ABSENCE OF GROWTH IN HYPOPHYSECTOMIZED RATS TREATED WITH THYROID HORMONES

1966 ◽  
Vol 51 (2) ◽  
pp. 315-320 ◽  
Author(s):  
C. M. Goodall ◽  
J. B. Gavin
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Thyroid Hormones ◽  
Body Mass ◽  
The Body ◽  
Male Rats ◽  
Radiographic Measurements ◽  
Morphological Criteria ◽  
Hypophysectomized Rats ◽  
Stimulation Of

ABSTRACT Male rats were hypophysectomized at four weeks of age, rested for four weeks, and then were fed a thyroid digest in their drinking water continuously for up to seventy weeks. The digest treatment supplied the equivalent of 1.25μg L-thyroxine per 100 g rat per day approximately. From the body weight curves and radiographic measurements of the skull and mandibles, it was shown that contrary to some previous reports in the literature there was no statistically significant change in the indices of growth or body mass when compared with controls receiving no thyroid treatment. It is suggested that data previously reported by others, indicating a stimulation of growth in hypophysectomized rats by thyroid hormones, may have been derived from animals having minute but still effective pituitary remnants, and somewhat more stringent morphological criteria of hypophysectomy are proposed.

The effect of glibenclamide on plasma insulin, plasma somatomedin bioactivity and skeletal growth in hypophysectomized rats

1982 ◽  
Vol 101 (2) ◽  
pp. 187-192 ◽  
Author(s):  
E. Heinze ◽  
M. Ranke ◽  
E. Manske ◽  
U. Vetter ◽  
K.-H. Voigt
Keyword(s):  
Body Weight ◽  
Serum Insulin ◽  
The Body ◽  
Skeletal Growth ◽  
Male Rats ◽  
Epiphyseal Growth Plate ◽  
Body Weights ◽  
Hypophysectomized Rats ◽  
Group A ◽  
Group B

Abstract. Male rats, body weight 60–75 g, were hypophysectomized. Three days after operation the animals were divided into two groups. Group B received solvent solution and group C 1 mg/kg body weight per day of glibenclamide ip for the following 9 days. Group A consisted on non-operated normal rats. Twenty-four hours after the last injections and after a 12 h overnight fast the body weights of groups B and C were not different, the increase during the 10 days being 10% in both groups. Serum insulin (IRI) was significantly higher in group C than in group B (C: 8.0 ± 0.3 μU/ml, n = 14 vs B: 4.9 ± 1.0 μU/ml, n = 14; P < 0.01, mean ± sem) as was serum somatomedin bioactivity (SM)-porcine cartilage assay — (C: 1.06 ± 0.1 U/ml, n = 14 vs B:0.41 ± 0.01 U/ml, n = 14; P < 0.001). Skeletal growth was determined with the tibia test and by a radiograph of each rat. The width of the proximal epiphyseal growth plate of the tibia was significantly increased in group C compared to group B (C: 204 ± 4.8 μm, n = 12 vs 181 ± 6.5 μm, n = 13; P < 0.005). On the radiograph the area of the right femur was not different between the two groups of animals, while the height and the area of the first lumbar spine were significantly augmented in group C. The results show that glibenclamide stimulates IRI, SM and skeletal growth in hypophysectomized rats. Compared to the glibenclamide treated hypophysectomized animals the normal rats of group A had doubled their body weights. IRI (59 ± 5 μU/ml, n = 4) and skeletal growth (tibia test: 454 ± 5.8 μm) were greatly increased. SM did not differ between group A (1.21 ± 0.35 U/ml and group C. T4 was much lower in group B (0.64 ± 0.09 μg/100 ml, n = 5) than in group A (4.1 ± 0.3 μg/100 ml, n = 6; P < 0.001). It is concluded that a normal SM concentration is not necessarily associated with appropriate growth.

Renaturalizing the sexually dimorphic profiles of circulating growth hormone in hypophysectomized rats

1991 ◽  
Vol 124 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Nisar A. Pampori ◽  
Arun K. Agrawal ◽  
Bernard H. Shapiro
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Body Weight Gain ◽  
The Body ◽  
Female Rats ◽  
Male Rats ◽  
Sexually Dimorphic ◽  
Plasma Growth Hormone ◽  
Indwelling Catheter ◽  
Hypophysectomized Rats

