≤ 0.05 and P ≤ 0.01).  

ABSENCE OF GROWTH IN HYPOPHYSECTOMIZED RATS TREATED WITH THYROID HORMONES

1966 ◽  
Vol 51 (2) ◽  
pp. 315-320 ◽  
Author(s):  
C. M. Goodall ◽  
J. B. Gavin
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Thyroid Hormones ◽  
Body Mass ◽  
The Body ◽  
Male Rats ◽  
Radiographic Measurements ◽  
Morphological Criteria ◽  
Hypophysectomized Rats ◽  
Stimulation Of

ABSTRACT Male rats were hypophysectomized at four weeks of age, rested for four weeks, and then were fed a thyroid digest in their drinking water continuously for up to seventy weeks. The digest treatment supplied the equivalent of 1.25μg L-thyroxine per 100 g rat per day approximately. From the body weight curves and radiographic measurements of the skull and mandibles, it was shown that contrary to some previous reports in the literature there was no statistically significant change in the indices of growth or body mass when compared with controls receiving no thyroid treatment. It is suggested that data previously reported by others, indicating a stimulation of growth in hypophysectomized rats by thyroid hormones, may have been derived from animals having minute but still effective pituitary remnants, and somewhat more stringent morphological criteria of hypophysectomy are proposed.

scholarly journals Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Fang Cui ◽  
Jing Guo ◽  
Hao-Fei Hu ◽  
Yi Zhang ◽  
Min Shi
Keyword(s):  
Body Weight ◽  
Risk Factor ◽  
Mrna Expression ◽  
Iron Metabolism ◽  
Hypobaric Hypoxia ◽  
The Body ◽  
High Fat ◽  
Intermittent Hypobaric Hypoxia ◽  
Obese Rats ◽  
Hepcidin Mrna

Abstract Background Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may ameliorate the abnormal iron metabolism in obesity. This study was aimed to investigate the effect and the underlying mechanisms of CIHH on iron metabolism in high-fat-high-fructose-induced obese rats. Methods Six to seven weeks old male Sprague-Dawley rats were fed with different diet for 16 weeks, and according to body weight divided into four groups: control (CON), CIHH (28-day, 6-h daily hypobaric hypoxia treatment simulating an altitude of 5000 m), dietary-induced obesity (DIO; induced by high fat diet and 10% fructose water feeding), and DIO + CIHH groups. The body weight, systolic arterial pressure (SAP), Lee index, fat coefficient, blood lipids, blood routine, iron metabolism parameters, interleukin6 (IL-6) and erythropoietin (Epo) were measured. The morphological changes of the liver, kidney and spleen were examined. Additionally, hepcidin mRNA expression in liver was analyzed. Results The DIO rats displayed obesity, increased SAP, lipids metabolism disorders, damaged morphology of liver, kidney and spleen, disturbed iron metabolism, increased IL-6 level and hepcidin mRNA expression, and decreased Epo compared to CON rats. But all the aforementioned abnormalities in DIO rats were improved in DIO + CIHH rats. Conclusions CIHH improves iron metabolism disorder in obese rats possibly through the down-regulation of hepcidin by decreasing IL-6 and increasing Epo.

scholarly journals PO-212 Effects of hypoxic endurance training on weight loss and Irisin expression in nutritional obese rats

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Zhigang Li ◽  
Wentao Lin
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Oxygen Concentration ◽  
Training Group ◽  
The Body ◽  
Hypoxia Exposure ◽  
Obese Rats ◽  
Group A ◽  
Group B ◽  
Group D

Objective Exercise can induce the release of various myokine such as Irisin, which promote browning of white fat, improve body metabolism, and loss weight. Appropriate hypoxic training plays a better role in weight loss than single exercise, but the effect of hypoxic training on muscle factors that promote browning of fat is rarely reported. Therefore, this study aims to observe different concentrations of hypoxia training on the PGC1α-Irisin-UCP1 signaling pathway in nutritional obese rats, and the role of weight loss. Methods Male Sprague-Dawley rats (n=140) of 6 weeks old were divided into normal diet feeding group (group N, n=20) and high-fat diet feeding group (group HFD, n=120). The HFD rats became obese after 8 weeks’ feeding, and they were further divided randomly into 8 groups. Including sedentary group(group A), training group (group AE), 16.3% hypoxia exposure group (group B), 16.3% hypoxia training group (group BE), and 13.3% hypoxia exposure group (group C), 13.3% hypoxia training group (group CE), 11.3% hypoxia exposure group (group D), 11.3% hypoxia training group (group DE), group B, group C and group D Rats were exposed to oxygen in concentrations of 16.3%, 13.3%, and 11.3% for 12 h/d, respectively. Rats in group BE, CE, and DE were subjected to animal treadmill training during hypoxic exposure with a slope of 0°, 20 m /min, 40min/d, 5d/w. After 8 weeks of intervention, blood, adipose tissue and skeletal muscle were collected and tested. Results (1) In group AE, the body weight of obese rats decreased in a short time, but bounced back later. The body weight of rats in group CE and group DE decreased continuously. Hypoxia exposure and hypoxia training can inhibit the food intake of obese rats in varying degrees, and group CE has the most obvious effect. Hypoxia, endurance training and hypoxia training all reduced the percentage of visceral fat to body weight, group C is significantly lower than group B and D group (p < 0.05), the effect of hypoxia training is more obvious than single hypoxia or exercise, and the lower oxygen concentration the more significant effect. Group C、group CE、group D and group DE significantly decreased the concentration of LDL-C, increased the content of HDL-C in serum than other groups (p < 0.05).(2) The concentration of serum Irisin in group AE, group BE, group CE and group DE rats was significantly higher than that in group A (p < 0.05), and the highest level was found in group CE and DE. The insulin resistance of obese rats in group CE and group DE was significantly better than that in group AE (p < 0.05). (3) Three different concentrations of hypoxia exposure and hypoxia training can significantly increase the skeletal muscle PGC-1 α and FNDC5 gene expression, showing that the lower the concentration of oxygen, the higher the expression, 13.3% and 16.3% hypoxia training can significantly promote the gene transcription of UCP1. The contents of PGC-1 α and FNDC5 protein in skeletal muscle of obese rats in group C, AE and DE were significantly higher than those in group A (p < 0. 05). The expression of UCP1 protein in skeletal muscle of rats in group C, CE and DE was significantly higher than that in group A (p < 0. 05). Conclusions 13.3% and 11.3% oxygen concentration combined with endurance training can effectively reduce the body weight and visceral fat of nutritional obese rats, enhance serum HDL-C and decrease LDL-C levels and insulin resistance. 13.3% and 11.3% oxygen concentration training can significantly improve the level of serum Irisin, 11.3% oxygen concentration training can significantly promote the expression of PGC1α-Irisin-UCP1 gene and protein in skeletal muscle.