Abstract. Hypophysectomy resulted in a total elimination of measurable circulating growth hormone with an associated loss of body weight gain. The typical sexually dimorphic plasma growth hormone patterns: pulsatile profiles in male rats and tonic-like secretion in female rats, were lost. The male- and female-dependent profiles of plasma growth hormone, monitored from serial blood collections, were restored by administering the hormone through a single electrically controlled external pump attached to an indwelling catheter, and by implanting osmotic pumps intraperitoneally, respectively. Restoring the natural patterns of plasma growth hormone in animals devoid of pituitaries, re-initiated body growth. However, the body weight gains in both sexes of hypophysectomized rats were much greater when rat growth hormone was introduced to the animals in a masculine (pulsatile) pattern that appeared to be independent of pulse frequency, rather than in a continuous feminine profile. Subcutaneous injections, the most commonly reported method of administration, produced low-amplitude, long-lasting plasma peaks that were not as effective as pulse infusion in restoring growth. The procedure allows manipulation of the hormone profile (i.e. number of pulses/day, pulse amplitude, and through duration in the pulsatile pattern, and plasma concentration in the tonic pattern) in order to identify, and thus study the presumed salient components of the pattern regulating growth hormone responses.

scholarly journals Correlation between Body Mass Index and Thyroid Function in Euthyroid Individuals in Greece

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anastasios Milionis ◽  
Charalampos Milionis
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Thyroid Hormones ◽  
Body Mass ◽  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
The Body ◽  
Weight Changes ◽  
Normal Thyroid Function ◽  
The Relationship

Although the effects of hypothyroidism and hyperthyroidism on body weight have been clearly demonstrated, there is no sufficient data on the relationship between the body mass index (BMI) and minor differences within the normal range of thyroid function. The present study aims to investigate the relationship of fluctuations of the thyroid stimulating hormone (TSH) and thyroid hormones with BMI in euthyroid subjects. The study included 736 euthyroid healthy individuals of known age, weight, height, and biochemical picture of the thyroid function. Individuals were classified according to BMI and thyroid hormones’ values. The variations of normal thyroid function in euthyroid individuals were associated with body weight changes. A statistically significant positive correlation between BMI and thyroid function in women was found, while in men the correlation was not statistically significant. The alterations in thyroid function are mainly primary, while changes in body weight are secondary. The reason may be simple or multifactorial, and the biological mechanism is not completely known. Finally, the thyroid function disorders in conjunction with the strong influence of various environmental factors can increase body weight and lead to obesity.

ANDROGENIC PROPERTIES AND ADRENAL DEPRESSANT ACTIVITY OF MEGESTROL ACETATE OBSERVED IN CASTRATED MALE RATS

1975 ◽  
Vol 78 (2) ◽  
pp. 316-324 ◽  
Author(s):  
Lars-Eric Tisell ◽  
Håkan Salander
Keyword(s):  
Body Weight ◽  
Levator Ani ◽  
Seminal Vesicles ◽  
The Body ◽  
Megestrol Acetate ◽  
Male Rats ◽  
Levator Ani Muscle ◽  
Morphological Criteria ◽  
Prostatic Diseases ◽  
Higher Doses

ABSTRACT Megestrol acetate (17α-acetoxy-6-dehydro-6-methylprogesterone), a synthetic steroid with high progestational activity, is used in oral contraceptives but also in the treatment of prostatic diseases in man. To investigate whether megestrol acetate has any androgenic properties the growth of the ventral and dorsolateral prostate, the coagulating glands and the seminal vesicles was studied morphologically in castrated rats treated with megestrol acetate and in non-treated castrated rats. The effect of megestrol acetate on the body weight, the levator ani muscle and the adrenals was also studied. Megestrol acetate was administered in daily doses of 0.02 mg, 0.2 mg, 2.0 mg or 20.0 mg for a period of 21 days. Megestrol acetate in the two higher doses retarded growth and gave a low weight for the levator ani muscle at autopsy indicating an anti-anabolic or catabolic action of megestrol acetate in high doses. Megestrol acetate in daily doses of 0.2, 2.0 and 20.0 mg caused an involution of the adrenal glands. After the two higher doses the weight of the adrenals amounted to only about a third of that of the untreated rats. Megestrol acetate in the lower doses had no demonstrable effect on the growth of the accessory reproductive glands. After the two higher doses of megestrol acetate some growth of the dorsal part of the dorsolateral prostate and of the coagulating glands was observed. Only the seminal vesicles exhibited complete morphological criteria of an androgenic stimulation and then only after the largest dose of megestrol acetate. The investigation shows that megestrol acetate has weak androgenic properties which are apparent at a dose per kg body weight approximately 200 times greater than that used in the treatment of prostatic diseases in man.

Inulin and thiocyanate spaces of rat in starvation and undernutrition

1961 ◽  
Vol 201 (2) ◽  
pp. 329-333 ◽  
Author(s):  
Ashton B. Morrison
Keyword(s):  
Body Weight ◽  
Lean Body Mass ◽  
Body Mass ◽  
The Body ◽  
Male Rats ◽  
Normal Male ◽  
Free Access ◽  
Final Body Weight ◽  
Absolute Increase ◽  
Inulin Space

Inulin space and thiocyanate space determinations were made on three groups of male rats: the first group was chronically undernourished by feeding a restricted ration for 10 weeks, the second group was starved with free access to water, and the third was made up of normal male controls. The inulin space was found to expand relative to the final body weight or lean body mass in the undernourished animal. No absolute increase in inulin space took place. In starvation the inulin space did not change in proportion to the body weight and its absolute value decreased. The thiocyanate space relative to the final body weight or lean body mass expanded slightly but significantly in chronic undernutrition and in starvation, but no absolute increase of the thiocyanate space took place.

scholarly journals Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110110
Author(s):  
Wiraphol Phimarn ◽  
Bunleu Sungthong ◽  
Hiroyuki Itabe
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Body Mass ◽  
The Body ◽  
Current Evidence ◽  
Diabetic Patients ◽  
Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

scholarly journals Chinese Herbal Medicine Alleviates Thyroidectomy-Induced Cardiopulmonary Exercise Dysfunction in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Tai-Yuan Chuang ◽  
Chia-Ying Lien ◽  
Chih-Hsiang Hsu ◽  
Chen-Wen Lu ◽  
Chung-Hsin Wu
Keyword(s):  
Blood Flow ◽  
Body Weight ◽  
Negative Control ◽  
The Body ◽  
Male Rats ◽  
Free Triiodothyronine ◽  
Cardiopulmonary Exercise ◽  
Chinese Herbal ◽  
Subcutaneous Blood Flow ◽  
Tsh Levels

Hypothyroidism frequently causes cardiopulmonary dysfunction, such as heart failure and respiratory and metabolic deficiencies. This study investigated the effects of Chinese herbal formula B307 on thyroidectomy-induced cardiopulmonary exercise dysfunction in rats. Twenty male rats were equally divided into four groups: negative control with sham treatment, positive control with oral B307 treatment only, thyroidectomy treatment only, and thyroidectomy with B307 posttreatment groups. The feeding dose of B307 was 50 mg/kg per day for 14 days. We examined and then compared the thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4), and reactive oxygen species (ROS) from the blood of these four groups. Also, we compared the body weight, neck subcutaneous blood flow, cardiac ejection function, cardiopulmonary exercise function of oxygen consumption (VO2), carbon dioxide production (VCO2), and respiratory quotient (RQ = VCO2/VO2) among the four groups. Our results indicated that thyroidectomized rats had significantly decreased body weight, neck subcutaneous blood flow, cardiac ejection function, serum T3 and T4, and VO2 and VCO2, but had significantly increased ROS and TSH levels and RQ values compared with sham rats (P<0.01–0.05). In addition, thyroidectomized rats receiving oral B307 treatment had significantly increased body weight, neck subcutaneous blood flow, cardiac ejection function, and VO2, but significantly decreased ROS and TSH levels and VCO2 and RQ values compared with thyroidectomized rats (P<0.01–0.05). We suggest that the B307 could be a protective and beneficial alternative treatment for thyroidectomy-induced cardiopulmonary exercise dysfunction.

scholarly journals Morphometric characteristics of the patellar tendon

2016 ◽  
Vol 69 (suppl. 1) ◽  
pp. 53-58
Author(s):  
Milodrag Vranjes ◽  
Ivan Vukasinovic ◽  
Mirko Obradovic ◽  
Mile Bjelobrk ◽  
Zlatko Budinski ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Body Weight ◽  
Body Mass ◽  
Patellar Tendon ◽  
Cruciate Ligament ◽  
The Body ◽  
Professional Athletes ◽  
Morphometric Characteristics ◽  
Significant Difference ◽  
Anterior Cruciate

Introduction. The most common injuries of the knee joint are injuries of the anterior cruciate ligament. The golden standard in reconstruction of this ligament is graft bone - patellar tendon - bone. Knowing the morphometric characteristics of these ligaments is crucial for anterior cruciate ligament reconstruction. This study was aimed at determining morphometric characteristics of the patellar tendon in vivo, measured intraoperatively, and at defining the correlation between the obtained values and body weight, height, gender and sport activity among different groups of athletes. Material and Methods. This study included 184 patients suffering from anterior cruciate ligament injuries who were admitted to the Clinical Center of Vojvodina, Department of Orthopedics and Traumatology. Results. The patellar tendon width ranged from 28 mm to 43 mm, averaging at 32.02 mm. The length of the patellar tendon ranged from 35 mm to 62 mm, averaging at 46.34 mm. The thickness of the patellar tendon ranged from 3 mm to 6 mm, averaging at 3.78 mm. The measured results were positively and statistically relevant with the body mass, height and body mass index. Discussion and Conclusion. The patellar tendon was thicker, longer and wider in persons with higher values of body weight and height. Men have statistically longer, thicker and wider patellar tendon than women. There was no statistically significant difference between morphometric characteristics of the patellar tendon among professional athletes and recreational athletes, neither was there one in the obtained geometric data of the patellar tendon among tested groups of professional athletes.