Hepatic PTP1B Expression Involvement in the Effects of Chinese Medicine Formula Xiao-Gao-Jiang-Zhuo Using an Obese Rat Model

2011 ◽  
Vol 39 (02) ◽  
pp. 301-313 ◽  
Author(s):  
Min Li ◽  
Bai Chang ◽  
Zhong Zhen ◽  
Pei-Jie Qin ◽  
Wen-Ke Liu ◽  
...  
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Serum Insulin ◽  
Blood Lipid ◽  
Abdominal Fat ◽  
The Body ◽  
High Dose ◽  
Model Group ◽  
High Fat ◽  
Obese Rats

In this study, we investigated the effects of a Chinese herbal medicine formula Xiao-Gao-Jiang-Zhuo (XGJZ) in obese rats induced by a high-fat diet. Ten male rats in the normal group were fed with a standard diet. Another 50 male obese rats were induced by a 12-week high-fat diet feeding, and were randomly divided into five groups (n = 10 per group): the model group, the high-dose XGJZ group, the middle-dose XGJZ group, the low-dose XGJZ group, and the sibutramine group. After 14 weeks of treatment, body weight, abdominal fat, blood lipid and serum insulin level were measured, and the protein and gene expression of PTP1B in liver tissue was tested. Our data showed that the body weight of the high-dose and middle-dose groups and the sibutramine group had significant differences in comparison with the model group (p < 0.05), and all three dose groups had significantly reduced abdominal fat (p < 0.05). The triglyceride level of the three dose groups and the sibutramine group, and the total cholesterol level of the middle-dose group were all significantly reduced (p < 0.05). The serum insulin of the high-dose and middle-dose groups also decreased significantly (p < 0.05). The expression of hepatic PTP1B mRNA of the three dose groups decreased significantly in comparison with the model group (p < 0.05 or 0.01). The expression of hepatic PTP1B protein of the high-dose and middle-dose groups decreased significantly (p < 0.05). Our data suggested that XGJZ can modulate the body weight, abdominal fat and blood lipid in the obese rats, and this modulation might improve insulin resistance by inhibiting the PTP1B signal pathway.

scholarly journals EXPERIMENT ON FISSION STIMULATION OF HOLOTHURIA ARTA (HOLOTHUROIDEA, ECHINODERMATA): CHANGING IN BODY WEIGHT AND MORPHOLOGY

2007 ◽  
Vol 32 (1) ◽  
pp. 1-6
Author(s):  
Pradina Purwati ◽  
Sigit A.P. Dwiono
Keyword(s):  
Body Weight ◽  
Asexual Reproduction ◽  
Minimum Weight ◽  
The Body ◽  
High Survival ◽  
Reproduction By Fission ◽  
Holothuria Atra ◽  
Stimulation Of

Experiment on Holothuria atra provided evidence that asexual reproduction by fission was possible to be stimulated at laboratory. The success of the experiment was determined based on the high survival of stimulated individuals that grew into intact. After being tightened, induced individuals divided into anterior- and posteriorend individuals. During regenerating into intact individuals, the body weight decreased to relatively minimum weight. Developing of new tentacles in posterior-end individuals and anal aperture in anterior-end individuals required 7-8 weeks after fission. These indicators may lead to anatomical recovery which may be a sign of feeding necessity.

Synergistic stimulation of food intake by simultaneous insulin and cold

1984 ◽  
Vol 57 (1) ◽  
pp. 28-33 ◽  
Author(s):  
S. D. Morrison
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Food Intake ◽  
Insulin Treatment ◽  
Metabolic Cost ◽  
The Body ◽  
Simultaneous Exposure ◽  
Feeding Control ◽  
Joint Treatment ◽  
Stimulation Of

Insulin administered to rats during simultaneous exposure to cold increases food intake by more than the sum of the separate feeding responses and prevents the normal cold-induced loss of body weight. On withdrawal of insulin with cold maintained, all the body weight maintained by insulin is immediately lost and body weight thereafter is identical to that of rats exposed to cold only. Accumulated food intake for the joint treatment and after withdrawal of insulin with cold maintained is greater than for cold exposure only. There is no increase in metabolic cost due to insulin. Energy density of weight gain during insulin treatment is high and of weight loss on withdrawal of insulin with cold maintained is very low. These responses do not conform with commonly proposed models of feeding control.

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