scholarly journals Toxicity assessment of a technical product of the triazole class

2020 ◽  
Vol 99 (11) ◽  
pp. 1276-1279
Author(s):  
Valery N. Rakitskii ◽  
Tatiana M. Epishina ◽  
Elena G. Chkhvirkiya
Keyword(s):  
Body Weight ◽  
The Body ◽  
Male Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
High Biological Activity ◽  
Experimental Animals ◽  
Technical Product ◽  
White Rats ◽  
Toxicological Studies

Introduction. Historically, pesticides are evaluated more strictly from a medical point of view than other chemicals. Since their features, such as deliberate introduction into the environment, the possibility of contact with them by large masses of the population, and the high biological activity determine their potential danger to humans. Purpose of research - study of the biological effect of a technical product derived from triazoles when it is repeatedly ingested orally in mammals (rats), establishment of inactive and active doses, justification of the permissible daily dose (DSD) for humans. Material and methods. In acute experiments, white rats were used, including 6 animals in the group. Tested dose: 500-4000 mg/kg of body weight. A chronic (12 months) experiment was performed on 80 male rats with a bodyweight of 180-190 g at the beginning of the study. Tested doses: 5.0; 16.0 and 55.0 mg/kg of body weight (1 control and 3 experimental animals, 20 individuals each). In the dynamics of the experiment, we observed the condition and behavior of animals, water, and food consumption, recorded the timing of death, changes in body weight, physiological, biochemical, and hematological indices. Results. Indices of the acute oral toxicity on the studied product LD50 male rats were 2250 ± 483 mg/kg body weight. The dose of 5.0 mg / kg of body weight was not found to cause significant changes in all studied indices. The doses of 16.0 and 55.0 mg/kg of body weight had a polytropic effect on the body in experimental animals. Discussion. The studied product for the acute oral toxicity refers to low-hazard compounds, the doses of 16.0 and 55.0 mg/kg of body weight has a polytropic effect on the mammalian body, causing changes in carbohydrate, lipid, and lipoprotein metabolism in the body of rats - was accepted as acting. The dose of 5.0 mg / kg of body weight, when administered in rats, there are no changes in all the studied parameters throughout the experiment, is accepted as invalid. Based on the inactive dose-5.0 mg/kg of body weight and taking into account the reserve factor of 100, we have scientifically justified DSD for a person at the level of 0.05 mg/kg. Summary. The conducted sanitary and Toxicological studies indicate the need to assess the toxicity of new technical products to the mammalian body, to increase the reliability of the developed hygiene standards in environmental objects and food products.

scholarly journals Pertambahan Bobot Badan dan Waktu Pembusukan Daging Ayam Broiler yang Diberi Ekstrak Jaloh Dikombinasi dengan Kromium

2010 ◽  
Vol 10 (2) ◽  
pp. 21-26
Author(s):  
Sugito Sugito ◽  
Erdiansyah Rahmi ◽  
Azhari Azhari ◽  
M. Isa
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Heat Stress ◽  
Broiler Chickens ◽  
Room Temperature ◽  
The Body ◽  
Feed Ratio ◽  
Treatment Groups ◽  
Randomized Design ◽  
Completely Randomized Design

The gain body weight and Spoilage of meat broiler which giving jaloh extract to combine with chromiumABSTRACT. A study was conducted on broiler chickens under heat stress to evaluate the effect of combined jaloh (Salix tetrasperma Roxb) extract with chromium mineral in the body weight, value of feed ratio conversion, and time to meat to become decomposed. Twenty four of 20-day old Cobb female broiler chickens were randomly assigned and divided to 4 treatment groups. Completely randomized design was used in this study. The treatments were as follows: 1) chickens given no heat stress and jaloh extract nor chromium (tCp); 2) chickens under heat stress without given jaloh extract nor chromium (Cp); 3) chickens under heat stress and given jaloh extract in 1.000 mg/lt drinking water (Cp+Ej); and 4) chickens under heat stress, given jaloh extract in 1.000 mg/lt drinking water, and chromium in 1.000 ug/lt drinking water (Cp+Ej+Cr). Heat stress given was 33 ± 1oC of cage temperature during 4 hours per day within 15 days. Jaloh extract and chromium treatments in drinking water were given at 2 hour before cage temperature reaching 33 ± 1oC and were stopped being given after 1 hour, when cage temperature back to room temperature. On the 16th day of the study chickens were measured before slaughtered. Samples obtained were chicken meat that taken from breast part (musculus pectoralis). The result suggested that either giving jaloh extract per se at the dose of 1.000 mg/lt in drinking water or combine it with chromium that given two hours before cage temperature reaching 33 ± 1oC, can prevent chickens from decreasing their body weight, decreasing value of feed ratio convertion, and extending time to meat to become decomposed.

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